CN114533659B - Angle-removing paste and preparation method and use method thereof - Google Patents

Angle-removing paste and preparation method and use method thereof Download PDF

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CN114533659B
CN114533659B CN202210229696.XA CN202210229696A CN114533659B CN 114533659 B CN114533659 B CN 114533659B CN 202210229696 A CN202210229696 A CN 202210229696A CN 114533659 B CN114533659 B CN 114533659B
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parts
horn
paste
fillet
ointment
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CN114533659A (en
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李杰超
冯小宇
陈琛
彭蓉
魏园园
杨作丰
李怀阳
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Beijing Dayou Tailai Biotechnology Co ltd
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Beijing Dayou Tailai Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

The invention discloses a horn-removing paste and a preparation method and a use method thereof. The paste for removing the horn consists of 1000 to 1200 parts of deionized water, 370 to 390 parts of sodium hydroxide powder, 830 to 850 parts of calcium hydroxide powder and 330 to 350 parts of glycerol. The preparation method of the fillet removing paste obtains a product with better quality by constraining the material mixing sequence, the material mixing speed and the material mixing temperature. The application method of the fillet removing ointment controls the usage amount and the drug effect area of the fillet removing ointment by designing and using a specific ointment packaging structure, and can effectively prevent the fillet removing ointment from corroding the surrounding tissues of the ox horn while being convenient for a user to operate. The horn-removing paste has proper dispersibility, viscosity and humidity, is not easy to flow, and contains an astringent which can effectively reduce exudation of tissue fluid, effectively avoid excessive corrosion of alkaline components of the horn-removing paste to tissues around horns of calves, and avoid triggering stress reaction. The use method of the angle-removing paste designed by the invention can further prevent alkali liquor from overflowing and excessive corrosion.

Description

Angle-removing paste and preparation method and use method thereof
Technical Field
The invention relates to the technical field of veterinary medicines, and particularly relates to a horn-removing paste as well as a preparation method and a use method thereof.
Background
The horn-removed cattle tend to be more quiet and easier to manage, and the risk of damaging human beings or other animals by the cattle can be reduced. Currently, the methods for removing the horn of cattle in the industry mainly comprise three methods, namely a thermal burning method, a mechanical method and a chemical burning method. The main principle of removing horn by using the horn removing paste is to burn the horn tissue to cause necrosis by using the strong alkali component in the horn removing paste. The cattle raising feed is popular among farmers because of convenient use and less pain to cattle, and the market demand is increasing in recent years.
However, the adoption of the fillet removing paste widely sold on the market has the following defects:
(1) Excessive corrosion is easily caused: the horned removing paste is added with excessive strong alkali components to enhance the horned removing effect, the fluidity of the horned removing paste is enhanced by the horned removing paste, and tissue fluid exuded by calves in the corrosion process can also enhance the fluidity of the horned removing paste, so that the calves are easy to burn around tissues, and further fester, hemorrhage and infection are caused; the horny removing paste containing a large amount of strong alkali components can burn the dermis layer below the horny layer if the horny removing paste is applied in a large amount, so that calf pain is increased; the alkaline components can cause burn and blindness when flowing into calf eye; excessive corrosion of the alkaline component to the dermis or hypodermis of the calf can cause stress reaction of the calf due to pain.
(2) Isolation needs to be performed strictly: the calves using the horn-removing paste need to be isolated independently, so that poisoning caused by other calves licking the horn-removing paste is prevented, and the horn-removing paste is prevented from being rubbed off by the calves; the alkaline components in the fillet removing paste are very easy to dissolve in water and corrode the surrounding tissues of the ox horn, so strict water resistance is required; the new born calf may rub the horn-removing cream on the cow breast to cause mastitis, which makes the calf troublesome to eat breast milk; the portion rubbed off with the keratolytic cream is highly likely to grow out of the cornea.
(3) Has higher requirements on the operation experience: all the fillet removing pastes on the market do not have corresponding quantitative and positioning smearing devices, an operator smears the fillet removing pastes too much or the smearing position has deviation to cause excessive corrosion, and the fillet removing effect is poor if the smearing position is too little.
Therefore, how to research a fillet-removing paste with proper corrosion components, scientific preparation method and convenient use method becomes a technical problem to be solved urgently by the technical personnel in the field.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a corner removing paste with proper corrosive components, convergence components, dryness, humidity and viscosity so as to solve the technical problems of overhigh strong base component, overhigh fluidity and excessive corrosion to ox horn surrounding tissues in the prior art.
The second purpose of the invention is to provide a preparation method of the fillet removing paste, which uses the components of the invention as raw materials and obtains products with better quality by restricting the mixing sequence, the mixing speed and the mixing temperature. The method can effectively ensure the drug effect of the obtained product, and the preparation process is simple and easy to master.
The third purpose of the invention is to provide a using method of the fillet removing cream, which can effectively prevent the fillet surrounding tissues from being corroded by the fillet removing cream while being convenient for a user to operate by designing and using a specific ointment packaging structure and controlling the using amount and the drug effect area of the fillet removing cream.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides a corner removing paste which is prepared from the following raw materials in parts by weight: 1000 to 1200 parts of deionized water, 370 to 390 parts of sodium hydroxide powder, 830 to 850 parts of calcium hydroxide powder and 330 to 350 parts of glycerol.
Optionally, in the invention, the raw material of the fillet-removing paste further comprises 4 to 7 parts of iron oxide micropowder.
Optionally, in the invention, the raw materials of the angle-removing paste further comprise 20 to 30 parts of an astringent.
Optionally, in the present invention, the astringent includes 10 to 15 parts of an organic solvent and 10 to 15 parts of an astringent micro powder.
Optionally, in the present invention, the astringent micro powder includes one or more of schisandra chinensis micro powder and smoked plum micro powder.
Optionally, in the invention, the raw materials of the angle-removing paste also comprise 20 to 30 parts of traditional Chinese medicine with the functions of removing necrosis, promoting granulation and diminishing inflammation.
Optionally, in the invention, the traditional Chinese medicine preparation comprises 10 to 15 parts of organic solvent and 10 to 15 parts of traditional Chinese medicine micro powder.
Optionally, in the invention, the traditional Chinese medicine micro powder comprises one or more of radix angelicae micro powder and radix astragali micro powder.
The invention also provides a preparation method of the angle-removing paste, which comprises the following steps:
s1, dissolving 370-390 parts of sodium hydroxide powder in 1000-1200 parts of deionized water to prepare a sodium hydroxide solution;
s2, adding the total sodium hydroxide solution prepared in the step S1, 830-850 parts of calcium hydroxide powder and 330-350 parts of glycerol into a stirrer, and stirring until the mixture is fine and has no particles;
s3, adding 4-7 parts of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding 20-30 parts of astringent into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the corner-removing ointment.
Optionally, in the invention, the stirrer in the steps S2 to S4 has sealing, heating and cooling functions, the stable working rotating speed of the blades of the stirrer ranges from 200 to 600r/min, and the stirring temperature ranges from 40 to 60 ℃.
The invention also provides a using method of the fillet removing paste, the fillet removing paste is packaged in a cavity which is made of materials with alkali corrosion resistance, water resistance and ductility, the appearance structure of the cavity is matched with the horn of the calf, a sticking layer is arranged on the periphery of the bottom of the cavity, and bottom film layers which are easy to uncover are arranged at the bottom of the cavity and the bottom of the sticking layer; when the horn removing cream is used, hair around horn is shaved off, the basement membrane layer is torn off, the chamber is pressed on horn of calf, and the adhesive layer is adhered to tissue around horn of calf.
Optionally, in the present invention, an absorbent cotton is disposed between the chamber and the adhesive layer, an isolation layer is disposed between the chamber and the absorbent cotton, the absorbent cotton contains a medicament, the medicament includes one or more of an antibacterial agent, an anti-inflammatory agent, and an astringent, and the adhesive layer is disposed around the absorbent cotton.
Optionally, in the invention, the medicament is weakly acidic, and alum is contained in the medicament.
Optionally, in the invention, the horn-removing paste is applied to horn removal of calves born for 2 to 3 days.
The invention can be used for removing horn of newborn calf, newborn sheep and other newborn bovidae animals, and can be used in large-scale breeding scenes (pastures) and free-ranging scenes.
Compared with the prior art, the invention has the beneficial effects that:
(1) By adopting the components and the preparation method of the fillet removing paste designed by the invention, the iron oxide added in the fillet removing paste has the functions of convergence and warning; the effective components in the horn-removing paste have high dispersibility and can be closely contacted with the horny layer, so that the required dosage of sodium hydroxide in the invention is far less than that of the commercially available products, and the damage to the tissues around the horn of the calf is small; the paste has proper viscosity and humidity and is not easy to flow, and the astringent contained in the paste can effectively reduce the exudation of tissue fluid and effectively avoid the corrosion of the alkaline components of the paste on the peripheral tissues of the horn of the calf; the astringent contained in the angle-removing paste is prepared from an organic solvent and astringent micropowder, and as the alkaline component in the angle-removing paste is insoluble in the organic solvent, the medicinal component in the astringent micropowder can be retained to the maximum extent; the strong alkali component of the keratolytic paste has good dispersibility and high viscosity, so the strong alkali component can fully react with the cuticle, and the strong alkali component has complete reaction when the keratolytic paste is corroded to the dermis, so the components for astringing, removing the necrotic tissue, promoting tissue regeneration and diminishing inflammation can play a role, and the corrosion rate is further reduced; the possibility that stress reaction is generated due to pain of the calf is low, the possibility that the ointment is rubbed off by the calf can be reduced, and the horn removal success rate is further ensured.
(2) By adopting the application method of the horn removing paste designed by the invention, the cavity structure is matched with the horn of the calf, and the excessive gas in the cavity can be discharged as much as possible after the absorbent cotton is compacted, so that the horn removing paste is convenient to fix; the weakly acidic medicament contained in the absorbent cotton can neutralize the alkaline components in the keratomile removal ointment to prevent the alkaline ointment from exosmosis; the antibacterial agent, the anti-inflammatory agent and the astringent contained in the medicament can effectively relieve the injury of the horn-removing ointment to the peripheral tissues of the horn of the calf, and effectively prevent the ulcer, bleeding and infection of the peripheral tissues of the horn of the calf; the calves can move normally after the absorbent cotton and the cavity are fixed by the surface film layer and the adhesive layer with waterproof functions, and the adverse effect on the production of eating breast milk by the calves is avoided; the dosage and the positioning of the fillet removing paste can be effectively controlled, the standardized operation of operators is convenient, and the requirement on the operation experience level of the operators is low; each packaging structure can be used for one calf horn, and waste caused by failure due to long-term use after the fillet removing paste is unpacked does not exist; the alum contained in the absorbent cotton medicament has an astringent effect, and the alum can react with sodium hydroxide alkali liquor to generate precipitate, so that the fluidity of alkaline components in the keratolytic paste is effectively reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a first cross-sectional view of a corner-removed paste package;
FIG. 2 is a cross-sectional view of a second embodiment of a corner-removed paste package;
fig. 3 is a bottom view of fig. 2.
In the figure: 1-surface film layer; 2-a sticking layer; 3-raising; 4-an isolation layer; 5-a circular chamber; 6-an annular chamber; 7-primer layer.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The term "comprising" as used in the embodiments of the present invention means that it may include other components in addition to the components, which impart different characteristics to the fillet paste. In addition, the ' including ' in the embodiment of the invention can be replaced by a closed ' being ' or ' consisting of ' 8230 ' \8230 '; and a composition '.
According to one aspect of the invention, the invention provides a corner removing paste which is prepared from the following raw materials in parts by weight: 1000 to 1200 parts of deionized water, 370 to 390 parts of sodium hydroxide powder, 830 to 850 parts of calcium hydroxide powder and 330 to 350 parts of glycerol.
Sodium hydroxide is the most key component for removing calves, and the removal of calves by rod-shaped sodium hydroxide is reported in the early nineties of the last century in China, but the sodium hydroxide is very soluble in water and interstitial fluid exuded from horn embryos due to high alkalinity, so that the condition that the facial skin and even eyes of calves are corroded frequently occurs.
Although calcium hydroxide has certain corrosiveness, the removal effect of the calcium hydroxide on the ox horn cuticle is not obvious, and the calcium hydroxide is mainly added to prepare a paste with certain viscosity from a sodium hydroxide solution.
The glycerin can effectively dissolve the sodium hydroxide, can play a moisturizing role, and the sodium hydroxide can be in close contact with the horny layer under the action of the glycerin, so that the chamfering effect can be good under the condition that the content of the sodium hydroxide is less than that of similar products in the market.
In a preferred embodiment of the invention, the raw material of the fillet-removing paste further comprises 4 to 7 parts of iron oxide micro powder.
On one hand, the iron oxide can be used as a toner to enable the whole body of the fillet removing paste to be red, which is helpful for warning operators, and on the other hand, the iron oxide added in the invention also has a certain effect of astringing wounds.
In a preferred embodiment of the invention, the raw materials of the angle-removing paste further comprise 20 to 30 parts of an astringent.
In a preferred embodiment of the present invention, the astringent includes 10 to 15 parts of an organic solvent and 10 to 15 parts of an astringent fine powder.
In a preferred embodiment of the present invention, the astringent micro powder comprises one or more of schisandra micro powder and dark plum micro powder.
In a preferred embodiment of the invention, the raw materials of the angle-removing paste further comprise 20 to 30 parts of traditional Chinese medicine with the functions of removing necrosis, promoting granulation and diminishing inflammation.
In a preferred embodiment of the invention, the traditional Chinese medicine preparation comprises 10 to 15 parts of organic solvent and 10 to 15 parts of traditional Chinese medicine micro powder.
In a preferred embodiment of the invention, the Chinese medicine micro powder comprises one or more of radix angelicae micro powder and radix astragali micro powder.
The organic solvent can be diethyl ether or dichloromethane insoluble with sodium hydroxide; chinese magnoliavine fruit, dark plum fruit, dahurian angelica root, astragalus and other Chinese medicinal micro powder with the functions of astringency, diminishing inflammation, removing necrotic tissue and promoting tissue regeneration are mixed with an organic solvent and then added into the horn-removing paste, so that the medicinal value of the horn-removing paste can be exerted after the horn-removing rapid reaction stage is finished. Meanwhile, the basic component in the angle-removing paste is difficult to dissolve in an organic solvent, so that the medicinal effect of the medicinal component can be maintained to the maximum extent after encapsulation.
According to another aspect of the present invention, the present invention also provides a method for preparing the above-mentioned fillet removing paste, comprising the steps of:
s1, dissolving 370-390 parts of sodium hydroxide powder in 1000-1200 parts of deionized water to prepare a sodium hydroxide solution;
s2, adding the total sodium hydroxide solution prepared in the step S1, 830-850 parts of calcium hydroxide powder and 330-350 parts of glycerol into a stirrer, and stirring until the mixture is fine and has no particles;
s3, adding 4-7 parts of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding 20-30 parts of astringent into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the fillet-removing ointment.
In a preferred embodiment of the invention, the stirrer has sealing, heating and cooling functions in the steps S2 to S4, the stable working rotating speed of the blades of the stirrer is 200 to 600r/min, and the stirring temperature is 40 to 60 ℃.
According to the preparation method of the fillet removing paste, disclosed by the invention, the product with better quality (including viscosity, dryness and humidity and dispersity) can be obtained by restricting the mixing sequence, the mixing speed and the mixing temperature.
According to another aspect of the invention, the invention further provides a using method of the fillet removing paste, the fillet removing paste is packaged in a cavity made of materials with alkali corrosion resistance, water resistance and ductility, the shape structure of the cavity is matched with the horn of the calf, a sticking layer is arranged on the periphery of the bottom of the cavity, and bottom film layers which are easy to uncover are arranged at the bottom of the cavity and the bottom of the sticking layer; when the horn removing cream is used, hair around horn is shaved off, the basement membrane layer is torn off, the chamber is pressed on the horn, and the adhesive layer is adhered to the tissue around horn.
The chamber material can be selected from various common rubbers, plastics and the like; the chamber can be designed to be dome-shaped; for firm adhesion, the adhesive layer can be selected from silica gel, non-setting adhesive, foam cotton adhesive, etc.; the adhesive layer can also be a magic tape, can be conveniently adhered to the cow hair, and can be repeatedly used.
In a preferred embodiment of the invention, absorbent cotton is arranged between the cavity and the adhesive layer, an isolation layer is arranged between the cavity and the absorbent cotton, the absorbent cotton contains medicament, the medicament comprises one or more of an antibacterial agent, an anti-inflammatory agent and an astringent, and the adhesive layer is arranged around the absorbent cotton.
In a preferred embodiment of the invention, the agent is weakly acidic and comprises alum.
The weak acidity of the medicament can be achieved by selecting acidic antibacterial, anti-inflammatory, astringent agents, such as salicylic acid; or other acidity regulators which stably coexist with the active ingredients of the medicament can be adopted; the weakly acidic medicament can neutralize alkali liquor which is externally permeated by the keratolytic ointment; the alum contained in the absorbent cotton medicament has an astringent effect, and the alum can react with sodium hydroxide alkali liquor to generate precipitate, so that the fluidity of alkaline components in the keratolytic paste is effectively reduced.
In a preferred embodiment of the invention, the fillet removing cream is applied to remove the fillet of calves born for 2 to 3 days.
The pain of the calves born for 2 to 3 days is less when the cornucopia eliminating cream is used because the nerve development is not completely established. The external application of the horn-removing paste to calves born for 2 to 3 days is easy to operate, the dosage of the horn-removing paste can be correspondingly reduced, and the cost can be saved. However, the calf born for 2 to 3 days is not very painful, so the dosage of the strong alkali component needs to be accurately controlled, otherwise, excessive corrosion may threaten the health and life of the newborn calf.
When the horn-removing paste is used for calves of a large age, a veterinarian is difficult to keep the head of the calves stable, assistance is needed, and the labor cost is increased. The existing horn-removing paste sold on the market is mostly used for removing horns of calves with the age of more than 7 days, because the horn-removing paste has high content of strong alkali components, poor dispersibility and high fluidity, and is easy to excessively corrode the surrounding dermis of the oxhorn, so that infection, injury and intracranial inflammation are caused, and the health hazard to the calves within one week of birth is great.
The technical principle of the horn removal of the invention is that the epidermal germinal layer of the horn primordium is destroyed by alkaline components, so that the horn primordium does not have the capability of differentiating horny layer cells any more, and the horn removal of calves is realized. Because the lower part of the epidermis occurrence layer is the dermis layer and the physiological structure of the target position is continuously changed along with the increase of the day age of calves, the using time and the using amount of the horn removing cream need to be well grasped.
In the aspect of a using method, the invention designs the packaging structure capable of realizing the quantitative and positioning smearing of the fillet removing paste and the using method, so that the fillets of calves of a specified age can be better removed.
In the aspects of components and preparation methods, the invention firstly reduces the dosage of the strong alkali component by increasing the dispersibility and viscosity of the strong alkali component, and secondly reduces the damage to the dermis by adding the components for astringency, removing the necrotic tissue, promoting tissue regeneration and diminishing inflammation. When the angle-removing paste is used, the alkaline component can be closely contacted with the horny layer and fully reacts, and when the strong alkali component is fully consumed when the horny layer is corroded, the angle-removing paste plays a role in astringing, removing the necrotic tissue, promoting granulation and diminishing inflammation, so that the corrosion rate is reduced. Because the invention has less damage to the dermis layer of the calf, the stress reaction is not easy to trigger, and the infection is not caused, the horn of the calf born for 2 to 3 days can be relieved.
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Example 1
The fillet-removing paste provided by the embodiment of the invention comprises the following raw material components in parts by weight:
1000g of deionized water, 370g of sodium hydroxide powder, 830g of calcium hydroxide powder, 330g of glycerol, 4g of iron oxide micro powder, 10g of dichloromethane and 10g of schisandra chinensis micro powder.
The preparation method comprises the following steps:
s1, dissolving 370g of sodium hydroxide powder in 1000g of deionized water to prepare a sodium hydroxide solution;
s2, adding the sodium hydroxide solution prepared in the step S1, 830g of calcium hydroxide powder and 330g of glycerol into a stirrer, and stirring until the sodium hydroxide solution, the calcium hydroxide powder and the glycerol are fine and smooth and have no particles;
s3, adding 4g of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding an astringent prepared from 10g of dichloromethane and 10g of schisandra chinensis micro powder into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the horn-removing ointment.
Example 2
The fillet-removing paste provided by the embodiment of the invention comprises the following raw material components in parts by weight:
1200g of deionized water, 390g of sodium hydroxide powder, 850g of calcium hydroxide powder, 350g of glycerol, 7g of iron oxide micro powder, 15g of dichloromethane and 15g of dark plum micro powder.
The preparation method comprises the following steps:
s1, dissolving 390g of sodium hydroxide powder in 1200g of deionized water to prepare a sodium hydroxide solution;
s2, adding the sodium hydroxide solution prepared in the step S1, 850g of calcium hydroxide powder and 350g of glycerol into a stirrer, and stirring until the sodium hydroxide solution, the calcium hydroxide powder and the glycerol are fine and smooth and have no particles;
s3, adding 7g of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding an astringent prepared from 15g of dichloromethane and 15g of schisandra chinensis micro powder into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the horn-removing ointment.
Example 3
The fillet-removing paste provided by the embodiment of the invention comprises the following raw material components in parts by weight:
1100g of deionized water, 380g of sodium hydroxide powder, 840g of calcium hydroxide powder, 340g of glycerol, 5g of iron oxide micro powder, 12g of dichloromethane, 6g of schisandra chinensis micro powder and 6g of dark plum micro powder.
The preparation method comprises the following steps:
s1, dissolving 380g of sodium hydroxide powder in 1100g of deionized water to prepare a sodium hydroxide solution;
s2, adding the sodium hydroxide solution prepared in the step S1, 840g of calcium hydroxide powder and 340g of glycerin into a stirrer, and stirring until the mixture is fine and has no particles;
s3, adding 5g of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding a astringing agent prepared from 12g of dichloromethane, 6g of schisandra chinensis micro powder and 6g of dark plum micro powder into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the horn-removing ointment.
Example 4
As shown in FIGS. 1 to 3, the application method of the angle-removing paste of the embodiment of the invention is as follows:
the fillet removing paste prepared in example 1 was packaged in a fillet removing patch of a specific structure. The corner removing plaster comprises a surface film layer 1, wherein a sticking layer 2 is arranged at the bottom of the edge of the surface film layer 1, a bulge 3 is arranged in the middle of the surface film layer 1, the bulge 3 is divided into a circular cavity 5 and an annular cavity 6 by an isolation layer 4, the surface film layer 1 is connected with a bottom film layer 7 through the sticking layer 2 and the isolation layer 4, a certain amount of corner removing plaster is filled in the circular cavity 5, and absorbent cotton is filled in the annular cavity 6; the surface film layer 1, the isolation layer 4 and the bottom film layer 7 are plastic film layers; the adhesive layer 2 is a non-dry adhesive layer; the bulge 3 is a circular arc bulge; the absorbent cotton contains medicinal preparation, which comprises antibacterial agent, antiinflammatory agent, astringent, salicylic acid, and Alumen, and has weak acidity; for convenient observation, the plastic film layer in this embodiment is a transparent plastic film.
When the horn removing cream is used, firstly, hairs around the horns are shaved, the basement membrane layer 7 is torn, the circular cavity 5 is aligned and pressed on the horns of the calves, and the adhesive layer 2 is adhered to tissues around the horns of the calves; because the circular cavity 5 that the plastics rete constitutes has the ductility, and the inside air can be got rid of as far as possible after the compaction of circular cavity 5, and the appearance structure can agree with the calf horn, and then makes the angle cream can contact closely with the ox horn cuticle.
Comparative example 1
The difference from example 1 is that no astringent was added.
Comparative example 2
The difference from example 2 is that the original astringent was replaced by an astringent made from 15g of deionized water and 15g of alum.
Comparative example 3
The difference from the embodiment 3 is that the original astringent is replaced by an astringent prepared by 12g of deionized water, 6g of schisandra chinensis micropowder and 6g of dark plum micropowder.
Comparative example 4
The nominal content of sodium hydroxide of a certain brand of fillet removing paste purchased from the market is more than 30 percent.
Performance test
The following tests were carried out on the fillets obtained in the above examples and comparative examples:
selecting 80 calves born for 2 to 3 days in 5 to 6 months, grouping every 10 calves, using the angle-removing paste of the same embodiment or comparative example for the left and right angles of the same group of calves, and dividing the angle-removing paste into 8 groups, wherein each group has 20 angles. Examples 1 to 3 and comparative examples 1 to 4 were applied by a veterinarian with a high experience in operation, and example 4 was applied by a feeder who never used a fillet-removing paste, which was prepared 1 month before. Isolating calves in a rain sheltering space 72 hours after the horn removing paste is used, and observing the condition of calf horn and peripheral tissue fluid exosmosis, the time for starting wound scabbing, whether stress reaction occurs or not (mainly various pain manifestations and poor feeding condition and poor rest and other manifestations caused by pain) once in two hours; after 2 months of using the cream, whether the horn removal was successful (whether ox horn grew) and whether hair grew on the horn-removed part were observed.
The test records are shown in table 1:
TABLE 1 Dekeratinizing cream usage test record
Figure 803001DEST_PATH_IMAGE001
The results show that the gonioapparatus prepared by the schemes of the embodiments 1 to 4 of the invention can control the extravasation of tissue fluid within 1cm, the scabbing time within 1 day, and the stress reaction can not be triggered, so that the excessive corrosion injury of alkaline liquor to the dermis layer and subcutaneous tissue of calves can be fully avoided; because the pain of the calf can be relieved, the possibility that the horn-removing ointment is rubbed off by the calf is further reduced, and the success rate of horn removal is high.
The application of the horn-removing ointment according to the method of the embodiment 4 of the invention has the best effect on controlling the wound of the calf, and can effectively prevent the alkali liquor from overflowing and the wound from being infected. The use of the angle-removing paste of the invention in the examples 1 to 3 is better than the angle-removing paste of the comparative examples 1 to 4 in terms of preventing the tissue fluid from seeping out and shortening the scab forming time, while the effect of the comparative example 3 is better than that of the comparative examples 1 to 2, which shows that the inorganic astringent (alum) is difficult to exert the effect due to the reaction with the alkali liquor, the Chinese medicinal astringent micro powder has certain effects on preventing the tissue fluid of calves from seeping out and shortening the scab forming time, and the mode of combining the organic solvent and the Chinese medicinal astringent micro powder can exert the wound astringing effect better.
Due to the high content and high fluidity of the strong alkali components of the prior fillets sold on the market, the commercial products of the fillets are mostly indicated to be used for calves with more than 7 days (because the calves with less than 7 days are corroded by the fillets more easily to cause infection, diseases and even death). In the performance test of the invention, the object of applying the angle-removing cream is the calf born for 2 to 3 days, the strong corrosion component of the comparative example 4 ensures that all 10 calves in the experimental group generate stress reaction, but no calf generates stress reaction in the experimental groups of the invention examples 1 to 4, which shows that the invention examples 1 to 4 have obvious effect on preventing the stress reaction of newborn calves.
Evaluation of the area after two months where the keratolytic composition was applied to develop hairs revealed that the keratolytic composition corroded the dermis layer, since the hair follicle was in the dermis layer, and if no hairs developed after two months, it indicated that the keratolytic composition had caused excessive corrosion of the dermis layer beneath the stratum corneum layer. In the examples 1 to 4 of the present invention and the comparative examples 1 to 3, no hair was produced, this indicates that the present invention is less corrosive to calf dermis when removing horn.
In conclusion, the horn removing paste has proper dispersibility, viscosity and humidity and is not easy to flow, and the astringent contained in the horn removing paste can effectively reduce the exudation of tissue fluid and effectively avoid the excessive corrosion of the alkaline components of the horn removing paste to the tissues around the horn of the calf. The use method of the fillet removing paste designed by the invention can further prevent alkali liquor from overflowing and excessive corrosion, can avoid triggering stress reaction, and has high fillet removing success rate.
While particular embodiments of the present invention have been illustrated and described, it would be obvious that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (3)

1. The fillet removing paste is characterized by being prepared from the following raw materials in parts by weight: 1000 to 1200 parts of deionized water, 370 to 390 parts of sodium hydroxide powder, 830 to 850 parts of calcium hydroxide powder, 330 to 350 parts of glycerol, 4 to 7 parts of iron oxide micropowder and 20 to 30 parts of astringent; the astringent comprises 10 to 15 parts of dichloromethane and 10 to 15 parts of convergence micropowder; the convergence micropowder is one or two of fructus Schisandrae micropowder and mume fructus micropowder.
2. A method of preparing the above-described paste according to claim 1, wherein the method comprises the steps of:
s1, dissolving 370-390 parts of sodium hydroxide powder in 1000-1200 parts of deionized water to prepare a sodium hydroxide solution;
s2, adding the total sodium hydroxide solution prepared in the step S1, 830-850 parts of calcium hydroxide powder and 330-350 parts of glycerol into a stirrer, and stirring until the mixture is fine and has no particles;
s3, adding 4-7 parts of iron oxide micro powder into the ointment prepared in the step S2, and uniformly stirring;
and S4, adding 20-30 parts of astringent into the ointment prepared in the step S3, uniformly stirring, cooling to room temperature, and packaging to obtain the corner-removing ointment.
3. The preparation method according to claim 2, wherein the stirrer has sealing, heating and cooling functions in steps S2-S4, the stable working speed of the blades of the stirrer is 200 to 600r/min, and the stirring temperature is 40 to 60 ℃.
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