CN114532534A - Preparation method of granules containing tea polyphenol - Google Patents
Preparation method of granules containing tea polyphenol Download PDFInfo
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- CN114532534A CN114532534A CN202111638641.6A CN202111638641A CN114532534A CN 114532534 A CN114532534 A CN 114532534A CN 202111638641 A CN202111638641 A CN 202111638641A CN 114532534 A CN114532534 A CN 114532534A
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- 235000013824 polyphenols Nutrition 0.000 title claims abstract description 48
- 150000008442 polyphenolic compounds Chemical class 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 241001122767 Theaceae Species 0.000 title description 39
- 239000000284 extract Substances 0.000 claims abstract description 60
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 21
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- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 2
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- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a preparation method of granules containing tea polyphenol, which comprises the steps of preparing an extract, modifying a liquorice extract, preparing a paste, drying, finishing and the like. The granule adopts tea polyphenol, radix astragali and modified Glycyrrhrizae radix as main components, has a more reasonable formula, and has synergistic effect of tea polyphenol and radix astragali, and is an gram of radioactive substance. Moreover, the preparation process of the granules has the advantages of simple process, short time consumption, low cost and the like, and the obtained product has high content of effective components, less impurities and good market prospect.
Description
Technical Field
The invention relates to a preparation method of granules, in particular to a preparation method of granules containing tea polyphenol.
Background
The traditional medication mode of the traditional Chinese medicine clinical treatment is mainly traditional Chinese medicine decoction, but the decoction is too big in bags and inconvenient to carry, so that the requirement of modern society for quick life cannot be met, on the basis of ensuring the product effect, the traditional Chinese medicine granules developed in recent years become popular preparations, the concentrated granules of single traditional Chinese medicine are prepared through the procedures of extraction, separation, concentration, drying, granulation, packaging and the like, the clinical effect is good, the traditional Chinese medicine granules have the advantage of easy storage and carrying, and great convenience is brought to important popularization and promotion.
The traditional granulation method is wet granulation, auxiliary materials such as adhesive and the like are added into product powder, and the powder is gathered together by the bridging or bonding action of the adhesive to prepare granules. The method has the advantages of beautiful appearance, good fluidity, good wear resistance, outstanding forming performance and the like.
Tea polyphenol is a natural product extracted from tea, the main component is a polyphenol compound using flavanol as a matrix, EGCG is the main component, accounts for about 30-50%, and the tea polyphenol has the effects of resisting bacteria, viruses and oxidation, preventing and treating cardiovascular and cerebrovascular diseases, senile neurodegenerative diseases and the like, and can also be used as an anti-radiation substance in a specific environment. However, most of the tea polyphenol granules obtained by the existing wet granulation are used as antibacterial and antiviral products, and the effect on radiation resistance is not obvious, so the biggest reason for causing the problem may be as follows: the radiation-resistant active ingredients in the product are not fully utilized and released in the traditional wet granulation process, so that the radiation-resistant effect is greatly reduced.
In view of the above, in order to further develop the efficacy of tea polyphenol granules, it is necessary to optimize and innovate the preparation method thereof.
Disclosure of Invention
In order to solve the defects of the prior art, the invention aims to provide the preparation method of the granules containing tea polyphenol, and the granules obtained by the method have better radiation resistance, and have multiple advantages of simple process, short time consumption, high efficiency, low cost and the like.
In order to achieve the above object, the present invention adopts the following technical solutions:
a preparation method of granules containing tea polyphenol comprises the following steps:
s1, preparing a tea polyphenol extract, an astragalus extract and a liquorice extract;
s2, modifying the licorice extract: adding NaOH solution into the licorice extract prepared in the step S1, adjusting the pH value of the mixed solution to 7.5-8.5, ultrasonically stirring for 2 hours at room temperature, separating and purifying at high speed, and filtering to remove precipitates to obtain a modified licorice extract;
s3, adding a proper amount of tea polyphenol extract, astragalus extract, modified liquorice extract and water into a container, stirring and heating to 50-60 ℃, continuously inputting air into the container, continuously stirring and keeping the temperature for 1-2 hours, naturally cooling to room temperature, filtering and concentrating to paste;
s4, adding auxiliary materials into the paste prepared in the step S3, uniformly mixing, drying, granulating and packaging to obtain the product.
Preferably, in step S1, the extracts are prepared one by one, and the specific extraction method is as follows: soaking the corresponding raw materials (tea polyphenol, astragalus and liquorice) one by one, decocting and extracting at the extraction temperature of 80-120 ℃, and performing solid-liquid separation after decoction extraction to obtain an extract.
Preferably, in step S2, the NaOH solution has a mass concentration of 5% and is added in an amount of 5-15% of the total volume of the licorice extract.
More preferably, in step S3, the mass ratio of the tea polyphenol extract to the astragalus extract to the modified licorice extract is (0.6-1) to (5-8) to 1, and the mass ratio of the total mass of the three extracts to water is 1: (8-13).
Further preferably, in step S3, the air is delivered through an air input tube inserted into the container and located above the extract, and the air input tube is provided with a plurality of through holes, so that air can be continuously input into the container to satisfy the requirement of sufficient oxygen during the extract compounding and oxidation reaction.
More preferably, the relative density of the paste obtained in step S3 is 1.30 to 1.35.
Still more preferably, in the step S4, the auxiliary material includes an excipient selected from one or more of dextrin, soluble starch, mannitol and powdered sugar, and a flavoring agent selected from one or more of stevioside, orange syrup, lemon syrup and cherry syrup.
Still more preferably, the mass ratio of the paste, the excipient and the flavoring agent is 1: 2-4: 0.1-0.3.
Still more preferably, in the step S4, the drying temperature is 80 to 150 ℃ and the drying time is 30 to 90 min.
Still more preferably, in the step S4, during the granulation, large particles are firstly left by a sieve No. one, small particles are then removed by a sieve No. five, the large particles left by the sieve No. one and the small particles filtered by the sieve No. five are added with water again to form a non-flowable paste, the granulation is carried out again, and the rest particles are packaged into granules to obtain the product.
Computers are modern high-tech products, bringing convenience to people's lives, and meanwhile, the harm caused by electromagnetic radiation is not small. Long-term, excessive electromagnetic radiation can cause direct shanghai to the skin, reproductive and immune systems of humans, and can also cause vision deterioration and memory loss. The application develops the granules containing tea polyphenol based on the practical problems, and has the advantages that:
(1) the granules provided by the invention adopt tea polyphenol, astragalus and liquorice as main components, the formula is more reasonable, the tea polyphenol and the astragalus play a synergistic effect, are the gram of radioactive substances, can promote the discharge of the radioactive substances such as cobalt and strontium in the human body, have an anti-radiation effect, and can relieve fatigue and enhance immunity;
(2) the liquorice is modified particularly, the system is in an alkaline condition, and sufficient oxygen atmosphere is ensured in the concentration process, so that tea polyphenol is oxidized and degraded in the alkaline condition, the radiation-resistant active ingredients in the liquorice can be released more fully, the active ingredients in the product can be enriched to the maximum extent, and the radiation-resistant effect of the product is improved;
(3) the preparation process of the granules has the advantages of simple process, short time consumption, low cost and the like, and the obtained traditional Chinese medicine granules have high content of effective components, less impurities and good market prospect.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
Example 1
The preparation method of the granules containing tea polyphenol comprises the following four steps:
s1, preparing the tea polyphenol extract, the astragalus extract and the liquorice extract one by one, wherein the specific extraction method comprises the following steps: soaking the corresponding materials (tea polyphenols, radix astragali and Glycyrrhrizae radix) one by one, decocting at 80 deg.C, and separating solid and liquid to obtain extractive solution.
S2, modifying the licorice extract: adding 5 wt% NaOH solution into the Glycyrrhrizae radix extract obtained in step S1, wherein the addition amount is 15% of the total volume of the Glycyrrhrizae radix extract, adjusting pH of the mixed solution to 7.5, ultrasonically stirring at room temperature for 2h, separating and purifying at high speed, and filtering to remove precipitate to obtain modified Glycyrrhrizae radix extract.
S3, adding a proper amount of tea polyphenol extract, astragalus extract, modified liquorice extract and water into a container, stirring and heating to 55 ℃, continuously introducing air into the container, continuously stirring and keeping the temperature for 1.5h, naturally cooling to room temperature, filtering and concentrating to obtain a paste, wherein the relative density of the obtained paste is 1.30;
wherein, the mass ratio of the tea polyphenol extract, the astragalus extract and the modified liquorice extract is 0.6: 5: 1, and the mass ratio of the total mass of the three extracts to water is 1: 8.
s4, adding auxiliary materials into the paste prepared in the step S3, wherein the auxiliary materials comprise an excipient and a flavoring agent, the excipient is selected from one or more of dextrin, soluble starch, mannitol and powdered sugar, and the flavoring agent is selected from one or more of stevioside, orange peel syrup, lemon syrup and cherry syrup. And the mass ratio of the paste, the excipient and the flavoring agent is 1: 4: 0.2.
And uniformly mixing the paste with auxiliary materials, drying at 120 ℃ for 60min, and finally, finishing and packaging to obtain the product.
In order to ensure that the obtained granules have basically consistent shapes, large granules are reserved by a first sieve during granule finishing, small granules are removed by a fifth sieve, the large granules reserved by the first sieve and the small granules filtered by the fifth sieve are added with water again to form a non-flowable paste, the granules are finished again, and the rest granules are packaged into granules to obtain the product.
Example 2
The preparation method of the granules containing tea polyphenol comprises the following four steps:
s1, preparing the tea polyphenol extract, the astragalus extract and the liquorice extract one by one, wherein the specific extraction method comprises the following steps: soaking the corresponding materials (tea polyphenols, radix astragali and Glycyrrhrizae radix) one by one, decocting at 120 deg.C, and separating solid and liquid to obtain extractive solution.
S2, modifying the licorice extract: adding 5 wt% NaOH solution into the Glycyrrhrizae radix extract obtained in step S1, wherein the addition amount is 10% of the total volume of the Glycyrrhrizae radix extract, adjusting pH of the mixed solution to 8, ultrasonically stirring at room temperature for 2h, separating and purifying at high speed, and filtering to remove precipitate to obtain modified Glycyrrhrizae radix extract.
S3, adding a proper amount of tea polyphenol extract, astragalus extract, modified liquorice extract and water into a container, stirring and heating to 60 ℃, continuously introducing air into the container, continuously stirring and keeping the temperature for 2 hours, naturally cooling to room temperature, filtering and concentrating to paste, wherein the relative density of the obtained paste is 1.35;
wherein, the mass ratio of the tea polyphenol extract, the astragalus extract and the modified liquorice extract is 1: 7: 1, and the mass ratio of the total mass of the three extracts to water is 1: 10.
s4, adding auxiliary materials into the paste prepared in the step S3, wherein the auxiliary materials comprise an excipient and a flavoring agent, the excipient is selected from one or more of dextrin, soluble starch, mannitol and powdered sugar, and the flavoring agent is selected from one or more of stevioside, orange peel syrup, lemon syrup and cherry syrup. And the mass ratio of the paste, the excipient and the flavoring agent is 1: 3: 0.1.
And uniformly mixing the paste with auxiliary materials, drying at 80 ℃ for 30min, and finally, finishing and packaging to obtain the product.
Example 3
The preparation method of the granules containing tea polyphenol comprises the following four steps:
s1, preparing the tea polyphenol extract, the astragalus extract and the liquorice extract one by one, wherein the specific extraction method comprises the following steps: soaking the corresponding materials (tea polyphenols, radix astragali and Glycyrrhrizae radix) one by one, decocting at 100 deg.C, and separating solid and liquid to obtain extractive solution.
S2, modifying the licorice extract: adding 5 wt% NaOH solution into the Glycyrrhrizae radix extract obtained in step S1, wherein the addition amount is 5% of the total volume of the Glycyrrhrizae radix extract, adjusting pH of the mixed solution to 8.5, ultrasonically stirring at room temperature for 2h, separating and purifying at high speed, and filtering to remove precipitate to obtain modified Glycyrrhrizae radix extract.
S3, adding a proper amount of tea polyphenol extract, astragalus extract, modified liquorice extract and water into a container, stirring and heating to 50 ℃, continuously introducing air into the container, continuously stirring and keeping the temperature for 1h, naturally cooling to room temperature, filtering and concentrating to paste, wherein the relative density of the obtained paste is 1.35;
wherein, the mass ratio of the tea polyphenol extract, the astragalus extract and the modified liquorice extract is 0.8: 8: 1, and the mass ratio of the total mass of the three extracts to water is 1: 13.
s4, adding auxiliary materials into the paste prepared in the step S3, wherein the auxiliary materials comprise an excipient and a flavoring agent, the excipient is selected from one or more of dextrin, soluble starch, mannitol and powdered sugar, and the flavoring agent is selected from one or more of stevioside, orange peel syrup, lemon syrup and cherry syrup. And the mass ratio of the paste, the excipient and the flavoring agent is 1: 2: 0.3.
And uniformly mixing the paste with auxiliary materials, drying at 150 ℃ for 90min, and finally, finishing and packaging to obtain the product.
It should be noted that, in step S3 of examples 1-3, air is delivered through an air inlet pipe inserted into the container and located above the extract, and the air inlet pipe is provided with a plurality of through holes, so that air can be continuously delivered into the container to satisfy the requirement of sufficient oxygen during the extract compounding and oxidation reaction. Under the condition, EGCG in the tea polyphenol can be more efficiently degraded or oxidized, and more radiation-resistant active ingredients can be enriched.
Comparative example
The comparative example has no modification step of licorice extract, and the rest process conditions are basically similar to those of example 2, and the specific procedures are as follows:
(1) preparing tea polyphenol extract, astragalus extract and licorice extract one by one, wherein the specific extraction method comprises the following steps: soaking the corresponding materials (tea polyphenols, radix astragali and Glycyrrhrizae radix) one by one, decocting at 120 deg.C, and separating solid and liquid to obtain extractive solution.
(2) Adding appropriate amount of tea polyphenols extract, radix astragali extract, Glycyrrhrizae radix extract and water into container, stirring, heating to 60 deg.C, continuously introducing air into the container, stirring, keeping the temperature for 2 hr, naturally cooling to room temperature, filtering, and concentrating to obtain paste with relative density of 1.35;
wherein, the mass ratio of the tea polyphenol extract, the astragalus extract and the modified liquorice extract is 1: 7: 1, and the mass ratio of the total mass of the three extracts to water is 1: 10.
(3) adding adjuvants into the paste obtained in the previous step, wherein the adjuvants comprise excipient and correctant, the excipient is selected from one or more of dextrin, soluble starch, mannitol and sugar powder, and the correctant is selected from one or more of stevioside, pericarpium Citri Junoris syrup, fructus Citri syrup, and fructus Pruni Pseudocerasi syrup. And the mass ratio of the paste, the excipient and the flavoring agent is 1: 3: 0.1. And uniformly mixing the paste with auxiliary materials, drying at 80 ℃ for 30min, and finally, finishing and packaging to obtain the granular product of the comparative example.
Effect testing
Testing the population: office workers 25-50 years old, 40 men and 40 women. The overall basic health condition of the tested population is good, no lactation or pregnancy exists, no hypertension, diabetes and other chronic diseases exist, and 2-3 exercise habits are provided for one week.
The test method comprises the following steps: granules prepared in examples 1 to 3 were used as a test group, and granules prepared in a comparative example were used as a control group. The male and female test populations were equally divided into 4 groups of 10 persons each, and the physical sensation, hair loss and skin condition changes after each group of populations continued to take the granules (twice a day, one bag at a time) for two months were recorded.
TABLE 1 comparison of the product effectiveness of examples 1-3 and comparative examples
From the table above, the granule of the invention has the effect on more than 60% of people, and improves the influence caused by sedentary offices, computer radiation and the like, including various problems of easy fatigue, alopecia, skin and the like. The granules adopt tea polyphenol, astragalus and liquorice as main components, and the liquorice is modified, so that the formula is more reasonable, the tea polyphenol and the astragalus play a synergistic effect, active ingredients in the product can be enriched to the maximum extent, radioactive substances such as cobalt, strontium and the like in a human body can be promoted to be discharged, the radiation-resistant effect is achieved, the fatigue can be relieved, and the immunity is enhanced. Meanwhile, the preparation process of the granules has the advantages of simple process, short time consumption, low cost and the like, and the obtained granules have high content of effective components, less impurities and good market prospect.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.
Claims (10)
1. A preparation method of granules containing tea polyphenol is characterized by comprising the following steps:
s1, preparing tea polyphenol extract, astragalus extract and liquorice extract;
s2, modifying the licorice extract: adding NaOH solution into the licorice extract prepared in the step S1, adjusting the pH value of the mixed solution to 7.5-8.5, ultrasonically stirring for 2 hours at room temperature, separating and purifying at high speed, and filtering to remove precipitates to obtain a modified licorice extract;
s3, adding a proper amount of tea polyphenol extract, astragalus extract, modified liquorice extract and water into a container, stirring and heating to 50-60 ℃, continuously inputting air into the container, continuously stirring and keeping the temperature for 1-2 hours, naturally cooling to room temperature, filtering and concentrating to paste;
s4, adding auxiliary materials into the paste prepared in the step S3, uniformly mixing, drying, granulating and packaging to obtain the product.
2. The method of claim 1, wherein the step S1 is a step of preparing an extract by: soaking the raw materials, decocting and extracting, wherein the extraction temperature is 80-120 ℃, and performing solid-liquid separation after decoction extraction to obtain an extract.
3. The method of claim 1, wherein in step S2, the NaOH solution has a mass concentration of 5% and is added in an amount of 5% to 15% of the total volume of the licorice extract.
4. The method of claim 1, wherein in step S3, the mass ratio of the tea polyphenol extract to the astragalus extract to the modified licorice extract is (0.6-1) to (5-8) to 1, and the mass ratio of the total mass of the three extracts to water is 1: (8-13).
5. The method of claim 1, wherein the air is delivered through an air inlet pipe inserted into the container and located above the extract in step S3, the air inlet pipe having a plurality of through holes.
6. The method of claim 1, wherein the paste obtained in step S3 has a relative density of 1.30-1.35.
7. The method of claim 1, wherein in step S4, the excipients include one or more excipients selected from dextrin, soluble starch, mannitol and powdered sugar, and the flavoring agent is one or more selected from stevioside, orange syrup, lemon syrup and cherry syrup.
8. The method for preparing the tea polyphenol-containing granules according to claim 7, wherein the mass ratio of the paste to the excipient to the flavoring agent is 1: 2-4: 0.1-0.3.
9. The method of claim 1, wherein in step S4, the drying temperature is 80-150 ℃ and the drying time is 30-90 min.
10. The method of claim 1, wherein in step S4, the granules are sized by using a sieve No. one to leave large granules, and then removing small granules by using a sieve No. five, and the large granules left by the sieve No. one and the small granules filtered by the sieve No. five are added with water again to form a non-flowable paste, and then the granules are sized again, and the rest of the granules are packaged into granules.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613572A (en) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | Composite astragalus root pharmaceutical preparation for producing refreshing effect to brain and preparation method of composite astragalus root pharmaceutical preparation |
| CN109260320A (en) * | 2018-11-12 | 2019-01-25 | 江苏千药堂国医研究院有限公司 | A kind of composition and purposes of tea polyphenols and Chinese medical extract |
| CN113116954A (en) * | 2019-12-31 | 2021-07-16 | 江苏天晟药业股份有限公司 | Preparation method of licoflavone |
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- 2021-12-30 CN CN202111638641.6A patent/CN114532534A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102613572A (en) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | Composite astragalus root pharmaceutical preparation for producing refreshing effect to brain and preparation method of composite astragalus root pharmaceutical preparation |
| CN109260320A (en) * | 2018-11-12 | 2019-01-25 | 江苏千药堂国医研究院有限公司 | A kind of composition and purposes of tea polyphenols and Chinese medical extract |
| CN113116954A (en) * | 2019-12-31 | 2021-07-16 | 江苏天晟药业股份有限公司 | Preparation method of licoflavone |
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