CN114524878B - 一种双特异性抗体及其用途 - Google Patents

一种双特异性抗体及其用途 Download PDF

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Publication number
CN114524878B
CN114524878B CN202011325843.0A CN202011325843A CN114524878B CN 114524878 B CN114524878 B CN 114524878B CN 202011325843 A CN202011325843 A CN 202011325843A CN 114524878 B CN114524878 B CN 114524878B
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Prior art keywords
antigen
seq
antibody
cell
light chain
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Chinese (zh)
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CN114524878A (zh
Inventor
徐刚
陈博
王常玉
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Connaught Biomedical Technology Chengdu Co ltd
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Connaught Biomedical Technology Chengdu Co ltd
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Priority to CN202410934007.4A priority Critical patent/CN118878693A/zh
Application filed by Connaught Biomedical Technology Chengdu Co ltd filed Critical Connaught Biomedical Technology Chengdu Co ltd
Priority to CN202011325843.0A priority patent/CN114524878B/zh
Priority to CN202410934201.2A priority patent/CN118878694A/zh
Priority to PCT/CN2021/132195 priority patent/WO2022105924A1/zh
Priority to US18/038,159 priority patent/US20240002540A1/en
Priority to CN202180078861.XA priority patent/CN116490614A/zh
Priority to CA3199721A priority patent/CA3199721A1/en
Priority to EP21894071.6A priority patent/EP4249514A4/en
Priority to JP2023530940A priority patent/JP2023550171A/ja
Priority to KR1020257013696A priority patent/KR20250060324A/ko
Priority to AU2021383901A priority patent/AU2021383901A1/en
Priority to KR1020237021199A priority patent/KR20230117160A/ko
Priority to EP25177852.8A priority patent/EP4591941A3/en
Publication of CN114524878A publication Critical patent/CN114524878A/zh
Application granted granted Critical
Publication of CN114524878B publication Critical patent/CN114524878B/zh
Priority to JP2024185456A priority patent/JP2025016538A/ja
Priority to JP2024185455A priority patent/JP2025016537A/ja
Priority to AU2025203320A priority patent/AU2025203320A1/en
Priority to US19/229,907 priority patent/US20250346685A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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CN202011325843.0A 2020-11-23 2020-11-23 一种双特异性抗体及其用途 Active CN114524878B (zh)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CN202011325843.0A CN114524878B (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
CN202410934201.2A CN118878694A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
CN202410934007.4A CN118878693A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
EP25177852.8A EP4591941A3 (en) 2020-11-23 2021-11-22 Bispecific antibody and use thereof
CN202180078861.XA CN116490614A (zh) 2020-11-23 2021-11-22 一种双特异性抗体及其用途
CA3199721A CA3199721A1 (en) 2020-11-23 2021-11-22 Bispecific antibody and use thereof
EP21894071.6A EP4249514A4 (en) 2020-11-23 2021-11-22 BISPECIFIC ANTIBODY AND ITS USE
JP2023530940A JP2023550171A (ja) 2020-11-23 2021-11-22 二重特異性抗体及びその使用
PCT/CN2021/132195 WO2022105924A1 (zh) 2020-11-23 2021-11-22 一种双特异性抗体及其用途
AU2021383901A AU2021383901A1 (en) 2020-11-23 2021-11-22 Bispecific antibody and use thereof
KR1020237021199A KR20230117160A (ko) 2020-11-23 2021-11-22 이중특이성 항체 및 그의 용도
US18/038,159 US20240002540A1 (en) 2020-11-23 2021-11-22 Bispecific antibody and use thereof
KR1020257013696A KR20250060324A (ko) 2020-11-23 2021-11-22 이중특이성 항체 및 그의 용도
JP2024185456A JP2025016538A (ja) 2020-11-23 2024-10-21 二重特異性抗体及びその使用
JP2024185455A JP2025016537A (ja) 2020-11-23 2024-10-21 二重特異性抗体及びその使用
AU2025203320A AU2025203320A1 (en) 2020-11-23 2025-05-08 Bispecific antibody and uses thereof
US19/229,907 US20250346685A1 (en) 2020-11-23 2025-06-05 Bispecific antibody and use thereof

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CN202011325843.0A CN114524878B (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途

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CN202410934007.4A Division CN118878693A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
CN202410934201.2A Division CN118878694A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途

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CN114524878A CN114524878A (zh) 2022-05-24
CN114524878B true CN114524878B (zh) 2024-08-02

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CN202410934007.4A Pending CN118878693A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
CN202410934201.2A Pending CN118878694A (zh) 2020-11-23 2020-11-23 一种双特异性抗体及其用途
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