CN114515352A - Process method for preparing selective oxidation chitosan-alginic acid medical dressing - Google Patents
Process method for preparing selective oxidation chitosan-alginic acid medical dressing Download PDFInfo
- Publication number
- CN114515352A CN114515352A CN202210245445.0A CN202210245445A CN114515352A CN 114515352 A CN114515352 A CN 114515352A CN 202210245445 A CN202210245445 A CN 202210245445A CN 114515352 A CN114515352 A CN 114515352A
- Authority
- CN
- China
- Prior art keywords
- alginic acid
- chitosan
- solution
- preparing
- medical dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The application discloses a process method for preparing a selective oxidation chitosan-alginic acid medical dressing, which comprises the following steps: preparing a chitosan solution; preparing a alginic acid solution; preparing a chitosan-alginic acid mixed solution; preparing the chitosan-alginic acid auxiliary material. The medical auxiliary material that chitosan and alginic acid mix has been adopted, utilize the compatibility of alginic acid and chitosan, the positive charge that carries through chitosan self attracts the red blood cell that has the negative charge, make red blood cell can condense fast and reduce the blood loss of wounded, reach quick hemostatic effect with this, antibacterial through chitosan simultaneously, can effectively prevent wound bacterial infection, alginic acid absorbs wound exudate simultaneously and forms the gel layer, and improve moist environment for the healing of wound, the healing of the wound of also being convenient for.
Description
Technical Field
The application relates to preparation of chitosan-alginic acid medical dressing, in particular to a process method for preparing selective oxidation chitosan-alginic acid medical dressing.
Background
Chitosan is a product of removing partial acetyl groups from natural polysaccharide chitin, has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, immunity enhancement and the like, is widely applied to food additives, textiles, agriculture, environmental protection, beauty and health care, cosmetics, antibacterial agents, medical fibers, medical dressings, artificial tissue materials and drug slow release materials, and alginic acid is a natural polyuronic acid existing in the cell walls of brown algae such as kelp, giant kelp and the like.
Chitosan and alginate are used as natural high molecular compounds extracted from oceans, so that the chitosan and alginate have outstanding hemostatic effects due to good biocompatibility, hemostatic property and antibacterial property, and a single chitosan or alginate medical auxiliary material is convenient to prepare, but has some defects in hemostasis and usability. Therefore, a process method for preparing the selective oxidized chitosan-alginic acid medical dressing is provided aiming at the problems.
Disclosure of Invention
In this embodiment, a process for preparing a medical dressing by selectively oxidizing chitosan-alginic acid is provided to solve the problem that a single medical auxiliary material of chitosan or alginic acid in the prior art still has certain defects.
According to one aspect of the application, a process method for preparing a chitosan-alginic acid medical dressing through selective oxidation is provided, and the preparation method of the chitosan-alginic acid medical dressing comprises the following steps:
(1) preparing a chitosan solution;
(2) preparing a alginic acid solution;
(3) preparing a chitosan-alginic acid mixed solution;
(4) and preparing the chitosan-alginic acid auxiliary material.
Further, in the step (1), the seaweed is firstly placed in clean water to be soaked for 8-10 hours, then the seaweed is repeatedly cleaned, the cleaned seaweed is ground and filtered to obtain a ground glue solution, weakly alkaline compound cellulase is added into the glue solution, the glue solution is placed in a microwave reaction device to assist enzymolysis, sodium carbonate and hot water are added into the glue solution after enzymolysis to be stirred, and the clear water is added to dilute the glue solution after stirring.
Further, after the dilution in the step (1), adding acetic acid and chitin, mixing and stirring, pumping the mixture into a floating tank through a centrifugal machine after stirring, standing to obtain clear glue solution, then respectively carrying out rough filtration and fine filtration on the clear glue solution, introducing chlorine into the glue solution after the fine filtration for bleaching, carrying out calcification and decalcification treatment, carrying out dehydration treatment on the treated alginic acid, crushing the dehydrated alginic acid, spraying hydrogen peroxide on the crushed alginic acid for degradation, drying the degraded alginic acid to obtain alginic acid, finally preparing 1000ml of distilled water, crushing and filtering 15-25g of alginic acid, dispersing the crushed alginic acid into 1000ml of distilled water, heating to 50 ℃, and stirring until the alginic acid is completely dissolved to obtain an alginic acid solution.
Further, when soaking in the step (1), the pure water submerges 5-10cm over the seaweed, when cleaning, the seaweed needs to be cleaned until the water after washing does not contain impurities, when in microwave reaction, the seaweed is reacted for 3-4h at the temperature of 35-45 ℃, a stirrer is started to stir at high speed for 5min every 1h, the temperature of hot water is 85-95 ℃, the seaweed stands for 4-5h after stirring, 120 times of pure water of 100 times is added into the seaweed during dilution, the seaweed is stored for 48-60h at normal temperature after being sprayed with hydrogen peroxide, and when in air drying, the air drying temperature is 80-100 ℃.
And (3) further, adding a hydrochloric acid solution into the ground chitin powder in the step (2), stirring and centrifuging, washing the centrifuged fixed distilled water to be neutral, adding sodium hydroxide, performing microwave enzymolysis for 3-5min, adding potassium permanganate for decoloring, sequentially adding a sodium hydroxide solution and a buffer solution for deacetylation after decoloring, and centrifuging and drying to obtain the chitosan.
Further, in the step (2), 35-45g of chitosan is crushed, filtered and dispersed in 1000ml of distilled water, and the mixture is heated to 60-70 ℃ and stirred until the chitosan is completely dissolved, so as to obtain the chitosan solution.
Further, the chitosan solution and the alginic acid solution after mixing are mixed in equal volume in the step (3), after mixing, the mixture is heated to 50-60 ℃ and stirred for 5-10min, so that the chitosan solution and the alginic acid solution are fully mixed, 75% -80% ethanol solution is added, the volume ratio of the ethanol solution to the chitosan solution and the alginic acid solution is 1-3:10, after adding ethanol, the mixture is heated to 50-60 ℃ and stirred for 10-15min, and the mucus of the chitosan solution and the alginic acid solution is obtained.
Further, after the non-woven fabric is cut to the required size in the step (4), sterilization and disinfection are carried out, and after the disinfection is finished, the non-woven fabric is repeatedly coated with the chitosan and the alginic acid mucus by the coating device.
Further, in the step (4), each layer of chitosan and alginic acid mucus is coated for 1-2 hours at intervals, and the chitosan solution and the alginic acid mucus are coated for multiple times until the thickness of the chitosan solution and the alginic acid mucus on the non-woven fabric is 0.3-0.8 cm.
Further, the chitosan and alginic acid colloid after coating in the step (4) is covered with plastic films with equal areas after sterilization and disinfection treatment to obtain the medical dressing, and finally the dressing is subjected to vacuum packaging treatment.
Through the above-mentioned embodiment of this application, the medical auxiliary material that chitosan and alginic acid mix has been adopted, utilize the compatibility of alginic acid and chitosan, positive charge attraction that carries through chitosan self has the red blood cell of negative charge, make red blood cell can condense fast and reduce the blood loss of wounded, with this effect that reaches quick hemostasis, simultaneously through chitosan's antibacterial activity, can effectively prevent wound department bacterial infection, alginic acid absorbs wound exudate simultaneously and forms the gel layer, and improve moist environment for the healing of wound, also be convenient for the healing of wound, through chitosan and alginic acid cooperation, the problem that single chitosan or alginic acid auxiliary material in the prior art still have certain defect is solved, guarantee the hemostasis antibacterial property of auxiliary material through chitosan-alginic acid medical dressing.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the description below are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without inventive labor.
Fig. 1 is a schematic flow chart of an embodiment of the present application.
Detailed Description
In order to make the technical solutions of the present application better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, and not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort shall fall within the protection scope of the present application.
It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the application described herein may be used. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
In the present application, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate an orientation or positional relationship based on the orientation or positional relationship shown in the drawings. These terms are used primarily to better describe the present application and its embodiments, and are not used to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation.
Moreover, some of the above terms may be used in other meanings besides orientation or positional relationship, for example, the term "upper" may also be used in some cases to indicate a certain attaching or connecting relationship. The specific meaning of these terms in this application will be understood by those of ordinary skill in the art as the case may be.
Furthermore, the terms "mounted," "disposed," "provided," "connected," and "coupled" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
Referring to fig. 1, a process for preparing a selective oxidized chitosan-alginic acid medical dressing,
the first embodiment is as follows:
the preparation method of the chitosan-alginic acid medical dressing comprises the following steps:
(1) preparing a chitosan solution;
(2) preparing a alginic acid solution;
(3) preparing a chitosan-alginic acid mixed solution;
(4) and preparing the chitosan-alginic acid auxiliary material.
In the step (1), firstly, soaking the seaweed in clean water for 8 hours, then, repeatedly cleaning the seaweed, grinding the cleaned seaweed, filtering to obtain a ground glue solution, adding alkalescent composite cellulase into the glue solution, placing the glue solution in a microwave reaction device for assisting enzymolysis, then adding sodium carbonate and hot water into the glue solution after enzymolysis for stirring, and adding clean water for dilution after stirring.
Adding acetic acid and chitin after dilution in the step (1), mixing and stirring, pumping into a floating tank through a centrifugal machine after stirring, standing to obtain clear glue solution, performing rough filtration and fine filtration on the clear glue solution respectively, introducing chlorine into the glue solution after fine filtration for bleaching, performing calcification and decalcification, performing dehydration on treated alginic acid, crushing the dehydrated alginic acid, spraying hydrogen peroxide on the crushed alginic acid, degrading, drying the degraded alginic acid to obtain alginic acid, preparing 1000ml of distilled water, crushing and filtering 15g of alginic acid, dispersing the crushed alginic acid in 1000ml of distilled water, heating to 50 ℃, and stirring until the alginic acid is completely dissolved to obtain an alginic acid solution.
When soaking in the step (1), purified water is 5-cm higher than the seaweed, when cleaning, the seaweed is required to be cleaned until the water after washing does not contain impurities, when microwave reaction is carried out, reaction is carried out for 3 hours at the temperature of 35 ℃, a stirrer is started every 1 hour, high-speed stirring is carried out for 5min, the temperature of hot water is 85 ℃, standing is carried out for 4 hours after stirring, 100 times of purified water is added to the seaweed in mass during dilution, the seaweed is stored at normal temperature for 48 hours after hydrogen peroxide is sprayed, and when air drying is carried out, the air drying temperature is 80 ℃.
And (2) adding a hydrochloric acid solution into the ground crustacean powder, stirring and centrifuging, washing the centrifuged fixed distilled water to be neutral, adding sodium hydroxide, performing microwave enzymolysis for 3-5min, adding potassium permanganate for decoloring, sequentially adding a sodium hydroxide solution and a buffer solution for deacetylation after decoloring, and performing centrifugal drying to obtain the chitosan.
In the step (2), 35g of chitosan is crushed, filtered and dispersed in 1000ml of distilled water, and the mixture is heated to 60 ℃ and stirred until the chitosan is completely dissolved, so that a chitosan solution is obtained.
And (3) mixing the mixed chitosan solution and alginic acid solution in equal volume, heating to 50 ℃ after mixing, stirring for 5min to fully mix the chitosan solution and the alginic acid solution, adding 75% ethanol solution, wherein the volume ratio of the ethanol solution to the chitosan solution to the alginic acid solution is 1:10, adding ethanol, heating to 50 ℃ and stirring for 10min to obtain the mucus of the chitosan solution and the alginic acid solution.
And (4) cutting the non-woven fabric to a required size in the step (4), sterilizing, and repeatedly coating the non-woven fabric with the treated chitosan and alginic acid mucus by using a coating device after the sterilization is finished.
In the step (4), each layer of chitosan and alginic acid mucus is coated for 1h at intervals, and the chitosan solution and the alginic acid mucus are coated for multiple times until the thickness of the chitosan solution and the alginic acid mucus on the non-woven fabric is 0.3 cm.
And (4) covering the chitosan and alginic acid colloid after coating with plastic films with the same area and subjected to sterilization and disinfection treatment to obtain the medical dressing, and finally performing vacuum packaging treatment on the dressing.
Example two:
the preparation method of the chitosan-alginic acid medical dressing comprises the following steps:
(1) preparing a chitosan solution;
(2) preparing a alginic acid solution;
(3) preparing a chitosan-alginic acid mixed solution;
(4) and preparing the chitosan-alginic acid auxiliary material.
In the step (1), firstly, soaking the seaweed in clean water for 10 hours, then, repeatedly cleaning the seaweed, grinding the cleaned seaweed, filtering to obtain a ground glue solution, adding alkalescent composite cellulase into the glue solution, placing the glue solution in a microwave reaction device for assisting enzymolysis, then adding sodium carbonate and hot water into the glue solution after enzymolysis for stirring, and adding clean water for dilution after stirring.
Diluting the solution obtained in the step (1), adding acetic acid and chitin, mixing and stirring, pumping the solution into a floating tank through a centrifugal machine after stirring, standing to obtain clear glue solution, performing coarse filtration and fine filtration on the clear glue solution respectively, introducing chlorine into the glue solution after fine filtration for bleaching, performing calcification and decalcification treatment, performing dehydration treatment on treated alginic acid, crushing the dehydrated alginic acid, spraying hydrogen peroxide for degradation, drying the degraded alginic acid to obtain alginic acid, preparing 1000ml of distilled water, crushing and filtering 20g of alginic acid, dispersing the alginic acid into 1000ml of distilled water, heating to 50 ℃, and stirring until the alginic acid is completely dissolved to obtain an alginic acid solution.
When soaking in the step (1), the pure water is 10cm higher than the seaweed, when cleaning, the seaweed needs to be cleaned until the water washed by the seaweed does not contain impurities, when in microwave reaction, the seaweed reacts for 4 hours at the temperature of 45 ℃, a stirrer is started every 1 hour to stir at high speed for 5 minutes, the temperature of hot water is 90 ℃, the seaweed stands for 5 hours after stirring, 110 times of pure water is added into the seaweed during dilution, the seaweed is stored for 55 hours at normal temperature after hydrogen peroxide is sprayed, and when in air drying, the air drying temperature is 90 ℃.
And (3) adding a hydrochloric acid solution into the ground crustacean powder, stirring and centrifuging, washing the centrifuged fixed distilled water to be neutral, adding sodium hydroxide, performing microwave enzymolysis for 5min, adding potassium permanganate to perform decolorization after treatment, sequentially adding a sodium hydroxide solution and a buffer solution to perform deacetylation after decolorization, and performing centrifugal drying to obtain the chitosan.
In the step (2), 40g of chitosan is crushed, filtered and dispersed in 1000ml of distilled water, and the mixture is heated to 70 ℃ and stirred until the chitosan is completely dissolved, so that a chitosan solution is obtained.
And (3) mixing the mixed chitosan solution and alginic acid solution in equal volume, heating to 60 ℃ after mixing, stirring for 10min to fully mix the chitosan solution and the alginic acid solution, adding an ethanol solution with the concentration of 80%, wherein the volume ratio of the ethanol solution to the chitosan solution to the alginic acid solution is 1-3:10, adding ethanol, heating to 60 ℃, and stirring for 15min to obtain the mucus of the chitosan solution and the alginic acid solution.
And (5) cutting the non-woven fabric to the required size in the step (4), sterilizing and disinfecting, and repeatedly coating the non-woven fabric with the processed chitosan and alginic acid mucus through a coating device after the disinfection is finished.
In the step (4), each layer of chitosan and alginic acid mucus is coated for 1.5 hours at intervals, and the chitosan solution and the alginic acid mucus are coated for multiple times until the thickness of the chitosan solution and the alginic acid mucus on the non-woven fabric is 0.6 cm.
And (5) covering the chitosan and alginic acid colloid which are coated in the step (4) with plastic films with equal areas and subjected to sterilization and disinfection treatment to obtain the medical dressing, and finally performing vacuum packaging treatment on the dressing.
It is well within the skill of those in the art to implement, without undue experimentation, the present application is not directed to software and process improvements, as they relate to circuits and electronic components and modules.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A process method for preparing selective oxidation chitosan-alginic acid medical dressing is characterized in that: the preparation method of the chitosan-alginic acid medical dressing comprises the following steps:
(1) preparing a chitosan solution;
(2) preparing a alginic acid solution;
(3) preparing a chitosan-alginic acid mixed solution;
(4) and preparing the chitosan-alginic acid auxiliary material.
2. The process method for preparing the selective oxidation chitosan-alginic acid medical dressing according to claim 1, is characterized in that: in the step (1), the seaweed is firstly placed in clean water to be soaked for 8-10h, then the seaweed is repeatedly cleaned, the cleaned seaweed is ground and filtered to obtain a ground glue solution, weak-alkaline compound cellulase is added into the glue solution, the glue solution is placed in a microwave reaction device to assist enzymolysis, then sodium carbonate and hot water are added into the glue solution after enzymolysis to be stirred, and the clear water is added for dilution after stirring.
3. The process method for preparing the selective oxidation chitosan-alginic acid medical dressing according to claim 1, is characterized in that: adding acetic acid and chitin after dilution in the step (1), mixing and stirring, pumping into a floating tank through a centrifugal machine after stirring, standing to obtain clear glue solution, performing rough filtration and fine filtration on the clear glue solution respectively, introducing chlorine into the glue solution after fine filtration for bleaching, performing calcification and decalcification, performing dehydration on treated alginic acid, crushing the dehydrated alginic acid, spraying hydrogen peroxide on the crushed alginic acid for degradation, drying the degraded alginic acid to obtain alginic acid, preparing 1000ml of distilled water, crushing and filtering 15-25g of alginic acid, dispersing the alginic acid in 1000ml of distilled water, heating to 50 ℃, and stirring until the alginic acid is completely dissolved to obtain an alginic acid solution.
4. The process method for preparing the selective oxidation chitosan-alginic acid medical dressing according to claim 1, is characterized in that: when soaking in the step (1), the purified water is 5-10cm higher than the seaweed, when cleaning, the seaweed needs to be cleaned until the water after washing does not contain impurities, when microwave reaction is carried out, the seaweed reacts at the temperature of 35-45 ℃ for 3-4h, a stirrer is started every 1h to stir at high speed for 5min, the temperature of hot water is 85-95 ℃, standing is carried out for 4-5h after stirring, 120 times of purified water of 100 times of the seaweed is added during dilution, hydrogen peroxide is sprayed, the seaweed is stored at normal temperature for 48-60h, and when air drying, the air drying temperature is 80-100 ℃.
5. The process method for preparing the selective oxidized chitosan-alginic acid medical dressing as claimed in claim 1, wherein the steps of: and (2) adding a hydrochloric acid solution into the ground crustacean powder, stirring and centrifuging, washing the centrifuged fixed distilled water to be neutral, adding sodium hydroxide, performing microwave enzymolysis for 3-5min, adding potassium permanganate for decoloring, sequentially adding a sodium hydroxide solution and a buffer solution for deacetylation after decoloring, and performing centrifugal drying to obtain the chitosan.
6. The process method for preparing the selective oxidized chitosan-alginic acid medical dressing as claimed in claim 1, wherein the steps of: in the step (2), 35-45g of chitosan is crushed, filtered and dispersed in 1000ml of distilled water, and the mixture is heated to 60-70 ℃ and stirred until the chitosan is completely dissolved, so that a chitosan solution is obtained.
7. The process method for preparing the selective oxidized chitosan-alginic acid medical dressing as claimed in claim 1, wherein the steps of: and (3) mixing the mixed chitosan solution and alginic acid solution in equal volume, heating to 50-60 ℃ after mixing, stirring for 5-10min to fully mix the chitosan solution and the alginic acid solution, adding 75-80% ethanol solution with the volume ratio of the ethanol solution to the chitosan solution and the alginic acid solution being 1-3:10, heating to 50-60 ℃ after adding ethanol, and stirring for 10-15min to obtain the mucus of the chitosan solution and the alginic acid solution.
8. The process method for preparing the selective oxidized chitosan-alginic acid medical dressing as claimed in claim 1, wherein the steps of: and (4) cutting the non-woven fabric to a required size in the step (4), sterilizing, and repeatedly coating the non-woven fabric with the treated chitosan and alginic acid mucus by using a coating device after the sterilization is finished.
9. The process method for preparing the selective oxidation chitosan-alginic acid medical dressing according to claim 1, is characterized in that: in the step (4), each layer of chitosan and alginic acid mucus is coated for 1-2h at intervals, and the chitosan solution and alginic acid mucus are coated for multiple times until the thickness of the non-woven fabric is 0.3-0.8 cm.
10. The process method for preparing the selective oxidation chitosan-alginic acid medical dressing according to claim 1, is characterized in that: and (4) covering the chitosan and alginic acid colloid after coating with plastic films with the same area and subjected to sterilization and disinfection treatment to obtain the medical dressing, and finally performing vacuum packaging treatment on the dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210245445.0A CN114515352A (en) | 2022-03-14 | 2022-03-14 | Process method for preparing selective oxidation chitosan-alginic acid medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210245445.0A CN114515352A (en) | 2022-03-14 | 2022-03-14 | Process method for preparing selective oxidation chitosan-alginic acid medical dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114515352A true CN114515352A (en) | 2022-05-20 |
Family
ID=81599930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210245445.0A Pending CN114515352A (en) | 2022-03-14 | 2022-03-14 | Process method for preparing selective oxidation chitosan-alginic acid medical dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114515352A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110183266A (en) * | 2019-04-17 | 2019-08-30 | 青岛明月蓝海生物科技有限公司 | A kind of small molecule alginic acid microbial manure |
| CN110684126A (en) * | 2019-11-13 | 2020-01-14 | 青岛聚大洋藻业集团有限公司 | Processing method of alginic acid |
| CN112741929A (en) * | 2020-12-28 | 2021-05-04 | 河南亚都实业有限公司 | Medical trauma hemostasis composite dressing |
-
2022
- 2022-03-14 CN CN202210245445.0A patent/CN114515352A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110183266A (en) * | 2019-04-17 | 2019-08-30 | 青岛明月蓝海生物科技有限公司 | A kind of small molecule alginic acid microbial manure |
| CN110684126A (en) * | 2019-11-13 | 2020-01-14 | 青岛聚大洋藻业集团有限公司 | Processing method of alginic acid |
| CN112741929A (en) * | 2020-12-28 | 2021-05-04 | 河南亚都实业有限公司 | Medical trauma hemostasis composite dressing |
Non-Patent Citations (2)
| Title |
|---|
| SHANMUGASUNDARAM, O等: "Development and characterization of cotton, organic cotton flat knit fabrics coated with chitosan, sodium alginate, calcium alginate polymers, and antibiotic drugs for wound healing", 《JOURNAL OF INDUSTRIAL TEXTILES》 * |
| 韩长日等: "《造纸用化学品生产工艺与技术》", 31 May 2019, 北京：科学技术文献出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109646710B (en) | A kind of hemostatic material and preparation method thereof of clinical department of internal medicine hemostasis | |
| CN1332081C (en) | Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof | |
| CN101816802B (en) | Chitosan-based medical dressing | |
| CN1296534C (en) | Blended fiber of sodium alginate/glutin, preparation method and application thereof | |
| JP6029078B2 (en) | Method for producing fibroin powder from silk products or silk filaments | |
| CN112853623B (en) | Preparation method of electrostatic spinning kaolinite reinforced natural polysaccharide porous fiber membrane | |
| CN111979642A (en) | Antibacterial cotton soft towel and preparation method thereof | |
| CN109157670A (en) | A kind of composite antibacterial gel rubber material | |
| Khan et al. | Extraction processes for deriving cellulose: A comprehensive review on green approaches | |
| CN109252356A (en) | A kind of fiber gauze production technology of high intensity | |
| CN108245700A (en) | A kind of hydroxypropyl methyl cellulose chitosan film dressing and preparation method thereof | |
| CN103243557A (en) | Oxidized sodium alginate modified textile fiber as well as preparation method and application thereof | |
| CN114515352A (en) | Process method for preparing selective oxidation chitosan-alginic acid medical dressing | |
| JPH02124903A (en) | Dispersion of and product from chitin | |
| CN102477592A (en) | Biodegradable tissue-engineering fiber | |
| CN102619143B (en) | Flocculent fiber film felt and preparation method thereof | |
| CN107754003A (en) | A kind of method that bleeding-stopping dressing is prepared with hydrogel | |
| CN105568675B (en) | A kind of preparation method of H-type carboxymethyl chitosan fiber | |
| CN106905553A (en) | A kind of cellulose acetate membrane material material of biological polyoses LBL self-assembly modification and preparation method thereof | |
| CN113150307A (en) | Glycosylated sericin, preparation method and application thereof | |
| KR102117643B1 (en) | Manufacturing method for chitin nanofiber having surface modified with chitosan, the chitin nanofiber having surface modified with chitosan made therefrom, chitin-collagen nanofiber made therefrom and wound dressing materials using this | |
| CN103014914A (en) | Method for preparing medical high-efficiency disinfected chitosan fibers by using disinfectant | |
| CN107447279A (en) | A kind of long-acting biological antibacterial nonwoven cloth and preparation method thereof | |
| CN111790001A (en) | Method for manufacturing absorbable surgical suture with three-layer annular structure for healing promotion and infection resistance | |
| CN101372764A (en) | Preparation of regenerated cellulose/chitin composite material and prepared composite fiber |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220520 |
|
| RJ01 | Rejection of invention patent application after publication |