CN111790001A - Method for manufacturing absorbable surgical suture with three-layer annular structure for healing promotion and infection resistance - Google Patents
Method for manufacturing absorbable surgical suture with three-layer annular structure for healing promotion and infection resistance Download PDFInfo
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- CN111790001A CN111790001A CN202010748375.1A CN202010748375A CN111790001A CN 111790001 A CN111790001 A CN 111790001A CN 202010748375 A CN202010748375 A CN 202010748375A CN 111790001 A CN111790001 A CN 111790001A
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
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- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/02—Preparation of spinning solutions
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D10/00—Physical treatment of artificial filaments or the like during manufacture, i.e. during a continuous production process before the filaments have been collected
- D01D10/06—Washing or drying
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/12—Stretch-spinning methods
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/40—Formation of filaments, threads, or the like by applying a shearing force to a dispersion or solution of filament formable polymers, e.g. by stirring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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Abstract
The invention discloses a method for manufacturing a three-layer annular structure absorbable surgical suture line for healing promotion and infection resistance, which comprises the following steps of respectively adopting 1.0mol/L HCI solution and 50% NaOH solution to treat a shell, extracting chitin, treating chitin deacetylation with 50% NaOH solution at the temperature of 90 ℃ for 3h to prepare chitosan stock solution, and carrying out carboxymethylation reaction with chloroacetic acid to prepare 2 parts of carboxymethyl chitosan serving as an outermost layer. Dissolving chitosan in 5-6% dilute acetic acid solution, adding urea and zinc acetate as auxiliary agents, stirring by using a stirring device, preparing a spinning solution of chitosan, solidifying, stretching, washing, and drying for 1h at 70 ℃ under a tension state by using a drying device. The invention achieves the purpose of controlling the degradation speed by controlling the mass ratio of the three components, so that the degradation speed of the suture is consistent with the wound healing speed, and the spinning speed is adjusted by adopting a PLC control mode, so that the suture structure is stable and uniform, and the probability of the organism generating foreign body reaction is reduced.
Description
Technical Field
The invention relates to the technical field of surgical sutures, in particular to a manufacturing method of an absorbable surgical suture with a three-layer annular structure for promoting healing and resisting infection.
Background
The surgical suture line is a special line for ligation hemostasis, suture hemostasis and tissue suture in the surgical operation or the trauma treatment, and is divided into absorbable lines and non-absorbable lines, wherein the absorbable surgical line on the market is mainly composed of artificially synthesized components, and the surgical line partially adopts mixed components, has no microstructure, and is woven by simply mixing the components into silk.
The prior domestic absorbable suture line product has the disadvantages of rough preparation method, uneven thickness of the suture line and poor structural stability, the specifications of the absorbable suture line product are not uniform, the absorbable suture line product cannot meet pharmacopoeia standards, and obviously the absorbable suture line product cannot meet the use requirements of people.
Disclosure of Invention
Based on the technical problems of the prior domestic absorbable suture line product in the background technology, such as rough process, uneven thickness of the suture line, poor structural stability, non-uniform specification and incapability of meeting pharmacopoeia standards, the invention provides a method for manufacturing a three-layer annular-structure absorbable surgical suture line for promoting healing and resisting infection.
The invention provides a method for manufacturing an absorbable surgical suture with a three-layer annular structure for promoting healing and resisting infection, which comprises the following steps:
s1: respectively adopting 1.0mol/L HCI solution and 50% NaOH solution to treat the carapace to extract chitin, treating chitosan deacetylation with 50% NaOH solution at 90 ℃ for 3h to prepare chitosan stock solution, and performing carboxymethylation reaction with chloroacetic acid to prepare 2 parts of carboxymethyl chitosan as an outermost layer;
s2: dissolving chitosan in 5-6% dilute acetic acid solution, adding urea and zinc acetate as auxiliaries, stirring by using a stirring device to prepare a spinning stock solution of chitosan, solidifying, stretching, washing, and drying for 1h by using a drying device at 70 ℃ under a tension state to finally obtain 3 parts of original-state chitosan fiber core with sufficient mechanical strength;
s3: cutting Os Sepiae into pieces of 1-3cm, adding appropriate amount of pepsin and acetic acid solution, standing, filtering the extractive solution, adding NaCl to final concentration of 10%, centrifuging at 1500r/min to obtain collagen precipitate, dissolving with 0.5mo/L acetic acid, and dialyzing to obtain purified collagen solution;
s4: preparing a saturated collagen solution at room temperature, putting the saturated collagen solution into the original state chitosan, soaking for 3min, airing, crosslinking by using glutaraldehyde with the concentration of 0.25%, washing by using distilled water, and dehydrating to obtain crosslinked original state chitosan-collagen with the mass ratio of 1: 1;
s5: degumming 1 part of raw silkworm silk in 15L of boiling Na2CO3(0.02M) aqueous solution for 30 minutes, washing with deionized water, carrying out air drying by using an air drying device, weighing dried silkworm fibroin fiber, dissolving in 120mL of LiBr (9.3M) solution, dissolving in a 65 ℃ oven, taking out the solution, pouring into a dialysis bag, dialyzing in deionized water for 36 hours, centrifuging the dialyzed solution twice in a high-speed centrifuge at 9000r/min, removing impurities, finally obtaining 1 part of fibroin protein solution, and drying to obtain a berberine-fibroin protein antibacterial coating material;
s6: and (3) putting the sample into 1 part of berberine-silk fibroin mixed solution for dipping to obtain an antibacterial coating, and then controlling a spinning device by the semi-finished product through a PLC (programmable logic controller) technology to obtain a finished product.
Preferably, the processing system comprises a stirring device, a drying device, an air drying device and a spinning device, and the spinning device comprises a spinning machine and a spinning device.
Preferably, agitating unit includes the agitator tank, and the top outer wall of agitator tank has agitator motor through the fix with screw, and agitator motor's output shaft has the puddler through the coupling joint.
Preferably, drying device includes the drying cabinet, and the both sides inner wall of drying cabinet all is provided with the heating wire, and the top inner wall of drying cabinet passes through the fix with screw temperature sensor.
Preferably, the air drying device comprises an air blowing cylinder, a support is arranged on the inner wall of the air blowing cylinder, a motor is fixed on the outer wall of the support through screws, and an output shaft of the motor is connected with fan blades through a coupling.
Preferably, S5 is replaced by weighing 1 part of berberine powder, dissolving the berberine powder in deionized water to prepare a berberine solution with the concentration of 4mg/mL, adding 0.5 part of glycerol into the silk fibroin solution, uniformly mixing the berberine solution and the silk fibroin glycerol mixed solution, wherein the mass ratio of the silk fibroin to the berberine is 10:1, and drying to obtain the berberine-silk fibroin antibacterial coating material.
The invention has the beneficial effects that:
1. the invention takes chitosan fiber as a core, a collagen layer is crosslinked on the surface of the chitosan fiber through special chemical reaction, a carboxymethyl chitosan layer is crosslinked outside the collagen layer, the carboxymethyl chitosan layer, the collagen layer and the chitosan core are degraded under the action of different enzymes in a human body, and as the 3 components have different spatial positions, the sequential action sequence of the enzymes is different, the carboxymethyl chitosan and the chitosan are degraded slowly, the collagen is degraded quickly, the purpose of controlling the degradation speed is achieved by controlling the mass ratio of the three components, and the degradation speed of the suture is consistent with the wound healing speed.
1. All main components of the suture are natural compounds, compared with an absorbable suture line artificially synthesized in the market, the suture line has the advantages of high tissue compatibility, good anti-inflammatory effect, stable property and the like, the infection risk of a wound inflammation exudation period can be greatly reduced in a surgical operation, the healing effect of a granulation tissue period is assisted, the product adopts a natural traditional Chinese medicine antibacterial compound berberine as an antibacterial coating, the pollution-free silk line is ensured, the suture line also has good safety performance in non-total disinfection operations of anorectal department, general surgery and the like, the overall degradation time of the suture line is adjusted by changing the proportion of the three layers of raw materials with different degradation energy efficiency, the healing time of the wound is more fit, and the adverse prognosis effect caused by early fracture or delayed absorption is avoided.
2. The invention combines the automation technology, adopts the PLC control mode, adjusts the spinning speed, ensures that the suture structure is stable and uniform, improves the operation hand feeling, and reduces the probability of foreign body reaction of the organism.
Drawings
FIG. 1 is a schematic view of the manufacturing process and structure of the manufacturing method of absorbable surgical suture with three-layer ring structure for healing and anti-infection provided by the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1:
referring to fig. 1, a method for manufacturing a absorbable surgical suture with a three-layer ring structure for promoting healing of infection resistance comprises the following steps:
s1: respectively adopting 1.0mol/L HCI solution and 50% NaOH solution to treat the carapace to extract chitin, treating chitosan deacetylation with 50% NaOH solution at 90 ℃ for 3h to prepare chitosan stock solution, and performing carboxymethylation reaction with chloroacetic acid to prepare 2 parts of carboxymethyl chitosan as an outermost layer;
s2: dissolving chitosan in 5-6% dilute acetic acid solution, adding urea and zinc acetate as auxiliaries, stirring by using a stirring device to prepare a spinning stock solution of chitosan, solidifying, stretching, washing, and drying for 1h by using a drying device at 70 ℃ under a tension state to finally obtain 3 parts of original-state chitosan fiber core with sufficient mechanical strength;
s3: cutting Os Sepiae into pieces of 1-3cm, adding appropriate amount of pepsin and acetic acid solution, standing, filtering the extractive solution, adding NaCl to final concentration of 10%, centrifuging at 1500r/min to obtain collagen precipitate, dissolving with 0.5mo/L acetic acid, and dialyzing to obtain purified collagen solution;
s4: preparing a saturated collagen solution at room temperature, putting the saturated collagen solution into the original state chitosan, soaking for 3min, airing, crosslinking by using glutaraldehyde with the concentration of 0.25%, washing by using distilled water, and dehydrating to obtain crosslinked original state chitosan-collagen with the mass ratio of 1: 1;
s5: degumming 1 part of raw silkworm silk in 15L of boiling Na2CO3(0.02M) aqueous solution for 30 minutes, washing with deionized water, carrying out air drying by using an air drying device, weighing dried silkworm fibroin fiber, dissolving in 120mL of LiBr (9.3M) solution, dissolving in a 65 ℃ oven, taking out the solution, pouring into a dialysis bag, dialyzing in deionized water for 36 hours, centrifuging the dialyzed solution twice in a high-speed centrifuge at 9000r/min, removing impurities, finally obtaining 1 part of fibroin protein solution, and drying to obtain a berberine-fibroin protein antibacterial coating material;
s6: and (3) putting the sample into 1 part of berberine-silk fibroin mixed solution for dipping to obtain an antibacterial coating, and then controlling a spinning device by the semi-finished product through a PLC (programmable logic controller) technology to obtain a finished product.
In the invention, the processing system comprises a stirring device, a drying device, an air drying device and a spinning device, and the spinning device comprises a spinning machine and a spinning device.
According to the invention, the stirring device comprises a stirring box, a stirring motor is fixed on the outer wall of the top of the stirring box through a screw, and an output shaft of the stirring motor is connected with a stirring rod through a coupling.
According to the invention, the drying device comprises a drying box, the inner walls of two sides of the drying box are respectively provided with an electric heating wire, and the inner wall of the top of the drying box is fixed with a temperature sensor through a screw.
In the invention, the air drying device comprises an air blowing cylinder, a support is arranged on the inner wall of the air blowing cylinder, a motor is fixed on the outer wall of the support through a screw, and an output shaft of the motor is connected with fan blades through a coupling.
Example 2:
referring to fig. 1, a method for manufacturing a absorbable surgical suture with a three-layer ring structure for promoting healing of infection resistance comprises the following steps:
s1: respectively adopting 1.0mol/L HCI solution and 50% NaOH solution to treat the carapace to extract chitin, treating chitosan deacetylation with 50% NaOH solution at 90 ℃ for 3h to prepare chitosan stock solution, and performing carboxymethylation reaction with chloroacetic acid to prepare 2 parts of carboxymethyl chitosan as an outermost layer;
s2: dissolving chitosan in 5-6% dilute acetic acid solution, adding urea and zinc acetate as auxiliaries, stirring by using a stirring device to prepare a spinning stock solution of chitosan, solidifying, stretching, washing, and drying for 1h by using a drying device at 70 ℃ under a tension state to finally obtain 3 parts of original-state chitosan fiber core with sufficient mechanical strength;
s3: cutting Os Sepiae into pieces of 1-3cm, adding appropriate amount of pepsin and acetic acid solution, standing, filtering the extractive solution, adding NaCl to final concentration of 10%, centrifuging at 1500r/min to obtain collagen precipitate, dissolving with 0.5mo/L acetic acid, and dialyzing to obtain purified collagen solution;
s4: preparing a saturated collagen solution at room temperature, putting the saturated collagen solution into the original state chitosan, soaking for 3min, airing, crosslinking by using glutaraldehyde with the concentration of 0.25%, washing by using distilled water, and dehydrating to obtain crosslinked original state chitosan-collagen with the mass ratio of 1: 1;
s5: weighing 1 part of berberine powder, dissolving in deionized water, and preparing 4mg/mL berberine solution. Adding 0.5 part of glycerol into the silk fibroin solution, uniformly mixing the berberine solution and the silk fibroin glycerol mixed solution, wherein the mass ratio of silk fibroin to berberine is 10:1, and drying to obtain a berberine-silk fibroin antibacterial coating material;
s6: and (3) putting the sample into 1 part of berberine-silk fibroin mixed solution for dipping to obtain an antibacterial coating, and then controlling a spinning device by the semi-finished product through a PLC (programmable logic controller) technology to obtain a finished product.
In the invention, the processing system comprises a stirring device, a drying device, an air drying device and a spinning device, and the spinning device comprises a spinning machine and a spinning device.
According to the invention, the stirring device comprises a stirring box, a stirring motor is fixed on the outer wall of the top of the stirring box through a screw, and an output shaft of the stirring motor is connected with a stirring rod through a coupling.
According to the invention, the drying device comprises a drying box, the inner walls of two sides of the drying box are respectively provided with an electric heating wire, and the inner wall of the top of the drying box is fixed with a temperature sensor through a screw.
In the invention, the air drying device comprises an air blowing cylinder, a support is arranged on the inner wall of the air blowing cylinder, a motor is fixed on the outer wall of the support through a screw, and an output shaft of the motor is connected with fan blades through a coupling.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. A method for manufacturing a three-layer ring structure absorbable surgical suture for promoting healing and resisting infection is characterized by comprising the following steps of:
s1: respectively adopting 1.0mol/L HCI solution and 50% NaOH solution to treat the carapace to extract chitin, treating chitosan deacetylation with 50% NaOH solution at 90 ℃ for 3h to prepare chitosan stock solution, and performing carboxymethylation reaction with chloroacetic acid to prepare 2 parts of carboxymethyl chitosan as an outermost layer;
s2: dissolving chitosan in 5-6% dilute acetic acid solution, adding urea and zinc acetate as auxiliaries, stirring by using a stirring device to prepare a spinning stock solution of chitosan, solidifying, stretching, washing, and drying for 1h by using a drying device at 70 ℃ under a tension state to finally obtain 3 parts of original-state chitosan fiber core with sufficient mechanical strength;
s3: cutting Os Sepiae into pieces of 1-3cm, adding appropriate amount of pepsin and acetic acid solution, standing, filtering the extractive solution, adding NaCl to final concentration of 10%, centrifuging at 1500r/min to obtain collagen precipitate, dissolving with 0.5mo/L acetic acid, and dialyzing to obtain purified collagen solution;
s4: preparing a saturated collagen solution at room temperature, putting the saturated collagen solution into the original state chitosan, soaking for 3min, airing, crosslinking by using glutaraldehyde with the concentration of 0.25%, washing by using distilled water, and dehydrating to obtain crosslinked original state chitosan-collagen with the mass ratio of 1: 1;
s5: degumming 1 part of raw silkworm silk in 15L of boiling Na2CO3(0.02M) aqueous solution for 30 minutes, washing with deionized water, carrying out air drying by using an air drying device, weighing dried silkworm fibroin fiber, dissolving in 120mL of LiBr (9.3M) solution, dissolving in a 65 ℃ oven, taking out the solution, pouring into a dialysis bag, dialyzing in deionized water for 36 hours, centrifuging the dialyzed solution twice in a high-speed centrifuge at 9000r/min, removing impurities, finally obtaining 1 part of fibroin protein solution, and drying to obtain a berberine-fibroin protein antibacterial coating material;
s6: and (3) putting the sample into 1 part of berberine-silk fibroin mixed solution for dipping to obtain an antibacterial coating, and then controlling a spinning device by the semi-finished product through a PLC (programmable logic controller) technology to obtain a finished product.
2. The method for preparing the absorbable surgical suture with the three-layer annular structure for promoting healing of infection resistance according to claim 1 is implemented by a processing system, wherein the processing system comprises a stirring device, a drying device, an air drying device and a spinning device, and the spinning device comprises a spinning machine and a spinning device.
3. The method for preparing the absorbable surgical suture with the three-layer ring structure for promoting healing and resisting infection as claimed in claim 2, wherein the stirring device comprises a stirring box, a stirring motor is fixed on the outer wall of the top of the stirring box through a screw, and an output shaft of the stirring motor is connected with a stirring rod through a coupling.
4. The method for preparing the absorbable surgical suture with the three-layer ring structure for promoting healing and resisting infection as claimed in claim 3, wherein the drying device comprises a drying oven, heating wires are arranged on the inner walls of two sides of the drying oven, and a temperature sensor is fixed on the inner wall of the top of the drying oven through screws.
5. The method for preparing an absorbable surgical suture with three layers of ring structures for promoting healing of infection according to claim 4, wherein the air drying device comprises an air blowing cylinder, a support is arranged on the inner wall of the air blowing cylinder, a motor is fixed on the outer wall of the support through screws, and fan blades are connected to the output shaft of the motor through a coupling.
6. The method for preparing the absorbable surgical suture with the three-layer ring structure for promoting healing and resisting infection as claimed in claim 1, wherein 1 part of berberine powder is weighed instead of S5, and the berberine powder is dissolved in deionized water to prepare a berberine solution with the concentration of 4 mg/mL. Adding 0.5 part of glycerol into the silk fibroin solution, uniformly mixing the berberine solution and the silk fibroin glycerol mixed solution, wherein the mass ratio of silk fibroin to berberine is 10:1, and drying to obtain the berberine-silk fibroin antibacterial coating material.
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| CN202010748375.1A CN111790001A (en) | 2020-07-30 | 2020-07-30 | Method for manufacturing absorbable surgical suture with three-layer annular structure for healing promotion and infection resistance |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171488A (en) * | 2021-04-23 | 2021-07-27 | 宁波市第一医院 | Absorbable suture line and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703794A (en) * | 2009-11-18 | 2010-05-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN107261196A (en) * | 2017-05-16 | 2017-10-20 | 苏州大学 | A kind of antibacterial fibroin material and preparation method thereof |
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2020
- 2020-07-30 CN CN202010748375.1A patent/CN111790001A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703794A (en) * | 2009-11-18 | 2010-05-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN107261196A (en) * | 2017-05-16 | 2017-10-20 | 苏州大学 | A kind of antibacterial fibroin material and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171488A (en) * | 2021-04-23 | 2021-07-27 | 宁波市第一医院 | Absorbable suture line and preparation method thereof |
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Application publication date: 20201020 |
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