CN114515306B - Nose-clearing essential oil patch and preparation method thereof - Google Patents

Nose-clearing essential oil patch and preparation method thereof Download PDF

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CN114515306B
CN114515306B CN202210295518.7A CN202210295518A CN114515306B CN 114515306 B CN114515306 B CN 114515306B CN 202210295518 A CN202210295518 A CN 202210295518A CN 114515306 B CN114515306 B CN 114515306B
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essential oil
microspheres
stirring
layer
taking
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CN114515306A (en
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周捷
高爱萍
林军
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CHANGZHOU MAJOR MEDICAL PRODUCTS CO LTD
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CHANGZHOU MAJOR MEDICAL PRODUCTS CO LTD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a nose-relieving essential oil patch and a preparation method thereof, wherein a non-woven fabric is used as a base layer for loading an essential oil layer and is used as a load carrier of plant essential oil, a polydopamine layer is formed on the surface of the non-woven fabric through dopamine polymerization, and essential oil microspheres loaded with the plant essential oil are coated by the polydopamine, so that the attachment of the essential oil microspheres on the surface of the non-woven fabric is ensured, the essential oil microspheres are not easy to fall off, and the slow-release effect of the essential oil microspheres is ensured; then, a polyethylene film is used as an anti-seepage film layer, and an anti-seepage film is compounded on one side of the essential oil layer to form an intermediate layer; the prevention of seepage membrane can play the effect with essential oil and viscose separation, lies in prevention of seepage membrane one side complex acrylic acid adhesive in the intermediate level afterwards, and outer complex is from the type membrane, and it can effectively be laminated with the clothing, is difficult for droing. The essential oil patch prepared by the scheme has the effects of soothing the nerves and relieving stuffy nose, can relieve nasal obstruction, can refresh the brain, refresh the brain and improve the sleep quality, has the long-acting slow-release effect, and is excellent in practical application effect.

Description

Nose-clearing essential oil patch and preparation method thereof
Technical Field
The invention relates to the technical field of essential oil patches, in particular to a nose-relieving essential oil patch and a preparation method thereof.
Background
Along with the improvement and development of science and technology, the air haze phenomenon is more serious, more and more people suffer from rhinitis, the existence of the rhinitis can cause the patients to breathe unsmoothly, the sleep quality and the life quality of the patients are influenced, and the life safety of the patients can be endangered in serious cases; under the condition, the nose-through essential oil patch gradually enters into the life of people, and can improve the nasal obstruction and the sleep quality when people have nasal obstruction or sleep disorder due to breathing.
Most of the existing nose-soothing essential oil patches on the market have skin irritation, red swelling and allergy can occur after long-time contact with the skin, the essential oil slow-release effect is poor, the essential oil patch effect is short, and the actual application effect is influenced; based on the situation, the application discloses a nose-relieving essential oil patch and a preparation method thereof, which aim to solve the technical problem.
Disclosure of Invention
The invention aims to provide a nose-relieving essential oil patch and a preparation method thereof, and aims to solve the problems in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme:
a preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 170-180 deg.C for 1-2 hr, mixing, adding carrier microsphere, and stirring for 2-3 hr to obtain essential oil microsphere;
(2) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 15-20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 20-30min by using deionized water, soaking the non-woven fabric in a dopamine hydrochloride solution and essential oil microsphere mixed solution for 10-20h, taking out, washing and drying to obtain a loaded essential oil layer;
(3) Taking the anti-seepage film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
According to an optimized scheme, in the step (1), the carrier microspheres are any one of silicon dioxide microspheres or corn starch microspheres; the lavender essence comprises, by mass, 20-30% of lavender, 20-30% of eucalyptus oil, 20-30% of menthol, 20-29% of camphor, 0.2-1% of polyvinylpyrrolidone and 0.2-1% of carrier microspheres.
According to an optimized scheme, the preparation steps of the silicon dioxide microspheres are as follows:
s1: mixing porous carbon microspheres and a hexadecyl trimethyl ammonium chloride solution, and stirring at the temperature of 20-25 ℃ to react for 12-14h to obtain modified carbon microspheres;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 8-10h at 40-50 ℃, carrying out suction filtration to collect a product, washing, carrying out vacuum drying, transferring the dried product to a muffle furnace, heating to 450-460 ℃ at a heating rate of 2-3 ℃/min, carrying out heat preservation treatment for 3-3.5h, cooling, and obtaining a material A;
s2: and (3) taking the material A and absolute ethyl alcohol, carrying out ultrasonic dispersion to obtain a dispersion liquid, adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3-4 hours at 70-80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres.
According to an optimized scheme, the preparation method of the porous carbon microsphere comprises the following steps: taking glucose and deionized water, uniformly mixing, adding sodium polystyrene sulfonate, continuously stirring until the sodium polystyrene sulfonate is dissolved, carrying out hydrothermal reaction for 8-9h at 160-180 ℃, filtering and collecting a product after the reaction is finished, washing the product by the deionized water and absolute ethyl alcohol in sequence, and drying the product in vacuum; and transferring the dried product to 850-900 ℃, and activating for 1-1.5h in air atmosphere to obtain the porous carbon microsphere.
In an optimized scheme, the addition amount of the sodium polystyrene sulfonate is 0.3-0.5wt% of the addition amount of the glucose.
In an optimized scheme, in the step S1, the concentration of the sodium silicate solution is 25-30mmol/L;
in step S2, the volume ratio of the dispersion to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
According to a more optimized scheme, in the step (2), the essential oil microspheres account for 6-8wt% of the mixed solution.
According to the optimized scheme, in the step (3), the impermeable layer is a polyethylene film, the gluing temperature is 120-140 ℃ when the acrylic acid adhesive is coated, and the gluing amount is 25-50g/m 2 The thickness of the PET release film is 0.015-0.03mm.
Compared with the prior art, the essential oil patch prepared by the preparation method of the nose-soothing essential oil patch according to any one of the above optimized schemes has the following beneficial effects:
the invention discloses a nose-relieving essential oil patch and a preparation method thereof, wherein a scheme is that non-woven fabrics are used as a base layer for loading an essential oil layer, the non-woven fabrics are made of polyester or viscose, or can be made of mixed fabrics of polyester and viscose, the non-woven fabrics are used as load carriers of plant essential oil, a polydopamine layer is formed on the surface of the non-woven fabrics through dopamine polymerization, essential oil microspheres loaded with the plant essential oil are coated by the polydopamine, so that the attachment of the essential oil microspheres on the surface of the non-woven fabrics is ensured, the essential oil microspheres are not easy to fall off, and the slow release effect of the essential oil microspheres is ensured; then, compounding an anti-seepage film on one side of the essential oil layer by using a polyethylene film as an anti-seepage film layer to form a middle layer; the anti-seepage film can play a role in blocking essential oil and viscose glue, and then an acrylic acid adhesive is compounded on one side of the anti-seepage film positioned in the middle layer, and the anti-seepage film is externally compounded from the type film, can be effectively attached to clothes and is not easy to fall off.
According to the scheme, porous silicon dioxide is used for loading plant essential oil, in order to improve the loading rate of the plant essential oil, porous carbon microspheres are used as hard templates, hollow multi-shell-layer silicon dioxide is formed by a subsequence template method, and the specific surface area of the silicon dioxide is further improved, so that the loading capacity is improved.
On the basis of the scheme, hexadecyl trimethyl ammonium chloride is introduced, the concentration of a sodium silicate solution is limited to be 25-30mmol/L, and the amount of silicate ions adsorbed on the surface of the carbon microsphere can be ensured under the limitation of the two condition parameters, so that the shell forms of the subsequently formed hollow silica multi-shell microspheres are more abundant.
Meanwhile, the modified carbon microspheres are calcined at high temperature to form hollow silica multi-shell microspheres, and the surfaces of the hollow silica multi-shell microspheres are treated by a silane coupling agent, wherein the silane coupling agent is KH-570, so that the surface hydrophobicity of the silica microspheres is improved to improve the surface essential oil loading rate of the silica microspheres; on the other hand, the adhesion performance of the silane coupling agent and polydopamine can be further improved through grafting, and groups on the surface of the silicon dioxide participate in polymerization through the actions of hydrogen bonds, chemical crosslinking and the like, so that the adhesion performance of the essential oil microspheres is guaranteed.
The essential oil formula in the scheme is as follows: the lavender-containing composite material comprises, by mass, 20-30% of lavender, 20-30% of eucalyptus oil, 20-30% of menthol, 20-29% of camphor, 0.2-1% of polyvinylpyrrolidone and 0.2-1% of carrier microspheres; wherein the lavender essential oil has the functions of flavoring and tranquilizing. Tasmanian Bluegum, menthol and camphor have the function of relieving stuffy nose. The povidone has the functions of volatilization and slow release of essential oil; the povidone component is added to promote the stabilization of essential oil in the storage machine of the spunlace fabric and reduce the volatilization speed of the essential oil. The essential oil has excellent slow release effect when in use.
The scheme discloses a nose-clearing essential oil patch and a preparation method thereof, the process design is reasonable, the component proportion is proper, the prepared essential oil patch has the functions of soothing the nerves and clearing the nose, the nasal obstruction can be relieved, the refreshing effect can be realized, the sleep quality is improved, the essential oil patch has the long-acting slow-release function, and the practical application effect is excellent.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following examples, the acrylic adhesive is a commercially available acrylic adhesive 8112.
Example 1:
a preparation method of a nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 9 hours at 160 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and drying the product in vacuum; and transferring the dried product to 850 ℃, and activating for 1.5h in air atmosphere to obtain the porous carbon microsphere.
Mixing the porous carbon microspheres with a hexadecyl trimethyl ammonium chloride solution, and stirring at the stirring speed of 180rpm at the temperature of 20 ℃ for reaction for 14 hours to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 10 hours at 40 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 450 ℃ at a heating rate of 2 ℃/min, performing heat preservation treatment for 3.5 hours, cooling to obtain a material A; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 4 hours at 70 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 170 deg.C for 2 hr, mixing, adding silica microsphere, and stirring for 2 hr to obtain essential oil microsphere; the lavender essential oil is composed of, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 15min in an acetone solution, ultrasonically cleaning the non-woven fabric for 20min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and an essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere accounts for 8wt% of the mixed solution; the soaking time is 10h, and the obtained product is washed and dried after being taken out to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Example 2:
a preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 8.5h at 170 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying; and transferring the dried product to 880 ℃, and activating for 1.2h in air atmosphere to obtain the porous carbon microsphere.
Mixing porous carbon microspheres and a hexadecyl trimethyl ammonium chloride solution, and stirring at a stirring speed of 180rpm at 25 ℃ for 13 hours to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 9 hours at 45 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, cooling, and obtaining a material A; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3 hours at the temperature of 80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing and stirring, adding polyvinylpyrrolidone, stirring at 175 deg.C for 1.5 hr, mixing, adding silica microsphere, and stirring for 2.5 hr to obtain essential oil microsphere; the lavender-containing composite material comprises, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and an essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere accounts for 8wt% of the mixed solution; the soaking time is 10h, and the obtained product is washed and dried after being taken out to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Example 3:
a preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 8 hours at 180 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and drying the product in vacuum; and transferring the dried product to 900 ℃, and activating for 1h in an air atmosphere to obtain the porous carbon microspheres.
Mixing porous carbon microspheres and a hexadecyl trimethyl ammonium chloride solution, and stirring at a stirring speed of 180rpm at 25 ℃ for 12 hours to react to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 8 hours at 50 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, cooling to obtain a material A; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3 hours at the temperature of 80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing and stirring, adding polyvinylpyrrolidone, stirring at 180 deg.C for 1 hr, adding silica microspheres, and stirring for 3 hr to obtain essential oil microspheres; the lavender essential oil is composed of, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and an essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere accounts for 8wt% of the mixed solution; soaking for 10h, taking out, washing and drying to obtain a loaded essential oil layer;
(4) Taking the polyethylene anti-seepage film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Comparative example 1: comparative example 1 is based on example 2, in comparative example 1 no activation is carried out, and the remaining steps are unchanged.
A preparation method of a nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; and continuously stirring until the porous carbon microspheres are dissolved, carrying out hydrothermal reaction for 8.5h at 170 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying to obtain the porous carbon microspheres.
Mixing porous carbon microspheres and a hexadecyl trimethyl ammonium chloride solution, and stirring at a stirring speed of 180rpm at 25 ℃ for 13 hours to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 9 hours at 45 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, cooling, and obtaining a material A; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3 hours at the temperature of 80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 175 deg.C for 1.5 hr, mixing, adding silica microsphere, and stirring for 2.5 hr to obtain essential oil microsphere; the lavender-containing composite material comprises, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere is 8wt% of the mixed solution; soaking for 10h, taking out, washing and drying to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Comparative example 2: comparative example 2 is based on example 2, and in comparative example 2, the porous carbon microspheres are not modified, and the rest steps are not changed.
A preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and then adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 8.5h at 170 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying; and transferring the dried product to 880 ℃, and activating for 1.2h in an air atmosphere to obtain the porous carbon microsphere.
Taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 9 hours at 45 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, and cooling to obtain a material A; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3 hours at the temperature of 80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 175 deg.C for 1.5 hr, mixing, adding silica microsphere, and stirring for 2.5 hr to obtain essential oil microsphere; the lavender essential oil is composed of, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere is 8wt% of the mixed solution; soaking for 10h, taking out, washing and drying to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Comparative example 3: comparative example 3 is based on example 2, in comparative example 3 material a was not modified with a silane coupling agent and the remaining steps were unchanged.
A preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and then adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 8.5h at 170 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying; and transferring the dried product to 880 ℃, and activating for 1.2h in an air atmosphere to obtain the porous carbon microsphere.
Mixing the porous carbon microspheres with a hexadecyl trimethyl ammonium chloride solution, and stirring at the stirring speed of 180rpm at 25 ℃ for reaction for 13 hours to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 9 hours at 45 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, cooling, and obtaining silicon dioxide microspheres; the concentration of the sodium silicate solution is 30mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing and stirring, adding polyvinylpyrrolidone, stirring at 175 deg.C for 1.5 hr, mixing, adding silica microsphere, and stirring for 2.5 hr to obtain essential oil microsphere; the lavender-containing composite material comprises, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and an essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere accounts for 8wt% of the mixed solution; soaking for 10h, taking out, washing and drying to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 The thickness of the PET release film is 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Comparative example 4: comparative example 4 is based on example 2, the concentration of the sodium silicate solution in comparative example 4 is 20mmol/L, and the rest of the procedure is unchanged.
A preparation method of the nose-relieving essential oil patch comprises the following steps:
(1) Preparing the silicon dioxide microspheres:
s1: taking glucose and deionized water, uniformly mixing, and adding sodium polystyrene sulfonate, wherein the addition amount of the sodium polystyrene sulfonate is 0.5wt% of the addition amount of the glucose; continuously stirring until the mixture is dissolved, carrying out hydrothermal reaction for 8.5h at 170 ℃, filtering and collecting a product after the reaction is finished, washing the product by deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying; and transferring the dried product to 880 ℃, and activating for 1.2h in air atmosphere to obtain the porous carbon microsphere.
Mixing porous carbon microspheres and a hexadecyl trimethyl ammonium chloride solution, and stirring at a stirring speed of 180rpm at 25 ℃ for 13 hours to obtain modified carbon microspheres; the concentration of the hexadecyl trimethyl ammonium chloride solution is 2mmol/L; the dosage of the porous carbon microsphere and the hexadecyl trimethyl ammonium chloride solution is 1g:100mL;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 9 hours at 45 ℃, performing suction filtration to collect a product, washing, performing vacuum drying, transferring the dried product to a muffle furnace, heating to 460 ℃ at a heating rate of 2 ℃/min, performing heat preservation for 3 hours, and cooling to obtain a material A; the concentration of the sodium silicate solution is 20mmol/L; the dosage of the modified carbon microsphere and the sodium silicate solution is 1g:50mL;
s2: taking the material A and absolute ethyl alcohol, and performing ultrasonic dispersion to obtain a dispersion liquid, wherein the concentration of the dispersion liquid is 10g/L; adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3 hours at the temperature of 80 ℃, centrifuging and collecting a product, washing and drying to obtain the silicon dioxide microspheres. The volume ratio of the dispersion liquid to the silane coupling agent is 20:1; the silane coupling agent is KH-570.
(2) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 175 deg.C for 1.5 hr, mixing, adding silica microsphere, and stirring for 2.5 hr to obtain essential oil microsphere; the lavender-containing composite material comprises, by mass, 25% of lavender, 24% of eucalyptus oil, 30% of menthol, 29% of camphor, 1% of polyvinylpyrrolidone and 1% of silica microspheres.
(3) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 30min by using deionized water, and soaking the non-woven fabric in a dopamine hydrochloride solution and essential oil microsphere mixed solution, wherein the concentration of the dopamine hydrochloride solution is 4g/L, and the essential oil microsphere is 8wt% of the mixed solution; the soaking time is 10h, and the obtained product is washed and dried after being taken out to obtain a loaded essential oil layer;
(4) Taking the polyethylene impermeable film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer; the coating temperature is 120 ℃ and the coating amount is 25g/m when the acrylic acid adhesive is coated 2 Thickness of PET Release filmIs 0.03mm;
and compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil patch.
Detection experiment:
detecting 1, taking the essential oil patches prepared in the embodiments 1-3 and the comparative examples 1-4, and carrying out an actual effect verification experiment, wherein the method comprises the following specific steps: taking a hard board, wherein the size of the hard board is 31.5cm multiplied by 21.5cm, a layer of cotton ammonia fabric is flatly laid on the surface of the hard board, the size of the fabric is about 35cm multiplied by 23cm, the periphery of the fabric is fixed on the hard board through dovetail clamps, essential oil is pasted on the surface of the fabric, four corners are pasted and leveled in place, the hard board is placed in a thermostat at 40 ℃ for 8 hours, a test board is taken out, the test board is placed in a normal temperature environment and is statically cooled for 1 hour, and then detection is carried out; the patch was removed by tearing with a finger without rubbing the hand cream during the test.
And (4) qualified standard: the glue on the essential oil patch and the double-sided adhesive tape cannot remain on the fabric; the double-sided adhesive layer cannot be directly separated by bare hands.
And 2, testing the peeling force of the essential oil prepared in the example 1-3 attached to the surface of the fabric on the basis of the test 1.
Figure BDA0003561664090000111
Figure BDA0003561664090000121
And (3) detection: and respectively selecting 30 persons, averagely dividing the persons into 3 groups, and carrying out fragrance test on the essential oil patches prepared in the examples 1-3 for 10 persons in each group, wherein the test time lasts 24 hours, the testers stick the essential oil patches to the surface of the fabric, smell the fragrance of the essential oil patches every day, score the essential oil patches according to sensory experience, and take and record the average value at intervals of 4 hours, wherein the score value is 1-5, and the effect is the most excellent at 5.
Figure BDA0003561664090000122
And (4) detection:
0.1g of the silica microspheres prepared in examples 1-3 and comparative examples 1-4 are respectively taken and placed in 50mL and 30mg/mL essential oil solutions (mixed by lavender, eucalyptus oil, menthol, camphor and polyvinylpyrrolidone), stirred for 2.5h, and the loading rate is detected and calculated, wherein the specific data are as follows:
and taking the loaded essential oil microspheres, and testing the average volatilization rate of the essential oil within 72 h.
Figure BDA0003561664090000123
And (4) conclusion: the scheme discloses a nose-soothing essential oil patch and a preparation method thereof, the process design is reasonable, the component proportion is proper, the prepared essential oil patch has the effects of soothing the nerves and soothing the nose, the nasal obstruction can be relieved, the refreshing effect can be realized, the sleep quality can be improved, the essential oil patch has the long-acting slow-release effect, and the practical application effect is excellent.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. A preparation method of a nose-relieving essential oil patch is characterized by comprising the following steps: the method comprises the following steps:
(1) Mixing Camphora and herba Menthae, adding lavender essential oil and oleum Eucalypti, mixing, stirring, adding polyvinylpyrrolidone, stirring at 170-180 deg.C for 1-2 hr, mixing, adding carrier microsphere, and stirring for 2-3 hr to obtain essential oil microsphere;
(2) Taking a non-woven fabric, ultrasonically cleaning the non-woven fabric for 15-20min in an acetone solution, ultrasonically cleaning the non-woven fabric for 20-30min in deionized water, soaking the non-woven fabric in a dopamine hydrochloride solution and essential oil microsphere mixed solution for 10-20h, taking out, washing and drying to obtain a loaded essential oil layer;
(3) Taking the anti-seepage film and the loaded essential oil layer, and performing hot-pressing compounding to form an intermediate layer;
coating an acrylic acid adhesive on the surface of a PET release film to obtain an adhesive layer;
compounding an adhesive layer on one side of the anti-seepage film in the middle layer to obtain the essential oil paste;
in the step (1), the lavender, the eucalyptus oil, the menthol and the camphor are respectively 20-30%, 20-29%, 0.2-1% and 0.2-1% by mass of carrier microspheres;
the carrier microspheres are silicon dioxide microspheres; the preparation steps of the silicon dioxide microspheres are as follows:
s1: mixing the porous carbon microspheres with a hexadecyl trimethyl ammonium chloride solution, and stirring at 20-25 ℃ for reaction for 12-14 hours to obtain modified carbon microspheres;
taking the modified carbon microspheres and a sodium silicate solution, adjusting the pH value to 5, mixing and stirring for 8-10h at 40-50 ℃, carrying out suction filtration, collecting a product, washing, carrying out vacuum drying, transferring the dried product to a muffle furnace, heating to 450-460 ℃ at a heating rate of 2-3 ℃/min, carrying out heat preservation treatment for 3-3.5h, cooling, and obtaining a material A;
s2: taking the material A and absolute ethyl alcohol, performing ultrasonic dispersion to obtain a dispersion liquid, adding a silane coupling agent into the dispersion liquid, stirring and reacting for 3-4 hours at 70-80 ℃, centrifuging and collecting a product, washing and drying to obtain silicon dioxide microspheres;
in the step S1, the concentration of the sodium silicate solution is 25-30mmol/L;
in step S2, the volume ratio of the dispersion to the silane coupling agent is 20:1; the silane coupling agent is KH-570;
the preparation method of the porous carbon microsphere comprises the following steps: taking glucose and deionized water, uniformly mixing, adding sodium polystyrene sulfonate, continuously stirring until the sodium polystyrene sulfonate is dissolved, carrying out hydrothermal reaction for 8-9h at 160-180 ℃, filtering and collecting a product after the reaction is finished, washing the product by the deionized water and absolute ethyl alcohol in sequence, and carrying out vacuum drying; and transferring the dried product to 850-900 ℃, and activating for 1-1.5h in air atmosphere to obtain the porous carbon microsphere.
2. The preparation method of the nasal obstruction clearing essential oil patch according to claim 1, which is characterized by comprising the following steps of: the addition amount of the sodium polystyrene sulfonate is 0.3-0.5wt% of the addition amount of glucose.
3. The preparation method of the nasal obstruction clearing essential oil patch according to claim 1, which is characterized by comprising the following steps of: in the step (2), the essential oil microspheres account for 6-8wt% of the mixed solution.
4. The preparation method of the nasal obstruction clearing essential oil patch according to claim 1, which is characterized by comprising the following steps of: in the step (3), the impermeable film is a polyethylene film, the coating temperature is 120-140 ℃ when the acrylic adhesive is coated, the coating quantity is 25-50g per square meter, and the thickness of the PET release film is 0.015-0.03mm.
5. The essential oil patch prepared by the preparation method of the nose-clearing essential oil patch according to any one of claims 1-4.
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CN105310819A (en) * 2015-10-30 2016-02-10 苏州求是艾康医疗器械科技有限公司 Essential oil patch and manufacturing method thereof
CN106268553A (en) * 2016-08-16 2017-01-04 天津市聚星康华医药科技有限公司 A kind of quintessence oil microsphere for mask filter disc and preparation method thereof
CN108354971A (en) * 2018-04-02 2018-08-03 山西康灵医疗器械有限公司 A kind of logical nose patch and preparation method thereof
CN112791131A (en) * 2020-12-30 2021-05-14 茂名市人民医院 Nasal cavity cold compress gel pastes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105310819A (en) * 2015-10-30 2016-02-10 苏州求是艾康医疗器械科技有限公司 Essential oil patch and manufacturing method thereof
CN106268553A (en) * 2016-08-16 2017-01-04 天津市聚星康华医药科技有限公司 A kind of quintessence oil microsphere for mask filter disc and preparation method thereof
CN108354971A (en) * 2018-04-02 2018-08-03 山西康灵医疗器械有限公司 A kind of logical nose patch and preparation method thereof
CN112791131A (en) * 2020-12-30 2021-05-14 茂名市人民医院 Nasal cavity cold compress gel pastes

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