CN114502201B - 靶向性树枝状体缀合物 - Google Patents

靶向性树枝状体缀合物 Download PDF

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Publication number
CN114502201B
CN114502201B CN202080064953.8A CN202080064953A CN114502201B CN 114502201 B CN114502201 B CN 114502201B CN 202080064953 A CN202080064953 A CN 202080064953A CN 114502201 B CN114502201 B CN 114502201B
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dendrimer
group
peg
compound
lys
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CN114502201A (zh
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D·欧文
S·采盖
S·申古尔
P·雷塔诺
C·波特
A·约翰生
D·袁
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Star Pharmaceutical Pte Ltd
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Star Pharmaceutical Pte Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202080064953.8A 2019-08-28 2020-08-28 靶向性树枝状体缀合物 Active CN114502201B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019903152A AU2019903152A0 (en) 2019-08-28 Targeted Dendrimer Conjugates
AU2019903152 2019-08-28
PCT/AU2020/050910 WO2021035310A1 (en) 2019-08-28 2020-08-28 Targeted dendrimer conjugates

Publications (2)

Publication Number Publication Date
CN114502201A CN114502201A (zh) 2022-05-13
CN114502201B true CN114502201B (zh) 2025-04-25

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US (1) US20220288216A1 (enExample)
EP (1) EP4021511A4 (enExample)
JP (2) JP2022547434A (enExample)
KR (1) KR20220052960A (enExample)
CN (1) CN114502201B (enExample)
AU (1) AU2020338481B2 (enExample)
BR (1) BR112022003628A2 (enExample)
CA (1) CA3149263A1 (enExample)
WO (1) WO2021035310A1 (enExample)

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US20180326081A1 (en) * 2011-06-06 2018-11-15 Starpharma Pty Ltd Macromolecules
JP7541978B2 (ja) * 2018-11-29 2024-08-29 スターファーマ ピーティーワイ エルティーディー 治療および画像化のためのデンドリマー
WO2023283537A2 (en) * 2021-07-07 2023-01-12 Institute For Systems Biology Cell analysis methods, compositions, and uses
EP4430076A2 (en) 2021-11-08 2024-09-18 Life Technologies AS Polymer-interaction molecule conjugates and methods of use
CN115991880B (zh) * 2022-12-08 2024-03-19 中国药科大学 一种树状大分子pamam-g5-tco及其制备方法与应用
WO2024182810A2 (en) * 2023-03-02 2024-09-06 Inmune Bio Inc. Bioconjugates of dominant negative tnf
KR20250100878A (ko) * 2023-12-26 2025-07-04 주식회사 압타머사이언스 분지형의 효소 절단 가능한 링커-페이로드와 이의 효율적인 제조방법
WO2025164814A1 (en) * 2024-02-01 2025-08-07 The University Of Tokyo Selective intracellular delivery of protein in cells with nanocarriers sensing cathepsin b activity
WO2025222234A1 (en) * 2024-04-24 2025-10-30 Starpharma Pty Ltd Targeted dendrimer conjugates
WO2026046228A1 (zh) * 2024-08-27 2026-03-05 苏州拓界医药有限公司 树枝状聚合物偶联物及其制备方法
CN119638781B (zh) * 2025-02-20 2025-05-16 瑞博(苏州)制药有限公司 一种抗体偶联药物连接子的合成方法

Citations (2)

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