CN114471367A - Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor - Google Patents
Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor Download PDFInfo
- Publication number
- CN114471367A CN114471367A CN202210093573.8A CN202210093573A CN114471367A CN 114471367 A CN114471367 A CN 114471367A CN 202210093573 A CN202210093573 A CN 202210093573A CN 114471367 A CN114471367 A CN 114471367A
- Authority
- CN
- China
- Prior art keywords
- air inlet
- air
- tank
- outlet
- horizontal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/28—Moving reactors, e.g. rotary drums
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention discloses a tank cover integrated type air inlet and exhaust device of a horizontal self-stirring in-vitro protein synthesis reactor, which comprises a cover body, an air inlet device and an exhaust device, wherein the air inlet device and/or the exhaust device and the cover body are integrated into a whole; the gas inlet device comprises a gas inlet movable part and a gas inlet static part, the gas inlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas inlet movable part and the cover body, the gas outlet device comprises a gas outlet movable part and a gas outlet static part, and the gas outlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas outlet movable part and the cover body. The invention solves the technical problem of difficult air supply of the horizontal moving reaction tank body, adopts the combined air inlet and outlet device with dynamic and static combination to realize the communication with the rotatable tank body, provides continuous fresh air for the normal work of the horizontal moving reaction tank body and can discharge waste gas generated in the reaction process in time.
Description
Technical Field
The invention belongs to the technical field of biological reaction equipment, and particularly relates to a tank cover integrated type air inlet and exhaust device of a horizontal self-stirring in-vitro protein synthesis reactor.
Background
The current biological reaction tank generally adopts a vertical tank body, the tank body is in a static state in the working process, the air supply mode of the corresponding air distribution device is an air lifting mode, namely air is introduced from the bottom of the tank, so that air can be supplied to a certain fixed direction in the reaction tank only, namely, only one air supply port is arranged in the tank, so that the fresh air in the tank is very uneven, and the biological reaction efficiency is seriously influenced.
The horizontal reaction tank body has certain difficulty in supplying air to the tank body which is in a rotary motion state in the working process, and no public report is found at present.
Disclosure of Invention
The invention aims to solve the technical problems that the air supply of the existing vertical reaction tank body is not uniform and the air supply of the existing horizontal movement reaction tank body is difficult.
In order to achieve the aim, the invention provides a tank cover integrated air inlet and exhaust device of a horizontal self-stirring in-vitro protein synthesis reactor, which comprises a cover body, an air inlet device and an exhaust device, wherein the air inlet device and/or the exhaust device is integrated with the cover body; the gas inlet device comprises a gas inlet movable part and a gas inlet static part, the gas inlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas inlet movable part and the cover body, the gas outlet device comprises a gas outlet movable part and a gas outlet static part, and the gas outlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas outlet movable part and the cover body.
Furthermore, the air inlet static part comprises an air inlet part outside the tank and an air inlet part inside the tank, the end part of the air inlet part inside the tank is closed, and a plurality of air outlet holes are formed in the pipe wall of the air inlet static part.
Further, the air outlet holes are uniformly distributed along the circumferential direction of the air supply part in the tank and extend along the axial direction of the air supply part in the tank.
Further, the length of the gas feeding part in the tank is equivalent to the length of the inner cavity of the horizontal tank of the reactor.
Furthermore, a heating device with adjustable temperature is arranged on the air inlet part outside the tank so as to adjust the temperature of air entering the horizontal tank body of the reactor.
Furthermore, a fan with adjustable air volume is arranged on the air inlet part outside the tank so as to adjust the pressure of air entering the horizontal tank body of the reactor.
Further, the air inlet device and the air outlet device are integrated with the cover body, and the air inlet part outside the tank is nested in the air outlet static part.
Further, the exhaust static part is communicated with the horizontal tank body of the reactor through an exhaust hole formed in the cover body.
Further, the exhaust hole has a plurality of holes and surrounds the in-tank intake portion.
Further, the exhaust device is integrated with the cover, and the intake device is independent of the cover.
Further, the air inlet movable part and the air outlet movable part are both rotary joints.
Compared with the prior art, the invention has the following beneficial effects:
1. the technical problem that the horizontal moving reaction tank body is difficult to supply air is solved, the dynamic and static combined air inlet and outlet device is adopted to realize the communication with the rotatable tank body, continuous fresh air is provided for the normal work of the horizontal moving reaction tank body, and waste gas generated in the reaction process can be discharged in time.
2. The structure form is various, can be that air inlet unit, exhaust apparatus and lid three are integrated as an organic whole, also can be that one of them of air inlet unit and exhaust apparatus and lid two are integrated as an organic whole, and another device is independent of the jar body. The three integrated structures can be arranged at one end of the tank body, so that the space is saved, but the waste gas can only be exhausted. The two integrated structures are respectively arranged at two ends of the tank body, and waste gas can be collected and treated in a centralized manner. Different structural forms can be flexibly selected according to actual requirements.
3. A plurality of air outlets on the air supply part in the tank are uniformly distributed along the circumferential direction of the air outlet part and extend along the axial direction of the air outlet part, so that air can be in full contact with the reaction liquid along the circumferential direction of the tank wall within a range of 360 degrees, and the reaction efficiency is improved.
Drawings
FIG. 1 is a schematic perspective view of an embodiment of the present invention;
FIG. 2 is a schematic diagram of a usage state of one embodiment of the present invention;
fig. 3 is a schematic view of a usage status of another embodiment of the present invention.
In the drawings, a fan 1; a horizontal tank body 2; a lid body 30; an exhaust hole 301; a tank outside intake portion 311; a tank gas supply section 312; an intake rotary joint 32; an exhaust stationary portion 33; an exhaust rotary joint 34; a can cover lock catch 35; a locking handle 36; a heating device 37.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
As shown in fig. 1 to 3, one embodiment of the tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor of the present invention comprises a cover body 30, an air inlet device and an air outlet device, wherein the air inlet device and/or the air outlet device is integrated with the cover body 30; the air inlet device comprises an air inlet movable part 32 and an air inlet static part, the air inlet static part is communicated with the rotatable horizontal tank body 2 of the reactor through the cover body 30 through the air inlet movable part 32, the air outlet device comprises an air outlet movable part 34 and an air outlet static part 33, and the air outlet static part 33 is communicated with the rotatable horizontal tank body 2 of the reactor through the cover body 30 through the air outlet movable part 34.
In the embodiment, the dynamic and static combined air inlet and exhaust device is communicated with the rotatable horizontal tank body 2, continuous fresh air is provided for the normal work of the horizontal moving reaction tank body, and waste gas generated in the reaction process can be discharged in time. Specifically, the air inlet movable part 32 and the air outlet movable part 34 both adopt rotary joints, and the rotary joints can realize the connection with the rotatable horizontal tank body 2 in the rotating process, so that the static part of the air passage can normally work, the problem of external connection of the rotary tank body is effectively solved, and the horizontal tank can replace a vertical tank.
In an embodiment of the present invention, the air intake static portion includes an external tank air intake portion 311 and an internal tank air intake portion 312, and an end of the internal tank air intake portion 312 is closed, and a plurality of air outlet holes are opened on a pipe wall thereof. Preferably, the air outlet holes are uniformly arranged in the circumferential direction of the in-tank air feed portion 312 and extend in the axial direction of the in-tank air feed portion 312. Therefore, the air can be in full contact with the reaction liquid in the circumferential direction of the tank wall within the range of 360 degrees, and the reaction efficiency is improved.
In one embodiment of the invention, the length of the in-tank plenum 312 corresponds to the length of the interior cavity of the rotatable horizontal reactor tank 2. The introduced air can be in full contact with the reaction liquid in the axial direction of the tank wall, so that the reaction efficiency is improved.
In one embodiment of the present invention, the external air inlet 311 is provided with a temperature-adjustable heating device 37 to adjust the temperature of the air entering the rotatable horizontal tank 2 of the reactor. Different reaction liquids have different optimal reaction temperatures, and the air inlet temperature can be adjusted according to actual needs so as to improve the reaction efficiency.
In one embodiment of the present invention, the air inlet 311 is provided with an air volume adjustable fan 1 to adjust the pressure of the air entering the horizontal and rotatable tank 2 of the reactor. Therefore, the air content in the tank cavity can be effectively controlled, different reaction liquid requirements are met, and the flexibility is improved.
In one embodiment of the present invention, as shown in fig. 1 and 2, the air intake device and the exhaust device are integrated with the cover 30, and the tank outside intake portion 311 is nested inside the exhaust stationary portion 33. The trinity integrated form structure is a whole, installs on the feed inlet of 2 left ends of horizontal tank body. Therefore, the space of the whole set of equipment can be saved, and the installation and the use in a small space are convenient. And an opening at the other end of the tank body is also omitted, so that the processing cost is reduced. The disadvantage is that the exhaust static part 33 can only be suspended and the exhaust gas is exhausted into the air.
In one embodiment of the present invention, as shown in fig. 1, the exhaust static part is communicated with the reactor rotatable horizontal tank 2 through an exhaust hole 301 formed in the cover 30. Preferably, the exhaust hole 301 has a plurality and surrounds the in-tank air intake portion 312. Exhaust waste gas can not enter the air inlet channel again from the exhaust hole 301 on the cover body 30, the air inlet channel and the air outlet channel are effectively isolated, the structure is exquisite, and the air inlet and exhaust effects are good.
In one embodiment of the present invention, as shown in fig. 3, the exhaust device is integrated with the cover, and the intake device is independent of the cover. The air inlet device is arranged at the left end of the rotatable horizontal tank body 2, and the exhaust device and the cover body are arranged at the right end of the rotatable horizontal tank body 2. The structure with separated air inlet and outlet channels reduces the complexity of structural design and improves the working reliability. And the exhaust passage is conveniently communicated with an external exhaust gas treatment device.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (11)
1. A tank cover integrated type air inlet and exhaust device of a horizontal self-stirring in-vitro protein synthesis reactor is characterized by comprising a cover body, an air inlet device and an exhaust device, wherein the air inlet device and/or the exhaust device is integrated with the cover body; the gas inlet device comprises a gas inlet movable part and a gas inlet static part, the gas inlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas inlet movable part and the cover body, the gas outlet device comprises a gas outlet movable part and a gas outlet static part, and the gas outlet static part is communicated with the rotatable horizontal tank body of the reactor through the gas outlet movable part and the cover body.
2. The can lid integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor as claimed in claim 1, wherein the air inlet static part comprises an out-of-can air inlet part and an in-can air inlet part, the end part of the in-can air inlet part is closed, and a plurality of air outlet holes are arranged on the tube wall of the in-can air inlet part.
3. The can lid integrated air inlet and outlet apparatus for a horizontal self-stirring in-vitro protein synthesis reactor according to claim 2, wherein the air outlet holes are uniformly arranged along the circumferential direction of the air supply part in the can and extend along the axial direction of the air supply part in the can.
4. The can lid integrated air inlet and outlet apparatus of the horizontal self-stirring in-vitro protein synthesis reactor according to claim 2, wherein the length of the air inlet part in the can is equivalent to the length of the inner cavity of the horizontal can body of the reactor.
5. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor as claimed in claim 2, wherein a temperature-adjustable heating device is arranged on the air inlet part outside the tank to adjust the temperature of air entering the horizontal tank body of the reactor.
6. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor as claimed in claim 2, wherein a fan with adjustable air volume is arranged on the air inlet part outside the tank to adjust the pressure of air entering the horizontal tank body of the reactor.
7. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor according to claim 2, wherein the air inlet device and the air outlet device are integrated with the cover body, and the tank outer air inlet part is nested in the air outlet static part.
8. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor as claimed in claim 7, wherein the air outlet static part is communicated with the horizontal tank body of the reactor through an air outlet hole formed in the cover body.
9. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor according to claim 8, wherein the air outlet hole is provided with a plurality of air inlet holes and surrounds the air inlet part in the tank.
10. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor according to claim 1, wherein the air inlet device is independent from the cover body and the air outlet device is integrated with the cover body.
11. The tank cover integrated air inlet and outlet device of the horizontal self-stirring in-vitro protein synthesis reactor according to claim 1, wherein the air inlet movable part and the air outlet movable part are both rotary joints.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2022/135274 WO2023098697A2 (en) | 2021-11-30 | 2022-11-30 | In-vitro biosynthesis reaction apparatus and in-vitro biosynthesis method |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111448968 | 2021-11-30 | ||
| CN2021114489687 | 2021-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114471367A true CN114471367A (en) | 2022-05-13 |
Family
ID=80796822
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210095041.8A Pending CN114307940A (en) | 2021-11-30 | 2022-01-26 | Tank device of horizontal self-stirring external protein synthesis reactor |
| CN202220250487.9U Active CN217473468U (en) | 2021-11-30 | 2022-01-26 | Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor |
| CN202210093587.XA Pending CN114247415A (en) | 2021-11-30 | 2022-01-26 | Horizontal self-stirring in-vitro protein synthesis reactor and in-vitro protein synthesis method |
| CN202210093573.8A Pending CN114471367A (en) | 2021-11-30 | 2022-01-26 | Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor |
| CN202220216939.1U Active CN216964638U (en) | 2021-11-30 | 2022-01-26 | Horizontal self-stirring in-vitro protein synthesis reactor |
| CN202210239438.XA Pending CN114405455A (en) | 2021-11-30 | 2022-03-11 | Reaction device for in vitro biosynthesis and in vitro biosynthesis method |
| CN202220528915.XU Active CN219279864U (en) | 2021-11-30 | 2022-03-11 | Bioreactor and corresponding partition, reaction device and shell |
| CN202220528922.XU Active CN217910448U (en) | 2021-11-30 | 2022-03-11 | Reaction device for in vitro biosynthesis |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210095041.8A Pending CN114307940A (en) | 2021-11-30 | 2022-01-26 | Tank device of horizontal self-stirring external protein synthesis reactor |
| CN202220250487.9U Active CN217473468U (en) | 2021-11-30 | 2022-01-26 | Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor |
| CN202210093587.XA Pending CN114247415A (en) | 2021-11-30 | 2022-01-26 | Horizontal self-stirring in-vitro protein synthesis reactor and in-vitro protein synthesis method |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220216939.1U Active CN216964638U (en) | 2021-11-30 | 2022-01-26 | Horizontal self-stirring in-vitro protein synthesis reactor |
| CN202210239438.XA Pending CN114405455A (en) | 2021-11-30 | 2022-03-11 | Reaction device for in vitro biosynthesis and in vitro biosynthesis method |
| CN202220528915.XU Active CN219279864U (en) | 2021-11-30 | 2022-03-11 | Bioreactor and corresponding partition, reaction device and shell |
| CN202220528922.XU Active CN217910448U (en) | 2021-11-30 | 2022-03-11 | Reaction device for in vitro biosynthesis |
Country Status (1)
| Country | Link |
|---|---|
| CN (8) | CN114307940A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023098697A3 (en) * | 2021-11-30 | 2023-08-17 | 康码（上海）生物科技有限公司 | In-vitro biosynthesis reaction apparatus and in-vitro biosynthesis method |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115320903B (en) * | 2022-10-14 | 2023-02-03 | 溧阳市宇峰新材料有限公司 | Filling equipment for sealant and using method thereof |
| CN117264764A (en) * | 2023-04-28 | 2023-12-22 | 哈尔滨工业大学 | Automatic stem cell culture equipment imitating human body internal environment |
-
2022
- 2022-01-26 CN CN202210095041.8A patent/CN114307940A/en active Pending
- 2022-01-26 CN CN202220250487.9U patent/CN217473468U/en active Active
- 2022-01-26 CN CN202210093587.XA patent/CN114247415A/en active Pending
- 2022-01-26 CN CN202210093573.8A patent/CN114471367A/en active Pending
- 2022-01-26 CN CN202220216939.1U patent/CN216964638U/en active Active
- 2022-03-11 CN CN202210239438.XA patent/CN114405455A/en active Pending
- 2022-03-11 CN CN202220528915.XU patent/CN219279864U/en active Active
- 2022-03-11 CN CN202220528922.XU patent/CN217910448U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023098697A3 (en) * | 2021-11-30 | 2023-08-17 | 康码（上海）生物科技有限公司 | In-vitro biosynthesis reaction apparatus and in-vitro biosynthesis method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN217910448U (en) | 2022-11-29 |
| CN114247415A (en) | 2022-03-29 |
| CN114405455A (en) | 2022-04-29 |
| CN219279864U (en) | 2023-06-30 |
| CN114307940A (en) | 2022-04-12 |
| CN216964638U (en) | 2022-07-15 |
| CN217473468U (en) | 2022-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114471367A (en) | Tank cover integrated type air inlet and exhaust device of horizontal self-stirring external protein synthesis reactor | |
| CN206168739U (en) | Drying solidification equipment | |
| CN109330867B (en) | Convenient fumigating device for gynecological nursing | |
| CN111473638A (en) | Heating gas structure in particle material drying and stirring device | |
| CN216080670U (en) | Water-based synthetic leather extrusion dryer with dehumidification function of disinfecting | |
| CN206799637U (en) | A kind of multifunctional integrated solid-state fermentation installation | |
| CN113106002B (en) | Anti-pollution fermentation machine for traditional Chinese medicine decoction pieces and working method thereof | |
| CN114873563A (en) | Dehydrogenation gas equipment in hydrogen chloride synthesis gas | |
| CN105836874A (en) | Biological contact oxidation pond | |
| CN111891666B (en) | Magnetic ferrite magnetic core former loading attachment | |
| KR101561561B1 (en) | coating pan for tablet coating apparatus | |
| CN206810246U (en) | A kind of easy cleaned air-flow heating cooling-down type synthesis reactor | |
| CN219922931U (en) | Liquid nitrogen bulk drug reation kettle | |
| CN208551332U (en) | Material cleaning device and cooking apparatus | |
| CN210036184U (en) | Tower type drying device | |
| CN103550974A (en) | Rapid filtering and continuous slagging device | |
| CN214142134U (en) | Organic fertilizer fermentation tank | |
| CN211754975U (en) | Protection type reaction system | |
| CN211434571U (en) | Atomizer for producing antidepressant | |
| CN208694959U (en) | A kind of horizontal reacting kettle | |
| CN213914771U (en) | Special electric heat blast air drying cabinet of organic fertilizer production | |
| CN216473174U (en) | Tank-type aerobic fermentation equipment | |
| CN219469842U (en) | Aerator for multi-angle sewage treatment | |
| CN217888035U (en) | Comprehensive drug stability test box | |
| CN220940234U (en) | Stirring equipment for producing dry suspending agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication |