CN114470106A - Garlic and zhiqin soft capsule and its preparing and storing method - Google Patents
Garlic and zhiqin soft capsule and its preparing and storing method Download PDFInfo
- Publication number
- CN114470106A CN114470106A CN202210024486.7A CN202210024486A CN114470106A CN 114470106 A CN114470106 A CN 114470106A CN 202210024486 A CN202210024486 A CN 202210024486A CN 114470106 A CN114470106 A CN 114470106A
- Authority
- CN
- China
- Prior art keywords
- parts
- capsule
- soft capsules
- garlic
- soft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 56
- 240000002234 Allium sativum Species 0.000 title claims abstract description 17
- 235000004611 garlic Nutrition 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 9
- 239000002775 capsule Substances 0.000 claims abstract description 51
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims abstract description 20
- 108010010803 Gelatin Proteins 0.000 claims abstract description 20
- 235000010081 allicin Nutrition 0.000 claims abstract description 20
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000008273 gelatin Substances 0.000 claims abstract description 20
- 229920000159 gelatin Polymers 0.000 claims abstract description 20
- 235000019322 gelatine Nutrition 0.000 claims abstract description 20
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 20
- 239000004014 plasticizer Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 16
- 239000000654 additive Substances 0.000 claims abstract description 14
- 239000000049 pigment Substances 0.000 claims abstract description 14
- 239000008213 purified water Substances 0.000 claims abstract description 14
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 14
- 230000000996 additive effect Effects 0.000 claims abstract description 13
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 12
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 12
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 12
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 12
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 11
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 11
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 6
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 6
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 6
- 240000006023 Trichosanthes kirilowii Species 0.000 claims abstract description 6
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 claims abstract description 6
- 235000020224 almond Nutrition 0.000 claims abstract description 6
- 241001633574 Adenophora stricta Species 0.000 claims abstract description 5
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 4
- 235000017443 Hedysarum boreale Nutrition 0.000 claims abstract description 4
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims abstract description 4
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims abstract description 4
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 2
- 239000011259 mixed solution Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 15
- 238000004945 emulsification Methods 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000004806 packaging method and process Methods 0.000 claims description 10
- 238000003825 pressing Methods 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 241001673966 Magnolia officinalis Species 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 239000000084 colloidal system Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 241000972672 Phellodendron Species 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 241000123646 Allioideae Species 0.000 claims description 3
- 241000234282 Allium Species 0.000 claims description 3
- 239000004593 Epoxy Substances 0.000 claims description 3
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 238000002834 transmittance Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 2
- 208000035473 Communicable disease Diseases 0.000 abstract description 2
- 244000301850 Cupressus sempervirens Species 0.000 abstract description 2
- 241000233866 Fungi Species 0.000 abstract description 2
- 206010035148 Plague Diseases 0.000 abstract description 2
- 206010057190 Respiratory tract infections Diseases 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract description 2
- 241000607479 Yersinia pestis Species 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 abstract description 2
- 230000008816 organ damage Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 241000245665 Taraxacum Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a garlic and scutellaria baicalensis soft capsule, which consists of capsule contents and capsule skin, wherein the capsule contents comprise, by mass, 1-8 parts of scutellaria baicalensis, 1-8 parts of garlicin, 1-6 parts of rhizoma anemarrhenae, 1-6 parts of golden cypress, 1-12 parts of trichosanthes kirilowii maxim, 1-10 parts of tabasheer, 1-6 parts of semen lepidii, 1-6 parts of almond, 1-6 parts of cortex mori radicis, 1-10 parts of dandelion, 1-10 parts of radix ophiopogonis, 1-10 parts of radix rehmanniae recen, 1-10 parts of adenophora stricta, 1-8 parts of mangnolia officinalis and 1-4 parts of honey-fried licorice root, and the capsule skin comprises, by mass, 1-40 parts of gelatin, 1-10 parts of an additive, 1-45 parts of purified water, 0.2-0.5 part of titanium dioxide, 1-5 parts of pigment, 0.3-1 part of ethylparaben and 0.2-0.5 part of plasticizer, and the invention has the advantages that 15 components such as scutellaria baicalensis, allicin, rhizoma anemarrhenae and the like are mutually matched, so that the traditional Chinese medicine can simultaneously resist bacteria, fungi and viruses, namely the functions of clearing heat, ventilating the lung and removing plagues, can avoid organ damage caused by side effects, and has the curative effect of treating both symptoms and root causes for various infectious diseases, particularly respiratory tract infection.
Description
Technical Field
The invention relates to the technical field of clinical application, in particular to a garlic-Zhiqin soft capsule and a preparation and storage method thereof.
Background
Because the existing antifungal drugs are generally resistant to drugs and are often overwhelmed by the middle-critical and severe patients, the research and development of an antifungal, antibacterial, antiviral and drug-resistant drug is needed.
Disclosure of Invention
The invention aims to provide a garlic and zhiqin soft capsule which comprises 1 to 8 parts of scutellaria baicalensis, 1 to 8 parts of garlicin, 1 to 6 parts of rhizoma anemarrhenae, 1 to 6 parts of phellodendron, 1 to 12 parts of trichosanthes kirilowii maxim, 1 to 10 parts of tabasheer, 1 to 6 parts of semen lepidii, 1 to 6 parts of almond, 1 to 6 parts of cortex mori radicis, 1 to 10 parts of dandelion, 1 to 10 parts of radix ophiopogonis, 1 to 10 parts of radix rehmanniae recen, 1 to 10 parts of adenophora stricta, 1 to 8 parts of mangnolia officinalis and 1 to 4 parts of honey-fried licorice root, wherein the capsule comprises 1 to 40 parts of gelatin, 1 to 10 parts of additives, 1 to 45 parts of purified water, 0.2 to 0.5 part of titanium dioxide, 1 to 5 portions of pigment, 0.3 to 1 portion of hydroxyphenyl ethylester and 0.2 to 0.5 portion of plasticizer.
Preferably, the allicin is an organic sulfide extracted from the bulb of garlic of the genus allium of the family alliaceae.
Preferably, the gelatin used in the capsule shell is medical food-grade gelatin, and is mainly extracted from animal skin and bones.
Preferably, the capsule shell has a thickness of 0.2mm and a light transmittance of less than 5%.
Preferably, the plasticizer in the capsule shell is an ESO epoxy plasticizer.
Preferably, the method comprises the following steps:
s1, preparing a capsule shell: weighing gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer according to the formula proportion, adding into a vacuum stirring tank, heating and stirring until the gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer are completely dissolved; uniformly coating the solution on the surface of a flat plate, and then heating at about 90 ℃ to evaporate the water on the surface of the flat plate to form a flexible film with certain toughness;
s2, preparing a capsule content I: weighing radix Scutellariae, garlicin, rhizoma anemarrhenae, cortex Phellodendri, fructus Trichosanthis, concretio silicea Bambusae seu Schizostachyi, semen Lepidii, semen Armeniacae amarum, cortex Mori, herba Taraxaci, radix Ophiopogonis, radix rehmanniae, radix Adenophorae, cortex Magnolia officinalis and radix Glycyrrhizae Preparata according to formula ratio, pulverizing, and sieving with 100 mesh sieve;
s3, mixing capsule content II: weighing allicin according to the formula proportion, filtering the allicin, and adding the filtered allicin into a blending tank;
s4, mixing and stirring: adding the capsule content I into the capsule content II in sequence, stirring for 30 minutes, and then adding the obtained solution into a colloid mill or an emulsification tank for grinding or emulsification;
s5, filling: filtering the mixed solution obtained in the step S4, and filling the mixed solution in a clean container;
s6, pressing soft capsules: putting the soft capsules obtained in the step S1 into an automatic rotary capsule-making machine, adding the mixture obtained in the step S4 to obtain a mixed solution, and pressing the mixed solution into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step S6, inspecting the soft capsules, and packaging the soft capsules after the soft capsules are qualified, and storing the soft capsules in a warehouse.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, 15 components such as scutellaria baicalensis, allicin, rhizoma anemarrhenae and the like are mutually matched, so that the traditional Chinese medicine composition can be used for resisting bacteria, fungi and viruses, namely the effect of clearing heat, ventilating the lung and removing plagues in the traditional Chinese medicine, can avoid organ damage caused by side effects, and has the curative effect of treating both symptoms and root causes for various infectious diseases, particularly respiratory tract infection.
Detailed Description
The invention provides a technical scheme that: a garlic and scutellaria baicalensis soft capsule consists of a capsule content and a capsule skin, wherein the capsule content comprises, by mass, 1-8 parts of scutellaria baicalensis, 1-8 parts of garlicin, 1-6 parts of rhizoma anemarrhenae, 1-6 parts of phellodendron, 1-12 parts of trichosanthes kirilowii maxim, 1-10 parts of tabasheer, 1-6 parts of semen lepidii, 1-6 parts of almond, 1-6 parts of cortex mori, 1-10 parts of dandelion, 1-10 parts of radix ophiopogonis, 1-10 parts of radix rehmanniae recen, 1-10 parts of adenophora stricta, 1-8 parts of mangnolia officinalis and 1-4 parts of honey-fried licorice root, and the capsule skin comprises, by mass, 1-40 parts of gelatin, 1-10 parts of an additive, 1-45 parts of purified water, 0.2-0.5 part of titanium dioxide, 1-5 parts of a pigment, 1-5 parts of a, 0.3 to 1 portion of ethylparaben and 0.2 to 0.5 portion of plasticizer.
Wherein the allicin is an organic sulfide extracted from the bulb of garlic of Allium of Alliaceae, and has excellent inhibitory effect on most bacterial and fungal infections.
The gelatin adopted in the capsule shell is medical food-grade gelatin which is mainly extracted from animal skin and bones and is convenient to prepare and use.
Wherein, the thickness of the capsule skin is 0.2mm, the light transmittance is lower than 5 percent, the influence of the direct irradiation of light on the content of the capsule is avoided, and the shelf life is prolonged.
Wherein, the plasticizer in the capsule skin is ESO epoxy plasticizer, which is economical, safe and environment-friendly.
The method comprises the following steps:
s1, preparing a capsule shell: weighing gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer according to the formula proportion, adding into a vacuum stirring tank, heating and stirring until the gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer are completely dissolved; uniformly coating the solution on the surface of a flat plate, and then heating at about 90 ℃ to evaporate the water on the surface of the flat plate to form a flexible film with certain toughness;
s2, preparing a capsule content I: weighing radix Scutellariae, garlicin, rhizoma anemarrhenae, cortex Phellodendri, fructus Trichosanthis, concretio silicea Bambusae seu Schizostachyi, semen Lepidii, semen Armeniacae amarum, cortex Mori, herba Taraxaci, radix Ophiopogonis, radix rehmanniae, radix Adenophorae, cortex Magnolia officinalis and radix Glycyrrhizae Preparata according to formula ratio, pulverizing, and sieving with 100 mesh sieve;
s3, mixing capsule content II: weighing allicin according to the formula proportion, filtering the allicin, and adding the filtered allicin into a blending tank;
s4, mixing and stirring: adding the capsule content I into the capsule content II in sequence, stirring for 30 minutes, and then adding the obtained solution into a colloid mill or an emulsification tank for grinding or emulsification;
s5, filling: filtering the mixed solution obtained in the step S4, and filling the mixed solution in a clean container;
s6, pressing soft capsules: putting the soft capsules obtained in the step S1 into an automatic rotary capsule-making machine, adding the mixture obtained in the step S4 to obtain a mixed solution, and pressing the mixed solution into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step S6, inspecting the soft capsules, and after the soft capsules are inspected to be qualified, externally packaging the soft capsules, and storing the soft capsules in a warehouse.
Example 1, a garlic and radix scutellariae soft capsule, which consists of a capsule content and a capsule skin, wherein the capsule content comprises 8 parts of scutellaria baicalensis, 3 parts of garlicin, 1 part of rhizoma anemarrhenae, 1 part of golden cypress, 1 part of trichosanthes kirilowii maxim, 1 part of concretio silicea bambusae, 1 part of semen lepidii, 6 parts of almond, 6 parts of cortex mori radicis, 6 parts of dandelion, 6 parts of radix ophiopogonis, 6 parts of radix rehmanniae recen, 5 parts of radix adenophorae, 2 parts of mangnolia officinalis and 4 parts of radix glycyrrhizae preparata according to the mass ratio.
A preparation and storage method of a garlic and zhiqin soft capsule comprises the following steps:
s1, preparing a capsule shell: weighing gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer according to the formula proportion, adding into a vacuum stirring tank, heating and stirring until the gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer are completely dissolved; uniformly coating the solution on the surface of a flat plate, and then heating at about 90 ℃ to evaporate the water on the surface of the flat plate to form a flexible film with certain toughness;
s2, preparing a capsule content I: weighing radix Scutellariae, garlicin, rhizoma anemarrhenae, cortex Phellodendri, fructus Trichosanthis, concretio silicea Bambusae seu Schizostachyi, semen Lepidii, semen Armeniacae amarum, cortex Mori, herba Taraxaci, radix Ophiopogonis, radix rehmanniae, radix Adenophorae, cortex Magnolia officinalis and radix Glycyrrhizae Preparata according to formula ratio, pulverizing, and sieving with 100 mesh sieve;
s3, mixing capsule content II: weighing allicin according to the formula proportion, filtering the allicin, and adding the filtered allicin into a blending tank;
s4, mixing and stirring: adding the capsule content I into the capsule content II in sequence, stirring for 30 minutes, and then adding the obtained solution into a colloid mill or an emulsification tank for grinding or emulsification;
s5, filling: filtering the mixed solution obtained in the step S4, and filling the mixed solution in a clean container;
s6, pressing soft capsules: putting the soft capsules obtained in the step S1 into an automatic rotary capsule-making machine, adding the mixture obtained in the step S4 to obtain a mixed solution, and pressing the mixed solution into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step S6, inspecting the soft capsules, and packaging the soft capsules after the soft capsules are qualified, and storing the soft capsules in a warehouse.
Embodiment 2, a garlic and radix scutellariae soft capsule, which consists of a capsule content and a capsule skin, wherein the capsule content comprises, by mass, 3 parts of scutellaria baicalensis, 8 parts of garlicin, 1 part of rhizoma anemarrhenae, 6 parts of phellodendron, 6 parts of trichosanthes kirilowii maxim, 6 parts of concretio silicea bambusae, 1 part of semen lepidii, 1 part of almond, 1 part of cortex mori radicis, 1 part of dandelion, 1 part of radix ophiopogonis, 6 parts of radix rehmanniae recen, 8 parts of adenophora stricta, 5 parts of mangnolia officinalis and 1 part of radix glycyrrhizae preparata.
A preparation and storage method of a garlic and zhiqin soft capsule comprises the following steps:
s1, preparing a capsule shell: weighing gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer according to the formula proportion, adding into a vacuum stirring tank, heating and stirring until the gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer are completely dissolved; uniformly coating the solution on the surface of a flat plate, and then heating at about 90 ℃ to evaporate the water on the surface of the flat plate to form a flexible film with certain toughness;
s2, preparing a capsule content I: weighing radix Scutellariae, garlicin, rhizoma anemarrhenae, cortex Phellodendri, fructus Trichosanthis, concretio silicea Bambusae seu Schizostachyi, semen Lepidii, semen Armeniacae amarum, cortex Mori, herba Taraxaci, radix Ophiopogonis, radix rehmanniae, radix Adenophorae, cortex Magnolia officinalis and radix Glycyrrhizae Preparata according to formula ratio, pulverizing, and sieving with 100 mesh sieve;
s3, mixing capsule content II: weighing allicin according to the formula proportion, filtering the allicin, and adding the filtered allicin into a blending tank;
s4, mixing and stirring: adding the capsule content I into the capsule content II in sequence, stirring for 30 minutes, and then adding the obtained solution into a colloid mill or an emulsification tank for grinding or emulsification;
s5, filling: filtering the mixed solution obtained in the step S4, and filling the mixed solution in a clean container;
s6, pressing soft capsules: putting the soft capsules obtained in the step S1 into an automatic rotary capsule-making machine, adding the mixture obtained in the step S4 to obtain a mixed solution, and pressing the mixed solution into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step S6, inspecting the soft capsules, and packaging the soft capsules after the soft capsules are qualified, and storing the soft capsules in a warehouse.
Furthermore, the terms "first", "second", "third", "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby the features defined as "first", "second", "third", "fourth" may explicitly or implicitly include at least one such feature.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "disposed," "connected," "secured," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A garlic and scutellaria baicalensis soft capsule is characterized by comprising 1-8 parts of scutellaria baicalensis, 1-8 parts of garlicin, 1-6 parts of rhizoma anemarrhenae, 1-6 parts of phellodendron, 1-12 parts of trichosanthes kirilowii maxim, 1-10 parts of tabasheer, 1-6 parts of semen lepidii, 1-6 parts of almond, 1-6 parts of cortex mori radicis, 1-10 parts of dandelion, 1-10 parts of radix ophiopogonis, 1-10 parts of radix rehmanniae recen, 1-10 parts of adenophora stricta, 1-8 parts of mangnolia officinalis and 1-4 parts of honey-fried licorice root, wherein the capsule skin comprises 1-40 parts of gelatin, 1-10 parts of an additive, 1-45 parts of purified water, 0.2-0.5 part of titanium dioxide and the like, 1 to 5 portions of pigment, 0.3 to 1 portion of hydroxyphenyl ethylester and 0.2 to 0.5 portion of plasticizer.
2. The garlic and zhiqin soft capsule as claimed in claim 1, wherein: the allicin is an organic sulfide extracted from bulb of Bulbus Allii of Allium of Alliaceae.
3. The garlic and zhiqin soft capsule as claimed in claim 1, wherein: the gelatin adopted in the capsule shell is medical food-grade gelatin which is mainly extracted from animal skin and bones.
4. The garlic and zhiqin soft capsule as claimed in claim 1, wherein: the thickness of the capsule shell is 0.2mm, and the light transmittance is lower than 5%.
5. The garlic and zhiqin soft capsule as claimed in claim 1, wherein: the plasticizer in the capsule shell is ESO epoxy plasticizer.
6. A garlic and zhiqin soft capsule and a mixed preparation method of a preparation and storage method thereof are characterized in that: the method comprises the following steps:
s1, preparing a capsule shell: weighing gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer according to the formula proportion, adding into a vacuum stirring tank, heating and stirring until the gelatin, additive, purified water, titanium dioxide, pigment, ethylparaben and plasticizer are completely dissolved; uniformly coating the solution on the surface of a flat plate, and then heating at about 90 ℃ to evaporate the water on the surface of the flat plate to form a flexible film with certain toughness;
s2, preparing a capsule content I: weighing radix Scutellariae, garlicin, rhizoma anemarrhenae, cortex Phellodendri, fructus Trichosanthis, concretio silicea Bambusae seu Schizostachyi, semen Lepidii, semen Armeniacae amarum, cortex Mori, herba Taraxaci, radix Ophiopogonis, radix rehmanniae, radix Adenophorae, cortex Magnolia officinalis and radix Glycyrrhizae Preparata according to formula ratio, pulverizing, and sieving with 100 mesh sieve;
s3, mixing capsule content II: weighing allicin according to the formula proportion, filtering the allicin, and adding the filtered allicin into a blending tank;
s4, mixing and stirring: adding the capsule content I into the capsule content II in sequence, stirring for 30 minutes, and then adding the obtained solution into a colloid mill or an emulsification tank for grinding or emulsification;
s5, filling: filtering the mixed solution obtained in the step S4, and filling the mixed solution in a clean container;
s6, pressing soft capsules: putting the soft capsules obtained in the step S1 into an automatic rotary capsule-making machine, adding the mixture obtained in the step S4 to obtain a mixed solution, and pressing the mixed solution into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step S6, inspecting the soft capsules, and packaging the soft capsules after the soft capsules are qualified, and storing the soft capsules in a warehouse.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210024486.7A CN114470106A (en) | 2022-01-11 | 2022-01-11 | Garlic and zhiqin soft capsule and its preparing and storing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210024486.7A CN114470106A (en) | 2022-01-11 | 2022-01-11 | Garlic and zhiqin soft capsule and its preparing and storing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114470106A true CN114470106A (en) | 2022-05-13 |
Family
ID=81510327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210024486.7A Pending CN114470106A (en) | 2022-01-11 | 2022-01-11 | Garlic and zhiqin soft capsule and its preparing and storing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114470106A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107619A (en) * | 2020-04-23 | 2020-12-22 | 广州宏康医药科技有限公司 | Allicin Chaiqin soft capsule and preparation and storage method thereof |
| CN113797289A (en) * | 2020-06-11 | 2021-12-17 | 广州宏康医药科技有限公司 | Coronaviral-resistant allicin related preparation and preparation method thereof |
-
2022
- 2022-01-11 CN CN202210024486.7A patent/CN114470106A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107619A (en) * | 2020-04-23 | 2020-12-22 | 广州宏康医药科技有限公司 | Allicin Chaiqin soft capsule and preparation and storage method thereof |
| CN113797289A (en) * | 2020-06-11 | 2021-12-17 | 广州宏康医药科技有限公司 | Coronaviral-resistant allicin related preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘兰萍: "知芩汤合大蒜素片治疗呼吸道继发真菌感染26例", 《中国中西医结合杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20110318438A1 (en) | Pharmacologically effective composition of herbs for treatment on symptoms of influenza and colds | |
| CN111298048A (en) | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof | |
| CN105535198A (en) | Traditional Chinese medicine composition for treating poultry hydropericardium | |
| CN101530570B (en) | Medicine for treating respiratory disease | |
| CN114470106A (en) | Garlic and zhiqin soft capsule and its preparing and storing method | |
| CN101194995B (en) | Proprietary Chinese medicine for treating animal virus, bacterium and mix infection | |
| CN102940764A (en) | Traditional Chinese medicine powder for treating gastrosis | |
| CN101683429A (en) | Animal Chinese medicine granular formulation for preventing and treating infectious bursal disease of fowl and preparation method thereof | |
| CN104146180A (en) | Preparation method of feed capable of preventing pig influenza | |
| CN102579593B (en) | Pure Chinese medicinal composition for treating infectious bursal disease, newcastle disease, duck virus hepatitis and other viral diseases, as well as preparation method thereof | |
| CN104547174B (en) | Preparation method of the fowl with anti virus herb granule | |
| CN102885884B (en) | Granule for treating poultry bacterial diseases and method for preparing granule | |
| CN1056301C (en) | 'Lanweiling' oral liquid for treating appendicitis | |
| CN111973719A (en) | Yi medicine for gout remission stage | |
| CN101332254B (en) | Traditional Chinese medicine composition for preventing and treating poultry respiratory disease | |
| CN108498745B (en) | Traditional Chinese medicine prescription and application thereof in preparation of pulmonary tuberculosis auxiliary medicine | |
| CN103638412B (en) | Multiple-effect Chinese medicinal formulae of a kind of quick elimination pulmonary persistent ailment and preparation method thereof | |
| CN105169327B (en) | A kind of pharmaceutical composition and preparation method thereof for treating porcine diarrhea disease | |
| CN103784904A (en) | Traditional Chinese medicine oral liquid for treating poultry common cold due to wind-cold and preparation method thereof | |
| CN104055845B (en) | A kind of composition and its preparation for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity | |
| CN103191386B (en) | Medicament for treating chronic hepatitis B | |
| CN113117011A (en) | Traditional Chinese medicine composition for preventing and treating poultry hydropericardium syndrome | |
| CN114344434B (en) | Traditional Chinese medicine composition for treating pulmonary nodules and preparation method thereof | |
| CN107019743A (en) | A kind of Chinese herbal feed additive for preventing and treating animal viral disease and preparation method thereof | |
| CN116785400A (en) | Traditional Chinese medicine for treating thyroid nodule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220513 |