CN114468288A - Hyaluronic acid oral liquid easy to absorb and application - Google Patents
Hyaluronic acid oral liquid easy to absorb and application Download PDFInfo
- Publication number
- CN114468288A CN114468288A CN202210142760.0A CN202210142760A CN114468288A CN 114468288 A CN114468288 A CN 114468288A CN 202210142760 A CN202210142760 A CN 202210142760A CN 114468288 A CN114468288 A CN 114468288A
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- China
- Prior art keywords
- extract
- hyaluronic acid
- oral liquid
- content
- xanthan gum
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 58
- 239000007788 liquid Substances 0.000 title claims abstract description 58
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 50
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 50
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 44
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000230 xanthan gum Substances 0.000 claims abstract description 31
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 31
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 31
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 31
- 229940109529 pomegranate extract Drugs 0.000 claims abstract description 29
- 229940059958 centella asiatica extract Drugs 0.000 claims abstract description 26
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960001948 caffeine Drugs 0.000 claims abstract description 22
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 22
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 22
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 22
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000014104 aloe vera supplement Nutrition 0.000 claims abstract description 18
- 229940069521 aloe extract Drugs 0.000 claims abstract description 13
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 11
- 239000003765 sweetening agent Substances 0.000 claims abstract description 11
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims abstract description 8
- 229940014041 hyaluronate Drugs 0.000 claims abstract description 8
- 241000167550 Centella Species 0.000 claims abstract description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 15
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 claims description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 15
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 235000010356 sorbitol Nutrition 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000012371 Aseptic Filling Methods 0.000 claims description 6
- 241000219991 Lythraceae Species 0.000 claims description 6
- 235000014360 Punica granatum Nutrition 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 238000005374 membrane filtration Methods 0.000 claims description 4
- 241001116389 Aloe Species 0.000 claims description 3
- 239000004677 Nylon Substances 0.000 claims description 3
- 235000011399 aloe vera Nutrition 0.000 claims description 3
- 230000005684 electric field Effects 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 244000146462 Centella asiatica Species 0.000 claims description 2
- 235000004032 Centella asiatica Nutrition 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002137 ultrasound extraction Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 19
- 238000005282 brightening Methods 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 10
- 230000003020 moisturizing effect Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 4
- 239000002932 luster Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an easily-absorbed hyaluronic acid oral liquid and application thereof. The oral liquid comprises hyaluronate, xanthan gum, vitamin B6, centella asiatica extract, aloe vera extract, caffeine, pomegranate extract, sweetener, and water; the molecular weight of the hyaluronate is 10-50 kDa, and the pH value is 6.5-7.0; the molecular weight of the xanthan gum is 300-500 ten thousand; the content of the hyaluronate is 1.0-1.85%; the content of the xanthan gum is 1.2-2.0%; the content of the vitamin B6 is 0.3-0.8%; the content of the centella extract is 0.2-0.5%; the content of the aloe extract is 2-2.6%; the content of caffeine is 0.05-0.2%; the content of the pomegranate extract is 6-9.5%; the sweetening agent is 0.01-0.05%. The oral liquid has the advantages of easy absorption of effective components, quick action, and long-term moisture keeping and skin brightening effects after being stopped use.
Description
Technical Field
The invention relates to an easily-absorbed hyaluronic acid oral liquid and application thereof.
Background
Hyaluronic acid, also known as hyaluronic acid, is an important component of cell matrix, is widely distributed in the human body, and exerts various physiological functions. The hyaluronic acid has strong biocompatibility, strong water locking property and viscoelastic lubricity, and has extremely high application value. In addition to being widely used in the medical field and in cosmetics/base cosmetics, hyaluronic acid has recently been used in health foods, and beauty has been a publicizing effect of most oral hyaluronic acid.
However, hyaluronic acid is partially destroyed when passing through the digestive tract during administration, and then absorbed by the intestinal tract to enter the blood for transportation, and hyaluronic acid entering the blood is easily degraded, so that it is difficult to achieve the intended effect. In addition, oral hyaluronic acid also has the problems of slow effect, quick loss of effect after being stopped, and the like.
Disclosure of Invention
The invention provides an easily-absorbed hyaluronic acid oral liquid and application thereof, aiming at solving the problems that hyaluronic acid in the prior art is difficult to absorb, slow in effect taking, quick in effect losing after being stopped and the like.
The inventor unexpectedly finds that when the hyaluronic acid salt is matched with xanthan gum, vitamin B6, centella extract, aloe extract, caffeine and pomegranate extract for use under the condition of meeting a certain dosage and proportion, the skin moisturizing effect is good, the skin luster is improved, the effective components are easy to absorb by a human body, the effect is quick, and the long-time moisturizing and skin brightening effects are still achieved after the skin moisturizing and brightening cream is stopped for use. In addition, centella asiatica extract, aloe vera extract and pomegranate extract are less stable and are prone to delamination when mixed directly with other substances. Through the improvement of the preparation process, the oral liquid has excellent stability and homogeneity.
The invention solves the technical problems through the following technical scheme.
The invention provides hyaluronic acid oral liquid which comprises hyaluronate, xanthan gum, vitamin B6, centella asiatica extract, aloe extract, caffeine, pomegranate extract, a sweetening agent and water;
the hyaluronic acid salt comprises sodium hyaluronate and/or zinc hyaluronate, the molecular weight of the hyaluronic acid salt is 10-50 kDa, and the pH value of the hyaluronic acid salt is 6.5-7.0;
the molecular weight of the xanthan gum is 300-500 ten thousand;
the hyaluronic acid oral liquid comprises the following components in percentage by mass:
the content of the hyaluronate is 1.0-1.85%; the content of the xanthan gum is 1.2-2.0%; the content of the vitamin B6 is 0.3-0.8%; the content of the centella extract is 0.2-0.5%; the content of the aloe extract is 2-2.6%; the content of the caffeine is 0.05-0.2%; the content of the pomegranate extract is 7.5-9%; the sweetening agent is 0.01-0.05%; the sum of the mass percentages of the components is 100%;
the product of the content of centella asiatica extract and the content of aloe vera extract is less than the content of xanthan gum; the ratio of the content of the xanthan gum to the content of the pomegranate extract is 0.15-0.25;
the hyaluronic acid oral liquid comprises the following steps:
uniformly mixing all the components of the hyaluronic acid oral liquid, and sequentially carrying out ultrasonic treatment, membrane filtration and aseptic filling;
the temperature of the ultrasonic wave is 30-50 ℃;
the power of the ultrasonic wave is 200-500W.
In the present invention, preferably, when the hyaluronate comprises sodium hyaluronate, the content of sodium hyaluronate is 1.0-1.8%, for example, 1%, 1.2%, 1.3% or 1.8%;
in the present invention, when the hyaluronic acid salt includes zinc hyaluronate, the content of the zinc hyaluronate is preferably 0.01% to 0.05%, for example, 0.01% or 0.02%.
In the invention, the xanthan gum can be xanthan gum with the molecular weight of 300-500 ten thousand, which is conventional in the field.
Wherein the xanthan gum is present in an amount of 1.3%, 1.4%, 1.5%, 1.7% or 2%.
In the present invention, the vitamin B6 may be vitamin B6 which is conventional in the art.
Wherein, the content of the vitamin B6 is preferably 0.3%, 0.41%, 0.45%, 0.66% or 0.76%.
In the present invention, the preparation method of the centella asiatica extract may comprise the following steps: soaking centella asiatica in water, heating and refluxing at 60-80 ℃ for 10-24 h, sequentially filtering, concentrating the filtrate, and drying to obtain the centella asiatica extract.
In the present invention, the content of the centella asiatica extract is preferably 0.27%, 0.3%, 0.35% or 0.43%.
In the present invention, the preparation method of the aloe extract may include the steps of: squeezing aloe, concentrating the squeezed liquid at 50-80 ℃ for 10-18 h, and drying the concentrated liquid in vacuum to obtain the aloe extract.
In the present invention, the content of the aloe extract is preferably 2%, 2.2%, 2.5% or 2.6%.
In the present invention, the caffeine may be caffeine which is conventional in the art.
Wherein the caffeine content is preferably 0.05%, 0.08%, 0.11%, 0.13% or 0.2%.
In the present invention, the preparation method of the pomegranate extract may include the steps of: soaking pomegranate peel, pomegranate pulp and pomegranate seed in water, performing ultrasonic extraction at 5-40 ℃ for 2-12 h, sequentially filtering, concentrating the filtrate, and drying to obtain the pomegranate extract.
In the invention, the content of the pomegranate extract is 7.5%, 8%, 8.2%, 8.5% or 9%.
In the present invention, the sweetener may be an edible sweetener conventional in the art, preferably one or more of sorbitol, mannitol and erythritol, for example sorbitol or mannitol.
Wherein the sweetener is preferably present in an amount of 0.01%, 0.02%, 0.03% or 0.05%.
In a preferred embodiment of the present invention, the hyaluronic acid oral liquid is composed of 1% sodium hyaluronate, 0.02% zinc hyaluronate, 1.3% xanthan gum, 0.76% vitamin B6, 0.35% centella asiatica extract, 2.2% aloe vera extract, 0.13% caffeine, 8.2% pomegranate extract, 0.05% sorbitol, and 85.99% water.
In a preferred embodiment of the present invention, the hyaluronic acid oral liquid is composed of 1.2% sodium hyaluronate, 0.01% zinc hyaluronate, 1.7% xanthan gum, 0.41% vitamin B6, 0.3% centella asiatica extract, 2% aloe vera extract, 0.05% caffeine, 9% pomegranate extract, 0.03% sorbitol, and 85.3% water.
In a preferred embodiment of the present invention, the hyaluronic acid oral liquid is composed of 1.8% sodium hyaluronate, 0.02% zinc hyaluronate, 1.5% xanthan gum, 0.66% vitamin B6, 0.27% centella asiatica extract, 2.5% aloe vera extract, 0.11% caffeine, 7.5% pomegranate extract, 0.02% sorbitol, and 85.62% water.
In a preferred embodiment of the present invention, the hyaluronic acid oral liquid is composed of 1.3% sodium hyaluronate, 0.02% zinc hyaluronate, 1.4% xanthan gum, 0.3% vitamin B6, 0.43% centella asiatica extract, 2.6% aloe vera extract, 0.08% caffeine, 8.5% pomegranate extract, 0.02% mannitol, and 85.35% water.
In a preferred embodiment of the present invention, the hyaluronic acid oral liquid is composed of 1.8% sodium hyaluronate, 0.02% zinc hyaluronate, 2% xanthan gum, 0.45% vitamin B6, 0.3% centella asiatica extract, 2% aloe vera extract, 0.2% caffeine, 8% pomegranate extract, 0.01% mannitol, and 85.22% water.
In the present invention, the mixing temperature is preferably 35 to 45 ℃.
In the present invention, the mixing is preferably performed by stirring.
In the present invention, preferably, the membrane of the membrane filtration is a nylon membrane with a pore size of 0.22 μm.
In the invention, preferably, the aseptic filling is to sterilize the filling bottle by using a high-voltage pulse electric field, and then fill the hyaluronic acid oral liquid into the filling bottle and seal the bottle.
Wherein, the sterilization field intensity is preferably 50-60K/cm.
Wherein, the pulse number of the sterilization is preferably 300 to 350.
Wherein, the pulse frequency of the sterilization is preferably 400 to 450 Hz.
Wherein, preferably, the specification of the sterile filling is 15 mL/bottle.
The invention also provides the application of the hyaluronic acid oral liquid in skin protection.
On the basis of the common knowledge in the field, the above preferred conditions can be combined randomly to obtain the preferred embodiments of the invention.
The reagents and starting materials used in the present invention are commercially available.
The positive progress effects of the invention are as follows:
the hyaluronic acid oral liquid has a good skin moisturizing effect, improves skin luster, has the advantages that active ingredients are easy to absorb by a human body, the effect is quick, and the hyaluronic acid oral liquid still has long-term moisturizing and skin brightening effects after being stopped. The oral liquid also has the advantages of excellent stability and homogeneity.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.
In the following examples and comparative examples, centella asiatica extract, aloe vera extract and pomegranate extract were prepared as follows, respectively.
The preparation method of the centella asiatica extract comprises the following steps: soaking herba Centellae in water, extracting at 80 deg.C under reflux for 20 hr, sequentially filtering, concentrating the filtrate, and drying to obtain herba Centellae extract.
The preparation method of the aloe extract comprises the following steps: squeezing Aloe, concentrating the squeezed solution at 70 deg.C for 15 hr, and vacuum drying to obtain Aloe extract.
The preparation method of the pomegranate extract comprises the following steps: soaking pericarpium Granati, pulp and seed in water, ultrasonic extracting at 40 deg.C for 10 hr, sequentially filtering, concentrating the filtrate, and drying to obtain fructus Granati extract.
Example 1
The mass percentage of each component of the hyaluronic acid oral liquid in example 1 is shown in the following table 1. The hyaluronic acid oral liquid of example 1 was prepared as follows:
(1) under the condition of keeping the room temperature, slowly adding the components shown in the table 1 into water at 35 ℃ according to the proportion, mixing and uniformly stirring until the components are completely dissolved;
(2) carrying out ultrasonic treatment on the oral liquid, wherein the ultrasonic treatment temperature is 50 ℃, and the ultrasonic treatment power is 300W;
(3) filtering the ultrasonic oral liquid with nylon membrane with pore diameter of 0.22 μm;
(4) cooling the oral liquid to below room temperature;
(5) aseptic filling is adopted;
specifically, the filling bottle is sterilized by a high-voltage pulse electric field (the field intensity is 50K/cm, the pulse number is 350, and the pulse frequency is 450Hz), and then the hyaluronic acid oral liquid is filled into the filling bottle (the volume is 15mL) and sealed.
TABLE 1 Components and amounts (in mass%) of examples 1 to 5 and comparative examples 1 to 5
Examples 2 to 5 and comparative examples 1 to 5
Oral liquids were prepared according to the component formulation shown in table 1, and the operating conditions of the preparation method were the same as in example 1.
Effect example 1: quality index detection
According to the industrial standard, the hyaluronic acid oral liquid prepared in the examples 1-5 and the comparative examples 1-5 is subjected to quality index detection, and the quality index detection result is shown in table 2.
TABLE 2 quality index test results
As can be seen from Table 2, the oral liquids of examples 1 to 5 and comparative examples 1 to 5 all meet the requirements.
The oral liquids of examples 1-5 have good stability within a shelf life (180 days), and no delamination occurs.
Effect example 2: quality index detection
200 adult female volunteers 25-40 years old were divided into 10 groups of 20 persons, and the hyaluronic acid oral liquids of examples 1-5 and comparative examples 1-5 were administered to 10 experimental groups once a day for 30 days.
During the experiment, questionnaires were conducted for skin conditions 15 days, 30 days, and 15 days after 30 days, respectively, and the results are shown in table 3.
TABLE 3 comparison table of skin conditions
As can be seen from table 3, the oral liquid of comparative example 1, in which xanthan gum was not added, had a slow onset of action and did not achieve the desired effect, and did not maintain the moisturizing and lightening effect on the skin after the oral liquid was taken out of use. The oral liquid of comparative example 2, to which vitamin C having an antioxidant effect was added, had no effect on moisturizing the skin or improving skin luster, unlike the present invention. Comparative example 3 also failed to achieve the desired moisturizing and skin lightening effects without the addition of vitamin B6, centella asiatica extract, aloe vera extract, and caffeine. The content of each component of comparative examples 4 and 5 was not sufficient to satisfy that the skin improvement effect was not as good as that of the present invention when "the product of the content of centella asiatica extract and the content of aloe vera extract was less than the content of xanthan gum" or "the ratio of the content of xanthan gum to the content of pomegranate extract was 0.15 to 0.25".
Claims (10)
1. A hyaluronic acid oral liquid is characterized in that it comprises hyaluronate, xanthan gum, vitamin B6, centella asiatica extract, aloe vera extract, caffeine, pomegranate extract, sweetener and water;
the hyaluronic acid salt comprises sodium hyaluronate and/or zinc hyaluronate, the molecular weight of the hyaluronic acid salt is 10-50 kDa, and the pH value of the hyaluronic acid salt is 6.5-7.0;
the molecular weight of the xanthan gum is 300-500 ten thousand;
the hyaluronic acid oral liquid comprises the following components in percentage by mass:
the content of the hyaluronate is 1.0-1.85%; the content of the xanthan gum is 1.2-2.0%; the content of the vitamin B6 is 0.3-0.8%; the content of the centella extract is 0.2-0.5%; the content of the aloe extract is 2-2.6%; the content of the caffeine is 0.05-0.2%; the content of the pomegranate extract is 7.5-9%; the sweetening agent is 0.01-0.05%; the sum of the mass percentages of the components is 100 percent;
the product of the content of centella asiatica extract and the content of aloe vera extract is less than the content of xanthan gum; the ratio of the content of the xanthan gum to the content of the pomegranate extract is 0.15-0.25;
the hyaluronic acid oral liquid comprises the following steps:
uniformly mixing all the components of the hyaluronic acid oral liquid, and sequentially carrying out ultrasonic treatment, membrane filtration and aseptic filling;
the temperature of the ultrasonic wave is 30-50 ℃;
the power of the ultrasonic wave is 200-500W.
2. The hyaluronic acid oral liquid of claim 1, wherein the sodium hyaluronate is present in an amount of 1.0 to 1.8%, such as 1%, 1.2%, 1.3% or 1.8%;
and/or the zinc hyaluronate is 0.01-0.05%, for example 0.01% or 0.02%;
and/or the xanthan gum is present in an amount of 1.3%, 1.4%, 1.5%, 1.7% or 2%.
3. The hyaluronic acid oral liquid of claim 1, wherein the vitamin B6 is present in an amount of 0.3%, 0.41%, 0.45%, 0.66% or 0.76%;
and/or the centella asiatica extract is present in an amount of 0.27%, 0.3%, 0.35% or 0.43%;
and/or the aloe extract is present in an amount of 2%, 2.2%, 2.5% or 2.6%.
4. The hyaluronic acid oral liquid of claim 1, wherein the caffeine content is 0.05%, 0.08%, 0.11%, 0.13%, or 0.2%;
and/or, the pomegranate extract content is 7.5%, 8%, 8.2%, 8.5% or 9%;
and/or the sweetener is one or more of sorbitol, mannitol and erythritol, preferably sorbitol or mannitol;
and/or the sweetener is present in an amount of 0.01%, 0.02%, 0.03%, or 0.05%.
5. The hyaluronic acid oral liquid of claim 1, which consists of 1% sodium hyaluronate, 0.02% zinc hyaluronate, 1.3% xanthan gum, 0.76% vitamin B6, 0.35% centella asiatica extract, 2.2% aloe vera extract, 0.13% caffeine, 8.2% pomegranate extract, 0.05% sorbitol, and 85.99% water;
or, the hyaluronic acid oral liquid consists of 1.2% of sodium hyaluronate, 0.01% of zinc hyaluronate, 1.7% of xanthan gum, 0.41% of vitamin B6, 0.3% of centella asiatica extract, 2% of aloe vera extract, 0.05% of caffeine, 9% of pomegranate extract, 0.03% of sorbitol, and 85.3% of water;
alternatively, the hyaluronic acid oral liquid consists of 1.8% sodium hyaluronate, 0.02% zinc hyaluronate, 1.5% xanthan gum, 0.66% vitamin B6, 0.27% centella asiatica extract, 2.5% aloe vera extract, 0.11% caffeine, 7.5% pomegranate extract, 0.02% sorbitol and 85.62% water;
or, the hyaluronic acid oral liquid consists of 1.3% of sodium hyaluronate, 0.02% of zinc hyaluronate, 1.4% of xanthan gum, 0.3% of vitamin B6, 0.43% of centella asiatica extract, 2.6% of aloe vera extract, 0.08% of caffeine, 8.5% of pomegranate extract, 0.02% of mannitol, and 85.35% of water;
alternatively, the hyaluronic acid oral liquid is composed of 1.8% of sodium hyaluronate, 0.02% of zinc hyaluronate, 2% of xanthan gum, 0.45% of vitamin B6, 0.3% of centella asiatica extract, 2% of aloe vera extract, 0.2% of caffeine, 8% of pomegranate extract, 0.01% of mannitol, and 85.22% of water.
6. The hyaluronic acid oral liquid of claim 1, wherein the centella asiatica extract is prepared by a method comprising the steps of: soaking centella asiatica in water, heating and refluxing at 60-80 ℃ for 10-24 hours, sequentially filtering, concentrating filtrate, and drying to obtain a centella asiatica extract;
the preparation method of the aloe extract comprises the following steps: squeezing aloe, concentrating the squeezed liquid at 50-80 ℃ for 10-18 h, and drying the concentrated liquid in vacuum to obtain an aloe extract;
the preparation method of the pomegranate extract comprises the following steps: soaking pomegranate peel, pomegranate pulp and pomegranate seed in water, performing ultrasonic extraction at 5-40 ℃ for 2-12 h, sequentially filtering, concentrating the filtrate, and drying to obtain the pomegranate extract.
7. The hyaluronic acid oral liquid of claim 1, wherein the mixing temperature is 35-45 ℃; the mixing mode is stirring.
8. The hyaluronic acid oral liquid of claim 1, wherein the membrane of the membrane filtration is a nylon membrane with a pore size of 0.22 μm.
9. The hyaluronic acid oral liquid of claim 1, wherein the aseptic filling is to sterilize the filling bottle by using a high-voltage pulse electric field, and then fill the hyaluronic acid oral liquid into the filling bottle and seal the bottle;
preferably, the sterilization field intensity is 50-60K/cm;
preferably, the number of the sterilization pulses is 300 to 350;
preferably, the pulse frequency of the sterilization is 400 to 450 Hz;
preferably, the aseptic filling specification is 15 mL/bottle.
10. Use of the hyaluronic acid oral liquid according to any of claims 1-5 for skin protection.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213700A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Herba Centellae health care oral liquid of a kind of eliminating toxin and beautifying the skin speckle dispelling and preparation method thereof |
| KR101699802B1 (en) * | 2015-07-21 | 2017-01-25 | 정길도 | Composition for percutaneous Energy Absorption |
| CN106998780A (en) * | 2014-07-22 | 2017-08-01 | Hl科学株式会社 | Contain pomegranate concentrate as active component for improving the composition of skin |
| CN108450956A (en) * | 2017-02-17 | 2018-08-28 | 王登国 | A kind of beautifying nourishing liquid |
| CN108925928A (en) * | 2018-08-20 | 2018-12-04 | 安徽蜂献蜂业有限公司 | A kind of tender skin queen bee paste composition of U.S. flesh |
| CN109805394A (en) * | 2017-11-20 | 2019-05-28 | 威海紫光科技园有限公司 | A kind of health food of anti-oxidant radiant skin |
-
2022
- 2022-02-16 CN CN202210142760.0A patent/CN114468288A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106998780A (en) * | 2014-07-22 | 2017-08-01 | Hl科学株式会社 | Contain pomegranate concentrate as active component for improving the composition of skin |
| KR101699802B1 (en) * | 2015-07-21 | 2017-01-25 | 정길도 | Composition for percutaneous Energy Absorption |
| CN105213700A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Herba Centellae health care oral liquid of a kind of eliminating toxin and beautifying the skin speckle dispelling and preparation method thereof |
| CN108450956A (en) * | 2017-02-17 | 2018-08-28 | 王登国 | A kind of beautifying nourishing liquid |
| CN109805394A (en) * | 2017-11-20 | 2019-05-28 | 威海紫光科技园有限公司 | A kind of health food of anti-oxidant radiant skin |
| CN108925928A (en) * | 2018-08-20 | 2018-12-04 | 安徽蜂献蜂业有限公司 | A kind of tender skin queen bee paste composition of U.S. flesh |
Non-Patent Citations (1)
| Title |
|---|
| 高福成等: "《食品工程高新技术》", 中国医药科技出版社 * |
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