CN114456238A - Preparation process and device of alpha-peptide - Google Patents
Preparation process and device of alpha-peptide Download PDFInfo
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- CN114456238A CN114456238A CN202210094505.3A CN202210094505A CN114456238A CN 114456238 A CN114456238 A CN 114456238A CN 202210094505 A CN202210094505 A CN 202210094505A CN 114456238 A CN114456238 A CN 114456238A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000002386 leaching Methods 0.000 claims abstract description 15
- 238000001816 cooling Methods 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 238000005406 washing Methods 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 238000011068 loading method Methods 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000007924 injection Substances 0.000 claims description 20
- 238000002347 injection Methods 0.000 claims description 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 239000002504 physiological saline solution Substances 0.000 claims description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- 239000003085 diluting agent Substances 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- 238000007664 blowing Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 abstract description 11
- 230000015572 biosynthetic process Effects 0.000 abstract description 8
- 238000006243 chemical reaction Methods 0.000 abstract description 8
- 238000003786 synthesis reaction Methods 0.000 abstract description 8
- 238000007865 diluting Methods 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 229940121896 radiopharmaceutical Drugs 0.000 description 2
- 230000002799 radiopharmaceutical effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
Abstract
The invention discloses a preparation process of alpha-peptide, which comprises the following steps: the method comprises the following steps: 18F-H2Collecting O target water; step two: 18F loading; step three: leaching by 18F, concentrating, and transferring to a reaction tube; step four: sealing the pipe and heating for marking; step five: cooling, transferring and diluting; step six: solid Phase Extraction (SPE); step seven: washing the solid phase extraction column; step eight: leaching the product; step nine: the product liquid is diluted, the preparation method is simple, and the automatic preparation can be realized by matching the deviceThe process takes 25-27min, the synthesis yield is 30-40%, the yield is greatly improved, the time consumption is shorter, the device is convenient to assemble and disassemble and move, the device has good portability, and the device can be rapidly prepared in hospitals.
Description
Technical Field
The invention relates to the technical field of preparation processes and equipment of alpha-peptide, in particular to a preparation process and a preparation device of alpha-peptide.
Background
The alpha-peptide is a radiopharmaceutical which is officially approved to enter clinical trials, and is also a new positron radiopharmaceutical which is the first clinical lot in China. The medicine can be used for early diagnosis of the high-expression tumor of the integrin avb3 and guiding accurate treatment of the tumor by matching with Positron Emission Tomography (PET).
The existing preparation method of alpha-peptide has low yield, long time consumption, large volume of a special device, complex structure and inconvenience for moving, so an improved technology is urgently needed to solve the problem in the prior art.
Disclosure of Invention
The present invention aims to provide a process and an apparatus for preparing alpha-peptide, so as to solve the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation process of alfasin comprises the following steps:
the method comprises the following steps: producing 18F by an accelerator;
step two: transferring the 18F to a QMA column of the apparatus;
step three: leaching the frozen tube which is freeze-dried in advance with the alpha peptide and a certain proportion of aluminum by using 170-200uL of physiological saline;
step four: sealing and heating at 110 ℃ for 12-14 min;
step five: cooling to below 70 ℃, and adding 6-8mL of injection water to dilute the system;
step six: the diluted solution slowly passes through a C18 column, and the product is adsorbed on the column;
step seven: washing the C18 column with 15mL of injection water, washing impurities clean, and blowing out residual liquid;
step eight: leaching the C18 column by using 1mL of 75% ethanol/normal saline mixed solution, and leaching the product to a product bottle;
step nine: according to the dosage, proper physiological saline is added for dilution, and the ethanol content of the final injection is ensured not to be higher than 10%.
Preferably, the preparation process and device of the alfa peptide provided by the invention are characterized in that the QMA column in the second step adopts a column with small dead volume.
Preferably, the preparation process and the device of the alpha peptide provided by the invention, wherein the leaching efficiency of 170-200uL of physiological saline in the third step can be ensured to be more than 90%.
Preferably, the preparation process and device of the alfa peptide provided by the invention are characterized in that the heating process in the fourth step is divided into two stages, wherein the first stage is a temperature rise stage, the temperature is raised for 100s, the temperature is raised to 105 ℃, the second stage is a heat preservation stage, and the temperature is maintained at 105 ℃ for 12 min.
Preferably, the preparation process and device of the alfa peptide provided by the invention are characterized in that the cooling process in the fifth step is 1.5-2.5 min.
Preferably, the preparation process and device of the alfa peptide provided by the invention are characterized in that the diluent in the sixth step is 8.5-9ml, and the acetonitrile content in the diluent is not more than 10%. The diluent is transferred in two times and the loading speed is not higher than 100 uL/s.
Preferably, the invention provides a process and a device for preparing alpha-peptide, wherein the process and the device comprise a shell, a three-way valve, a first four-way valve, a second four-way valve, a first multi-way valve, a second multi-way valve, a third multi-way valve, a cooling fan, a control motor, a control box and a shell cover, wherein the three-way valve, the first four-way valve and the second four-way valve are arranged on the surface of the shell, the first multi-way valve, the second multi-way valve and the third multi-way valve are also arranged on the surface of the shell, the first multi-way valve and the second multi-way valve are all matched with an injection pump bracket, the cooling fan is also arranged on the surface of the shell, the three-way valve, the first four-way valve, the second four-way valve, the first multi-way valve, the second multi-way valve and the third multi-way valve are respectively connected with one control motor, the control motor is arranged in the shell, the control box is also arranged in the shell, and is connected with the control motor, the upper surface and the rear end of the shell are both open, and the upper surface and the rear end of the shell are matched with the shell cover.
Preferably, the casing cover is L-shaped, the casing cover is connected with the casing body through screws, a handle is arranged on the upper surface of the casing cover, and a wiring port is arranged at the rear end of the casing cover.
Compared with the prior art, the invention has the beneficial effects that:
the preparation method is simple, the automatic preparation can be realized by matching with a device, the time of the process is 25-27min, the synthesis yield is 30-40%, the yield is greatly improved, the time consumption is shorter, the device is convenient to assemble and disassemble, the device is convenient to move, the portability is good, and the quick preparation in hospitals can be realized.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the housing;
FIG. 3 is a schematic view of a housing cover structure;
FIG. 4 is a schematic wiring diagram of the present invention;
FIG. 5 is a table diagram of synthetic records.
In the figure: the device comprises a shell 1, a three-way valve 2, a first four-way valve 3, a second four-way valve 4, a first multi-way valve 5, a second multi-way valve 6, a third multi-way valve 7, a cooling fan 8, a shell cover 9, an injection pump bracket 10, a handle 11, a wiring port 12, a transfer pipe 13, a negative pressure pump 14 and target water 15.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present invention without any creative effort belong to the protection scope of the present invention;
it should be noted that, in the description of the present invention, it should be noted that the terms "inside", "outside", "upper", "lower", "both sides", "one end", "the other end", "left", "right", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be configured and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
The invention provides a technical scheme that: a preparation process of alfasin comprises the following steps:
the method comprises the following steps: producing 18F by an accelerator;
step two: transferring the 18F to a QMA column of the apparatus;
step three: leaching the frozen tube which is freeze-dried in advance with the alpha peptide and a certain proportion of aluminum by using 170-200uL of physiological saline;
step four: sealing and heating at 110 ℃ for 12-14 min;
step five: cooling to below 70 ℃, and adding 6-8mL of injection water to dilute the system;
step six: the diluted solution slowly passes through a C18 column, and the product is adsorbed on the column;
step seven: washing the C18 column with 15mL of injection water, washing impurities clean, and blowing out residual liquid;
step eight: leaching the C18 column by using 1mL of 75% ethanol/normal saline mixed solution, and leaching the product to a product bottle;
step nine: according to the dosage, proper physiological saline is added for dilution, and the ethanol content of the final injection is ensured not to be higher than 10%.
More specific automated key process flow:
starting up self-checking;
equipment initialization;
cleaning a pipeline;
SP1 (syringe pump 1) and related line cleaning;
SP2 (syringe pump 2) and related line cleaning; (ethanol is used firstly, then water is injected, and finally the residue is dried and dried)
Preparing before synthesis; (preliminary Synthesis)
The method comprises the following steps: 18F-H2Collecting O target water; (the material of the accelerator target may affect the 18F-AlF mark, and at present, the silver target and the niobium target are mainly available in the market)
Preparing related switching valves and flow paths;
performing heat labeling, synthesis and purification;
step two: 18F loading; (1. target water sampling speed is controlled by negative pressure on the device to pass through QMA column, and too fast sampling speed can cause radioactive activity to leak through; 2. QMA is used as column with smaller dead volume, so that the volume of the washed 18F is reduced.)
Step three: leaching by 18F, concentrating, and transferring to a reaction tube; (1.18F sample QMA is finished and then eluted with 200uL of 170-ammonia normal saline, the elution efficiency can be ensured to be more than 90%, and the key points of automation are that 1, the elution liquid is accurately measured, 2, the elution liquid passes through the QMA at a high speed, so that the activity elution is not complete, the QMA remains a lot)
Step four: sealing the pipe and heating for marking; (1, the activity of 18F is concentrated in 170-200uL of physiological saline and transferred into a reaction tube through automatic control; 2. the material of the reaction tube is 3mL of brown penicillin bottle which is frozen in advance and has related precursors and a certain proportion of aluminum; 3. the heating stage is mainly divided into two stages, namely a temperature raising stage of 100s, the temperature is raised to 105 ℃ and is maintained for 12min, and 4, the volume of the marking system is about 1000 uL)
Step five: cooling, transferring and diluting; (1, cooling the reaction system to below 70 ℃ and approximately consuming 2 min; 2, transferring the reaction system to a transfer bottle, adding water for injection for dilution, simultaneously cleaning the reaction tube and transferring the reaction tube to the transfer bottle to ensure that the acetonitrile content in the diluent cannot be more than 10 percent, otherwise, the SPE solid phase extraction has the risk of leakage penetration)
Step six: solid Phase Extraction (SPE); (8.5-9 mL of the dilution was transferred in two portions and passed through SPE solid phase extraction cartridge (C18, Light) at a rate of not higher than 100uL/s)
Step seven: washing the solid phase extraction column (washing the SPE column with 3X 5mL, about 15mL of water injection, using no less than 15mL of water, otherwise the injection 18F ion content may increase)
Step eight: leaching the product; (1. rinsing the C18 column with 1mL of 75% ethanol/physiological saline solution, rinsing the product into a product bottle; 2. the product collection bottle is preceded by a sterile filter membrane which has several features, 1. it can filter ethanol; 2. it can filter aqueous media; 3. it has little adsorption to polypeptides)
Step nine: diluting the product liquid; (the product eluent contains about 750uL of ethanol, the volume of the final injection cannot be lower than 8mL, and the final injection is diluted by using normal saline to ensure the isotonicity of the injection as much as possible.)
And (5) after the synthesis is finished, storing the record. (automatic recording device)
A total of 9 counts were made, as shown in fig. 5.
The whole current automatic process takes 25-27min, the synthesis yield is 30-40% (time correction), 25% -34% (time correction), and the highest yield is 130mci (yield 38%, time correction).
As shown in fig. 1-4, a device for preparing alpha-peptide comprises a housing 1, a three-way valve 2, a first four-way valve 3, a second four-way valve 4, a first multi-way valve 5, a second multi-way valve 6, a third multi-way valve 7, a heat dissipation fan 8 and a housing cover 9, wherein the three-way valve 2, the first four-way valve 3 and the second four-way valve 4 are arranged on the surface of the housing 1, the first multi-way valve 5, the second multi-way valve 6 and the third multi-way valve 7 are further arranged on the surface of the housing 1, the first multi-way valve 5 and the second multi-way valve 6 are all matched with an injection pump bracket 10, the heat dissipation fan 8 is further arranged on the surface of the housing 1, the three-way valve 2, the first four-way valve 3, the second four-way valve 4, the first multi-way valve 5, the second multi-way valve 6 and the third multi-way valve 7 are respectively connected with a control motor, the control motor is arranged inside the housing 1, a control box is further arranged inside the housing 1, and is connected with the control motor, the upper surface and the rear end of the shell 1 are both open, and the upper surface and the rear end of the shell 1 are matched with the shell cover 9. The shell cover 9 is L-shaped, the shell cover 9 is connected with the shell 1 through screws, a handle 11 is arranged on the upper surface of the shell cover 9, and a wiring port 12 is arranged at the rear end of the shell cover 9.
The wiring method comprises the following steps: the first multi-way valve 5 is respectively connected with the transit pipe 13, the three-way valve 2 and the second four-way valve 4, the three-way valve 2 is connected with the first four-way valve 3, the three-way valve 2 is connected with the third multi-way valve 7, two ports in the third multi-way valve 7 are connected, the third multi-way valve 7 is further connected with the second multi-way valve 6, and the third multi-way valve 7 is further respectively connected with the negative pressure pump 14 and the target water 15. Wherein, the first multi-way valve 5 is connected with injection water and normal saline, the second four-way valve 4 is connected with a first waste liquid outlet and a product outlet, the first four-way valve 3 is connected with a second waste liquid outlet, and the second multi-way valve 6 is connected with injection water, buffer solution, leacheate and a third waste liquid outlet.
The preparation method is simple, the automatic preparation can be realized by matching with a device, the time of the process is 25-27min, the synthesis yield is 30-40%, the yield is greatly improved, the time consumption is shorter, the device is convenient to assemble and disassemble, the device is convenient to move, the portability is good, and the quick preparation in hospitals can be realized.
The invention is not described in detail, but is well known to those skilled in the art.
Finally, it is to be noted that: although the present invention has been described in detail with reference to examples, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (8)
1. A preparation process of alpha-peptide is characterized by comprising the following steps: the method comprises the following steps:
the method comprises the following steps: producing 18F by an accelerator;
step two: transferring the 18F to a QMA column of the apparatus;
step three: leaching the frozen tube which is freeze-dried in advance with the alpha peptide and a certain proportion of aluminum by using 170-200uL of physiological saline;
step four: sealing and heating at 110 ℃ for 12-14 min;
step five: cooling to below 70 ℃, and adding 6-8mL of injection water to dilute the system;
step six: the dilution was passed slowly through a C18 column, adsorbing the product onto the column;
step seven: washing the C18 column with 15mL of injection water, washing impurities clean, and blowing out residual liquid;
step eight: leaching the C18 column by using 1mL of 75% ethanol/normal saline mixed solution, and leaching the product to a product bottle;
step nine: according to the dosage, proper physiological saline is added for dilution, and the ethanol content of the final injection is ensured not to be higher than 10%.
2. The process according to claim 1, wherein the alpha peptide is prepared by the following steps: and in the second step, a QMA column with small dead volume is adopted.
3. The process according to claim 1, wherein the alpha peptide is prepared by the following steps: the leaching efficiency of 170-200uL of physiological saline in the third step can be ensured to be more than 90%.
4. The process according to claim 1, wherein the alpha peptide is prepared by the following steps: the heating process in the fourth step is divided into two stages, wherein the first stage is a temperature rise stage, the temperature is raised for 100s, the temperature is raised to 105 ℃, the second stage is a heat preservation stage, and the temperature is maintained for 12min at 105 ℃.
5. The process according to claim 1, wherein the alpha peptide is prepared by the following steps: the cooling process in the step five is 1.5-2.5 min.
6. The process according to claim 1, wherein the alpha peptide is prepared by the following steps: and in the sixth step, the diluent is 8.5-9ml, and the acetonitrile content in the diluent is not more than 10%. The diluent is transferred in two times and the loading speed is not higher than 100 uL/s.
7. A preparation device of alfa peptide, relating to the preparation process of the alfa peptide of any one of claims 2 to 6, is characterized in that: comprises a shell, a three-way valve, a first four-way valve, a second four-way valve, a first multi-way valve, a second multi-way valve, a third multi-way valve, a heat radiation fan, a control motor, a control box and a shell cover, the surface of the shell is provided with a three-way valve, a first four-way valve and a second four-way valve, the surface of the shell is also provided with a first multi-way valve, a second multi-way valve and a third multi-way valve, the first multi-way valve and the second multi-way valve are both matched with the injection pump bracket, the surface of the shell is also provided with a cooling fan, the three-way valve, the first four-way valve, the second four-way valve, the first multi-way valve, the second multi-way valve and the third multi-way valve are respectively connected with a control motor, and the control motors are arranged in the shell, the shell is characterized in that a control box is further arranged inside the shell and connected with a control motor, the upper surface and the rear end of the shell are both open, and the upper surface and the rear end of the shell are matched with the shell cover.
8. The device for preparing afatin according to claim 7, wherein: the shell cover is L-shaped and is connected with the shell body through a screw, a handle is arranged on the upper surface of the shell cover, and a wiring port is formed in the rear end of the shell cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202210094505.3A CN114456238A (en) | 2022-01-26 | 2022-01-26 | Preparation process and device of alpha-peptide |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210094505.3A CN114456238A (en) | 2022-01-26 | 2022-01-26 | Preparation process and device of alpha-peptide |
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| CN114456238A true CN114456238A (en) | 2022-05-10 |
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| CN202210094505.3A Pending CN114456238A (en) | 2022-01-26 | 2022-01-26 | Preparation process and device of alpha-peptide |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103483422A (en) * | 2013-09-22 | 2014-01-01 | 中国人民解放军第四军医大学 | NGR polypeptide radiopharmaceutical as well as preparation method and application thereof |
| CN103537239A (en) * | 2012-07-08 | 2014-01-29 | 复旦大学附属肿瘤医院 | Small-volume [<18>F] fluorine isotope labeled reactor and application thereof |
| CN105031675A (en) * | 2015-07-22 | 2015-11-11 | 周彤 | Process and module capable of continuously synthesizing fluorine-18 radiopharmaceuticals at two times |
| CN107614482A (en) * | 2015-06-05 | 2018-01-19 | 日本医事物理股份有限公司 | The manufacture device and manufacture method of radio-labelled compound |
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2022
- 2022-01-26 CN CN202210094505.3A patent/CN114456238A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103537239A (en) * | 2012-07-08 | 2014-01-29 | 复旦大学附属肿瘤医院 | Small-volume [<18>F] fluorine isotope labeled reactor and application thereof |
| CN103483422A (en) * | 2013-09-22 | 2014-01-01 | 中国人民解放军第四军医大学 | NGR polypeptide radiopharmaceutical as well as preparation method and application thereof |
| CN107614482A (en) * | 2015-06-05 | 2018-01-19 | 日本医事物理股份有限公司 | The manufacture device and manufacture method of radio-labelled compound |
| CN105031675A (en) * | 2015-07-22 | 2015-11-11 | 周彤 | Process and module capable of continuously synthesizing fluorine-18 radiopharmaceuticals at two times |
Non-Patent Citations (1)
| Title |
|---|
| 张健等: "基于新型18F微反应器的18F-阿法肽的自动化制备及microPET/CT显像", 中华核医学与分子影像杂质, vol. 39, no. 4, 30 April 2019 (2019-04-30), pages 198 * |
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