CN105031675A - Process and module capable of continuously synthesizing fluorine-18 radiopharmaceuticals at two times - Google Patents

Process and module capable of continuously synthesizing fluorine-18 radiopharmaceuticals at two times Download PDF

Info

Publication number
CN105031675A
CN105031675A CN201510434051.XA CN201510434051A CN105031675A CN 105031675 A CN105031675 A CN 105031675A CN 201510434051 A CN201510434051 A CN 201510434051A CN 105031675 A CN105031675 A CN 105031675A
Authority
CN
China
Prior art keywords
response system
value linear
synthesis
radiopharmaceutic
drip washing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201510434051.XA
Other languages
Chinese (zh)
Other versions
CN105031675B (en
Inventor
周彤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pat (Beijing) Technology Co., Ltd.
Original Assignee
周彤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 周彤 filed Critical 周彤
Priority to CN201510434051.XA priority Critical patent/CN105031675B/en
Publication of CN105031675A publication Critical patent/CN105031675A/en
Application granted granted Critical
Publication of CN105031675B publication Critical patent/CN105031675B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention belongs to the technical field of synthesis of positive electron radiopharmaceutical in the nuclear medicine, and specifically relates to a process and a module capable of continuously synthesizing same or different fluorine-18 radiopharmaceuticals at two times through once medicine loading. According to the process, two groups of leacheates are prepared in a fluorine-18 ion capturing and releasing system, for leaching anion capturing column (QMA) at two times, the leaching liquids of two times are respectively guided into two independent reaction systems through distribution valves, fluorine-18 radiopharmaceutical is independently synthesized in each reaction system, and the synthesized fluorine-18 radiopharmaceuticals are purified to obtain a final product. With the process and the module, two different (or same) fluorine-18 radiopharmaceuticals can be synthesized on the same module each time in the nuclear medicine, meanwhile, the utilization ratio of the equipment is improved, and the operation cost of the equipment is reduced.

Description

A kind of radiopharmaceutic technique of double synthesis Value linear and module
Technical field
The invention belongs to the positron emission sex pill synthesis technical field of nuclear medicine, be specifically related to that one can once be feeded, the radiopharmaceutic technique of the identical or different Value linear of double synthesis and module.
Background technology
Along with the development of PET/CT, the clinical needs to positron emitting tracer also progressively improve.Routine clinical on the one hand 18f-FDG amount increases obviously, and the half-life due to Value linear is only 110 minutes, therefore needs secondary production more than a day can meet clinical needs; Two is the different Value linear medicines of clinical needs, to meet the requirement of clinical various disease diagnosis, as synthesized based on DNA 18f-FLT, based on cell membrane synthesis 18f-monoethyl choline, dementia senilis developer based on amyloid proteins 18f-AV45 and based on tumor receptor 18f-FES etc.
For meeting synthesis in a day repeatedly 18f-FDG, GE and Siemens and domestic product man have developed the FDG module of 2 times and 4 times respectively.Wherein, the technique of 2 secondary modules of GE two overlaps independently FDG module, and Siemens and domestic FDG module have employed a reaction tube, the technique repeatedly reused.The module of multi-stage synthesis have employed the mode of continuous feed liquid, limits by raw material, can only produce single medicine.For meeting the requirement of clinical various disease diagnosis, General Electric Apparatus Co.'s (medical system) develops fluorine-18 multifunctional automated synthesis module: TracerLabFXF-N, Raytest company of Germany develops fluorine-18 multifunctional automated synthesis module SynChromR & D, domestic double-tube method fluorine-18 multifunctional module (see Chinese patent ZL200910119295.3); Above fluorine multifunctional module is radioactive residual after being limited to and running, and within one day, only can run once.If need the Value linear medicine that two different, need independent production in two days, not only waste the time, and need accelerator operation secondary, use secondary target material, waste resource.Therefore all at present fluorine multifunctional modules have the following disadvantages in technique:
1) owing to running rear radioactive residual reason, fluorine multifunctional module only can use once for one day, after residual activity decay in second day, can reuse, comprise the fluorine-18 multifunctional module of double-reaction tube after manual cleaning.If need synthesis more than two kinds medicines, two modules need be equipped with, or produce every other day.
2) continuous synthesis is single 18the module of F-FDG, can not share anion and catch post (QMA) capture systems, as the Explor4 of Siemens, has 4 to overlap independently QMA system.GETracerlabFX-FDG has 2 to overlap independently QMA system.Can share the domestic FDGN module of QMA capture systems, the drip washing composition of QMA is the same, drenches fluid and passes into same reaction tube (see Chinese patent application 200710129912.9), cannot meet the different drip washing required.Same QMA can not be realized, the requirement of secondary drip washing in batches.
3) because radioactivity remains, in fluorine multifunctional module, HPLC piece-rate system only can use once.
Summary of the invention
The object of the invention is to the defect for prior art, provide one can in one day double synthesis two kinds of radiopharmaceutic techniques of identical or different Value linear and module, to make full use of resource, meet clinical requirement.
Technical scheme of the present invention is as follows: the radiopharmaceutic technique of a kind of double synthesis Value linear, two groups of leacheates are prepared in Value linear ion trap and delivery system, two groups of leacheates distinguish drip washing QMA (anion catches post) at twice, drench fluid twice and lead to two independently response systems respectively by distributing valve, in each response system, synthesize Value linear radiopharmaceutical separately, the purified process of Value linear radiopharmaceutical after synthesis obtains final products.
Further, the radiopharmaceutic technique of double synthesis Value linear as above, wherein, the water of two groups of described leacheates is different from the ratio of acetonitrile, two groups of leacheates can divide two batches by the radioactive substance on QMA respectively drip washing enter different response systems.
Further, in two groups of described leacheates, the volumetric concentration of water of a group is 4 ~ 7% (V/V), and the volumetric concentration of the water of another group is 7 ~ 15% (V/V).
Further, the radiopharmaceutic technique of double synthesis Value linear as above, wherein, by connection valve and purification column by described two independently response system connect, the intermedium generated in first response system is transferred in the second response system, the Value linear radiopharmaceutical that synthesis is complicated further in the second response system.
A kind of module realizing above-mentioned double synthesis Value linear radiopharmaceutical technique, comprise Value linear ion trap and delivery system, the first response system, the second response system, purification devices, wherein, described Value linear ion trap and delivery system have two independently drip washing bottles, leacheate in two drip washing bottles is drip washing QMA respectively, the pouring fluid output pipe of QMA is connected with the first response system and the second response system respectively by three-way valve, and the first response system is connected purification devices respectively with the second response system.
Further, the radiopharmaceutic module of double synthesis Value linear as above, wherein, has the first reaction bulb in the first described response system, and pouring fluid and the first response system raw material of first time drip washing QMA inject the first reaction bulb respectively; Have the second reaction bulb in the second described response system, pouring fluid and the second response system raw material of second time drip washing QMA inject the second reaction bulb respectively.
Further, be connected with purification column by connection valve between the first described reaction bulb and the second reaction bulb, the intermedium generated in the first reaction bulb is transferred to the second reaction bulb.
Further, the radiopharmaceutic module of double synthesis Value linear as above, wherein, described purification devices comprises performance liquid chromatographic column (HPLC) purification system or purification column; Have rolling bottle in HPLC in described performance liquid chromatographic column (HPLC) purification system, reactant rolling bottle in HPLC that the first response system or the second response system generate enters same HPLC purification column (performance liquid chromatographic column) and carries out purification process; Also there is in described performance liquid chromatographic column (HPLC) purification system the acetonitrile bottle for rolling bottle in HPLC described in drip washing.
Beneficial effect of the present invention is as follows: (1) two independently drip washing bottle can according to the ratio of K222/K2CO3 in synthesis different medicine adjustment leacheate, to reach the highest combined coefficient; The ratio of water in leacheate and acetonitrile can be adjusted, at twice by radioactive substance drip washing on same QMA in two reaction bulbs; (2) two independently response system by share QMA and HPLC, independent operating successively can be separated and synthesize different Value linear radiopharmaceutical; (3) two independently response system can be connected by connection valve and purification column, as the radiopharmaceutical that two-tube multi-functional synthesis is complicated.
Accompanying drawing explanation
Fig. 1 is the radiopharmaceutic process flow diagram of double synthesis Value linear of the present invention;
Fig. 2 is continuous 2 synthesis in specific embodiment 18the process flow diagram of F-FDG;
Fig. 3 is continuous synthesis in specific embodiment 18f-FDG and 18the process flow diagram of F-FLT;
Fig. 4 is continuous synthesis in specific embodiment 18f-FLT and 18the process flow diagram of F-AV45;
Fig. 5 is complicated in conjunction with two response system synthesis in specific embodiment 18the process flow diagram of F-Link-peptide.
In figure, A. Value linear ion trap and delivery system, B. first response system, C. second response system, D.HPLC purification system.
X1. leacheate enters the first reaction bulb, and X2. leacheate enters the second reaction bulb, and the thick product of X3. enters rolling bottle in HPLC, and X4. connects the first reaction bulb and the second reaction bulb.
1. the first drip washing bottle, 2. the second drip washing bottle, 3. the first reaction bulb, 4. the second reaction bulb, rolling bottle in 5.HPLC, 6. acetonitrile bottle, 7.QMA, 8. the first response system material container, 9. the second response system material container, 10.HPLC purification column, 11. waste gas, 12. products.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described in detail.
As shown in Figure 1, the invention provides a kind of can the identical or different radiopharmaceutic technique of Value linear of double synthesis two kinds and correlation module, this module is made up of four systems, be respectively Value linear ion trap and delivery system A, the first response system B, second response system C, HPLC purification system D (also can be purification column).Value linear ion trap and delivery system comprise a six-way valve and QMA, there are two independently drip washing bottles 1,2 simultaneously, the acetonitrile leacheate different from the ratio of water (identical leacheate can be loaded when preparing same medicine) can be loaded in two drip washing bottles, the volumetric concentration such as, loading water in drip washing bottle 1 is the leacheate of 4 ~ 7% (V/V), the volumetric concentration loading water in drip washing bottle 2 is the leacheate of 7 ~ 15% (V/V), can repeat QMA drip washing at twice; Secondary drenches fluid and leads to two independently response system B, C respectively by distributing valve (three-way valve), realizes secondary synthesis.Two response systems B, C can be independently, have independently application of sample bottle respectively, the Value linear radiopharmaceutical of synthesis different (or identical); Also can be connected by connection valve and purification column, the intermedium completed be shifted to the second response system C, realizes the chain reaction of two response systems B, C, the Value linear radiopharmaceutical that synthesis is complicated in the first response system B.The HPLC purification system D shared is made up of rolling bottle 5 in the acetonitrile bottle 6 for cleaning, HPLC and semipreparative LOOP ring, HPLC purification column 10, radioactivity and UV-detector; Acetonitrile in acetonitrile bottle 6 can add rolling bottle 5 in HPLC in batches, rolling bottle and LOOP ring and HPLC purification column in cleaning, eliminates the interference of last synthesis; Final product 12 is formed after HPLC purification column 10 purification process.
Embodiment 1
The present embodiment produces secondary Value linear ion in same module, and continuous quadratic synthesizes 18f-FDG.
Value linear ion trap and delivery system A, the first response system B, the second response system C tri-systems are applied, continuous 2 synthesis can be realized 18f-FDG.As shown in Figure 2, drip washing bottle 1,2 is loaded identical leacheate, in the in-built synthesis of reaction raw materials container 8 and 9 18reagent (acetonitrile, precursor, NaOH and water) needed for F-FDG, a SEP-PAKC-18 post is respectively filled between valve V9 and V10 (V20 and V21), V10 with V21 outlet is connected purification column (IC-H, Al2O3, C-18 post) respectively.
First time synthesis: treat that radioactivity Value linear ion is transferred on QMA7, start first time synthesis: with the leacheate in drip washing bottle 1 by the drip washing of Value linear ion after X1 to the first reaction bulb 3, add reagent in container 8 successively, product completes first time synthesis after V10 to purification column, obtains 18f-FDG.
Second time synthesis: treat that the Value linear ion again produced is transferred on QMA7, start second time synthesis: with the leacheate in drip washing bottle 2 by the drip washing of Value linear ion after X2 to the second reaction bulb 4, add reagent in container 9 successively, product completes second time synthesis after V21 to purification column, again obtains 18f-FDG.
Embodiment 2
The present embodiment realizes production Value linear ion in same module, continuous synthesis 18f-FDG and 18f-FLT.
Value linear ion trap and delivery system A, the first response system B, second response system C, HPLC purification system D four systems are applied, can continuous synthesis be realized 18f-FDG and 18f-FLT.As shown in Figure 3, will fill different leacheates (mixed liquor of water and acetonitrile) in drip washing bottle 1,2, the volumetric concentration of the water of No. 1 leacheate is 5% (V/V), and the volumetric concentration of the water of No. 2 leacheates is 10% (V/V); The in-built synthesis of container 8 18reagent (acetonitrile, precursor, NaOH and water) needed for F-FDG, the in-built synthesis of container 9 18reagent (acetonitrile, precursor, HCl and water etc.) needed for F-FLT.
Between valve V9 and V10, fill a SEP-PAKC-18 post, V10 connects purification column (IC-H, Al 2o 3, C-18 post) for 18the synthesis of F-FDG; Between valve V20 and V21, fill a SEP-PAK aluminum post, the HPLC purification column of V21 through X3 path with HPLC purification system D is connected.
18the synthesis of F-FDG: treat that radioactivity Value linear ion is transferred on QMA7, first time synthesis is started as embodiment 1, unlike, volumetric concentration due to No. 1 leacheate water is 5% (V/V), radioactivity on QMA only has 50% to be leached the first reaction bulb 3, Automatic Program is synthesized, until terminate, obtains 18f-FDG.
18the synthesis of F-FLT: utilize the volumetric concentration of No. 2 leacheate water to be 10% (V/V), all will to remain on QMA radioactivity drip washing through X2 to the second reaction bulb 4, Automatic Program is synthesized, add reagent in container 9 successively, semi-finished product are rolling bottle 5 in valve V21 to HPLC, be separated through HPLC purification column 10, obtain 18f-FLT, completes second time synthesis.
Embodiment 3
The present embodiment is continuous synthesis in same module 18f-FLT and 18f-AV45.
Value linear ion trap and delivery system A, the first response system B, second response system C, HPLC purification system D four systems are applied, can continuous synthesis be realized 18f-FLT and 18f-AV45.As shown in Figure 4, load different leacheates by drip washing bottle 1,2, the in-built synthesis of container 8 18reagent (acetonitrile, precursor, HCl and water) needed for F-FLT, the in-built synthesis of container 9 18reagent (acetonitrile, precursor, HCl and water etc.) needed for F-AV45; Acetonitrile bottle 6 for cleaning is interior loads acetonitrile.
Between valve V9 and V10, fill a SEP-PAK aluminum post, V10 is connected with rolling bottle in HPLC 5 by X3 path; Between valve V20 and V21, fill a SEP-PAK aluminum post, V21 is connected with rolling bottle in HPLC 5 through X3 path.Treat that radioactivity Value linear ion is transferred on QMA7, synthesize 18F-FLT as embodiment 2 starts first time, semi-finished product are rolling bottle 5 in valve V10 to HPLC, is separated, obtains 18F-FLT through HPLC purification column 10, completes first time synthesis.
After completing first time synthesis, with rolling bottle 5 and LOOP ring in the acetonitrile cleaning HPLC in acetonitrile bottle 6 and HPLC purification column 3 times, to eliminate the impact of first time synthesis.
Treat that the Value linear ion again produced is transferred on QMA7, when starting to synthesize for the second time, with the leacheate in drip washing bottle 2 by the drip washing of Value linear ion after X2 to the second reaction bulb 4, add reagent in container 9 successively, semi-finished product are rolling bottle 5 in valve V21 to HPLC, be separated through HPLC purification column 10, obtain 18F-AV45, complete second time synthesis.
The present embodiment also by the water ratio of leacheate in adjustment drip washing bottle 1,2, can realize production Value linear ion, continuous synthesis 18f-FLT and 18f-AV45.
Embodiment 4
The present embodiment synthesizes complicated medicine in conjunction with two response systems in same module 18f-Link-peptide.
Value linear ion trap and delivery system A, the first response system B, second response system C, HPLC purification system D four systems are applied, can realize synthesizing complicated medicine 18f-Link-peptide.As shown in Figure 5, leacheate is loaded by drip washing bottle 1, the in-built synthesis of container 8 18reagent (acetonitrile, precursor, NaOH and water) needed for F-pentyne, the in-built synthesis of container 9 18reagent (nitrine-peptide, catalyst etc.) needed for F-Link-peptide, treats that radioactivity Value linear ion is transferred on QMA7, starts synthesis: the drip washing of Value linear ion in the first reaction bulb 3, is added reagent in container 8 by leacheate in drip washing bottle 1 successively.The raw materials evaporate of being synthesized by the first response system B, in the second reaction bulb 4 in the second response system C, with the raw material reaction in the second reaction bulb 4, then is separated through the HPLC purification column 10 of HPLC purification system D, obtains qualified product 18f-Link-peptide.
Present invention achieves and utilize in same module two reaction bulbs to carry out twice different necleophilic reaction, synthesize two kinds of different medicines.By being equipped with the leacheate of the different water of two covers and acetonitrile ratio, the three-way valve of 180 degree is adopted to transmit successively to two reaction bulbs.The leacheate of different proportion can in batches by the Value linear drip washing on QMA in differential responses bottle, realize once producing Value linear ion, secondary utilizes.In addition, utilize the acetonitrile in same module automatically to clean HPLC purification column and piece-rate system, in one day, same HPLC can be separated twice radiopharmaceutical.
Obviously, those skilled in the art can carry out change on various forms and modification to the present invention and not depart from the spirit and scope of the present invention.Like this, if these amendments of the present invention and modification belong within the scope of the claims in the present invention and equivalent technologies thereof, then the present invention is also intended to comprise these change and modification.

Claims (10)

1. the radiopharmaceutic technique of double synthesis Value linear, it is characterized in that: in Value linear ion trap and delivery system, prepare two groups of leacheates, two groups of leacheates distinguish drip washing QMA at twice, drench fluid twice and lead to two independently response systems respectively by distributing valve, in each response system, synthesize Value linear radiopharmaceutical separately, the purified process of Value linear radiopharmaceutical after synthesis obtains final products.
2. the radiopharmaceutic technique of double synthesis Value linear as claimed in claim 1, it is characterized in that: the water of two groups of described leacheates is different from the ratio of acetonitrile, two groups of leacheates can divide two batches by the radioactive substance on QMA respectively drip washing enter different response systems.
3. the radiopharmaceutic technique of double synthesis Value linear as claimed in claim 2, is characterized in that: in two groups of described leacheates, the volumetric concentration of water of a group is 4 ~ 7%(V/V), the volumetric concentration of the water of another group is 7 ~ 15%(V/V).
4. as the radiopharmaceutic technique of double synthesis Value linear in claim 1-3 as described in any one, it is characterized in that: by connection valve and purification column by described two independently response system connect, the intermedium generated in first response system is transferred in the second response system, the Value linear radiopharmaceutical that synthesis is complicated further in the second response system.
5. the radiopharmaceutic module of double synthesis Value linear, it is characterized in that: comprise Value linear ion trap and delivery system, the first response system, the second response system, purification devices, described Value linear ion trap and delivery system have two independently drip washing bottles, leacheate in two drip washing bottles is drip washing QMA respectively, the pouring fluid output pipe of QMA is connected with the first response system and the second response system respectively by three-way valve, and the first response system is connected purification devices respectively with the second response system.
6. the radiopharmaceutic module of double synthesis Value linear as claimed in claim 5, is characterized in that: have the first reaction bulb in the first described response system, and pouring fluid and the first response system raw material of first time drip washing QMA inject the first reaction bulb respectively; Have the second reaction bulb in the second described response system, pouring fluid and the second response system raw material of second time drip washing QMA inject the second reaction bulb respectively.
7. the radiopharmaceutic module of double synthesis Value linear as claimed in claim 6, it is characterized in that: be connected by connection valve and purification column between the first described reaction bulb and the second reaction bulb, the intermedium generated in the first reaction bulb is transferred to the second reaction bulb.
8. the radiopharmaceutic module of double synthesis Value linear as claimed in claim 5, is characterized in that: described purification devices comprises performance liquid chromatographic column purification system or purification column.
9. the radiopharmaceutic module of double synthesis Value linear as claimed in claim 8, it is characterized in that: have rolling bottle in HPLC in described performance liquid chromatographic column purification system, reactant rolling bottle in HPLC that the first response system or the second response system generate enters same HPLC purification column and carries out purification process.
10. the radiopharmaceutic module of double synthesis Value linear as claimed in claim 9, is characterized in that: also have the acetonitrile bottle for rolling bottle in HPLC described in drip washing in described performance liquid chromatographic column purification system.
CN201510434051.XA 2015-07-22 2015-07-22 A kind of technique and module for synthesizing Value linear radiopharmaceutical twice in succession Active CN105031675B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510434051.XA CN105031675B (en) 2015-07-22 2015-07-22 A kind of technique and module for synthesizing Value linear radiopharmaceutical twice in succession

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510434051.XA CN105031675B (en) 2015-07-22 2015-07-22 A kind of technique and module for synthesizing Value linear radiopharmaceutical twice in succession

Publications (2)

Publication Number Publication Date
CN105031675A true CN105031675A (en) 2015-11-11
CN105031675B CN105031675B (en) 2018-07-03

Family

ID=54439028

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510434051.XA Active CN105031675B (en) 2015-07-22 2015-07-22 A kind of technique and module for synthesizing Value linear radiopharmaceutical twice in succession

Country Status (1)

Country Link
CN (1) CN105031675B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662865A (en) * 2016-04-01 2016-06-15 原子高科股份有限公司 [18F] sodium fluoride preparation device
CN106098128A (en) * 2016-08-17 2016-11-09 天津医科大学总医院 Radiopharmaceutic hot cell system is repeatedly produced in short time
CN106749435A (en) * 2016-12-01 2017-05-31 浙江大学 A kind of Novel PET probe synthesis system
CN107970458A (en) * 2018-01-03 2018-05-01 山东省肿瘤防治研究院（山东省肿瘤医院） A kind of positron emitting tracer Fully automated synthesis module based on 18F-BF3 marks
CN114456238A (en) * 2022-01-26 2022-05-10 江苏新瑞药业有限公司 Preparation process and device of alpha-peptide

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2468490Y (en) * 2000-09-25 2002-01-02 杜宜奎 Installation for prodn. of fluorine-18 making drug
CN101104627A (en) * 2007-07-20 2008-01-16 张锦明 18F-FDG automatization synthetic method and device
CN101333138A (en) * 2008-07-23 2008-12-31 北京师范大学 Device and process capable of simultaneously preparing three different <18>F radiopharmaceuticals
CN102941048A (en) * 2012-10-30 2013-02-27 无锡江原安迪科分子核医学研究发展有限公司 System for automatically synthesizing 18F-FDG

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2468490Y (en) * 2000-09-25 2002-01-02 杜宜奎 Installation for prodn. of fluorine-18 making drug
CN101104627A (en) * 2007-07-20 2008-01-16 张锦明 18F-FDG automatization synthetic method and device
CN101333138A (en) * 2008-07-23 2008-12-31 北京师范大学 Device and process capable of simultaneously preparing three different <18>F radiopharmaceuticals
CN102941048A (en) * 2012-10-30 2013-02-27 无锡江原安迪科分子核医学研究发展有限公司 System for automatically synthesizing 18F-FDG

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662865A (en) * 2016-04-01 2016-06-15 原子高科股份有限公司 [18F] sodium fluoride preparation device
CN106098128A (en) * 2016-08-17 2016-11-09 天津医科大学总医院 Radiopharmaceutic hot cell system is repeatedly produced in short time
CN106098128B (en) * 2016-08-17 2018-07-24 天津医科大学总医院 The hot cell system of radiopharmaceutical is repeatedly produced in short time
CN106749435A (en) * 2016-12-01 2017-05-31 浙江大学 A kind of Novel PET probe synthesis system
CN107970458A (en) * 2018-01-03 2018-05-01 山东省肿瘤防治研究院（山东省肿瘤医院） A kind of positron emitting tracer Fully automated synthesis module based on 18F-BF3 marks
CN114456238A (en) * 2022-01-26 2022-05-10 江苏新瑞药业有限公司 Preparation process and device of alpha-peptide

Also Published As

Publication number Publication date
CN105031675B (en) 2018-07-03

Similar Documents

Publication Publication Date Title
CN105031675A (en) Process and module capable of continuously synthesizing fluorine-18 radiopharmaceuticals at two times
AU2010298725B2 (en) Chemical production module and dose synthesis card for pet biomarker production system
US20110070158A1 (en) Quality Control Module for Biomarker Generator System
JP2017503752A5 (en)
CN101104627A (en) 18F-FDG automatization synthetic method and device
Radchenko et al. Separation of 90Nb from zirconium target for application in immuno-PET
Boschi et al. Interdisciplinary tasks in the cyclotron production of Radiometals for medical applications. The case of 47Sc as example
TW201201844A (en) Gallium-68 radioisotope generator and generating method thereof
Mallapura et al. Production of [11C] carbon labelled flumazenil and L-deprenyl using the iMiDEV™ automated microfluidic radiosynthesizer
CN103301484A (en) Cassette for radioactive isotope handling apparatus, radioactive isotope handling apparatus, and radioactive isotope handling system
Mathiessen et al. Automated solid-phase radiofluorination using polymer-supported phosphazenes
CN102391318B (en) Fluorine-18 fluorodeoxyglucose (18F-FDG) kit and application thereof in synthesis of positron emission tomography (PET) developer FDG
CN107474082A (en) Double batch PET developers18F FDG pharmaceutical synthesis device and method
CN107108393A (en) PET indicator purification systems
US9266084B2 (en) Automatic synthesizer apparatus for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE and method thereof
US7556780B1 (en) Device for 123I-ADAM and automatic manufacturing device thereof
CN208927120U (en) Disposable cutting ferrule prepares the device of -11 radiopharmaceuticals of carbon
KR102490458B1 (en) Methods for purifying Ga-68 from eluate from 68Ge/68Ga generators and chromatographic columns for use in such methods
Sugo et al. Rapid Flow-Based System for Separation of Radioactive Metals by Selective Complex Formation
Wang et al. Automated synthesis of hypoxia imaging agent [18 F] FMISO based upon a modified Explora FDG 4 module
CN204407025U (en) The isotope labeling synthesizer of multiple radiotracer can be synthesized simultaneously
RU158401U1 (en) RADIONUCLIDE GENERATOR DEVICE
CN202410235U (en) Purification column for purifying positron radiopharmaceuticals 18F-FDG (fluorodeoxyglucose)
RU152519U1 (en) DEVICE FOR CONTROLLED DILUTION AND PACKAGING OF RADIO PHARMACEUTICALS INTO BOTTLES
CN203568823U (en) Automatic fluorine ion split charging device

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160819

Address after: 100195, room four, floor 2, building four, West 403, creative garden, Haidian District, Beijing

Applicant after: Pat (Beijing) Technology Co., Ltd.

Address before: 100853 nuclear medicine, tumor building, 28 Fuxing Road, Beijing, Haidian District

Applicant before: Zhou Tong

GR01 Patent grant
GR01 Patent grant