CN114452361A

CN114452361A - External application plaster for treating neck, shoulder, waist and leg pain and preparation method thereof

Info

Publication number: CN114452361A
Application number: CN202210243609.6A
Authority: CN
Inventors: 陈志云; 陈志贵
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-03-12
Filing date: 2022-03-12
Publication date: 2022-05-10
Also published as: CN117838811A

Abstract

The application provides an external application plaster for treating neck, shoulder, waist and leg pain and a preparation method thereof, relating to the technical field of traditional Chinese medicines. An external application plaster for treating neck, shoulder, waist and leg pains comprises the following raw materials in parts by weight: 10-19 parts of salvia miltiorrhiza, 10-21 parts of radix angelicae pubescentis, 5-15 parts of cinnamon, 2-8 parts of asarum, 5-15 parts of entada, 25-35 parts of notopterygium root, 10-20 parts of teasel root, 10-20 parts of angelica, 15-25 parts of kadsura pepper stem, 15-25 parts of tinospora sinensis stem, 5-15 parts of frankincense, 10-20 parts of safflower, 5-15 parts of pseudo-ginseng, 8-16 parts of cassia twig, 7-17 parts of peach kernel, 10-20 parts of dried orange peel, 8-16 parts of ephedra, 8-16 parts of radix angelicae, 10-20 parts of radix sileris, 10-20 parts of fructus aurantii, 8-16 parts of golden cypress, 8-16 parts of rhizoma sparganii, 10-20 parts of eucommia ulmoides and 7-13 parts of ligusticum wallichii. In addition, the plaster has the advantages of short treatment course, good effect and quick effect on treating neck, shoulder, waist and leg pains.

Description

External application plaster for treating neck, shoulder, waist and leg pain and preparation method thereof

Technical Field

The application relates to the technical field of traditional Chinese medicines, and in particular relates to an external application plaster for treating neck, shoulder, waist and leg pain and a preparation method thereof.

Background

Pain in the neck, shoulder, waist and leg is a group of diseases mainly caused by chronic strain and aseptic inflammation and mainly caused by pain, swelling and even limited function of the affected part. Common diseases include: cervical spondylosis, scapulohumeral periarthritis, tenosynovitis, lumbar intervertebral disc prolapse, lumbar muscle strain, and hyperosteogeny. The disease is hidden, the symptoms are not typical, the pain is mild and severe, and sometimes the pain can be relieved by self, so that the disease is not known by the majority of patients, and the best time for treatment is missed. The clinical manifestations are: (1) persistent pain, pain that forms part of life. (2) It can be caused by slight movement, even bending over to pick up the object or sneezing, and has difficulty in relieving pain and limited physical function. (3) A cloudy or rainy day or a cold from wind may cause a recurrence or aggravation of the pain.

At present, the number of patients suffering from neck, shoulder, waist and leg pain is the most in outpatient clinics of orthopedics and traumatology, currently, acupuncture, massage, traction, oral medicine or local closure and other therapies are mostly adopted for treating neck, shoulder, waist and leg pain, and due to long treatment course, poor effect, slow effect taking, time and labor waste, great mental pain and economic burden are brought to the patients, the expected effect is difficult to achieve, the operation cost is high, the expected effect of the patients is not achieved in the later period, and the pain of the patients is increased.

Therefore, a medicament which has short treatment course, good effect and quick effect on treating neck, shoulder, waist and leg pain is urgently needed.

Disclosure of Invention

The application aims to provide the external plaster for treating the pain in the neck, the shoulder, the waist and the lower extremities, and the external plaster has the advantages of short treatment course, good effect and quick effect on treating the pain in the neck, the shoulder, the waist and the lower extremities.

Another purpose of the application is to provide a preparation method of the externally applied plaster for treating pain in neck, shoulder, waist and leg, so as to obtain the externally applied plaster for treating pain in neck, shoulder, waist and leg.

The technical problem to be solved by the application is solved by adopting the following technical scheme.

On one hand, the embodiment of the application provides an externally-applied plaster for treating neck, shoulder, waist and leg pain, which comprises the following raw materials in parts by weight: 10-19 parts of salvia miltiorrhiza, 10-21 parts of radix angelicae pubescentis, 5-15 parts of cinnamon, 2-8 parts of asarum, 5-15 parts of entada, 25-35 parts of notopterygium root, 10-20 parts of teasel root, 10-20 parts of angelica, 15-25 parts of kadsura pepper stem, 15-25 parts of tinospora sinensis stem, 5-15 parts of frankincense, 10-20 parts of safflower, 5-15 parts of pseudo-ginseng, 8-16 parts of cassia twig, 7-17 parts of peach kernel, 10-20 parts of dried orange peel, 8-16 parts of ephedra, 8-16 parts of radix angelicae, 10-20 parts of radix sileris, 10-20 parts of fructus aurantii, 8-16 parts of golden cypress, 8-16 parts of rhizoma sparganii, 10-20 parts of eucommia ulmoides and 7-13 parts of ligusticum wallichii.

On the other hand, the embodiment of the application provides a preparation method of an externally applied plaster for treating neck, shoulder, waist and leg pain, which is characterized by comprising the following steps:

cleaning the raw materials, drying, and crushing to obtain raw material powder;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

mixing the mixed powder with ethanol, soaking, adding carbomer, syrup and melted maleic gum, heating, decocting, and stirring to obtain the final product.

Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:

according to western medicine, the causes of neck, shoulder, waist and leg pain include acute injury, chronic strain, rheumatism, allergy or immunity and other factors, but the applicant sees that most of the factors are soft tissue inflammation caused by cold and dampness, the external environment is humid or the living environment is heavy in humidity, and people are easy to be infected by damp; in the human body, the kidney failing to control water and accumulating to form dampness affects the transportation and transformation of the spleen due to kidney yang deficiency, the dampness is generated internally, the internal and external dampness act on the collaterals, the meridian obstruction, qi and blood stasis, obstruction causes pain, and the pain is manifested in the body. Based on the above, the applicant mainly warms the kidney and promotes yang, eliminates dampness and dredge collaterals, and promotes blood circulation to remove blood stasis, takes the notopterygium root, the kadsura pepper stem and the kadsura pepper stem as monarch drugs, and uses the effects of the notopterygium root and the kadsura pepper stem on dispelling cold and eliminating dampness, and the kadsura pepper stem on dredging collaterals and relieving pain to eliminate cold dampness in vivo and dredge stagnation of channels and collaterals; the radix salviae miltiorrhizae, the radix angelicae pubescentis, the radix dipsaci, the angelica sinensis, the safflower, the pericarpium citri reticulatae, the radix sileris, the fructus aurantii and the eucommia ulmoides are used as ministerial drugs, the effects of activating blood circulation, removing stasis and relieving pain of the radix salviae miltiorrhizae, the angelica sinensis and the safflower are used in cooperation with the radix angelicae pubescentis, the pericarpium citri reticulatae and the radix sileris for dispelling wind-damp, the radix dipsaci and the eucommia ulmoides are used for tonifying kidney and strengthening channels and collaterals, the pericarpium citri reticulatae and the fructus aurantii are used for tonifying spleen and regulating qi, the spleen and the kidney are strengthened, the problem of endogenous dampness and heat is fundamentally solved, and the angelica sinensis can activate blood, dredge channels and collaterals and activate qi and blood and are matched with each other; cinnamon, caulis spatholobi, frankincense, pseudo-ginseng, cassia twig, peach kernel, ephedra herb, radix angelicae, golden cypress, rhizoma sparganii and ligusticum wallichii are taken as adjuvant medicines, the effects of tonifying fire and yang and dispelling cold and promoting blood circulation of the cinnamon are utilized, the cassia twig is reinforced with the cassia twig, the radix angelicae and the golden cypress are used for tonifying yang and regulating qi, the effects of strengthening kidney are achieved, the effects of dispelling wind and eliminating dampness of the caulis spatholobi are utilized, the radix angelicae and the golden cypress are used for dispelling cold and eliminating dampness, the effects of dispelling dampness and promoting blood circulation of the frankincense, the pseudo-ginseng, the peach kernel and the ligusticum wallichii are used for promoting qi and activating blood circulation, the effects of breaking blood circulation and promoting qi of the rhizoma sparganii, removing blood stasis and enhancing the effects of clearing and activating channels and collaterals are utilized, and the ephedra herb can reduce swelling and promote diuresis, and help dispel cold and dampness; finally, the asarum is used as a guiding drug, so that the property is warm, the drug properties are harmonized, the muscles and tendons are relaxed, the blood circulation is promoted, the drugs are guided to directly reach the kidney, and the effects of the whole formula of dispelling dampness, promoting blood circulation, warming channels and activating collaterals can be enhanced.

According to the application, the raw materials are crushed into powder, so that the medicinal components in the raw materials can be conveniently dispersed in the subsequent soaking and decocting processes, and a plaster with outstanding effect can be conveniently obtained; the active ingredients in the tea can be fully dissolved out by soaking the tea in ethanol; the effective substances can be fully extracted by decocting the raw materials, so that the effect of the ointment is outstanding.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.

Red sage root: bitter taste and slightly cold nature; it enters heart, pericardium and liver meridians. Promoting blood circulation to regulate menstruation, removing blood stasis to relieve pain, cooling blood to relieve carbuncle, relieving restlessness and tranquilizing mind. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, cardialgia, abdominal pain, abdominal mass, traumatic injury, rheumatism, skin sore, carbuncle, toxic swelling, fever, dysphoria, unconsciousness, palpitation, and insomnia.

Radix angelicae pubescentis: pungent and bitter taste, slightly warm in nature; it enters kidney and bladder meridians. Dispel wind-damp, alleviate pain, release exterior. It is mainly used for treating arthralgia due to wind-cold-dampness, exterior syndrome due to wind-cold with dampness, headache due to shaoyin, and skin pruritus.

Cinnamon: pungent and sweet in flavor and strong in heat; it enters kidney and spleen meridians. Tonify fire and strengthen yang, dispel cold and alleviate pain, activate blood and dredge meridians. Can be used for treating kidney yang deficiency, sexual impotence, cold womb, giddiness, conjunctival congestion, heart and abdomen psychroalgia, cold arthralgia, lumbago, cold hernia, dolphin, cold coagulation, blood stasis, amenorrhea, dysmenorrhea, dorsal furuncle, and multiple abscess.

Asarum: pungent taste and warm nature; it enters lung, kidney and heart meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm. It can be used for treating wind-cold type common cold, headache, toothache, rheumatic arthralgia, nasosinusitis, and cough with asthma due to lung cold.

And (3) crossing the river: pungent and bitter taste, warm nature; it enters liver and bladder meridians. Dispel wind and remove dampness, relax muscles and tendons and promote blood circulation. It can be used for treating rheumatalgia, numbness of limbs, traumatic injury, and menoxenia.

Notopterygium root: pungent and bitter taste, warm nature; it enters bladder and kidney meridians. Relieve exterior syndrome, dispel cold, expel wind and dampness, and alleviate pain. It can be used for treating wind-cold type common cold and arthralgia due to wind-cold-dampness.

Teasel root: bitter, sweet and pungent in flavor, slightly warm in nature; it enters liver meridian. Tonify liver and kidney, reunite tendons and strengthen bones, and promote blood circulation. Can be used for treating deficiency of liver and kidney, soreness of waist and knees, arthralgia due to cold-dampness, metrorrhagia, metrostaxis, threatened abortion, traumatic injury, fracture and injury of bones and muscles, etc.

Chinese angelica: sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. It can be used for treating blood deficiency, chlorosis, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.

Caulis piperis futokadsurae: pungent and bitter taste, slightly warm in nature; it enters liver meridian. Dispel wind-damp, unblock collaterals and alleviate pain. It is mainly used for treating arthralgia due to wind-cold-dampness, traumatic injury, cough, dyspnea, chest distress, excessive phlegm and short breath.

And (3) widening tendon rattan: bitter taste and cool nature; it enters liver meridian. Relaxing muscles and tendons, activating collateral flow, expelling pathogenic wind, and relieving pain. Can be used for treating rheumatic arthralgia, sciatica, lumbar muscle strain, and traumatic injury.

Frankincense: pungent and bitter taste, warm nature; it enters heart, liver and spleen meridians. Promote blood circulation, move qi and alleviate pain, resolve swelling and promote tissue regeneration. It can be used for treating traumatic injury, pyocutaneous disease, carbuncle, swelling, stagnation of qi, blood stasis, and pain.

Safflower: pungent taste and warm nature; it enters heart and liver meridians. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Is mainly used for treating amenorrhea due to blood stagnation, dysmenorrhea, postpartum abdominal stasis and pain, abdominal mass, thoracic obstruction and heart pain, abdominal pain due to blood stasis, hypochondriac pain, traumatic injury, swelling and pain due to blood stasis, and macula due to blood stasis with dark color.

Pseudo-ginseng: sweet, slightly bitter and warm in nature; it enters liver and stomach meridians. Remove blood stasis, stop bleeding, activate blood and relieve pain. It is mainly used for various bleeding syndromes, blood stasis with swelling pain, traumatic injury, etc. which belong to blood stasis stagnation.

Cassia twig: pungent and sweet in flavor and warm in nature; it enters heart, lung and bladder meridians. Induce sweating to expel pathogenic factors from the muscles, warm and dredge meridians, strengthen yang and transform qi. It can be used for treating wind-cold type common cold, pain due to cold accumulation and blood stagnation, phlegm and fluid retention, and palpitation.

Peach kernel: bitter and sweet in taste and mild in nature; it enters heart, liver and large intestine meridians. Promote blood circulation to remove blood stasis, moisten intestines to relieve constipation, relieve cough and relieve asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal abscess, traumatic injury, constipation due to intestinal dryness, cough, and asthma.

Dried orange peel: pungent and bitter taste, warm nature; it enters spleen and lung meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. It can be used for treating qi stagnation of spleen and stomach, emesis, singultus, cough due to damp-phlegm and cold-phlegm, and thoracic obstruction.

Herba ephedrae: pungent, slightly bitter and warm in nature; it enters lung and bladder meridians. Induce sweating to relieve exterior syndrome, ventilate lung and relieve asthma, induce diuresis to alleviate edema. It is mainly used for treating exterior excess syndrome due to exogenous wind-cold, cough, asthma, edema due to wind-cold-dampness, arthralgia due to wind-cold-dampness, dorsal furuncle, and phlegm-nodule.

Radix angelicae: pungent taste and warm nature; it enters lung, stomach and large intestine meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind, and relieving itching. Can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, leukorrhagia, skin sore, carbuncle, skin pruritus, etc

Wind prevention: pungent and sweet in flavor and slightly warm in nature; it enters bladder, liver and spleen meridians. Dispel wind and relieve exterior syndrome, subdue dampness and alleviate pain, stop spasm. It can be used for treating exterior syndrome due to exogenous pathogenic factors, rubella pruritus, rheumatalgia, and tetanus.

Fructus aurantii: bitter, pungent and sour, slightly cold; it enters spleen and stomach meridians. Regulate qi, relieve chest stuffiness, move stagnation and remove food retention. Can be used for treating upper-jiao qi stagnation, fullness and fullness in chest and diaphragm, hypochondrium distending pain, dyspepsia, abdominal distention and pain, belching, vomiting, diarrhea, prolapse of anus due to qi deficiency, metroptosis, intestinal wind and hematochezia, rubella, pruritus, and abdominal pain during pregnancy.

Phellodendron bark: bitter taste and cold nature; it enters kidney, bladder and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity, remove bone and steam. Can be used for treating leukorrhagia due to damp-heat, stranguria due to heat, dysentery due to damp-heat, jaundice, tinea pedis due to damp-heat, flaccidity syndrome, hectic fever due to yin-deficiency, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and pruritus.

Three-edge: pungent, bitter and neutral in flavor; it enters liver and spleen meridians. Break blood and move qi, resolve food stagnation and alleviate pain. Break blood, move qi, resolve food stagnation and alleviate pain. It is used to treat abdominal pain, abdominal distention, amenorrhea, puerperal abdominal pain, traumatic injury, skin ulcer, hard mass, and abdominal pain.

Eucommia ulmoides: sweet taste and warm nature; it enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, prevent abortion. It is indicated for lumbago due to kidney deficiency and various kinds of lumbago, threatened abortion and habitual abortion.

Ligusticum wallichii: pungent taste and warm nature; it enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain. Chest stuffiness and pain due to heart vessel stagnation, hypochondriac distending pain due to liver depression and qi stagnation, chest and hypochondriac pricking pain due to liver blood stagnation, traumatic injury due to blood stasis, sore and ulcer swelling and pain, irregular menstruation, amenorrhea and dysmenorrhea, postpartum stagnant pain, lochiorrhea, various headaches and rheumatism pain.

The application provides an external application plaster for treating neck, shoulder, waist and leg pain, which comprises the following raw materials in parts by weight: 10-19 parts of salvia miltiorrhiza, 10-21 parts of radix angelicae pubescentis, 5-15 parts of cinnamon, 2-8 parts of asarum, 5-15 parts of entada, 25-35 parts of notopterygium root, 10-20 parts of teasel root, 10-20 parts of angelica, 15-25 parts of kadsura pepper stem, 15-25 parts of tinospora sinensis stem, 5-15 parts of frankincense, 10-20 parts of safflower, 5-15 parts of pseudo-ginseng, 8-16 parts of cassia twig, 7-17 parts of peach kernel, 10-20 parts of dried orange peel, 8-16 parts of ephedra, 8-16 parts of radix angelicae, 10-20 parts of radix sileris, 10-20 parts of fructus aurantii, 8-16 parts of golden cypress, 8-16 parts of rhizoma sparganii, 10-20 parts of eucommia ulmoides and 7-13 parts of ligusticum wallichii. The applicant mainly warms kidney and promotes yang, eliminates dampness and dredge collaterals and activates blood and removes blood stasis, takes notopterygium root, kadsura pepper stem and kadsura pepper stem as monarch drugs, and uses the effects of expelling cold and eliminating dampness of the notopterygium root and kadsura pepper stem and dredging collaterals and relieving pain to eliminate cold and dampness in vivo and dredge the stasis of the meridians and collaterals; the radix salviae miltiorrhizae, the radix angelicae pubescentis, the radix dipsaci, the angelica sinensis, the safflower, the pericarpium citri reticulatae, the radix sileris, the fructus aurantii and the eucommia ulmoides are used as ministerial drugs, the effects of activating blood circulation, removing stasis and relieving pain of the radix salviae miltiorrhizae, the angelica sinensis and the safflower are used in cooperation with the radix angelicae pubescentis, the pericarpium citri reticulatae and the radix sileris for dispelling wind-damp, the radix dipsaci and the eucommia ulmoides are used for tonifying kidney and strengthening channels and collaterals, the pericarpium citri reticulatae and the fructus aurantii are used for tonifying spleen and regulating qi, the spleen and the kidney are strengthened, the problem of endogenous dampness and heat is fundamentally solved, and the angelica sinensis can activate blood, dredge channels and collaterals and activate qi and blood and are matched with each other; cinnamon, caulis spatholobi, frankincense, pseudo-ginseng, cassia twig, peach kernel, ephedra herb, radix angelicae, golden cypress, rhizoma sparganii and ligusticum wallichii are taken as adjuvant medicines, the effects of tonifying fire and yang and dispelling cold and promoting blood circulation of the cinnamon are utilized, the cassia twig is reinforced with the cassia twig, the radix angelicae and the golden cypress are used for tonifying yang and regulating qi, the effects of strengthening kidney are achieved, the effects of dispelling wind and eliminating dampness of the caulis spatholobi are utilized, the radix angelicae and the golden cypress are used for dispelling cold and eliminating dampness, the effects of dispelling dampness and promoting blood circulation of the frankincense, the pseudo-ginseng, the peach kernel and the ligusticum wallichii are used for promoting qi and activating blood circulation, the effects of breaking blood circulation and promoting qi of the rhizoma sparganii, removing blood stasis and enhancing the effects of clearing and activating channels and collaterals are utilized, and the ephedra herb can reduce swelling and promote diuresis, and help dispel cold and dampness; finally, the asarum is used as a guiding drug, so that the properties are warm, the drug properties are harmonized, the muscles and the tendons are relaxed, the blood circulation is promoted, the drugs are guided to directly reach the kidney, and the effects of the whole formula of clearing damp, promoting blood circulation, warming channels and activating collaterals can be enhanced.

In some embodiments of the present application, the external plaster further comprises the following raw materials in parts by weight: 550 parts of maleic gum, 20-70 parts of syrup and 30-100 parts of carbomer. Increase the consistency that maleate, syrup and carbomer can increase the medicament, the plaster shaping of being convenient for, the plaster soft or hard under this ratio is moderate moreover, when needs are torn from the person, can not adhere to the human body too firm, when tearing, all remove easily to reduce the painful sense of tearing, use experience is good.

In some embodiments of the present application, the external plaster comprises the following raw materials in parts by weight: 13-16 parts of salvia miltiorrhiza, 14-17 parts of radix angelicae pubescentis, 9-11 parts of cinnamon, 4-6 parts of asarum, 9-11 parts of entada, 29-31 parts of notopterygium root, 14-16 parts of teasel root, 14-16 parts of angelica, 19-21 parts of kadsura pepper stem, 19-21 parts of tinospora sinensis, 9-11 parts of frankincense, 14-16 parts of safflower, 9-11 parts of pseudo-ginseng, 11-13 parts of cassia twig, 11-13 parts of peach kernel, 14-16 parts of dried orange peel, 11-13 parts of ephedra, 11-13 parts of radix angelicae, 14-16 parts of divaricate saposhnikovia root, 14-16 parts of fructus aurantii, 11-13 parts of golden cypress, 11-13 parts of rhizoma sparganii, 14-16 parts of eucommia ulmoides and 9-11 parts of ligusticum wallichii. Under the proportion, the treatment effect is better, and the clinical effect is better.

The application provides a preparation method of an externally-applied plaster for treating neck, shoulder, waist and leg pain, which comprises the following steps:

cleaning the raw materials, drying, and crushing to obtain raw material powder;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

mixing the mixed powder with ethanol, soaking, adding carbomer, syrup and melted maleic gum, heating, decocting, and stirring to obtain the final product. According to the application, the raw materials are crushed into powder, so that the medicinal components in the raw materials can be conveniently dispersed in the subsequent soaking and decocting processes, and a plaster with outstanding effect can be conveniently obtained; the active ingredients in the tea can be fully dissolved out by soaking the tea in ethanol; the effective substances can be fully extracted by decocting the raw materials, so that the effect of the ointment is outstanding.

In some embodiments of the present application, the above drying temperature is 45-55 ℃. Drying under the condition can retain more drug properties, so that the prepared plaster has better effect.

In some embodiments of the present application, the size of the crushed raw material is 100-150 mesh. After the raw materials are fully crushed, the effective substances can be more easily dissolved in the ethanol when the raw materials are soaked.

In some embodiments of the present application, the weight ratio of the mixed powder to ethanol is (3-5): 2. under the proportion, the effective components in the extract can be fully extracted.

In some embodiments of the present application, the ethanol is present in a concentration of 70-75% by volume. The ethanol with the concentration has the best extraction effect on medicinal materials.

In some embodiments of the present application, the soaking time is 40-56 hours. Too short soaking time can cause the effective substances in the medicinal materials not to be fully extracted, and too long soaking time can not cause more effective substances to be extracted, and soaking in the time can fully extract the effective substances.

In some embodiments of the present application, the heating and boiling temperature is 85-95 ℃, and the heating and boiling time is 5-15 min. The existing plaster processing is that prepared Chinese herbal medicines are mostly decocted in an oil pan by fire, and residue is removed after the oil is burnt, so that the preparation method has large loss of medicine properties, more loss of effective components and poorer effect of the obtained plaster.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1

A preparation method of an externally applied plaster for treating neck, shoulder, waist and leg pain comprises the following steps:

raw materials: 10g of salvia miltiorrhiza, 10g of radix angelicae pubescentis, 5g of cinnamon, 2g of asarum, 5g of entada, 25g of notopterygium root, 10g of teasel root, 10g of angelica sinensis, 15g of kadsura pepper stem, 15g of tinospora sinensis, 5g of frankincense, 10g of safflower, 5g of pseudo-ginseng, 8g of cassia twig, 7g of peach kernel, 10g of dried orange peel, 8g of ephedra, 8g of radix angelicae, 10g of radix sileris, 10g of fructus aurantii, 8g of golden cypress, 8g of rhizoma sparganii, 10g of eucommia ulmoides, 7g of ligusticum wallichii, 450g of maleic gum, 20g of syrup and 30g of carbomer.

Cleaning the raw materials, drying at 45 ℃, and crushing to 100 meshes;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

according to the following steps of 3: 2, mixing the mixed powder with ethanol with the volume concentration of 70%, soaking for 40h, adding carbomer, syrup and molten maleic gum, heating and decocting at 85 ℃ for 5min, and continuously stirring in the decocting process to obtain the finished product of the external plaster.

Example 2

raw materials: 13g of salvia miltiorrhiza, 14g of radix angelicae pubescentis, 9g of cinnamon, 4g of asarum, 9g of entada, 29-31g of notopterygium root, 14g of teasel root, 14g of angelica, 19g of kadsura pepper stem, 19g of tinospora sinensis, 9g of frankincense, 14g of safflower, 9g of pseudo-ginseng, 11g of cassia twig, 11g of peach kernel, 14g of dried orange peel, 11g of ephedra, 11g of angelica dahurica, 14g of divaricate saposhnikovia root, 14g of fructus aurantii, 11g of golden cypress, 11g of rhizoma sparganii, 14g of eucommia ulmoides, 9g of ligusticum wallichii, 480g of maleic gum, 30g of syrup and 50g of carbomer.

Cleaning the raw materials, drying at 48 ℃, and crushing to 100 meshes;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

according to the following steps of 4: 2, mixing the mixed powder with 73% ethanol by volume concentration, soaking for 44h, adding carbomer, syrup and molten maleic gum, heating and decocting at 88 deg.C for 8min, and stirring continuously during decocting to obtain the final product of the plaster.

Example 3

raw materials: 15g of salvia miltiorrhiza, 16g of radix angelicae pubescentis, 10g of cinnamon, 5g of asarum, 10g of entada, 30g of notopterygium root, 15g of teasel root, 15g of angelica, 20g of kadsura pepper stem, 20g of tinospora sinensis, 10g of frankincense, 15g of safflower, 10g of pseudo-ginseng, 12g of cassia twig, 12g of peach kernel, 15g of dried orange peel, 12g of ephedra, 12g of radix angelicae, 15g of radix sileris, 15g of fructus aurantii, 12g of golden cypress, 12g of rhizoma sparganii, 15g of eucommia ulmoides, 10g of ligusticum wallichii, 500g of maleic gum, 40g of syrup and 65g of carbomer.

Cleaning the raw materials, drying at 50 ℃, and crushing to 150 meshes;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

according to the following steps of 4: 2, mixing the mixed powder with 73% ethanol by volume concentration, soaking for 48h, adding carbomer, syrup and molten maleic gum, heating and decocting at 90 ℃ for 10min, and continuously stirring in the decocting process to obtain the finished product of the external plaster.

Example 4

raw materials: 16g of salvia miltiorrhiza, 17g of radix angelicae pubescentis, 11g of cinnamon, 6g of asarum, 11g of entada, 31g of notopterygium root, 16g of teasel root, 16g of angelica, 21g of kadsura pepper stem, 21g of tinospora sinensis, 11g of frankincense, 16g of safflower, 11g of pseudo-ginseng, 13g of cassia twig, 13g of peach kernel, 16g of dried orange peel, 13g of ephedra, 13g of radix angelicae, 16g of radix sileris, 16g of fructus aurantii, 13g of golden cypress, 13g of rhizoma sparganii, 16g of eucommia ulmoides, 11g of ligusticum wallichii, 520g of maleic gum, 60g of syrup and 80g of carbomer.

Cleaning the raw materials, drying at 53 ℃, and crushing to 150 meshes;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

according to the following steps: 2, mixing the mixed powder with 75% ethanol by volume concentration, soaking for 56h, adding carbomer, syrup and molten maleic gum, heating and decocting at 95 ℃ for 15min, and continuously stirring in the decocting process to obtain the finished product of the external plaster.

Example 5

raw materials: 19g of salvia miltiorrhiza, 21g of radix angelicae pubescentis, 15g of cinnamon, 8g of asarum, 15g of entada, 35g of notopterygium root, 20g of teasel root, 20g of angelica, 25g of kadsura pepper stem, 25g of tinospora sinensis, 15g of frankincense, 20g of safflower, 15g of pseudo-ginseng, 16g of cassia twig, 17g of peach kernel, 20g of dried orange peel, 16g of ephedra, 16g of radix angelicae, 20g of radix sileris, 20g of fructus aurantii, 16g of golden cypress, 16g of rhizoma sparganii, 20g of eucommia ulmoides, 13g of ligusticum wallichii, 550g of maleic gum, 70g of syrup and 100g of carbomer.

Cleaning the raw materials, drying at 55 ℃, and crushing to 150 meshes;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

according to the following steps: 2, mixing the mixed powder with 75 percent ethanol by volume concentration, soaking for 56 hours, adding carbomer, syrup and molten maleic gum, heating and decocting for 15 minutes at 95 ℃, and continuously stirring in the decocting process to obtain a finished product of the external application plaster.

Comparative example 1

This comparative example is essentially the same as example 3, except that: notopterygium root is not added.

Comparative example 2

This comparative example is essentially the same as example 3, except that: the caulis Piperis Futokadsurae is replaced by herba Begoniae Laciniatae.

Examples of the experiments

Clinical experiments are as follows:

1. clinical data: 158 patients suffering from neck, shoulder, waist and leg pain, 85 men and 73 women with the disease of 11 months and 11 months diagnosis in 2020 to 2021 are selected, and the age is 35 to 64 years old. Dividing patients into a treatment group and an effect comparison group randomly, wherein the treatment group is divided into 5 groups of 110 patients, and each group is divided into 22 patients; the effect comparison groups were equally divided into 2 groups of 24 persons each. The treatment groups were treated with the plasters of examples 1-5, respectively, and the efficacy control groups were treated with the plasters of comparative examples 1-2, respectively.

2. The using method comprises the following steps: applying the plaster (7 cm × 10cm) to affected part every morning for 1 day, and changing into new plaster the next day, with 7 days as 1 treatment course.

3. The curative effect standard is as follows: before and after the treatment, the subjective pain and the curative effect of the patient are observed.

And (3) curing: after treatment, the pain of neck, shoulder, waist and legs disappears, and the affected part moves freely.

The method has the following advantages: after treatment, the pain of neck, shoulder, waist and legs is obviously relieved, and the affected part can act greatly.

And (4) invalidation: after treatment, neck, shoulder, waist and leg pain does not improve, and the state of the affected part is the same as that before treatment.

After 2 treatment sessions, the patient profiles were summarized and the results are shown in table 1.

TABLE 1

Group of	Cure/human	Effective/human	Invalid/human	The effective rate is 100%
					Treatment 1 group	15	3	4	81.8
Treatment of 2 groups	15	5	2	90.9
					Treatment of 3 groups	20	2	0	100
Treatment of 4 groups	16	5	1	95.5
					Treatment of 5 groups	18	3	1	95.5
Comparative 1 group	6	8	10	58.3
					Comparative 2 group	6	5	13	45.8

Analyzing the table 1, it can be seen that the treatment effect of example 3 on neck, shoulder, waist and leg pain is the best, and comparing treatment 3 groups and comparison 1-2 groups, it can be seen that the formula of the present application is selected after precise matching, lack of any one medicinal material can lead to the treatment effect being greatly reduced, and select similar medicaments for replacement can lead to the medicinal effect being greatly reduced, because although the medicinal effects are similar, the compatibility of the medicaments is more complex, after replacement, the medicaments are easily disliked, so that the action effect of the medicaments is worse.

Typical cases are as follows:

1. in 49 years old men, the plaster of example 3 is used for 3 courses of treatment, the symptoms basically disappear, and the men can work and live normally.

2. Yellow certain, female 38 years old, cervical vertebra pain, upper limb numbness, and hand weakness, after working for one day, cervical vertebra rotation difficulty, using the plaster of example 4 for treatment, after 1 course of treatment, symptoms are obviously improved, and after lasting for 3 days, the disease is cured.

In conclusion, the applicant mainly warms the kidney and strengthens yang, eliminates dampness and dredges collaterals and activates blood and removes blood stasis, takes the notopterygium root, the kadsura pepper stem and the kadsura pepper stem as monarch drugs, and uses the effects of the notopterygium root and the kadsura pepper stem on dispelling cold and eliminating dampness and the kadsura pepper stem on dredging collaterals and relieving pain to eliminate cold and dampness in the body and dredge the stasis of the meridians; the radix salviae miltiorrhizae, the radix angelicae pubescentis, the radix dipsaci, the angelica sinensis, the safflower, the pericarpium citri reticulatae, the radix sileris, the fructus aurantii and the eucommia ulmoides are used as ministerial drugs, the effects of activating blood circulation, removing stasis and relieving pain of the radix salviae miltiorrhizae, the angelica sinensis and the safflower are used in cooperation with the radix angelicae pubescentis, the pericarpium citri reticulatae and the radix sileris for dispelling wind-damp, the radix dipsaci and the eucommia ulmoides are used for tonifying kidney and strengthening channels and collaterals, the pericarpium citri reticulatae and the fructus aurantii are used for tonifying spleen and regulating qi, the spleen and the kidney are strengthened, the problem of endogenous dampness and heat is fundamentally solved, and the angelica sinensis can activate blood, dredge channels and collaterals and activate qi and blood and are matched with each other; cinnamon, caulis spatholobi, frankincense, pseudo-ginseng, cassia twig, peach kernel, ephedra herb, radix angelicae, golden cypress, rhizoma sparganii and ligusticum wallichii are taken as adjuvant medicines, the effects of tonifying fire and yang and dispelling cold and promoting blood circulation of the cinnamon are utilized, the cassia twig is reinforced with the cassia twig, the radix angelicae and the golden cypress are used for tonifying yang and regulating qi, the effects of strengthening kidney are achieved, the effects of dispelling wind and eliminating dampness of the caulis spatholobi are utilized, the radix angelicae and the golden cypress are used for dispelling cold and eliminating dampness, the effects of dispelling dampness and promoting blood circulation of the frankincense, the pseudo-ginseng, the peach kernel and the ligusticum wallichii are used for promoting qi and activating blood circulation, the effects of breaking blood circulation and promoting qi of the rhizoma sparganii, removing blood stasis and enhancing the effects of clearing and activating channels and collaterals are utilized, and the ephedra herb can reduce swelling and promote diuresis, and help dispel cold and dampness; finally, the asarum is used as a guiding drug, so that the properties are warm, the drug properties are harmonized, the muscles and the tendons are relaxed, the blood circulation is promoted, the drugs are guided to directly reach the kidney, and the effects of the whole formula of clearing damp, promoting blood circulation, warming channels and activating collaterals can be enhanced. The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims

1. An externally applied plaster for treating neck, shoulder, waist and leg pain is characterized by comprising the following raw materials in parts by weight: 10-19 parts of salvia miltiorrhiza, 10-21 parts of radix angelicae pubescentis, 5-15 parts of cinnamon, 2-8 parts of asarum, 5-15 parts of entada, 25-35 parts of notopterygium root, 10-20 parts of teasel root, 10-20 parts of angelica, 15-25 parts of kadsura pepper stem, 15-25 parts of tinospora sinensis stem, 5-15 parts of frankincense, 10-20 parts of safflower, 5-15 parts of pseudo-ginseng, 8-16 parts of cassia twig, 7-17 parts of peach kernel, 10-20 parts of dried orange peel, 8-16 parts of ephedra, 8-16 parts of radix angelicae, 10-20 parts of radix sileris, 10-20 parts of fructus aurantii, 8-16 parts of golden cypress, 8-16 parts of rhizoma sparganii, 10-20 parts of eucommia ulmoides and 7-13 parts of ligusticum wallichii.

2. The externally applied plaster for treating pain in neck, shoulders, waist and legs according to claim 1, further comprising the following raw materials in parts by weight: 550 parts of maleic gum, 20-70 parts of syrup and 30-100 parts of carbomer.

3. The externally applied plaster for treating neck, shoulder, waist and leg pain according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 13-16 parts of salvia miltiorrhiza, 14-17 parts of radix angelicae pubescentis, 9-11 parts of cinnamon, 4-6 parts of asarum, 9-11 parts of entada, 29-31 parts of notopterygium root, 14-16 parts of teasel root, 14-16 parts of angelica, 19-21 parts of kadsura pepper stem, 19-21 parts of tinospora sinensis, 9-11 parts of frankincense, 14-16 parts of safflower, 9-11 parts of pseudo-ginseng, 11-13 parts of cassia twig, 11-13 parts of peach kernel, 14-16 parts of dried orange peel, 11-13 parts of ephedra, 11-13 parts of radix angelicae, 14-16 parts of divaricate saposhnikovia root, 14-16 parts of fructus aurantii, 11-13 parts of golden cypress, 11-13 parts of rhizoma sparganii, 14-16 parts of eucommia ulmoides and 9-11 parts of ligusticum wallichii.

4. The preparation method of the externally applied plaster for treating pain in neck, shoulder, waist and leg as claimed in claim 2, comprising the following steps:

cleaning the raw materials, drying and crushing to obtain raw material powder;

mixing the raw material powders to obtain mixed powder;

heating and melting the maleic glue;

5. The preparation method of the externally applied plaster for treating pain in neck, shoulders, waist and legs as claimed in claim 4, wherein the drying temperature is 45-55 ℃.

6. The preparation method of the externally applied plaster for treating pain in neck, shoulder, waist and leg as claimed in claim 4, wherein the size of the crushed raw material is 100-150 mesh.

7. The preparation method of the externally applied plaster for treating pain in neck, shoulders, waist and legs according to claim 4, wherein the weight ratio of the mixed powder to the ethanol is (3-5): 2.

8. the preparation method of the externally applied plaster for treating pain in neck, shoulders, waist and legs as claimed in claim 4, wherein the volume concentration of the ethanol is 70-75%.

9. The preparation method of the externally applied plaster for treating pain in neck, shoulders, waist and legs as claimed in claim 4, wherein the soaking time is 40-56 h.

10. The preparation method of the externally applied plaster for treating pain in neck, shoulder, waist and leg according to claim 4, wherein the heating and decocting temperature is 85-95 ℃ and the heating and decocting time is 5-15 min.