CN114450440A - 用于人类癌症综合功能分析的遗传药典 - Google Patents

用于人类癌症综合功能分析的遗传药典 Download PDF

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CN114450440A
CN114450440A CN202080059227.7A CN202080059227A CN114450440A CN 114450440 A CN114450440 A CN 114450440A CN 202080059227 A CN202080059227 A CN 202080059227A CN 114450440 A CN114450440 A CN 114450440A
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gene
library
cancer
sequence
homology
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克里斯蒂安·施密特
斯里哈里·C·萨姆帕斯
斯里纳特·C·萨姆帕斯
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Functional Oncology
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CN202080059227.7A 2019-06-21 2020-06-18 用于人类癌症综合功能分析的遗传药典 Pending CN114450440A (zh)

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US201962865047P 2019-06-21 2019-06-21
US62/865,047 2019-06-21
PCT/US2020/038503 WO2020257504A1 (en) 2019-06-21 2020-06-18 A genetic pharmacopeia for comprehensive functional profiling of human cancers

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US (1) US20220244244A1 (https=)
EP (1) EP3987087A4 (https=)
JP (1) JP2022538084A (https=)
KR (1) KR20220052902A (https=)
CN (1) CN114450440A (https=)
AU (1) AU2020294772A1 (https=)
CA (1) CA3144356A1 (https=)
WO (1) WO2020257504A1 (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US20190127713A1 (en) 2016-04-13 2019-05-02 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
EP3740580A4 (en) 2018-01-19 2021-10-20 Duke University GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS
CA3110837A1 (en) 2018-08-28 2020-03-05 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof
JP2023541457A (ja) * 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３８修飾のための化合物および方法
WO2022072643A1 (en) * 2020-09-30 2022-04-07 Vor Biopharma Inc. Compositions and methods for cd30 gene modification
KR20240095529A (ko) * 2021-07-16 2024-06-25 오르토바이오 테라퓨틱스, 인크. 관절 기능 개선을 위한 유전자 편집
JP2024540723A (ja) * 2021-11-03 2024-11-01 インテリア セラピューティクス，インコーポレーテッド 免疫療法のためのｃｄ３８組成物及び方法
CN114703191A (zh) * 2022-04-19 2022-07-05 华南农业大学 基于crsipr技术构建rictor基因敲除细胞株的方法及其应用
AU2024217832A1 (en) * 2023-02-10 2025-10-02 Integrate Bioscience Llc Personalized crispr profiling for cancer
EP4698657A2 (en) * 2023-04-21 2026-02-25 Duke University Epigenetic targets for enhancing cancer immunotherapy
WO2025063185A1 (ja) * 2023-09-19 2025-03-27 国立大学法人東海国立大学機構 １本鎖ポリヌクレオチド

Citations (2)

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US20090306094A1 (en) * 2006-03-17 2009-12-10 Bristol-Myers Squibb Company Methods Of Identifying And Treating Individuals Exhibiting Mutant Bcr/Abl Kinase Polypeptides
US20160251648A1 (en) * 2013-10-28 2016-09-01 The Broad Institute Inc. Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090306094A1 (en) * 2006-03-17 2009-12-10 Bristol-Myers Squibb Company Methods Of Identifying And Treating Individuals Exhibiting Mutant Bcr/Abl Kinase Polypeptides
US20160251648A1 (en) * 2013-10-28 2016-09-01 The Broad Institute Inc. Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAN，K等: "Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions", NAT BIOTECHNOL., vol. 35, no. 5, 31 May 2017 (2017-05-31), pages 463 *

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JP2022538084A (ja) 2022-08-31
KR20220052902A (ko) 2022-04-28
AU2020294772A1 (en) 2022-02-03
US20220244244A1 (en) 2022-08-04
WO2020257504A1 (en) 2020-12-24
EP3987087A1 (en) 2022-04-27
CA3144356A1 (en) 2020-12-24
EP3987087A4 (en) 2023-11-15

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