CN114432401A

CN114432401A - Dried orange peel cough-relieving herbal atomized composition and preparation method and application thereof

Info

Publication number: CN114432401A
Application number: CN202210059771.2A
Authority: CN
Inventors: 杨继广; 杨占文
Original assignee: Qihuang Treasure Beijing Technology Co ltd
Current assignee: Qihuang Treasure Beijing Technology Co ltd
Priority date: 2022-01-19
Filing date: 2022-01-19
Publication date: 2022-05-06

Abstract

The invention belongs to the technical field of Chinese herbal medicine atomized products, and discloses a dried orange peel cough-relieving herbal atomized composition and a preparation method and application thereof. Is prepared from pure plant Chinese herbal medicines. It is pungent, bitter and warm in nature. It enters lung and spleen meridians as the therapeutic channel. The dried orange peel can regulate qi and invigorate spleen; honey pomelo contains abundant vitamin C; the grape seeds contain amino acids, vitamins and minerals; semen Ginkgo has effects of astringing lung and relieving asthma; lophatherum gracile has the effects of clearing heat and purging fire; the almond can relieve cough and asthma; the fingered citron eliminates dampness and phlegm; exocarpium Citri rubrum is used for eliminating dampness and phlegm; hyacinth dolichos flower has the functions of strengthening spleen and stomach; honey can moisten intestine and promote fluid production. The prescription is an integral prescription, and the prescription is helpful for relieving cough and asthma, nourishing yin and moistening dryness, regulating qi and relieving epigastric distention, eliminating dampness and reducing phlegm after being combined.

Description

Dried orange peel cough-relieving herbal atomized composition and preparation method and application thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicine atomized products, and particularly relates to a dried orange peel cough-relieving herbal atomized composition and a preparation method and application thereof.

Background

In the current situation of the current commercial society, environmental and air pollution and fast-paced life lead to poor immune function of many caregivers in a gentle age, the pressure of work and life of many workers is great, most people form smoking habits to relieve pressure, and cough or respiratory diseases are easily caused.

The most common food therapy is the food therapy effect of adopting fruit pears. The related technology discloses a fresh pear or fresh fruit, which is prepared by mixing 0.01 to 3-money fritillary bulb mother powder or fritillary bulb mother powder into water leaching liquor per kilogram of water; or 0.0001 mg to 6 mg of fritillaria cirrhosa alkali or sipeimine, or fibraurine or alburnine or kurbeitine or coniferitrine per kg of water; soaking at 0-37 deg.C, and drying in the shade to obtain fresh pear or fruit with antitussive effect. The preparation process of the product is complex and inconvenient.

The related technology discloses a blend oil for relieving cough and moistening lung, which is prepared by taking black sesame oil as a base, sunflower seed oil, a composition for relieving cough and moistening lung, and ginger, radix bupleuri, folium eriobotryae and bezoar according to a proportion. All the raw materials are obtained by vacuum drying, vacuum squeezing and the like. It can have the process of heating as blend oil during the use, and the heating can destroy the property of a medicine once more, and the drug effect is relatively poor after using.

The related technology discloses a cough relieving plaster, which is an acupoint plaster mainly composed of ceramic powder, medical pressure sensitive adhesive and the like, and has the function of relieving cough and asthma by stimulating Feishu acupoint and Dazhui acupoint through far infrared rays. Resolve phlegm, stop cough, regulate qi and relieve asthma. The cough relieving plaster is suitable for treating cough caused by acute and chronic bronchitis and cold. However, the cough relieving plaster as an external preparation has a very slow effect, and part of the cough relieving plaster has a sensitization effect on the attached skin.

The related technology discloses a cough relieving electuary which is large in dosage, cannot directly act on a diseased part, needs to enter a circulatory system through the first pass effect of a liver to act on the diseased part, is slow in effect, and limits the medication of a patient to a certain extent.

Currently, the solution preparations for aerosol inhalation are relatively few products on the market, mainly imported products. The aerosol inhalation solution preparation can be directly applied to the affected part as a respiratory tract or pharynx administration preparation, can improve the administration concentration of the respiratory tract or the pharynx, has quick response, avoids the first pass effect of the liver, reduces the administration dosage of the medicine, improves the bioavailability of the medicine, reduces the distribution of the medicine in other tissues, and reduces the side effect.

At present, a plurality of health care products, medicines and the like for relieving cough or relieving asthma in daily life exist. Many health care products on the market are only used for improving the immunity of the organism, the actual treatment effect on the states of no dry itching and the like of the lung or throat part using the organism is very weak, the moisture degree can be kept in a very short time, and the long-term treatment cannot be finished. At present, a lot of cough syrup and other medicines appear in the market, the syrup has poor mouthfeel in the using process, and a lot of patients frequently have the condition that the syrup cannot be taken. Therefore, there is a need for a Chinese medicinal composition with cough and asthma relieving effects, which combines the effects of dried orange peel and Chinese medicinal herbs.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a dried orange peel cough-relieving herbal atomized composition and a preparation method and application thereof.

The technical scheme adopted by the invention is as follows: the dried orange peel cough-relieving herbal atomized composition is mainly prepared from the following raw materials in parts by mass:

3-10 parts of dried orange peel, 8-15 parts of honey pomelo, 8-15 parts of grape seed, 3-9 parts of ginkgo seed, 6-9 parts of lophatherum gracile, 3-10 parts of almond, 3-10 parts of fingered citron, 3-10 parts of exocarpium citri rubrum, 8-15 parts of white hyacinth dolichos flower, 12-20 parts of honey and 60-90 parts of oil agent.

Pericarpium Citri Tangerinae, mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. Compendium (compendium): orange peel, bitter in flavor and purging in property can dry, pungent in flavor and dispersing in property and warm in property. For all kinds of diseases, it is always used to regulate qi and dry dampness, tonics are used to tonify qi, purgatives are used to purge qi, ascending qi and descending qi. The spleen is the mother of original qi and the lung is the key of qi absorption, so orange peel is the key of qi of the two meridians, but it can tonify and purge ascending and descending along with it. "nature and taste: warm in nature, pungent and bitter in flavor. Meridian tropism: enter spleen, stomach and lung meridians.

The honey pomelo is sour and sweet in taste, slightly bitter, rich in vitamin C and a large amount of other signboard nutrients, and is the fruit which is recognized by the medical field and has the best food therapy benefit. Patients with cardiovascular and cerebrovascular diseases and kidney diseases often use drugs to remove excessive sodium from the body. Pomelo contains potassium, which is a natural mineral essential for these patients, but hardly contains sodium, and is the best fruit for dietetic therapy. The pomelo contains a large amount of vitamin C, can reduce cholesterol in blood, and is an ideal food for modern people to pursue health. The American research shows that people drinking the pomelo juice everyday rarely have respiratory system diseases, especially cold and sore throat, and can feel comfortable and natural when eating a fresh honey pomelo. The natural vitamin P contained in pomelo can strengthen the capillary function of skin and accelerate the recovery of the injured skin tissue function. The principle of 'natural beauty' is most satisfied when women eat honey pomelos frequently. The honey pomelo also has the effect of strengthening physique. It can help body to absorb calcium and iron more easily; meanwhile, the natural folic acid contained in the product has the effects of preventing anemia symptoms and promoting fetal development for the administration of contraceptives or pregnant women.

Grape seeds contain amino acids, vitamins and minerals. Grape seeds contain polyphenols (GPS), mainly catechins and proanthocyanidins. Catechin compounds including catechin, epicatechin and gallate thereof are main monomers in grape seeds, and are also constituent units of oligomeric and polymeric procyanidins. Grape seeds contain abundant oil accounting for 12-15 wt%, and the oil contains a large amount of unsaturated fatty acids, wherein the content of linoleic acid is 58-78%. The grape seeds also contain a small amount of volatile components, and most of the volatile components belong to alcohol, phenol and terpenoid substances and have high biological activity. The grape seed contains crude protein, amino acids, vitamin A, E, D, K, P, and trace elements such as calcium, zinc, ferrum, magnesium, copper, potassium, sodium, manganese, and cobalt.

Gingko, name of traditional Chinese medicine. Is seed of Ginkgo biloba L. of Ginko of Ginkgoaceae. Has effects of astringing lung, relieving asthma, stopping leukorrhagia, and reducing urination. It can be used for treating asthma, cough with phlegm, leukorrhagia, whitish and turbid urine, frequent micturition, enuresis, etc. Sweet, bitter and astringent taste, mild in nature; it enters lung and kidney meridians.

Lophatherum gracile, the name of Chinese medicine. Is dried stem and leaf of Lophatherum gracile Brongn of Lophatherum of Gramineae. Has effects of clearing heat-fire, relieving restlessness, and promoting urination. It can be used for treating fever, polydipsia, aphtha, dark urine, pyretic stranguria, and odynuria. Sweet and light taste, cold in nature; it enters heart, stomach and small intestine meridians.

Almond, the name of traditional Chinese medicine. The seeds are seeds of apricot Armeniaca vulgaris Lam. [ Prunus Armeniaca L. ], wild apricot A. vulgaria Lam. var. ansu et Lu [ Prunus Armeniaca L. var. ansu Maxim. ], apricot A. sibirica (L.) Lam. [ Prunus sibirica L. ], and northeast apricot A. mandshurica (Maxim.) Skv. [ Prunus dshurica (Maxim.) Koehne ]. Has the effects of relieving cough and asthma, and loosening bowel to relieve constipation. It can be used for treating cough, asthma, chest fullness, excessive phlegm, blood deficiency, dry body fluid, constipation due to intestinal dryness. Bitter taste and slightly warm nature; it enters lung and large intestine meridians.

Fingered citron, the name of traditional Chinese medicine. Is dried fruit of Citrus medica L.var.sarcodactylis Swingle belonging to Citrus of Rutaceae. Has the effects of soothing liver-qi stagnation, regulating qi, regulating the middle warmer, eliminating dampness and phlegm. Is mainly used for treating liver depression and qi stagnation, chest and hypochondrium distending pain caused by liver-stomach disharmony, abdominal fullness and distention, abdominal distending pain caused by spleen-stomach qi stagnation, nausea, poor appetite, cough with profuse sputum for a long time, and chest pain caused by falsework. Pungent, bitter and sour taste, warm in nature; it enters liver, spleen and stomach meridians.

Exocarpium Citri rubrum, named as Chinese medicine. Is dried outer peel of Citrus reticulata Blanco of Rutaceae and its cultivar. Pungent and bitter with warm nature. It enters lung and spleen meridians. The functions are as follows: to regulate qi, relax middle energizer, dry dampness and resolve phlegm. The main treatment is as follows: can be used for treating cough with excessive phlegm, food stagnation, alcohol impairment, nausea, and oppression. Exocarpium Citri rubrum, named as Chinese medicine. Is dried outer peel of Citrus reticulata Blanco of Rutaceae and its cultivar. Harvesting after fruit ripening in late autumn and early winter, cutting off exocarp, and sun drying or shade drying. Pungent and bitter with warm nature. It enters lung and spleen meridians.

Dolichos lablab flower is bean hyacinth bean, is collected in 7-8 months and dried in the sun or in the shade. Zhejiang, Anhui and Henan provinces. Strengthen spleen and stomach, relieve summer heat and resolve dampness. It is indicated for dysentery, diarrhea, leucorrhea with reddish discharge. Mild in nature, sweet and light in taste, and non-toxic. Strengthen spleen and stomach, relieve summer heat and resolve dampness. It is indicated for dysentery, diarrhea, leucorrhea with reddish discharge.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

5-8 parts of dried orange peel, 10-14 parts of honey pomelo, 10-14 parts of grape seed, 5-8 parts of ginkgo seed, 7-8 parts of lophatherum gracile, 5-8 parts of almond, 5-8 parts of fingered citron, 5-8 parts of exocarpium citri rubrum, 10-14 parts of white hyacinth dolichos flower and 15-19 parts of honey.

6 parts of dried orange peel, 12 parts of honey pomelo, 12 parts of grape seed, 6 parts of ginkgo, 7.5 parts of lophatherum gracile, 6 parts of almond, 6 parts of fingered citron, 6 parts of tangerine peel, 13 parts of white hyacinth bean flower and 18 parts of honey.

A method for preparing a dried orange peel cough-relieving herbal atomized composition, the method comprising the steps of:

(1) selecting pericarpium Citri Tangerinae, fructus Citri Grandis, exocarpium Citri Tangerinae and flos lablab album respectively according to corresponding proportion, and mixing to obtain a mixture A;

(2) pulverizing the material A with a pulverizer at a temperature below 60 deg.C, treating raw water for extraction with deionized pure water;

(3) mixing the pretreated A with pure water, extracting, mixing the A decoctions, cooling at room temperature, and filtering to obtain extract A;

(4) selecting grape seeds, ginkgo seeds, lophatherum gracile, almonds and fingered citron according to a corresponding proportion, drying, crushing and grinding to obtain standby grape seed powder, white fruit powder, phyllostachys pubescens leaf powder, almond powder and fingered citron powder, adding honey and water, uniformly mixing, and steaming to obtain a standby B extract;

(5) and mixing the essence extract of the standby product A and the standby product B to obtain a finished product of the dried orange peel cough-relieving herbal atomized composition.

Preferably, in the step (2), the fineness after crushing is 8-10 meshes.

Preferably, in the step (3), the extraction temperature is 20-50 ℃;

the extraction times are 2-4.

Preferably, in the step (3), the extraction time is 10 to 60 minutes each time.

Preferably, in the step (4), when the grape seeds, the ginkgo seeds, the lophatherum gracile, the almond and the fingered citron are dried, the drying temperature is 20-55 ℃;

the drying time is 5-10 minutes.

Preferably, the ratio of the total mass of the standby grape seed powder, the white fruit powder, the phyllostachys edulis powder, the almond powder and the fingered citron powder to the total volume of the honey and the water is 100 g: 5-15 mL;

the volume ratio of the honey to the water is 1: 3-5.

An application of an orange peel cough-relieving herbal atomized composition is to apply the orange peel cough-relieving herbal atomized composition to an atomized essential oil product.

The beneficial effects of the invention are as follows:

the invention provides a dried orange peel cough-relieving herbal atomized composition which is prepared from pure plant Chinese herbal medicines.

The composition is mainly pungent, bitter and warm in nature. It enters lung and spleen meridians as the therapeutic channel. The tangerine peel is used for regulating qi, strengthening spleen, regulating middle energizer, eliminating dampness and phlegm, and promoting qi circulation of spleen and stomach, wherein the spleen and stomach are in middle energizer and the middle energizer is in qi circulation so that the qi of the triple energizer is also surged; honey pomelo, rich in vitamin C; grape seeds contain amino acids, vitamins, minerals and the like, and are rich in grease; gingko, semen Ginkgo, astringes lung and relieves asthma, stops leukorrhagia and reduces urination; lophatherum gracile has the effects of clearing heat, purging fire, relieving restlessness and promoting urination; the almond has the functions of relieving cough and asthma and relaxing bowel; the fingered citron has the effects of soothing liver-qi stagnation, regulating qi and harmonizing middle warmer, and eliminating dampness and phlegm; chrysoidine, regulating qi-flowing for relieving epigastric distention, eliminating dampness and resolving phlegm; the hyacinth dolichos flower has the effects of strengthening the spleen and stomach, relieving summer heat and eliminating dampness; honey has the effects of moistening intestines, promoting the production of body fluid, nourishing yin and moistening dryness. The prescription is an integral prescription, and the prescription is helpful for relieving cough and asthma, nourishing yin and moistening dryness, regulating qi and relieving epigastric distention, eliminating dampness and reducing phlegm after being combined.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

(1) respectively selecting 30 g of dried orange peel, 80 g of honey pomelo, 30 g of tangerine peel and 80 g of white hyacinth bean flower according to corresponding proportion, and mixing to obtain a standby product A;

(2) pulverizing the material A with a pulverizer at a temperature below 60 deg.C to obtain a pulverized material with fineness of 8 meshes, treating raw water for extraction with deionized pure water;

(3) mixing the pretreated A with pure water, extracting at 20 deg.C for 10 min for 2 times, mixing the A decoctions, cooling at room temperature, and filtering to obtain A essence extract;

(4) selecting 80 g of grape seeds, 30 g of ginkgo seeds, 60 g of lophatherum gracile, 30 g of almond and 30 g of fingered citron according to a corresponding proportion, drying for 5 minutes at 20 ℃, crushing and grinding to obtain standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder, adding 2.8 g of honey and 8.6 g of water, uniformly mixing, and steaming to obtain an extract of the standby B;

Example 2:

(1) selecting 100g of dried orange peel, 150 g of honey pomelo, 100g of tangerine peel and 150 g of white hyacinth bean flower according to corresponding proportion, and mixing to obtain a spare substance A;

(2) pulverizing the material A with a pulverizer at a temperature below 60 deg.C to obtain 10 mesh powder, treating raw water for extraction with deionized pure water;

(3) mixing the pretreated A with pure water, extracting at 50 deg.C for 60 min for 4 times, mixing the A decoctions, cooling at room temperature, and filtering to obtain A essence extract;

(4) selecting 150 g of grape seeds, 90 g of ginkgo seeds, 90 g of lophatherum gracile, 100g of almond and 100g of fingered citron according to corresponding proportion, drying for 10 minutes at 55 ℃, crushing and grinding to obtain standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder, adding 19.8 g of honey and 59.6 g of water, uniformly mixing, and steaming to obtain an extract of the standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder;

Example 3:

(1) respectively selecting 50 g of dried orange peel, 100g of honey pomelo, 50 g of tangerine peel and 100g of white hyacinth bean flower according to corresponding proportion, and mixing to obtain a standby product A;

(2) pulverizing the material A with a pulverizer at a temperature below 60 deg.C to obtain pulverized material A with fineness of 8 mesh, treating raw water for extraction with deionized pure water;

(3) mixing the pretreated A with pure water, extracting at 20 deg.C for 60 min for 4 times, mixing the A decoctions, cooling at room temperature, and filtering to obtain A essence extract;

(4) selecting 100g of grape seeds, 50 g of ginkgo seeds, 70 g of lophatherum gracile, 50 g of almond and 50 g of fingered citron according to a corresponding proportion, drying for 10 minutes at 20 ℃, crushing and grinding to obtain standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder, adding 2.6 g of honey and 13.4 g of water, uniformly mixing, and steaming to obtain an extract of the standby B;

Example 4:

(1) selecting 80 g of dried orange peel, 140 g of honey pomelo, 80 g of tangerine peel and 140 g of white hyacinth bean flower according to corresponding proportion, and mixing to obtain a standby product A;

(3) mixing the pretreated A with pure water, extracting at 50 deg.C for 10 min for 2 times, mixing the A decoctions, cooling at room temperature, and filtering to obtain A essence extract;

(4) selecting 140 g of grape seeds, 80 g of ginkgo seeds, 80 g of lophatherum gracile, 80 g of almond and 80 g of fingered citron according to a corresponding proportion, drying for 5 minutes at 55 ℃, crushing and grinding to obtain standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder, adding 3.8 g of honey and 19.2 g of water, uniformly mixing, and steaming to obtain an extract of the standby B;

(5) and mixing the extract A and the extract B to obtain the finished product of the dried orange peel cough-relieving herbal atomized composition.

Example 5:

(1) respectively selecting 60 g of dried orange peel, 120 g of honey pomelo, 60 g of tangerine peel and 130 g of white hyacinth bean flower according to corresponding proportion, and mixing to obtain a standby product A;

(4) selecting 120 g of grape seeds, 60 g of ginkgo seeds, 75 g of lophatherum gracile, 60 g of almond and 60 g of fingered citron according to a corresponding proportion, drying for 5 minutes at 20 ℃, crushing and grinding to obtain standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder, adding 4.6 g of honey and 14.1 g of water, uniformly mixing, and steaming to obtain an extract of the standby grape seed powder, white fruit powder, lophatherum gracile powder, almond powder and fingered citron powder;

The using method comprises the following steps: can be applied by adding into a daily atomizer.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The dried orange peel cough-relieving herbal atomization composition is characterized by being prepared from the following raw materials in parts by mass:

3-10 parts of dried orange peel, 8-15 parts of honey pomelo, 8-15 parts of grape seed, 3-9 parts of ginkgo seed, 6-9 parts of lophatherum gracile, 3-10 parts of almond, 3-10 parts of fingered citron, 3-10 parts of exocarpium citri rubrum, 8-15 parts of hyacinth dolichos flower and 12-20 parts of honey.

2. The dried orange peel cough-relieving herbal atomized composition as claimed in claim 1, wherein the composition is prepared from the following raw materials in parts by mass:

3. The dried orange peel cough-relieving herbal atomized composition as claimed in claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. A process for the preparation of an aerosolized herbal cough suppressing citrus peel composition according to any one of claims 1-3, said process comprising the steps of:

5. The method for preparing an herbal aerosolized composition of dried orange peel for cough suppression according to claim 4, wherein in the step (2), the fineness after pulverization is 8-10 mesh.

6. The method for preparing an herbal aerosolized composition of pericarpium Citri Reticulatae in relieving cough according to claim 4, wherein in the step (3), the temperature of extraction is 20-50 ℃;

the extraction times are 2-4.

7. The method of claim 6, wherein the extraction time in step (3) is 10-60 minutes each time.

8. The method for preparing an herbal aerosolized composition of dried orange peel for cough suppression according to claim 4, wherein in the step (4), the grape seed, ginkgo seed, lophatherum gracile, almond and fingered citron are dried at a temperature of 20-55 ℃;

the drying time is 5-10 minutes.

9. The method for preparing an orange peel cough-relieving herbal atomized composition according to claim 4, wherein the ratio of the total mass of the standby grape seed powder, the white fruit powder, the phyllostachys edulis powder, the almond powder and the finger citron powder to the total volume of honey and water is 100 g: 5-15 mL;

the volume ratio of the honey to the water is 1: 3-5.

10. Use of a dried orange peel cough suppressing herbal atomized composition characterized in that the composition prepared according to any one of claims 4-9 is used in atomized essential oil products.