CN114423790A - 靶向caix抗原的纳米抗体及其应用 - Google Patents

靶向caix抗原的纳米抗体及其应用 Download PDF

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CN114423790A
CN114423790A CN202080064128.8A CN202080064128A CN114423790A CN 114423790 A CN114423790 A CN 114423790A CN 202080064128 A CN202080064128 A CN 202080064128A CN 114423790 A CN114423790 A CN 114423790A
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caix
single domain
domain antibody
antibody
seq
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缪小牛
徐祎凤
伊刚
李志远
曾竣玮
刘晓林
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Biotheus Inc
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Biotheus Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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Abstract

提供了一种抗CAIX单域抗体及其VHH链以及相关的编码序列、表达载体和宿主细胞，还提供了该CAIX单域抗体的生产方法及应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080064128.8A 2019-09-10 2020-08-25 靶向caix抗原的纳米抗体及其应用 Pending CN114423790A (zh)

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CN2019108536999 2019-09-10
CN201910853699.9A CN112552408B (zh) 2019-09-10 2019-09-10 靶向caix抗原的纳米抗体及其应用
PCT/CN2020/111112 WO2021047386A1 (zh) 2019-09-10 2020-08-25 靶向caix抗原的纳米抗体及其应用

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CN202210915913.0A Pending CN116217728A (zh) 2019-09-10 2019-09-10 靶向caix抗原的纳米抗体及其应用
CN202080064128.8A Pending CN114423790A (zh) 2019-09-10 2020-08-25 靶向caix抗原的纳米抗体及其应用

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CN117384299B (zh) * 2022-11-01 2024-04-30 邦恩泰(山东)生物医药科技集团股份有限公司 靶向bcma和/或fcrh5的嵌合抗原受体、car-t细胞及其应用

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WO2016199097A1 (en) * 2015-06-10 2016-12-15 National Research Council Of Canada Carbonic anhydrase ix-specific antibodies and uses thereof
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