CN1144121A - Chinese medicine composite for preventing dental caries - Google Patents
Chinese medicine composite for preventing dental caries Download PDFInfo
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- CN1144121A CN1144121A CN 96104671 CN96104671A CN1144121A CN 1144121 A CN1144121 A CN 1144121A CN 96104671 CN96104671 CN 96104671 CN 96104671 A CN96104671 A CN 96104671A CN 1144121 A CN1144121 A CN 1144121A
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- extractum
- chewing gum
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- chinese medicine
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Abstract
The present invention discloses a medicine composite for preventing and curing dental caries and chewing gum made of said medicine composite. Said composite includes licorice extract,honeysuckle flower, extract and cloves extract. In addition to the described composite the invented chewing gum also contains sweetening agent, gum substrate, starch syrup, antioxidant and filling auxiliary material.
Description
The present invention is a kind of pharmaceutical composition of preventing and treating dental caries, be specifically a kind of be the Chinese medicine composition of effective ingredient with the Chinese herbal medicine, the invention still further relates to a kind of prevent and treat dental caries contain the Chinese medicine chewing gum.
Dental caries is a kind of commonly encountered diseases, frequently-occurring disease, and epidemiological study shows that countries in the world child's average prevalence in China, along with the raising of people's living standard, is made with extra care a large amount of absorptions of food more than 50%, and the sickness rate of dental caries is also rising.Recent statistics shows that the adult prevalence of China is 45-60%, and child's sickness rate is 80-85%.Therefore, in fact the whole nation has the dental caries of suffering from about 600,000,000 people in various degree.The generation of dental caries is very big to the human beings'health influence, and it not only damages tissue of tooth, and, continue development, can cause disease of pulp of tooth, produce pain and also destroy masticatory function, the harm body health.Therefore the research and development of dental caries product are one of focuses of various countries medicine worker concern always.
Modern medicine study shows that antibacterial is the main cause that dental caries takes place, and wherein Streptococcus mutans is the main pathogenic bacterium of dental caries.The research of early prevention and treatment dental caries mainly concentrates on antibacterials and uses, and as chlohexidine, metronidazole etc., but significant side effects is arranged, and clinical practice is restricted.In addition, some scholar also inquires into and developmental research from influencing other factor aspects that dental caries takes place, and has developed the collutory (CN90100975) that contains complexation zinc, contains the medicine that fluoride preparation (CN89100003) etc. has certain prevention effect.After this, some scholar attempts to seek effective medicine from plant, and many effective low toxicities or nontoxic medicine have been found, and gargarism (CN1093569) that Chinese herbal medicine extract makes and chewing gum (CN1096699A) etc. arranged, control has certain effect to dental caries for it, but it is medicine, needs to use under physician guidance.
We are principle with effective low toxicity, adopt modern means of science and technology, by the systematic study to Chinese medicine, have developed a kind of Chinese medicine composition of preventing and treating dental caries.
Therefore, the purpose of this invention is to provide a kind of medicine-food dual-purpose composition of preventing and treating dental caries.
Another object of the present invention is a kind of chewing gum of preventing and treating dental caries of preparation.
According to the principle of above-mentioned effective low toxicity, we are through screening, and selecting Radix Glycyrrhizae, Flos Lonicerae, Flos Caryophylli for use is base stock.Radix Glycyrrhizae, Flos Caryophylli are the medicine of the integration of edible and medicinal herbs of Ministry of Public Health promulgation, and be both effective in cure, can be used as food again, long-term edible having no side effect, and Flos Lonicerae is widely drunk with making among the people as tea.This three flavors Chinese medicine composition is used, and has good effect.
The composition of pharmaceutical composition of the present invention is:
Radix Glycyrrhizae extractum 1-5 weight portion Flos Lonicerae extractum 2-8 weight portion
Flos Caryophylli extractum 0.1-3 weight portion
The best of pharmaceutical composition of the present invention is formed:
Radix Glycyrrhizae extractum 2 weight portion Flos Lonicerae extractums 4 weight portions
Flos Caryophylli extractum 0.5 weight portion
The above-mentioned extract making method of the present invention can be water or aqueous alcohol aqueous solution (0-80% methanol, ethanol) merceration, percolation or hot dipping, as:
1, the Radix Glycyrrhizae section decocts with water three times, collecting decoction, and standing over night is got supernatant concentration to doing, and gets dry extract, the about 30%-40% of yield.
2, Flos Lonicerae adds 70% alcohol reflux 3 times, and each 2 hours, merging filtrate was concentrated into dried, gets dry extract, yield 35%-45%.
3, Flos Caryophylli breaks into coarse powder, adds 7 times of 70% ethanol, and merceration 3 times filters, and mixes filtrate, be concentrated into dried, yield 30-50%.
4, with above-mentioned three kinds of dry extracts with Radix Glycyrrhizae: Flos Lonicerae: 2: 4: 0.5 mix homogeneously of the ratio of Flos Caryophylli, the Chinese medicine extraction mixture.
Anticariogenic compositions of the present invention can be prepared into various suitable dosage forms, for example, and toothpaste, dentifrice, collutory, chewing gum, chewing gum, bubble gum, buccal tablet, spray etc.
Chewing gum is considered as improving the health food of oral hygiene always by people, its chewiness is strong, certain viscosity is arranged, can in the process of chewing, rub, glue tartar and the bacterial plaque falling to be attached on the tooth, and can impel facial muscle health, help the beauty treatment, and carry, easy to use, therefore, the preferred dosage form of the present invention is a chewing gum.Can prepare chewing gum of the present invention according to the method for routine.
About the content of composite for preventing dental caries of the present invention in chewing gum, should be between 1-15%.
Chewing gum of the present invention composed as follows:
Chinese medicine extract 1-15%
Sweeting agent 5-60%
Gum base 15-25%
Starch syrup 15-25%
Antioxidant 0.01-0.5%
Fill adjuvant 0-30%
Can also contain spice in the chewing gum of the present invention, its content is no more than 5%, and said spice can be commercially available various conventional perfumes, as, rose essence, orange flavor essence, Fructus Fragariae Ananssae flavor essence, Fructus Musae flavor essence etc.
Above-mentioned Chinese medicine extract is meant Radix Glycyrrhizae, Flos Lonicerae, the Flos Caryophylli extractum compositions of ratio of the present invention.
Sweeting agent in the above-mentioned chewing gum can be Icing Sugar, aspartame, glucose, xylitol etc.
Gum base in the above-mentioned chewing gum comprises that commercially available is the various gum base that are used for chewing gum that primary raw material is made by natural gum and paragutta.
Antioxidant in the above-mentioned chewing gum comprises Butylated hydroxyanisole (BHA), arabo-ascorbic acid, butylated hydroxytoluene etc.
Packing material in the above-mentioned chewing gum comprises starch, plant cellulose etc.
The preparation method of chewing gum of the present invention is:
Take by weighing Chinese medicine extract, sweeting agent, gum base, starch syrup, spice, antioxidant in proportion, put into blender and stir, extrude tabletting, stripping and slicing packing behind the cooling forming.
To the Streptococcus mutans bacteriostatic experiment, the result shows that its minimum inhibitory concentration of mixture (MIC) of different proportion is all between 6.25mg/ml-1.56mg/ml with the orthogonal experiment design with Radix Glycyrrhizae, Flos Lonicerae, the different proportionings of Flos Caryophylli extractum mixture for we.
With Radix Glycyrrhizae, Flos Lonicerae, Flos Caryophylli extractum ratio is that dynamics research sterilizes for 2: 4: 0.5 extractum mixture (its minimum inhibitory concentration (MIC) is 3.125mg/ml), the result shows that 88% thalline was killed with the drug level effect thalline of 25mg/ml 5 minutes.Therefore, pharmaceutical composition of the present invention and chewing gum all possess good anti-caries effect.
Embodiment 1: gum base 2.5kg
Starch 2kg
Calcium carbonate 0.5kg
Aspartame 0.15kg
Granular glucose 3kg
Chinese medicine extraction mixture 0.1kg
Plant cellulose 1.65kg
Spice 0.1kg
Glycerol 0.2kg embodiment 2: gum base 2.5kg
Starch 2kg
Calcium carbonate 0.5kg
Aspartame 0.15kg
Granular glucose 3kg
Chinese medicine extraction mixture 0.3kg
Plant cellulose 1.45kg
Spice 0.1kg
Glycerol 0.2kg embodiment 3: gum base 2.5kg
Starch 2kg
Calcium carbonate 0.5kg
Aspartame 0.15kg
Granular glucose 3kg
Chinese medicine extraction mixture 0.5kg
Plant cellulose 1.25kg
Spice 0.1kg
Glycerol 0.2kg embodiment 4: gum base 2kg
Icing Sugar 6kg
Starch syrup 2kg
Antioxidant BHA 12g
Chinese medicine extraction mixture 80g
Spice 0.1kg embodiment 5: gum base 2.5kg
Icing Sugar 2kg
Calcium carbonate 0.5kg
Glycerol 1g
Plant cellulose 2kg
Aspartame 0.15kg
Starch 1kg
Chinese medicine extraction mixture 0.1kg
Spice 0.1kg
In the foregoing description, every chewing gum weighs 5 grams, and is edible after meal every day 3 times when edible, chews in mouth 5-10 minute at every turn, also can suitably increase edible number of times as required.
Embodiment 6: the preparation of oral spray
Take by weighing Chinese medicine extract 4 grams, add 5 milliliter of 95% ethanol and 90 ml distilled waters, dissolve rearmounted refrigerator and cooled Tibetan and spend the night, it is standby to get supernatant; Claim 10 milligrams of menthols, 1 milligram of propylparaben, add 2 milliliter of 95% dissolve with ethanol; With above-mentioned two kinds of solution mix homogeneously, packing into has in the bottle of sprayer unit, promptly.
Every day three times, use after meal, spray 3-5 time at every turn; Also can use at any time as required.
Claims (10)
1, a kind of composite for preventing dental caries is characterized in that it is made up of following component:
Radix Glycyrrhizae extractum 1-5 weight portion Flos Lonicerae extractum 2-8 weight portion
Flos Caryophylli extractum 0.1-3 weight portion
2,, it is characterized in that it is made up of following component according to the composite for preventing dental caries of claim 1:
Radix Glycyrrhizae extractum 2 weight portion Flos Lonicerae extractums 4 weight portions
Flos Caryophylli extractum 0.5 weight portion
3, a kind of anti-caries mouth preparation is characterized in that it contains the compositions of the claim 1 of 1-15% weight portion.
4, according to the preparation of claim 3, wherein said preparation formulation comprises toothpaste, dentifrice, collutory, chewing gum, buccal tablet, chewing gum, reaches spray.
5, chewing gum according to claim 4 is characterized in that it contains sweeting agent, gum base, starch syrup, antioxidant, filling adjuvant.
6, a kind of anti-caries chewing gum is characterized in that it contains:
Chinese medicine extract 1-15%
Sweeting agent 5-60%
Gum base 15-25%
Starch syrup 15-25%
Antioxidant 0.01-0.5%
Fill adjuvant 0-30%
Chinese medicine extract wherein comprises
Radix Glycyrrhizae extractum 1-5 weight portion Flos Lonicerae extractum 2-8 weight portion
Flos Caryophylli extractum 0.1-3 weight portion
7,, it is characterized in that said Chinese medicine extract is the extractum mixture that Radix Glycyrrhizae extractum, Flos Lonicerae extractum, Flos Caryophylli extractum ratio were followed successively by 2: 4: 0.5 according to the chewing gum of claim 6.
8, according to the chewing gum of claim 6, wherein said sweeting agent is Icing Sugar, aspartame, glucose, xylitol.
9, according to the chewing gum of claim 6, wherein said gum base is the commercially available various gum base that are used to prepare chewing gum, comprises that with natural gum and paragutta be the gum base that primary raw material is made.
10, according to the chewing gum of claim 6, wherein said packing material comprises starch, plant cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96104671A CN1052903C (en) | 1996-04-18 | 1996-04-18 | Chinese medicine composite for preventing dental caries |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96104671A CN1052903C (en) | 1996-04-18 | 1996-04-18 | Chinese medicine composite for preventing dental caries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1144121A true CN1144121A (en) | 1997-03-05 |
| CN1052903C CN1052903C (en) | 2000-05-31 |
Family
ID=5118438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96104671A Expired - Fee Related CN1052903C (en) | 1996-04-18 | 1996-04-18 | Chinese medicine composite for preventing dental caries |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1052903C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036679B (en) * | 2007-04-08 | 2010-11-10 | 谢平 | Gynura procumbens chewing gums |
| CN101306099B (en) * | 2008-06-10 | 2011-10-12 | 叶明伟 | Decoction for treating dental caries |
| CN102246829A (en) * | 2011-07-28 | 2011-11-23 | 北京农学院 | Clove extract for killing nematode and preparation method thereof |
| WO2012068730A1 (en) * | 2010-11-25 | 2012-05-31 | 吴桂谦 | Toothpaste composition for tooth health |
| CN103315938A (en) * | 2013-07-12 | 2013-09-25 | 孙佳丽 | Anti-oxidative mouthwash |
| CN107233265A (en) * | 2017-08-09 | 2017-10-10 | 周善永 | Strong tooth bacteriostatic gel |
| CN113384620A (en) * | 2021-07-14 | 2021-09-14 | 青岛市口腔医院 | Traditional Chinese medicine composition for preventing and/or treating dental caries as well as preparation method and application thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009037596A2 (en) | 2007-09-17 | 2009-03-26 | Barrick Gold Corporation | Method to improve recovery of gold from double refractory gold ores |
| US8262770B2 (en) | 2007-09-18 | 2012-09-11 | Barrick Gold Corporation | Process for controlling acid in sulfide pressure oxidation processes |
| AU2008300273B2 (en) | 2007-09-18 | 2012-03-22 | Barrick Gold Corporation | Process for recovering gold and silver from refractory ores |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078882A (en) * | 1992-05-20 | 1993-12-01 | 吴海元 | Multipurpose anti-caries liquid tooth-paste and compound method thereof |
-
1996
- 1996-04-18 CN CN96104671A patent/CN1052903C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036679B (en) * | 2007-04-08 | 2010-11-10 | 谢平 | Gynura procumbens chewing gums |
| CN101306099B (en) * | 2008-06-10 | 2011-10-12 | 叶明伟 | Decoction for treating dental caries |
| WO2012068730A1 (en) * | 2010-11-25 | 2012-05-31 | 吴桂谦 | Toothpaste composition for tooth health |
| CN102858308A (en) * | 2010-11-25 | 2013-01-02 | 吴桂谦 | Toothpaste composition for tooth health |
| CN102858308B (en) * | 2010-11-25 | 2013-10-23 | 吴桂谦 | Toothpaste composition for tooth health |
| CN102246829A (en) * | 2011-07-28 | 2011-11-23 | 北京农学院 | Clove extract for killing nematode and preparation method thereof |
| CN102246829B (en) * | 2011-07-28 | 2013-05-01 | 北京农学院 | Clove extract for killing nematode and preparation method thereof |
| CN103315938A (en) * | 2013-07-12 | 2013-09-25 | 孙佳丽 | Anti-oxidative mouthwash |
| CN103315938B (en) * | 2013-07-12 | 2014-12-10 | 孙佳丽 | Anti-oxidative mouthwash |
| CN107233265A (en) * | 2017-08-09 | 2017-10-10 | 周善永 | Strong tooth bacteriostatic gel |
| CN113384620A (en) * | 2021-07-14 | 2021-09-14 | 青岛市口腔医院 | Traditional Chinese medicine composition for preventing and/or treating dental caries as well as preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1052903C (en) | 2000-05-31 |
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