CN114404325A - 一种可无限稀释水包油型菜籽油微乳液及其制备方法和应用 - Google Patents
一种可无限稀释水包油型菜籽油微乳液及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种可无限稀释的水包油型菜籽油微乳液及其制备方法和应用。本发明的水包油型菜籽油微乳液是由油相、助溶剂、乳化剂、助乳化剂和水相组成。其制备方法是将油相与助溶剂按比例混合,搅拌均匀得到A相;将A相与乳化剂按比例混合,搅拌均匀后得到B相;向B相中加入助乳化剂,得到C相。向C相中加入蒸馏水,放置于恒温振荡器上持续振摇12~24h,温度20~40℃,始终保持体系澄清透明,得到水包油型菜籽油微乳液。本发明所制备的可无限稀释型菜籽油微乳液解决了菜籽油难溶于水的问题,且通过o/w体系保护油脂不易氧化酸败。其在5~60℃下均保持良好的稳定性,且保持澄清透明的特性,具有广泛的应用价值。
Description
技术领域
本发明涉及一种可无限稀释的水包油型菜籽油微乳液及其制备方法和应用,属于化妆品技术领域。
背景技术
菜籽油在化妆品、护肤品里主要作用是皮肤调理剂,适合所有肤质,可以高度调节皮肤的保护屏障,防止肌肤受到外界损害;油菜籽富含不饱和脂肪酸和多种维生素,容易被肌肤和头发快速吸收,无油腻感,可以为头发提供优异的光泽。菜籽油含有特有的天然抗氧化剂菜籽多酚,以及维生素E、角鲨烯等天然活性成分与杜仲籽油、美藤果油、橄榄油均表现出同样良好的抗氧化活性。
由于菜籽油难溶于水,易受外界环境而发生氧化酸败,使其活性成分遭到破坏,无法满足实际化妆品应用需求,且受温度和pH的影响而不稳定等问题。
发明内容
本发明解决的技术问题是:菜籽油难溶于水、不稳定导致其在化妆品领域应用受限的技术问题。
为了解决上述技术问题,本发明提供了一种可无限稀释的水包油型菜籽油微乳液,其制备原料包括油相、助溶剂、乳化剂、助乳化剂和水相;其中,所述的油相为菜籽油,所述的助溶剂为乙酸乙酯、乙酸丙酯、乙酸正丁酯和乙酸戊酯中的至少一种,所述的乳化剂为聚氧乙烯40氢化蓖麻油、鲸蜡油醇聚醚、吐温-80、司盘-80和聚氧乙烯10油醚中的至少一种,所述的助乳化剂为无水乙醇、1,2-丙二醇、1,3-丁二醇和聚乙二醇-400中的至少一种,所述的水相为蒸馏水。
优选地,所述的混合油相与乳化剂的质量比为1~9:9~1;所述油相与助溶剂的质量比为1~3:0~3;所述油相与助乳化剂的质量比为1:0~4。
优选地,所述的乳化剂为聚氧乙烯10油醚或吐温-80和司盘-80的组合物;所述吐温-80和司盘-80的质量比为4~6:0~1。
本发明还提供了上述的可无限稀释的水包油型菜籽油微乳液的制备方法,包括以下步骤:
步骤1:在室温下,将油相与助溶剂按比例混合,搅拌均匀后转移至容器中,放置于恒温振荡器上持续振摇,得到A相;
步骤2:在室温下,A相与乳化剂按比例混合,搅拌均匀后转移至容器中直至得到澄清透明溶液,得到B相;向B相中加入助乳化剂,得到C相。
步骤3:向C相中加入蒸馏水,放置于恒温振荡器上持续振摇,始终保持体系澄清透明,得到水包油型菜籽油微乳液。
优选地,所述步骤1和步骤3中在恒温振荡器上持续振摇的条件均为:温度20~40℃,时间12~24h。
优选地,所述步骤1中的油相与助溶剂混合的质量比为1~3:0~3。
优选地,所述步骤2中的A相与乳化剂混合的质量比为1~9:9~1。
优选地,所述步骤2中的B相与助乳化剂的质量比为1:0~4。
本发明还提供了上述可无限稀释的水包油型菜籽油微乳液在制备化妆品中的应用。
本发明与现有技术相比,具有如下有益效果:
1.本发明提供了一种可无限稀释水包油型菜籽油微乳液的制备方法,制备所得的微乳液在5~60℃下均能保持澄清透明的状态,具有良好的稳定性;经过粒径测试表明本发明所制备的水包油型菜籽油微乳液粒径小于20nm,且粒度分布较为均匀;
2.本发明的制备方法增加了菜籽油的溶解度,解决了菜籽油难溶和油脂易氧化变质的问题,本发明制备的水包油型菜籽油微乳液中菜籽油含量高,在化妆品领域具有良好的应用前景和实际应用价值。
附图说明
图1为实施例2的制备体系下的三元相图;
图2为实施例2制备所得的水包油型菜籽油微乳液的粒径分布图。
具体实施方式
为使本发明更明显易懂,兹以优选实施例,作详细说明如下。
以下实施例中,所用到的各原料均为市售产品,所用的各原料或试剂的规格及生产厂家的信息如表1所示:
表1试剂信息
试剂名称 | 规格 | 生产厂家 |
菜籽油 | 食品级 | 上海嘉里食品工业有限公司 |
鲸蜡油醇聚醚 | 分析纯 | 南通辰润化工有限公司 |
乙酸乙酯 | 分析纯 | Greagent试剂 |
乙酸丙酯 | 分析纯 | Greagent试剂 |
乙酸正丁酯 | 分析纯 | Greagent试剂 |
乙酸戊酯 | 分析纯 | Greagent试剂 |
吐温-80 | 分析纯 | 无锡市亚泰联合化工有限公司 |
司盘-80 | 分析纯 | 无锡市亚泰联合化工有限公司 |
聚氧乙烯40氢化蓖麻油 | 分析纯 | 北京凤礼精求商贸有限责任公司 |
聚氧乙烯10油醚 | 分析纯 | 阿拉丁试剂 |
无水乙醇 | 分析纯 | 国药集团化学试剂有限公司 |
1,2-丙二醇 | 分析纯 | 国药集团化学试剂有限公司 |
1,3-丁二醇 | 分析纯 | 国药集团化学试剂有限公司 |
聚乙二醇-400 | 分析纯 | 国药集团化学试剂有限公司 |
以下实施例中,所用的部分仪器生产厂家和型号如表2所示:
表2仪器信息
仪器设备 | 型号 | 生产厂家 |
电子天平 | PL403 | 梅特勒-托利多仪器有限公司 |
数显恒温水浴锅 | HH-2 | 上海力辰邦西仪器科技有限公司 |
水浴恒温振荡器 | SHZ-B | 上海博迅医疗生物仪器股份有限公司 |
手动移液器 | 200μL | 梅特勒-托利多仪器有限公司 |
实施例1
一种可无限稀释的水包油型菜籽油微乳液,以菜籽油为油相,聚氧乙烯10油醚为乳化剂进行制备,具体包括如下步骤:
(1)在室温下,将油相与乳化剂按照1:9的质量比进行混合,搅拌均匀后转移至一个容器中,放置于恒温振荡器上,持续振摇12h,温度30℃,得到A相;
(2)向A相中加入蒸馏水,保持体系澄清透明。制备菜籽油微乳液样品,并测定平均粒径,结果表明该微乳液粒径分布均匀,平均粒径值为18.0977nm。
实施例2
一种可无限稀释水包油型菜籽油微乳液,以菜籽油为油相,乙酸乙酯为助溶剂,吐温-80和司盘-80复配为乳化剂,以1,2-丙二醇为助乳化剂进行制备,具体包括以下步骤:
(1)在室温下,将油相与助溶剂按2:3的质量比进行混合,搅拌均匀后转移至一个容器中,放置于恒温振荡器上,持续振摇12h,温度30℃,得到A相;
(2)将A相与乳化剂(质量比为5:1吐温-80和司盘-80)按质量比为2:8的比例混合,搅拌均匀后转移至一个容器中,放置于恒温振荡器上,持续振摇12h,温度30℃,得到B相;
(3)向B相加入助乳化剂,按1:1的质量比混合,放置于恒温振荡器上,持续振摇12~24h,温度20~40℃得到C相;
(4)向C相中加入蒸馏水,保持体系澄清透明,制得可无限稀释的水包油型菜籽油微乳液。
根据不同配比下体系增溶水的量绘制三元相图(图1),之后在三元相图上的单向区选取合适的配方制备可无限稀释水包油型微乳液。
如图1所示,在实施例2中,油相(含助溶剂)、水相、乳化剂(含助乳化剂)组成的三元相图。1Φ为微乳液区,所制备的微乳液表现出澄清透明的状态;2Φ为乳液区,所制备的乳液呈现出浑浊不透明外观。
如图2所示,在实例2中,选取单相区配方,制备菜籽油微乳液样品,并测定平均粒径,结果表明该微乳液粒径分布均匀,平均粒径值为13.4119nm。
耐热、耐寒实验:
将实施例2中制备出的水包油型菜籽油微乳液分别置于5℃、25℃、40℃、60℃环境下6h、12h、24h,观察微乳液状态,结果如表3所示。
表3耐热、耐寒实验结果
实验编号 | 试验温度/℃ | 实验时间/h | 微乳液状态 |
A<sub>1</sub> | 5 | 6 | 澄清透明 |
A<sub>2</sub> | 5 | 12 | 澄清透明 |
A<sub>3</sub> | 5 | 24 | 澄清透明 |
B<sub>1</sub> | 25 | 6 | 澄清透明 |
B<sub>2</sub> | 25 | 12 | 澄清透明 |
B<sub>3</sub> | 25 | 24 | 澄清透明 |
C<sub>1</sub> | 40 | 6 | 澄清透明 |
C<sub>2</sub> | 40 | 12 | 澄清透明 |
C<sub>3</sub> | 40 | 24 | 澄清透明 |
D<sub>1</sub> | 60 | 6 | 澄清透明 |
D<sub>2</sub> | 60 | 12 | 澄清透明 |
D<sub>3</sub> | 60 | 24 | 澄清透明 |
由表3的结果可知,本发明的可无限稀释水包油型菜籽油微乳液在5~60℃下均能保持良好的稳定性,耐热、耐寒性能好,可以广泛地应用于化妆品中。
以上所述,仅为本发明的较佳实施例,并非对本发明任何形式上和实质上的限制,应当指出,对于本技术领域的普通技术人员,在不脱离本发明的前提下,还将可以做出若干改进和补充,这些改进和补充也应视为本发明的保护范围。
Claims (9)
1.一种可无限稀释的水包油型菜籽油微乳液,其特征在于,其制备原料包括油相、助溶剂、乳化剂、助乳化剂和水相;其中,所述的油相为菜籽油,所述的助溶剂为乙酸乙酯、乙酸丙酯、乙酸正丁酯和乙酸戊酯中的至少一种,所述的乳化剂为聚氧乙烯40氢化蓖麻油、鲸蜡油醇聚醚、吐温-80、司盘-80和聚氧乙烯10油醚中的至少一种,所述的助乳化剂为无水乙醇、1,2-丙二醇、1,3-丁二醇和聚乙二醇-400中的至少一种,所述的水相为蒸馏水。
2.如权利要求1所述的可无限稀释的水包油型菜籽油微乳液,其特征在于,所述的油相与乳化剂的质量比为1~9:9~1;所述油相与助溶剂的质量比为1~3:0~3;所述油相与助乳化剂的质量比为1:0~4。
3.如权利要求1所述的可无限稀释的水包油型菜籽油微乳液,其特征在于,所述的乳化剂为聚氧乙烯10油醚或吐温-80和司盘-80的组合物;所述吐温-80和司盘-80的质量比为4~6:0~1。
4.权利要求1~3中任意一项所述的可无限稀释的水包油型菜籽油微乳液的制备方法,其特征在于,包括以下步骤:
步骤1:在室温下,将油相与助溶剂按比例混合,搅拌均匀后转移至容器中,放置于恒温振荡器上持续振摇,得到A相;
步骤2:在室温下,A相与乳化剂按比例混合,搅拌均匀后转移至容器中直至得到澄清透明溶液,得到B相;向B相中加入助乳化剂,得到C相。
步骤3:向C相中加入蒸馏水,放置于恒温振荡器上持续振摇,始终保持体系澄清透明,得到水包油型菜籽油微乳液。
5.如权利要求4所述的可无限稀释的水包油型菜籽油微乳液的制备方法,其特征在于,所述步骤1和步骤3中在恒温振荡器上持续振摇的条件均为:温度20~40℃,时间12~24h。
6.如权利要求4所述的可无限稀释的水包油型菜籽油微乳液的制备方法,其特征在于,所述步骤1中的油相与助溶剂混合的质量比为1~3:0~3。
7.如权利要求4所述的可无限稀释的水包油型菜籽油微乳液的制备方法,其特征在于,所述步骤2中的A相与乳化剂混合的质量比为1~9:9~1。
8.如权利要求4所述的可无限稀释的水包油型菜籽油微乳液的制备方法,其特征在于,所述步骤2中的B相与助乳化剂的质量比为1:0~4。
9.权利要求1~3中任意一项所述的可无限稀释的水包油型菜籽油微乳液在制备化妆品中的应用。
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