CN114375337A - 具有改进包装效率的重组修饰的腺相关病毒(rAAV) - Google Patents
具有改进包装效率的重组修饰的腺相关病毒(rAAV) Download PDFInfo
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- CN114375337A CN114375337A CN202080064371.XA CN202080064371A CN114375337A CN 114375337 A CN114375337 A CN 114375337A CN 202080064371 A CN202080064371 A CN 202080064371A CN 114375337 A CN114375337 A CN 114375337A
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| US20060205079A1 (en) * | 1997-10-21 | 2006-09-14 | Lynch Carmel M | Amplifiable adeno-associated virus (AAV) packaging cassettes for the production of recombinant AAV vectors |
| CN108727486A (zh) * | 2017-04-24 | 2018-11-02 | 舒泰神（北京）生物制药股份有限公司 | 长效神经生长因子、制备方法及其组合物 |
| CN108884446A (zh) * | 2016-01-29 | 2018-11-23 | 西里昂生物技术有限责任公司 | 基于aav的条件表达系统 |
| EP3461893A1 (en) * | 2014-05-02 | 2019-04-03 | Iontas Limited | Preparation of libraries of protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| CN109844124A (zh) * | 2016-05-20 | 2019-06-04 | 哈佛学院董事及会员团体 | 年龄相关疾病和病症的基因治疗方法 |
| US20220257678A1 (en) * | 2019-07-15 | 2022-08-18 | Charles River Laboratories, Inc. | Recombinantly-modified adeno-associated virus (raav) having improved packaging efficiency |
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| US6342390B1 (en) | 1994-11-23 | 2002-01-29 | The United States Of America As Represented By The Secretary Of Health And Human Services | Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| AU4645697A (en) | 1996-09-11 | 1998-04-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Aav4 vector and uses thereof |
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| IT1297074B1 (it) | 1997-11-21 | 1999-08-03 | Angeletti P Ist Richerche Bio | Forme ormone-dipendenti delle proteine rep del virus adeno-associato (aav-2), sequenze di dna codificanti per esse, vettori che le |
| US6984517B1 (en) | 1998-05-28 | 2006-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | AAV5 vector and uses thereof |
| DE69939169D1 (de) | 1998-05-28 | 2008-09-04 | Us Gov Health & Human Serv | Aav5 vektoren und deren verwendung |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
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| US20220257678A1 (en) | 2022-08-18 |
| US12156894B2 (en) | 2024-12-03 |
| EP3999648A1 (en) | 2022-05-25 |
| US10653731B1 (en) | 2020-05-19 |
| KR20220034214A (ko) | 2022-03-17 |
| AU2020315513A1 (en) | 2022-02-17 |
| WO2021011034A1 (en) | 2021-01-21 |
| JP2022542829A (ja) | 2022-10-07 |
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