CN114366799A - 一种高原甘露药浴制剂及其制作工艺 - Google Patents
一种高原甘露药浴制剂及其制作工艺 Download PDFInfo
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- CN114366799A CN114366799A CN202210061118.XA CN202210061118A CN114366799A CN 114366799 A CN114366799 A CN 114366799A CN 202210061118 A CN202210061118 A CN 202210061118A CN 114366799 A CN114366799 A CN 114366799A
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Abstract
本发明涉及一种高原甘露药浴制剂及其制作工艺,该颗粒组合物由以下重量份的中药制成:烈香杜鹃5‑8g、水柏枝5‑8g、麻黄5‑8g、大籽蒿5‑8g、高山柏5‑8g、当归0.5‑1、黄精0.5‑1g、天门冬0.5‑1g、紫茉莉0.5‑1g、蒺藜0.5‑1g、诃子0.8‑1.2g、毛诃子0.6‑1g、余甘子0.5‑1g、琥珀0.3‑1.2g、黄葵0.3‑1.2kg、决明子0.3‑1.2g、宽筋藤0.6‑1g、甘青青兰0.8‑5g、檀香0.1‑0.8kg、紫檀香0.1‑0.8g、党参0.1‑0.8g、天竹黄0.4‑1g、草红花0.1‑0.6kg、白豆蔻0.2‑1g、草果0.2‑1g、肉豆蔻0.2‑1g、丁香0.2‑1g、冰片0.1‑0.5g、锦鸡儿0.4‑0.8kg、干姜0.1‑0.6g、儿茶0.3‑0.6g和轮叶刺豆0.1‑0.2g。本发明所述的制剂能促进血液循环,加强机体代谢,提高白细胞吞噬能力,还能调节神经,增强免疫力。
Description
技术领域
本发明涉及药浴制剂技术领域,具体是一种高原甘露药浴制剂及其制作工艺。
背景技术
随着社会的发展,人们的生活环境以及工作压力都在发生不同的变化,有的一些人会患得风湿性关节炎、类风湿性关节炎、神经性疾病、足跟痛,痛风等骨关节及免疫系统疾病,各种皮肤疾病(湿疹等),妇女产后疾病等,这些疾病非常顽固,严重的时候会影响人们的正常生活,现有技术中的一些药物大都会存在一定的副作用,长时间使用后也会对身体造成二次伤害,另外,由于生活条件在不断变好,人们越来越重视养生健康,经常会有一些人用一些保健品,然而有的一些保健品所吹捧的效果与实际产品所产生的疗效相差甚远,难以满足用户的需求。
发明内容
本发明的目的在于提供一种高原甘露药浴制剂及其制作工艺,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种高原甘露药浴制剂,该颗粒组合物由以下重量份的中药制成:烈香杜鹃5-8g、水柏枝5-8g、麻黄5-8g、大籽蒿5-8g、高山柏5-8g、当归0.5-1、黄精0.5-1g、天门冬0.5-1g、紫茉莉0.5-1g、蒺藜0.5-1g、诃子0.8-1.2g、毛诃子0.6-1g、余甘子0.5-1g、琥珀0.3-1.2g、黄葵0.3-1.2kg、决明子0.3-1.2g、宽筋藤0.6-1g、甘青青兰0.8-5g、檀香0.1-0.8kg、紫檀香0.1-0.8g、党参0.1-0.8g、天竹黄0.4-1g、草红花0.1-0.6kg、白豆蔻0.2-1g、草果0.2-1g、肉豆蔻0.2-1g、丁香0.2-1g、冰片0.1-0.5g、锦鸡儿0.4-0.8kg、干姜0.1-0.6g、儿茶0.3-0.6g和轮叶刺豆0.1-0.2g。
作为本发明进一步的方案:该制剂组合物由以下重量份的中药制成:烈香杜鹃5g、水柏枝5g、麻黄5g、大籽蒿5g、高山柏5g、当归0.5、黄精0.5g、天门冬0.5g、紫茉莉0.5g、蒺藜0.5g、诃子0.8g、毛诃子0.6g、余甘子0.5g、琥珀0.3g、黄葵0.3kg、决明子0.3g、宽筋藤0.6g、甘青青兰0.8g、檀香0.1kg、紫檀香0.1g、党参0.1g、天竹黄0.4g、草红花0.1kg、白豆蔻0.2g、草果0.2g、肉豆蔻0.2g、丁香0.2g、冰片0.1g、锦鸡儿0.4kg、干姜0.1g、儿茶0.3g和轮叶刺豆0.1g。
作为本发明再进一步的方案:该制剂组合物由以下重量份的中药制成:烈香杜鹃8g、水柏枝8g、麻黄8g、大籽蒿8g、高山柏8g、当归1、黄精0.5-1g、天门冬1g、紫茉莉1g、蒺藜1g、诃子1.2g、毛诃子1g、余甘子1g、琥珀1.2g、黄葵1.2kg、决明子1.2g、宽筋藤1g、甘青青兰5g、檀香0.8kg、紫檀香0.8g、党参0.8g、天竹黄1g、草红花0.6kg、白豆蔻1g、草果1g、肉豆蔻1g、丁香1g、冰片0.5g、锦鸡儿0.8kg、干姜0.6g、儿茶0.6g和轮叶刺豆0.2g。
作为本发明再进一步的方案:所述制剂为药丸或颗粒。
本发明还包括一种高原甘露药浴制剂的制作工艺,其包括以下步骤:
步骤一:准备各项原材料,对一些原料做预处理,清洗,并且将其晾干;
步骤二:对一些原材料进行粉碎,然后将各项原材料投入到混料机中进行混合,最后得到混合物;
步骤三:将所有的原料混合后投入到制粒机中,从而得到药浴颗粒,在此步骤中,也可以人工对其制作,从而制得药丸;
步骤四:对制作好的药浴颗粒进行打包封装,50g/袋。
相比于现有技术,本发明的优点在于:
本发明所述的制剂能促进血液循环,加强机体代谢,提高白细胞吞噬能力,还能调节神经,增强免疫力,散寒祛风、发汗利尿、消肿止痛、活血化瘀、燥湿止痒,用于风湿性关节炎、类风湿性关节炎、神经性疾病、足跟痛,痛风等骨关节及免疫系统疾病,各种皮肤疾病(湿疹等),妇女产后疾病等,从儿童到老人皆可使用,有病治病,没病养生保健作用。
具体实施方式
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
一种高原甘露药浴制剂,该制剂组合物由以下重量份的中药制成:烈香杜鹃5-8g、水柏枝5-8g、麻黄5-8g、大籽蒿5-8g、高山柏5-8g、当归0.5-1、黄精0.5-1g、天门冬0.5-1g、紫茉莉0.5-1g、蒺藜0.5-1g、诃子0.8-1.2g、毛诃子0.6-1g、余甘子0.5-1g、琥珀0.3-1.2g、黄葵0.3-1.2kg、决明子0.3-1.2g、宽筋藤0.6-1g、甘青青兰0.8-5g、檀香0.1-0.8kg、紫檀香0.1-0.8g、党参0.1-0.8g、天竹黄0.4-1g、草红花0.1-0.6kg、白豆蔻0.2-1g、草果0.2-1g、肉豆蔻0.2-1g、丁香0.2-1g、冰片0.1-0.5g、锦鸡儿0.4-0.8kg、干姜0.1-0.6g、儿茶0.3-0.6g和轮叶刺豆0.1-0.2g。
为了更好的使用该制剂,在本实施例中:该制剂组合物由以下重量份的中药制成:烈香杜鹃5g、水柏枝5g、麻黄5g、大籽蒿5g、高山柏5g、当归0.5、黄精0.5g、天门冬0.5g、紫茉莉0.5g、蒺藜0.5g、诃子0.8g、毛诃子0.6g、余甘子0.5g、琥珀0.3g、黄葵0.3kg、决明子0.3g、宽筋藤0.6g、甘青青兰0.8g、檀香0.1kg、紫檀香0.1g、党参0.1g、天竹黄0.4g、草红花0.1kg、白豆蔻0.2g、草果0.2g、肉豆蔻0.2g、丁香0.2g、冰片0.1g、锦鸡儿0.4kg、干姜0.1g、儿茶0.3g和轮叶刺豆0.1g。
为了更好的使用该制剂,在本实施例中:该制剂组合物由以下重量份的中药制成:烈香杜鹃8g、水柏枝8g、麻黄8g、大籽蒿8g、高山柏8g、当归1、黄精0.5-1g、天门冬1g、紫茉莉1g、蒺藜1g、诃子1.2g、毛诃子1g、余甘子1g、琥珀1.2g、黄葵1.2kg、决明子1.2g、宽筋藤1g、甘青青兰5g、檀香0.8kg、紫檀香0.8g、党参0.8g、天竹黄1g、草红花0.6kg、白豆蔻1g、草果1g、肉豆蔻1g、丁香1g、冰片0.5g、锦鸡儿0.8kg、干姜0.6g、儿茶0.6g和轮叶刺豆0.2g。
在本实施例中:所述制剂为药丸或颗粒。将其制作为药丸或者颗粒,使得其可以针对不同的情况或者人群使用,提高了其实用性。
实施例2:
本发明还包括一种高原甘露药浴制剂的制作工艺,其包括以下步骤:
步骤一:准备各项原材料,烈香杜鹃、水柏枝、麻黄、大籽蒿、高山柏、当归、黄精、天门冬、紫茉莉、蒺藜、诃子、毛诃子、余甘子、琥珀、黄葵、决明子、宽筋藤、甘青青兰、檀香、紫檀香、党参、天竹黄、草红花、白豆蔻、草果、肉豆蔻、丁香、冰片、锦鸡儿、干姜、儿茶和轮叶刺豆对一些原料做预处理,清洗,并且将其晾干;
步骤二:对一些原材料进行粉碎,然后将各项原材料投入到混料机中进行混合,最后得到混合物;
步骤三:将所有的原料混合后投入到制粒机中,从而得到药浴颗粒,在此步骤中,也可以人工对其制作,从而制得药丸;
步骤四:对制作好的药浴颗粒进行打包封装,50g/袋。
实施例3:
综上所述,在使用时,一次一袋,根据病人情况,熏蒸或浸泡全身或半身、双足都可以。
使用时间:全身或半身浸泡10-20、双足20-40分钟左右,浸泡时用双足相互搓擦或用手按摩效果更佳;洗浴后,干净毛巾擦干即可。
贮藏:密闭,置阴凉干燥处。
注意事项:禁忌外伤、烧伤,疫病,全身或半身浸泡注意心脏病和高血压疾病。
实施例4:
制剂临床研究方法的建立是依据藏医药理论体系结合现代中西医临床研究方案,根据制剂适用人群,熏蒸或浸泡疗程,确定了临床研究方案。规定了病历的入选标准、对照药品、病人基础体征检查、特征生化指标检查、熏蒸或浸泡疗程、期间与熏蒸或浸泡后检查,疗效评价,不良反应等,经统计学分析科学评估制剂的有效性。共观察类风湿性关节炎患者60例,随机分为治疗组和对照组各30例,治疗组中男15例,女15例,年龄30-60岁,平均年龄45岁,平均病程5年。对照组中男15例,女15例,年龄30-60岁,平均年龄45岁,平均病程5年。2组患者的性别、年龄、病程等一般资料比较差异无统计学意义(P>0.05),具有可比性。
其中治疗组采用本发明中的制剂进行蒸熏或者浸泡,对照组采用西药口服治疗。
治疗组:30人,其中治愈的有18人,好转的有11人,无效的有1人,总有效率为96%;
对照组:30人,其中治愈的有1人,好转的有3人,无效的有26人,总有效率为13%。
综合评价:
通过临床试验,治疗组的效果明显优于对照组,达到极显著差异,总有效率达96%,在临床症状改善方面,其均显现出较好的有效率和治愈率,未发生不良反应,验证了本发明制剂传统医学的科学性。
结合本发明,列举以下实际患者的治疗情况:
患者一病历:
姓名:张** 性别:女 65岁 农民 汉族
主诉:四肢关节炎畸形伴间断性疼痛12年,疼痛加重伴心慌2月,
现病史:患者12年前无明显诱因出现四肢小关节肿胀、疼痛。到县人民医院检查诊断:类风湿性关节炎。住院对症治疗症状缓解。但仍有关节肿痛,慢慢四肢畸形。近2月来,四肢关节肿痛疼痛加重,伴心慌、头晕,口服药不能缓情,为求治疗来我院。发病以来,神志清、精神差,饮食及睡眠正常,大小便正常,体重无明显变化。
既往史:无外伤及手术病史、无食物、药物过敏史、无输血及有偿献血史、无高血压、糖尿病慢性病史,无肝炎结合、传染病接触史。预防接种随社会进行史。
婚姻史:20岁结婚,爱人体健,无早产、流产史。
家族史;否认有家族性遗传病史。
体格检查:T37.2℃ P91次/分 R19次/分 BP100/70mmHg;
发育正常,营养中等、神志清楚、精神可、查体合作、扶入病房、全身皮肤黏膜无皮疹黄染及出血点、浅表淋巴结未触及肿大。头颅无畸形,胸廓正常。
辅助检查:肝肾功能无异常 TU/ML 抗“O”正常;
(RF)类风湿因子(RF): 120LU/ml C反应蛋白(CRP):20mg/L;
诊断:类风湿性关节炎和神经炎;
治疗:1天2次全身泡高原药浴颗粒药浴治疗,一次10-15分钟,针灸,口服藏药经过10天治疗后,四小肢关节肿痛疼痛缓解良好;
复查:抗“O”正常,RF: 90lu/ml , CRK:7mg/L
诊断:CT检查后,腰椎间盘突出伴坐骨神经痛
出院建议:休息2月后,再来住院药浴巩固治疗。
患者二病历:
姓名:才** 男 48岁 农民 藏族
主诉:间隔性腰痛1年,加重伴右下肢麻木放射疼4天。
现病史:患者汽修工,长期弯腰工作。自述1年前无明显诱因出现右下肢疼痛麻木,晚间疼痛渐增,时痛如刀割,火㸌,并以蚁行感,沿右下肢放射,在私人诊所予;腰痛宁胶囊,VB1 、VB12、肌肉注射,
未见好转,以后法反复发作,腰部酸软、困痛,喜揉喜按、遇劳加重,卧则减轻。4天前因劳累过度,致腰痛加重生,2019年11月6日来我院,行CT检查:L4-5、Ls-s1椎间盘突出,L3-4椎体骨质增生,门诊以:腰痛腰椎键盘突出症L4-L5 L5-S1,收住入院住院,症见;神志清、精神差、表情痛苦、面色咣白、手足不温、少气乏力、上述腰痛症状仍存。纳可夜寐安、大小便日调。
无传染病及遗传疾病,无输血、手术史,未发现药物及食物过敏史。
体格检查:T:36℃ P:76次/分 R:20次/分
BP:140/90mmHg,专科检查:腰脊椎姿势,腰椎生现前突消失,腰椎轻度侧右臂畸形,右下肢压腿抬高试验30(+)右侧(-),腹压增高则且右下肢麻木加重。
辅助检查:CT检查 L4-5、L5-S1椎间盘突出L3-4椎体骨质增生。
诊断为;腰椎间盘突出伴坐骨神经痛。
治疗:1天两次全身泡高原药浴颗粒药水中,一次10-15分钟,口服藏药,经过住院7天治疗,患者右下肢痛麻症状减轻,腰及双下困损痛缓解。PE
见患者神志清、精神佳,心肺正常,棘间压痛(一)右臂部环跳穴压痛(一)无右下肢放射性疼痛麻木,右下肢压腿抬高试验(一)
辅助检查:腰椎正侧位显示:腰椎间盘退行性改变。
患者三病历:
姓名:拉xx、性别:女、年龄:60岁、职业:农民、名族:藏族、
主诉:四肢关节对称性肿痛9年,加重15天。
现病史:患者自诉9年前无明显诱因出现双腕、掌指关节、近端指间关节肿痛,于县人民医院确诊为“类风湿性关节炎”。9年来问断行、拔罐、针灸、口服中药、西药(具体不详)治疗,症状时轻时重,多于劳累及遇寒遇冷时诱发或加重,渐出现双踝关节、肘关节、膝关节肿痛,晨僵常约一小时以上,2020年10月28日来我院就诊,门诊诊断以“类风湿性关节炎”收住入院。病程中出现全身低热,精神恍惚、睡眠差、食纳差、大小便尚可,体重有所减轻、常感乏力。
既往史:无其他特殊病史,否认“肝炎”、“肺结核”等传染性疾病史,无过敏史,无家族遗传性病史、
体格检查:T:36.4℃,P:82次/分、R:20次/分,BP:150/100mmHg.神志清,发育正常,营养中等,痛苦面容,扶入病房,舌淡苔白,脉沉细。皮肤正常。全体淋巴结未触及肿大,头颅五官无畸形,心肺腹未查检异常,四肢关节肤色,肤温正常。双腕关节、双手掌指关节及极端指间关节,双膝关节、右踝关节肿胀,压痛阳性、左踝关节肿胀,压痛阳性,关节不同程度功能障碍,以双腕关节一下为甚,余关节无明显肿痛,病现在未引出。
辅助检查:肝肾功能正常,抗“O”:310U/ML 类风湿因子正常,C反应蛋白正常,血沉正常。
诊断:类风湿性关节炎
治疗:一天两次全省泡高原药浴颗粒药水中,一次泡10-15分钟。口服藏药。
经过7天的泡药浴治疗后,双腕,双手掌指间关节及近端指间关节,双膝关节、右踝关节肿胀缓解,压痛阴性,左踝关节肿胀减轻,压痛阴性,各关节不同程度功能恢复良好。
复查:抗‘O”:153U/ML
建议:出院后休息3个月再来进行巩固药浴治疗。
患者四病历:
姓名:张** 男 职工 汉族
主诉:双小腿内侧条索状包块10余年。
现病史:患者10年前发现双小腿内侧条索状包块,平卧消失,直立出现,无不适,未治疗。包块渐渐增多增粗,延及大腿内侧。一月前,双小腿内侧瘙痒,,2020年5月16日入院要求高原药浴颗粒泡双下肢治疗。门诊拟诊“双侧大隐静脉曲张”,精神饮食好,大小便正常。
既往史:否认肝炎,结核等传染病史。无手术外伤史,无食物,药物过敏史。
个人史:生于本地,无外地久居史,无疫情接触史,无不良生活习惯及嗜好。经常站立工作。
家族史:家族无传染病史,无家族遗传性疾病。
体格检查
T:36℃ P:62次/分 R:18次/分 BP:120/80mmHg
神志清晰,自主体位,检查合作。全身皮肤黏膜无黄染。右腹股沟区可触及花生米样大淋巴结一枚,头颅无畸形。五官无异常,胸廓无畸形,心肺正常,腹平软,肝脾于肋下未触及,腰椎后凸畸形,四肢见专科情况,生理反射存在,病理反射未引出。
专科情况:双下肢内侧可见迂曲成团之条索状包块,以小腿内侧为剧,双胫、髁前内见色素沉着及搔抓痕迹。深静脉通畅试验阴性。
辅助检查:血常规 WBC:5.1X10*9/L NO:566 Hb:131g/L 彩超显示:1.双腿静脉曲张 2.胆囊炎
诊断:1.双腿静脉曲张
2.胆囊炎
治疗:一天两次双腿泡高原药浴颗粒药水中,泡完轻轻按摩,连续治疗12天后,第一次疗程消失双小腿内侧瘙痒,包块变细而无胀痛,下肢感觉轻松。经过3疗程后,双小腿内侧条索状包块消失。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (5)
1.一种高原甘露药浴制剂,其特征在于,该颗粒组合物由以下重量份的中药制成:烈香杜鹃5-8g、水柏枝5-8g、麻黄5-8g、大籽蒿5-8g、高山柏5-8g、当归0.5-1、黄精0.5-1g、天门冬0.5-1g、紫茉莉0.5-1g、蒺藜0.5-1g、诃子0.8-1.2g、毛诃子0.6-1g、余甘子0.5-1g、琥珀0.3-1.2g、黄葵0.3-1.2kg、决明子0.3-1.2g、宽筋藤0.6-1g、甘青青兰0.8-5g、檀香0.1-0.8kg、紫檀香0.1-0.8g、党参0.1-0.8g、天竹黄0.4-1g、草红花0.1-0.6kg、白豆蔻0.2-1g、草果0.2-1g、肉豆蔻0.2-1g、丁香0.2-1g、冰片0.1-0.5g、锦鸡儿0.4-0.8kg、干姜0.1-0.6g、儿茶0.3-0.6g和轮叶刺豆0.1-0.2g。
2.根据权利要求1所述的一种高原甘露药浴制剂,其特征在于:该制剂组合物由以下重量份的中药制成:烈香杜鹃5g、水柏枝5g、麻黄5g、大籽蒿5g、高山柏5g、当归0.5、黄精0.5g、天门冬0.5g、紫茉莉0.5g、蒺藜0.5g、诃子0.8g、毛诃子0.6g、余甘子0.5g、琥珀0.3g、黄葵0.3kg、决明子0.3g、宽筋藤0.6g、甘青青兰0.8g、檀香0.1kg、紫檀香0.1g、党参0.1g、天竹黄0.4g、草红花0.1kg、白豆蔻0.2g、草果0.2g、肉豆蔻0.2g、丁香0.2g、冰片0.1g、锦鸡儿0.4kg、干姜0.1g、儿茶0.3g和轮叶刺豆0.1g。
3.根据权利要求1所述的一种高原甘露药浴制剂,其特征在于:该制剂组合物由以下重量份的中药制成:烈香杜鹃8g、水柏枝8g、麻黄8g、大籽蒿8g、高山柏8g、当归1、黄精0.5-1g、天门冬1g、紫茉莉1g、蒺藜1g、诃子1.2g、毛诃子1g、余甘子1g、琥珀1.2g、黄葵1.2kg、决明子1.2g、宽筋藤1g、甘青青兰5g、檀香0.8kg、紫檀香0.8g、党参0.8g、天竹黄1g、草红花0.6kg、白豆蔻1g、草果1g、肉豆蔻1g、丁香1g、冰片0.5g、锦鸡儿0.8kg、干姜0.6g、儿茶0.6g和轮叶刺豆0.2g。
4.根据权利要求1所述的一种高原甘露药浴制剂,其特征在于:所述制剂为药丸或颗粒。
5.根据权利要求1所述本发明还包括一种高原甘露药浴制剂的制作工艺,其包括以下步骤:
步骤一:准备各项原材料,对一些原料做预处理,清洗,并且将其晾干;
步骤二:对一些原材料进行粉碎,然后将各项原材料投入到混料机中进行混合,最后得到混合物;
步骤三:将所有的原料混合后投入到制粒机中,从而得到药浴颗粒,在此步骤中,也可以人工对其制作,从而制得药丸;
步骤四:对制作好的药浴颗粒进行打包封装,50g/袋。
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