CN114348329A - Aseptic production transfer system of potassium dehydroandrographolide succinate for injection - Google Patents
Aseptic production transfer system of potassium dehydroandrographolide succinate for injection Download PDFInfo
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- CN114348329A CN114348329A CN202110463845.4A CN202110463845A CN114348329A CN 114348329 A CN114348329 A CN 114348329A CN 202110463845 A CN202110463845 A CN 202110463845A CN 114348329 A CN114348329 A CN 114348329A
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- 238000002347 injection Methods 0.000 title claims abstract description 43
- 239000007924 injection Substances 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 36
- YTHKMAIVPFVDNU-GPTWTFMPSA-N 4-[[(1r,2r,4ar,5r,8as)-2-(3-carboxypropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(e)-2-(5-oxo-2h-furan-4-yl)ethenyl]-3,4,5,7,8,8a-hexahydro-2h-naphthalen-1-yl]methoxy]-4-oxobutanoic acid Chemical compound C(/[C@@H]1C(=C)CC[C@H]2[C@@]1(C)CC[C@H]([C@]2(COC(=O)CCC(O)=O)C)OC(=O)CCC(O)=O)=C\C1=CCOC1=O YTHKMAIVPFVDNU-GPTWTFMPSA-N 0.000 title claims abstract description 28
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229910052700 potassium Inorganic materials 0.000 title claims abstract description 28
- 239000011591 potassium Substances 0.000 title claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 89
- 238000004108 freeze drying Methods 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000004891 communication Methods 0.000 claims abstract description 7
- 230000007723 transport mechanism Effects 0.000 claims abstract description 6
- 238000007710 freezing Methods 0.000 claims abstract description 4
- 230000008014 freezing Effects 0.000 claims abstract description 4
- 230000005540 biological transmission Effects 0.000 claims description 38
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 230000007306 turnover Effects 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims description 4
- 230000005389 magnetism Effects 0.000 claims description 3
- 238000009432 framing Methods 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims 1
- 238000004801 process automation Methods 0.000 abstract 1
- 230000032258 transport Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000007599 discharging Methods 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 230000005571 horizontal transmission Effects 0.000 description 3
- 230000003749 cleanliness Effects 0.000 description 2
- 230000003028 elevating effect Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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Abstract
The invention discloses an aseptic production and transfer system of potassium dehydroandrographolide succinate for injection, which comprises a controller, a production mechanism, a product frame for injection set, a conveying mechanism positioned at the outlet end of the production mechanism, a transfer mechanism which is butted with the conveying mechanism and is used for transferring potassium dehydroandrographolide succinate injection, and a freeze-drying unit which is butted with the transfer mechanism and is used for freezing potassium dehydroandrographolide succinate injection, wherein the conveying mechanism and the transfer mechanism are respectively in communication connection with the controller; its reliable structure, performance is good, whole automation operation, injection after the production carries out putting of cover frame and product cover frame neat material work through conveying mechanism, and then the transportation dolly through transport mechanism comes and goes between conveying mechanism and freeze-drying unit and shifts the transportation to product cover frame, and whole transportation process automation has cancelled current manual transfer operation, has stopped because of the potential hidden danger that manual operation brought pharmaceutical production to effectual transportation efficiency that has improved.
Description
Technical Field
The invention relates to the technical field of biological pharmacy, in particular to an aseptic production and transfer system of potassium dehydroandrographolide succinate for injection.
Background
The potassium dehydroandrographolide succinate injection production line enters the upgrading and updating period, two freeze dryer feeding modes are available on the market, the automatic feeding and discharging mode is selected for newly built plants in recent years, the manual feeding and discharging mode is adopted for old plants of a large department, namely, the products are transferred into the laminar flow transfer trolley through manual feeding, and then the products are transferred into the freeze dryer through the laminar flow transfer trolley. Human intervention during sterile transfer is increasingly challenged in current GMP inspections, with increasing demand to reduce human intervention. The existing domestic optimization mode is changed into an automatic feeding and discharging mode, if the automatic feeding and discharging mode needs to be changed, the existing freeze dryer needs to be greatly changed or replaced, a laminar flow conveying line is added, the room layout and an air conditioning purification system and other hardware facilities need to be improved, the capital investment is very large, the construction period is long, and the enterprise is very unfavorable.
Disclosure of Invention
In order to solve the technical problems, the invention provides an aseptic production and transfer system of potassium dehydroandrographolide succinate for injection.
The technical scheme for solving the technical problems is as follows: an aseptic production and transfer system of potassium dehydroandrographolide succinate for injection comprises a controller, a production mechanism, a product frame for injection set, a conveying mechanism positioned at the outlet end of the production mechanism, a transfer mechanism which is in butt joint with the conveying mechanism and is used for transferring potassium dehydroandrographolide succinate injection, and a freeze-drying unit which is in butt joint with the transfer mechanism and is used for freezing potassium dehydroandrographolide succinate injection, wherein the conveying mechanism and the transfer mechanism are respectively in communication connection with the controller;
the transfer mechanism comprises a conveying track paved between the conveying mechanism and the freeze-drying unit, a transfer trolley connected on the conveying track in a matching mode, and a fresh air circulation assembly arranged in the transfer trolley, wherein a product accommodating port of the transfer trolley corresponds to an outlet end of the conveying mechanism and an inlet end of the freeze-drying unit respectively.
Further, the transfer trolley comprises a trolley body, a lifting mechanism arranged on the trolley body and a box body arranged at the upper end of the lifting mechanism, the fresh air circulation assembly is located in the box body, an opening for the product sleeve frame to pass in and out is formed in the end face of the box body, a driving mechanism used for driving the product sleeve frame to move is arranged in the box body, and a door body turnover mechanism is arranged at the opening.
Further, actuating mechanism is including setting up driving motor in the box, the screw rod of cooperation connection on the driving motor output and setting up the fixing base at the screw rod tip, and the fixing base setting is provided with the bearing that matches with the screw rod tip in the inner wall of box, be provided with on the fixing base with product cover frame matched with installation component, driving motor and controller communication connection.
Further, the mounting assembly comprises a mounting seat which is connected to the screw in a matched mode and a push-pull seat which is arranged on the mounting seat, a through hole is axially formed in the mounting seat, a thread groove which is matched with thread teeth of the screw is formed in the through hole, and the product sleeve frame is connected with the push-pull seat;
the push-pull seat is provided with a first magnetic attraction buckle, and the product sleeve frame is provided with a second magnetic attraction buckle with the magnetism opposite to that of the first magnetic attraction buckle.
Further, the door body turnover mechanism comprises a door body arranged at the opening of the box body, a driving rod arranged on the door body and a driving cylinder connected to the end part of the driving rod, and the driving cylinder is arranged in the box body.
Further, the conveying mechanism comprises a transverse transmission assembly arranged at the outlet end of the production mechanism, a radial transmission assembly connected to the outlet end of the transverse transmission assembly and a transfer assembly arranged at the outlet end of the radial transmission assembly, and the transverse transmission assembly is perpendicular to the radial transmission assembly.
Further, the transfer subassembly includes the transfer frame, set up the transfer platform on the transfer frame and set up the neat material subassembly on the transfer platform, the entrance point of transfer platform meets with radial drive assembly's exit end, the side of transfer platform is provided with transports the export, transports the export and dock with the opening of the box on the transport mechanism, and the actuating mechanism through transport mechanism removes the product cover frame to the box in by the transfer platform, forwards to freeze-drying unit inside again.
Further, horizontal transmission subassembly and radial transmission subassembly all include the support frame, set up the bearing roller on the support frame, lay conveyer belt and the drive bearing roller pivoted inverter motor on the bearing roller, and the conveyer belt of horizontal transmission subassembly is mutually perpendicular with the conveyer belt of radial transmission subassembly, is formed with operating space between the side of horizontal transmission subassembly and the side of radial transmission subassembly, is provided with the robotic arm that is used for carrying out the cover frame to the injection in the operating space.
Further, the aligning component comprises a telescopic cylinder arranged on the transfer platform and an aligning plate arranged on the telescopic cylinder, and the lower edge of the aligning plate is flush with the upper surface of the transfer platform.
Further, the fresh air circulation assembly comprises a circulating fan arranged in the box body, an air supply duct arranged in the box body and positioned at the outlet end of the circulating fan, a clean bin arranged in the box body and positioned at the air outlet of the air supply duct, and an air return channel arranged at the air outlet of the clean bin, wherein the clean bin is provided with an inlet communicated with the opening; a high-efficiency filter is arranged between the air supply duct and the clean cabin, a primary filter and a medium-efficiency filter are respectively arranged in the air return channel, the primary filter and the medium-efficiency filter are sequentially arranged along the wind conveying direction, a valve hole is formed in the side wall of the air return channel, which is close to the primary filter, and an adjusting valve is arranged in the valve hole;
the adjusting valve piece comprises an adjusting frame arranged on the side wall of the return air channel and an adjusting valve plate arranged on the adjusting frame, and the adjusting valve plate is arranged along the adjusting frame in a sliding mode.
The invention has the following beneficial effects: the sterile production and transfer system for the potassium dehydroandrographolide succinate for injection provided by the invention has the advantages that the structure is reliable, the service performance is good, the whole process is automated, the injection after production is placed and aligned with the product sleeve frame through the conveying mechanism, the product sleeve frame is transferred and transferred between the conveying mechanism and the freeze-drying unit through the transfer trolley of the transfer mechanism, the whole transfer process is automated, the existing manual transfer operation is cancelled, the potential hidden danger caused by manual operation on medicine production is avoided, and the transfer efficiency is effectively improved. In addition, in the transportation process of the transportation trolley, the fresh air circulation assembly inside the transportation trolley is used for positive and negative pressure adjustment, a reliable sterile environment is formed, injection in the product sleeve frame is guaranteed to be aseptically stored and transported, and cleanliness of air in the box body in the transportation trolley is guaranteed.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the structure of the transfer mechanism of the present invention;
FIG. 3 is a schematic view of the mounting assembly of the transfer mechanism of the present invention;
FIG. 4 is a schematic view of the structure of the conveying mechanism of the present invention;
FIG. 5 is a top view of the transfer assembly of the present invention;
FIG. 6 is a schematic view of the material alignment assembly of the conveying mechanism of the present invention;
FIG. 7 is a schematic structural view of a fresh air circulation assembly according to the present invention;
fig. 8 is a schematic structural diagram of an adjusting valve of the fresh air circulation assembly according to the present invention.
Detailed Description
The principles and features of this invention are described below in conjunction with the following drawings, which are set forth by way of illustration only and are not intended to limit the scope of the invention.
As shown in figure 1, an aseptic production transfer system of potassium dehydroandrographolide succinate for injection comprises a controller, a production mechanism 1, a product frame 2 for injection set, a conveying mechanism 3 positioned at the outlet end of the production mechanism 1, a transfer mechanism 4 butted with the conveying mechanism 3 and used for transferring potassium dehydroandrographolide succinate injection, and a freeze-drying unit 5 butted with the transfer mechanism 4 and used for freezing potassium dehydroandrographolide succinate injection, wherein the conveying mechanism 3 and the transfer mechanism 4 are respectively in communication connection with the controller. The production mechanism 1 adopts the existing potassium dehydroandrographolide succinate injection production structure. Product cover frame 2 is used for carrying out the suit to the injection, and the product cover frame 2 that the cover was equipped with the injection is placed and is carried on conveying mechanism 3, carries to the assigned position after, transports product cover frame 2 through transport mechanism 4 and shifts to freeze-drying unit 5 in, carries out freeze-drying operation to the injection, and rethread transport mechanism 4 transports product cover frame 2 to the assigned position after freeze-drying operation position accomplishes. The controller adopts STM32 singlechip.
As shown in fig. 1 to 2, the transfer mechanism 4 includes a conveying track 40 laid between the conveying mechanism 3 and the freeze-drying unit 5, a transfer cart 41 connected to the conveying track 40 in a matching manner, and a fresh air circulation assembly 42 disposed in the transfer cart 41, wherein product receiving ports of the transfer cart 41 correspond to an outlet end of the conveying mechanism 3 and an inlet end of the freeze-drying unit 5, respectively. The bottom end of the transfer trolley 41 is provided with a roller matched with the conveying track 40 and can move along the conveying track 40. The transfer trolley 41 is driven under the control of the controller to convey the product package frame 2 to the freeze-drying unit 5.
The transfer trolley 41 comprises a trolley body 410, a lifting mechanism 411 arranged on the trolley body 410 and a box 412 arranged at the upper end of the lifting mechanism 411, the fresh air circulation component 42 is located in the box 412, an opening 413 for the product frame 2 to enter and exit is formed in the end face of the box 412, a driving mechanism 414 for driving the product frame 2 to move is arranged in the box 412, and a door turnover mechanism 415 is arranged at the opening 413. Automobile body 410 drives whole dolly motion, thereby elevating system 411 liftable realizes the altitude mixture control of parts such as upper end box 412, make the opening 413 of box 412 aim at conveying mechanism 3's product cover frame 2 and place the department, and then store in pulling back product cover frame 2 to box 412 through actuating mechanism 414, and then transport to freeze-drying unit 5 department, highly adjust through elevating system 411 according to the entry of freeze-drying unit 5, make opening 413 be in the entry of freeze-drying unit 5 and align, and then through actuating mechanism 414 action with product cover frame 2 propelling movement to freeze-drying unit 5 in. The door body turning mechanism 415 is used for turning over the door body 422 covered at the opening 413 to open or close, when the product frame set 2 is placed in the box body 412, the door body 422 is covered at the opening 413 through the door body turning mechanism 415, and when the product frame set 2 is required to be transferred and pulled, the door body 422 is opened through the door body turning mechanism 415. The fresh air circulation component 42 is used for ensuring the sterile environment state in the box body 412, ensuring the injection in the product sleeve frame 2 to be in a clean environment, and simultaneously adjusting the positive pressure or negative pressure state in the box body 412. The lifting mechanism 4112 includes a base 20 provided on the vehicle body 4101, a lifting frame 21 provided on the base 20, and a fixing plate 22 provided on the lifting frame 21, and the box 4123 is provided on the fixing plate 22. The lifting frame 21 adopts a lifting frame 21 structure in the prior art, is of a plurality of crossed X-shaped structures, and drives the height adjustment of the upper end box 4123 through the lifting of the lifting frame 21, so that the alignment of the position of the opening 4137 and the storage position of the injection is ensured.
As shown in fig. 2, the driving mechanism 414 includes a driving motor 416 disposed in the box 412, a screw 417 coupled to an output end of the driving motor 416, and a fixing seat 418 disposed at an end of the screw 417, wherein the fixing seat 418 is disposed on an inner wall of the box 412, a bearing matched with the end of the screw 417 is disposed in the fixing seat 418, a mounting assembly 419 disposed on the fixing seat 418 and coupled to the product frame 2 is disposed, and the driving motor 416 is in communication connection with the controller. One end of the screw 417 is in power fit with the driving motor 416, and the other end is in rotational fit with a bearing of the fixing seat 418. The product frame 2 is fixed on the screw 417 through the mounting component 419, the rotation of the screw 417 is realized through the rotation of the driving motor 416, and in the rotation process of the screw 417, the mounting component 419 moves along the screw 417 to drive the product frame 2 to move. The driving motor 416 adopts a bidirectional forward and reverse rotation servo motor, and can easily realize the switching between forward rotation and reverse rotation. As shown in fig. 3, the mounting assembly 419 includes a mounting seat 420 connected to the screw 417 in a matching manner, and a push-pull seat 421 disposed on the mounting seat 420, the mounting seat 420 has an axial through hole, a thread groove matched with the thread tooth of the screw 417 is disposed in the through hole, and the product frame 2 is connected to the push-pull seat 421. The push-pull seat 421 is provided with a first magnetic buckle, and the product cover frame 2 is provided with a second magnetic buckle with opposite magnetism to the first magnetic buckle. The connection or disconnection between the push-pull seat 421 and the product frame 2 is realized by the attraction of the first magnetic attraction buckle and the second magnetic attraction buckle, the operation is convenient and reliable, and the first magnetic attraction buckle and the second magnetic attraction buckle are both electromagnets.
The door body turnover mechanism 415 includes a door body 422 provided at an opening 413 of the cabinet 412, a driving rod 423 provided on the door body 422, and a driving cylinder 424 connected to an end of the driving rod 423, the driving cylinder 424 being provided inside the cabinet 412. The actuating cylinder 424 adopts electronic jar, and electronic jar has flexible function, and for the push-and-pull action of actuating lever 423 provides power, when opening 413 is opened to needs, actuating cylinder 424 action drives actuating lever 423 extension and backs down a body 422 for opening 413 is opened, and when opening 413 was closed to needs, actuating cylinder 424 action drives actuating lever 423 withdrawal and pulls back a body 422, makes a body 422 lid close in opening 413 department.
As shown in fig. 4 to 5, the conveying mechanism 3 includes a transverse transmission assembly 30 disposed at an outlet end of the production mechanism 1, a radial transmission assembly 31 connected to an outlet end of the transverse transmission assembly 30, and a transfer assembly 32 disposed at an outlet end of the radial transmission assembly 31, wherein the transverse transmission assembly 30 is perpendicular to the radial transmission assembly 31. The transverse motion of the product is converted into radial motion through the cooperation of the transverse transmission assembly 30 and the radial transmission assembly 31, so that the subsequent transfer trolley 41 is transferred on the transfer platform 321, the transfer is reliable, and the stability is good.
The transfer assembly 32 includes a transfer frame 320, a transfer platform 321 disposed on the transfer frame 320, and a material alignment assembly 322 disposed on the transfer platform 321, an inlet end of the transfer platform 321 is connected to an outlet end of the radial transmission assembly 31, a transfer outlet is disposed on a side surface of the transfer platform 321, the transfer outlet is connected to an opening 413 of a box 412 on the transfer mechanism 4, and the product frame 2 is moved into the box 412 from the transfer platform 321 by a driving mechanism 414 of the transfer mechanism 4 and then transferred into the freeze-drying unit 5. Well revolving rack 320 provides reliable support for transfer in-process product cover frame 2, the high and radial transmission assembly 31's of transfer platform 321 outlet end parallel and level, guarantee that product cover frame 2 can link up and transport to the transfer platform 321 on, after product cover frame 2 reachs transfer platform 321, carry out the alignment arrangement operation in position to product cover frame 2 through neat material subassembly 322, this neat material subassembly 322 is three groups, set up respectively in the both sides of transfer platform 321 and keep away from the one end of radial conveying assembly.
The transverse transmission assembly 30 and the radial transmission assembly 31 both comprise a support frame 301, a carrier roller 302 arranged on the support frame 301, a conveyor belt 305 laid on the carrier roller 302 and a variable frequency motor 306 driving the carrier roller 302 to rotate, the conveyor belt 305 of the transverse transmission assembly 30 is perpendicular to the conveyor belt 305 of the radial transmission assembly 31, an operation space 303 is formed between the side surface of the transverse transmission assembly 30 and the side surface of the radial transmission assembly 31, and a mechanical arm 304 for framing the injection is arranged in the operation space 303. The driving motor 416 drives the carrier roller 302 to rotate, and further drives the conveyor belt 305 to move, so as to convey and transport the product sleeve frame 2.
As shown in fig. 6, the material aligning assembly 322 includes a telescopic cylinder 323 disposed on the transfer platform 321 and a material aligning plate 324 disposed on the telescopic cylinder 323, and a lower edge of the material aligning plate 324 is flush with an upper surface of the transfer platform 321. The telescopic cylinder 323 adopts an electric cylinder or an air cylinder, the aligning plate 324 is arranged on a piston rod of the telescopic cylinder 323, the aligning plate 324 is driven to move by the extension or retraction of the piston rod, and then the aligning plate 324 is used for arranging and aligning the product sleeve frame 2 on the transfer platform 321.
As shown in fig. 7 to 8, the fresh air circulation assembly 42 includes a circulation fan 420 disposed in the box 412, an air supply duct 421 disposed in the box 412 and at an outlet end of the circulation fan 420, a clean bin 422 disposed in the box 412 and at an air outlet of the air supply duct 421, and an air return duct 423 disposed at an air outlet of the clean bin 422, wherein the clean bin 422 has an inlet communicated with the opening 413; a high efficiency filter 424 is arranged between the air supply duct 421 and the clean cabin 422, a primary filter 425 and a secondary filter 426 are respectively arranged in the air return channel 423, the primary filter 425 and the secondary filter 426 are sequentially arranged along the wind conveying direction, a valve hole is arranged on the side wall of the air return channel 423 close to the primary filter 425, and an adjusting valve 427 is arranged in the valve hole. The triple filtering effect is formed by the primary filter 425, the middle filter 426 and the high-efficiency filter 424, the cleanness of air in the box body 412 is guaranteed, the free switching of positive pressure or negative pressure in the box body 412 is realized through the adjustment of the arranged adjusting valve 427, the control of a pressure adjusting range is realized through the limitation of the opening or closing size of the adjusting valve 427, the using performance is good, the cleaning reliability during the transfer in the laminar flow transfer trolley is guaranteed, the cleanliness of the laminar flow trolley is kept, the sterile transfer is achieved, and the safety performance in the transfer process is improved.
The regulating valve member 427 includes a regulating frame 428 provided on the side wall of the return air passage 423, a regulating valve plate 429 provided on the regulating frame 428, and the regulating valve plate 429 is slidably provided along the regulating frame 428. The size of this adjusting valve board 429 and alignment jig 428 looks adaptation, and through the restriction of adjusting the sliding position of valve board 429 along alignment jig 428, and then realize adjusting valve board 429 and open or close the control of size, promptly with the control of return air passageway 423 intercommunication mouth size, and then form the free regulation of malleation or negative pressure according to actual use needs.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The sterile production and transfer system of the potassium dehydroandrographolide succinate for injection is characterized by comprising a controller, a production mechanism (1), a product sleeve frame (2) for injection set, a conveying mechanism (3) positioned at the outlet end of the production mechanism (1), a transfer mechanism (4) which is in butt joint with the conveying mechanism (3) and is used for transferring the potassium dehydroandrographolide succinate injection, and a freeze-drying unit (5) which is in butt joint with the transfer mechanism (4) and is used for freezing the potassium dehydroandrographolide succinate injection, wherein the conveying mechanism (3) and the transfer mechanism (4) are respectively in communication connection with the controller;
transport mechanism (4) are including laying conveying mechanism (3) with delivery track (40), cooperation between freeze-drying unit (5) are connected transport dolly (41), setting on delivery track (40) are in fresh air circulation subassembly (42) in transport dolly (41), the product of transport dolly (41) accomodate the mouth respectively with the exit end of conveying mechanism (3) with the entrance point of freeze-drying unit (5) is corresponding.
2. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 1, wherein the transfer trolley (41) comprises a trolley body (410), a lifting mechanism (411) arranged on the trolley body (410) and a box body (412) arranged at the upper end of the lifting mechanism (411), the fresh air circulation component (42) is located in the box body (412), an opening (413) for the product frame (2) to enter and exit is arranged on the end surface of the box body (412), a driving mechanism (414) for driving the product frame (2) to move is arranged in the box body (412), and a door turnover mechanism (415) is arranged at the opening (413).
3. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 2, wherein the driving mechanism (414) comprises a driving motor (416) disposed in the box (412), a screw rod (417) fittingly connected to the output end of the driving motor (416), and a fixing seat (418) disposed at the end of the screw rod (417), the fixing seat (418) is disposed on the inner wall of the box (412), a bearing matched with the end of the screw rod (417) is disposed in the fixing seat (418), a mounting assembly (419) matched with the product casing (2) is disposed on the fixing seat (418), and the driving motor (416) is in communication connection with the controller.
4. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 3, wherein the mounting assembly (419) comprises a mounting seat (420) connected to the screw rod (417) in a matching manner and a push-pull seat (421) arranged on the mounting seat (420), the mounting seat (420) is axially provided with a through hole, a thread groove matched with the thread tooth of the screw rod (417) is arranged in the through hole, and the product sleeve frame (2) is connected with the push-pull seat (421);
the push-pull seat (421) is provided with a first magnetic attraction buckle, and the product sleeve frame (2) is provided with a second magnetic attraction buckle with the magnetism opposite to that of the first magnetic attraction buckle.
5. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in any one of claims 2 to 4, wherein the door body overturning mechanism (415) comprises a door body (422) arranged at the opening (413) of the box body (412), a driving rod (423) arranged on the door body (422), and a driving cylinder (424) connected to the end of the driving rod (423), the driving cylinder (424) is arranged in the box body (412).
6. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 1, wherein the conveying mechanism (3) comprises a transverse transmission assembly (30) disposed at the outlet end of the production mechanism (1), a radial transmission assembly (31) connected to the outlet end of the transverse transmission assembly (30), and a transfer assembly (32) disposed at the outlet end of the radial transmission assembly (31), wherein the transverse transmission assembly (30) and the radial transmission assembly (31) are perpendicular to each other.
7. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 6, wherein the transfer assembly (32) comprises a transfer frame (320), a transfer platform (321) disposed on the transfer frame (320) and a material alignment assembly (322) disposed on the transfer platform (321), the inlet end of the transfer platform (321) is connected to the outlet end of the radial transmission assembly (31), the side of the transfer platform (321) is provided with a transfer outlet, the transfer outlet is connected to the opening (413) of the box (412) on the transfer mechanism (4), and the product casing frame (2) is moved from the transfer platform (321) to the box (412) by the driving mechanism (414) of the transfer mechanism (4) and then transferred to the inside of the freeze-drying unit (5).
8. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 6, wherein each of the transverse transmission assembly (30) and the radial transmission assembly (31) comprises a support frame (301), a supporting roller (302) arranged on the support frame (301), a conveyor belt (305) laid on the supporting roller (302) and a variable frequency motor (306) for driving the supporting roller (302) to rotate, the conveyor belt (305) of the transverse transmission assembly (30) is perpendicular to the conveyor belt (305) of the radial transmission assembly (31), an operation space (303) is formed between the side surface of the transverse transmission assembly (30) and the side surface of the radial transmission assembly (31), and a mechanical arm (304) for framing the injection is arranged in the operation space (303).
9. The sterile production and transfer system of potassium dehydroandrographolide succinate for injection as claimed in claim 7, wherein the material alignment assembly (322) comprises a telescopic cylinder (323) arranged on the transfer platform (321), guide seats (325) respectively arranged at two sides of the telescopic cylinder (323), a guide rod (326) penetrating through the guide seats (325), and material alignment plates (324) arranged at the ends of the telescopic cylinder (323) and the guide rod, wherein the lower edges of the material alignment plates (324) are flush with the upper surface of the transfer platform (321).
10. The sterile production and transportation system of potassium dehydroandrographolide succinate for injection as claimed in claim 2, wherein the fresh air circulation assembly (42) comprises a circulation fan (420) disposed in the box body (412), an air supply duct (421) disposed in the box body (412) and located at an outlet end of the circulation fan (420), a clean bin (422) disposed in the box body (412) and located at an air outlet of the air supply duct (421), and a return air channel (423) disposed at an air outlet of the clean bin (422), the clean bin (422) having an inlet communicated with the opening (413); a high-efficiency filter (424) is arranged between the air supply duct (421) and the clean bin (422), a primary filter (425) and a middle-efficiency filter (426) are respectively arranged in the air return channel (423), the primary filter (425) and the middle-efficiency filter (426) are sequentially arranged along the wind conveying direction, a valve hole is formed in the side wall, close to the primary filter (425), of the air return channel (423), and an adjusting valve (427) is arranged in the valve hole;
the regulating valve member (427) comprises a regulating frame (428) arranged on the side wall of the return air channel (423), a regulating valve plate (429) arranged on the regulating frame (428), and the regulating valve plate (429) is arranged along the regulating frame (428) in a sliding way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110463845.4A CN114348329A (en) | 2021-04-28 | 2021-04-28 | Aseptic production transfer system of potassium dehydroandrographolide succinate for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110463845.4A CN114348329A (en) | 2021-04-28 | 2021-04-28 | Aseptic production transfer system of potassium dehydroandrographolide succinate for injection |
Publications (1)
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Citations (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002046854A (en) * | 2000-07-28 | 2002-02-12 | Fuji Electric Co Ltd | Alignment-transferring device of work |
| CN201530399U (en) * | 2009-10-09 | 2010-07-21 | 南京固延制药设备有限公司 | Class 100 laminar flow moving transport vehicle |
| CN102022809A (en) * | 2010-12-24 | 2011-04-20 | 奇瑞汽车股份有限公司 | Heating ventilating and air conditioning (HVAC) inner and outer circulation air door capable of regulating fresh air and return air ratio and regulation method of HVAC inner and outer circulation wind door |
| CN202207518U (en) * | 2011-08-15 | 2012-05-02 | 东莞市富莱仕空调净化科技有限公司 | Workbench with air return function |
| CN202320438U (en) * | 2011-11-28 | 2012-07-11 | 山东北大高科华泰制药有限公司 | Laminar flow car |
| CN202703201U (en) * | 2012-04-01 | 2013-01-30 | 苏州工业园区鸿基洁净科技有限公司 | Transfer vehicle |
| CN102963408A (en) * | 2012-12-14 | 2013-03-13 | 上海东富龙爱瑞思科技有限公司 | Horizontal laminar flow transfer trolley used for asepsis medicine transfer |
| CN103303676A (en) * | 2013-06-18 | 2013-09-18 | 深圳市华星光电技术有限公司 | Automation equipment for picking and placing large-sized liquid crystal substrate |
| CN203593412U (en) * | 2013-09-27 | 2014-05-14 | 上海东富龙科技股份有限公司 | Frame sleeving type automatic feeding-discharging system |
| CN103895902A (en) * | 2014-04-10 | 2014-07-02 | 江苏爱动力自动化设备有限公司 | Automatic arrangement device for storage battery packaging lines |
| CN204096448U (en) * | 2014-07-29 | 2015-01-14 | 上海东富龙科技股份有限公司 | A kind of frame of cover is automatically pneumatic pushes away frame reason bottle tables |
| CN204227877U (en) * | 2014-10-30 | 2015-03-25 | 上海东富龙科技股份有限公司 | Portable automatic feed/discharge system is gone out after a kind of advance |
| CN204549393U (en) * | 2015-03-25 | 2015-08-12 | 中山海济医药生物工程股份有限公司 | A kind of aseptic medicine is produced and is used dust-proof transport carriage |
| CN105173674A (en) * | 2015-08-28 | 2015-12-23 | 江苏通达动力科技股份有限公司 | Conveying belt for right-angled steering conveying for sheet materials |
| CN105293128A (en) * | 2015-11-12 | 2016-02-03 | 镇江市远兴包装机械有限公司 | Right-angle turning mechanism for paper conveying |
| CN205187301U (en) * | 2015-11-12 | 2016-04-27 | 青岛铸英特陶科技有限公司 | From turn tray conveyor |
| CN105947655A (en) * | 2016-06-24 | 2016-09-21 | 张家港市兰航机械有限公司 | Centering rail for mechanical arm |
| CN106123160A (en) * | 2016-06-08 | 2016-11-16 | 杭州龙碧科技有限公司 | A kind of new wind devices of variable air rate |
| CN106167166A (en) * | 2016-08-30 | 2016-11-30 | 河南启德隆实业有限公司 | A kind of automatic ejection alignment means cutting off production line for porous micro channel flat tube |
| CN107098013A (en) * | 2017-06-20 | 2017-08-29 | 天海欧康科技信息(厦门)有限公司 | A kind of bar cigarette conveying centralising device and centering method |
| CN107264900A (en) * | 2017-05-24 | 2017-10-20 | 李宪刚 | Industrial robot automatic processing method and device for logistics system |
| CN109693816A (en) * | 2017-10-23 | 2019-04-30 | 楚天科技股份有限公司 | A kind of pharmaceutical production system |
| CN110921248A (en) * | 2019-12-27 | 2020-03-27 | 东莞中睿智能设备有限公司 | AGV dolly with elevation structure |
| CN110980087A (en) * | 2019-12-18 | 2020-04-10 | 常州工学院 | Intelligent automatic book fetching bookshelf based on electromagnetic adsorption and control method thereof |
| CN111532809A (en) * | 2020-05-18 | 2020-08-14 | 中铁第四勘察设计院集团有限公司 | Horizontal push-pull type container alignment synchronous loading and unloading system |
| CN212299262U (en) * | 2020-09-25 | 2021-01-05 | 四川川净洁净技术股份有限公司 | Negative pressure sterile laminar flow transfer trolley |
| CN112320314A (en) * | 2020-11-27 | 2021-02-05 | 河北凡度机械科技有限公司 | Automatic feeding and discharging device and method for freeze-drying plate on freeze dryer |
-
2021
- 2021-04-28 CN CN202110463845.4A patent/CN114348329A/en active Pending
Patent Citations (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002046854A (en) * | 2000-07-28 | 2002-02-12 | Fuji Electric Co Ltd | Alignment-transferring device of work |
| CN201530399U (en) * | 2009-10-09 | 2010-07-21 | 南京固延制药设备有限公司 | Class 100 laminar flow moving transport vehicle |
| CN102022809A (en) * | 2010-12-24 | 2011-04-20 | 奇瑞汽车股份有限公司 | Heating ventilating and air conditioning (HVAC) inner and outer circulation air door capable of regulating fresh air and return air ratio and regulation method of HVAC inner and outer circulation wind door |
| CN202207518U (en) * | 2011-08-15 | 2012-05-02 | 东莞市富莱仕空调净化科技有限公司 | Workbench with air return function |
| CN202320438U (en) * | 2011-11-28 | 2012-07-11 | 山东北大高科华泰制药有限公司 | Laminar flow car |
| CN202703201U (en) * | 2012-04-01 | 2013-01-30 | 苏州工业园区鸿基洁净科技有限公司 | Transfer vehicle |
| CN102963408A (en) * | 2012-12-14 | 2013-03-13 | 上海东富龙爱瑞思科技有限公司 | Horizontal laminar flow transfer trolley used for asepsis medicine transfer |
| CN103303676A (en) * | 2013-06-18 | 2013-09-18 | 深圳市华星光电技术有限公司 | Automation equipment for picking and placing large-sized liquid crystal substrate |
| CN203593412U (en) * | 2013-09-27 | 2014-05-14 | 上海东富龙科技股份有限公司 | Frame sleeving type automatic feeding-discharging system |
| CN103895902A (en) * | 2014-04-10 | 2014-07-02 | 江苏爱动力自动化设备有限公司 | Automatic arrangement device for storage battery packaging lines |
| CN204096448U (en) * | 2014-07-29 | 2015-01-14 | 上海东富龙科技股份有限公司 | A kind of frame of cover is automatically pneumatic pushes away frame reason bottle tables |
| CN204227877U (en) * | 2014-10-30 | 2015-03-25 | 上海东富龙科技股份有限公司 | Portable automatic feed/discharge system is gone out after a kind of advance |
| CN204549393U (en) * | 2015-03-25 | 2015-08-12 | 中山海济医药生物工程股份有限公司 | A kind of aseptic medicine is produced and is used dust-proof transport carriage |
| CN105173674A (en) * | 2015-08-28 | 2015-12-23 | 江苏通达动力科技股份有限公司 | Conveying belt for right-angled steering conveying for sheet materials |
| CN105293128A (en) * | 2015-11-12 | 2016-02-03 | 镇江市远兴包装机械有限公司 | Right-angle turning mechanism for paper conveying |
| CN205187301U (en) * | 2015-11-12 | 2016-04-27 | 青岛铸英特陶科技有限公司 | From turn tray conveyor |
| CN106123160A (en) * | 2016-06-08 | 2016-11-16 | 杭州龙碧科技有限公司 | A kind of new wind devices of variable air rate |
| CN105947655A (en) * | 2016-06-24 | 2016-09-21 | 张家港市兰航机械有限公司 | Centering rail for mechanical arm |
| CN106167166A (en) * | 2016-08-30 | 2016-11-30 | 河南启德隆实业有限公司 | A kind of automatic ejection alignment means cutting off production line for porous micro channel flat tube |
| CN107264900A (en) * | 2017-05-24 | 2017-10-20 | 李宪刚 | Industrial robot automatic processing method and device for logistics system |
| CN107098013A (en) * | 2017-06-20 | 2017-08-29 | 天海欧康科技信息(厦门)有限公司 | A kind of bar cigarette conveying centralising device and centering method |
| CN109693816A (en) * | 2017-10-23 | 2019-04-30 | 楚天科技股份有限公司 | A kind of pharmaceutical production system |
| CN110980087A (en) * | 2019-12-18 | 2020-04-10 | 常州工学院 | Intelligent automatic book fetching bookshelf based on electromagnetic adsorption and control method thereof |
| CN110921248A (en) * | 2019-12-27 | 2020-03-27 | 东莞中睿智能设备有限公司 | AGV dolly with elevation structure |
| CN111532809A (en) * | 2020-05-18 | 2020-08-14 | 中铁第四勘察设计院集团有限公司 | Horizontal push-pull type container alignment synchronous loading and unloading system |
| CN212299262U (en) * | 2020-09-25 | 2021-01-05 | 四川川净洁净技术股份有限公司 | Negative pressure sterile laminar flow transfer trolley |
| CN112320314A (en) * | 2020-11-27 | 2021-02-05 | 河北凡度机械科技有限公司 | Automatic feeding and discharging device and method for freeze-drying plate on freeze dryer |
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