CN114343066B - 一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 - Google Patents
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 Download PDFInfo
- Publication number
- CN114343066B CN114343066B CN202210047837.6A CN202210047837A CN114343066B CN 114343066 B CN114343066 B CN 114343066B CN 202210047837 A CN202210047837 A CN 202210047837A CN 114343066 B CN114343066 B CN 114343066B
- Authority
- CN
- China
- Prior art keywords
- parts
- feed additive
- scorched
- cows
- dairy cows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000283690 Bos taurus Species 0.000 title claims abstract description 104
- 239000003674 animal food additive Substances 0.000 title claims abstract description 55
- 235000013365 dairy product Nutrition 0.000 title claims abstract description 43
- 208000007976 Ketosis Diseases 0.000 title claims abstract description 31
- 230000004140 ketosis Effects 0.000 title claims abstract description 31
- 230000001850 reproductive effect Effects 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 14
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 14
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 14
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 14
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 14
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 14
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 14
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 14
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 14
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 14
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 14
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 14
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 14
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 14
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 14
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 14
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 14
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 14
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 14
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 12
- 241000132012 Atractylodes Species 0.000 claims abstract description 12
- 235000017443 Hedysarum boreale Nutrition 0.000 claims abstract description 12
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims abstract description 12
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 12
- 244000197580 Poria cocos Species 0.000 claims abstract description 12
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims abstract description 12
- 240000004064 Poterium sanguisorba Species 0.000 claims abstract description 11
- 235000008291 Poterium sanguisorba Nutrition 0.000 claims abstract description 11
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims abstract description 11
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 10
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 9
- 235000006533 astragalus Nutrition 0.000 claims abstract description 9
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 6
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 6
- 240000004980 Rheum officinale Species 0.000 claims abstract description 6
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 17
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims description 9
- 240000009138 Curcuma zedoaria Species 0.000 claims description 9
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims description 9
- 235000019509 white turmeric Nutrition 0.000 claims description 9
- 244000164480 Curcuma aromatica Species 0.000 claims description 7
- 241000219061 Rheum Species 0.000 claims description 7
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 244000183685 Citrus aurantium Species 0.000 claims description 6
- 235000007716 Citrus aurantium Nutrition 0.000 claims description 6
- 235000014375 Curcuma Nutrition 0.000 claims description 6
- 244000008991 Curcuma longa Species 0.000 claims description 6
- 241000329195 Sparganium erectum Species 0.000 claims description 6
- 240000008042 Zea mays Species 0.000 claims description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 235000005822 corn Nutrition 0.000 claims description 6
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 241000228245 Aspergillus niger Species 0.000 claims description 5
- 240000006439 Aspergillus oryzae Species 0.000 claims description 5
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims description 5
- 241000223261 Trichoderma viride Species 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 235000003398 Curcuma aromatica Nutrition 0.000 claims description 4
- 229940107666 astragalus root Drugs 0.000 claims description 4
- 241001061264 Astragalus Species 0.000 claims description 3
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 3
- 235000003373 curcuma longa Nutrition 0.000 claims description 3
- 210000004233 talus Anatomy 0.000 claims description 3
- 235000013976 turmeric Nutrition 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 abstract description 38
- 239000008267 milk Substances 0.000 abstract description 38
- 210000004080 milk Anatomy 0.000 abstract description 38
- 230000008901 benefit Effects 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000002349 favourable effect Effects 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 14
- 230000001737 promoting effect Effects 0.000 description 13
- 235000021050 feed intake Nutrition 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 230000002354 daily effect Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 240000001972 Gardenia jasminoides Species 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 230000006651 lactation Effects 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 6
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 241000186660 Lactobacillus Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 230000001079 digestive effect Effects 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- 229940039696 lactobacillus Drugs 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000756943 Codonopsis Species 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 102000014171 Milk Proteins Human genes 0.000 description 3
- 108010011756 Milk Proteins Proteins 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 208000030159 metabolic disease Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000021243 milk fat Nutrition 0.000 description 3
- 235000021239 milk protein Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 210000004994 reproductive system Anatomy 0.000 description 3
- 210000001082 somatic cell Anatomy 0.000 description 3
- 244000061520 Angelica archangelica Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 description 2
- 244000170916 Paeonia officinalis Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 210000000003 hoof Anatomy 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 235000011477 liquorice Nutrition 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 235000006226 Areca catechu Nutrition 0.000 description 1
- 244000080767 Areca catechu Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 240000007890 Leonurus cardiaca Species 0.000 description 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 1
- 241000212322 Levisticum officinale Species 0.000 description 1
- 241001673966 Magnolia officinalis Species 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 208000021129 Postpartum disease Diseases 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 206010046793 Uterine inflammation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- 229960000355 copper sulfate Drugs 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000001645 levisticum officinale Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
Abstract
本发明公开了一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，所述饲料添加剂按重量计由如下组分制成：黄芪160‑230份、党参40‑80份、炒白术40‑60份、茯苓40‑60份、炙甘草40‑60份、当归50‑70份、茵陈80‑120份、栀子20‑40份、焦山楂50‑70份、焦麦芽50‑70份、焦神曲50‑70份、枳壳40‑60份、三棱20‑40份、莪术10‑20份、郁金10‑20份、地榆10‑30份、大黄10‑20份。该饲料添加剂口感良好，利于吸收，不仅能够有效防治新产牛酮病，而且能提升产奶量和乳品质，同时还能全面改善新产牛代谢，提高繁殖性能，能够从多方面提升新产奶牛各项机体指标，增加经济收益。
Description
技术领域
本发明涉及奶牛饲养领域，具体涉及一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂。
背景技术
奶牛酮病是泌乳奶牛常见的群发性疾病，也是围产期奶牛多发的一种营养代谢性疾病，以奶牛血清、尿液以及牛奶中酮体(β-羟丁酸、乙酰乙酸、丙酮)升高为主要特征，没有明显的季节性限制，产前21天至产后21天极易发生，多发于高产奶牛，影响重大，且近年来有逐渐上升的趋势。另外，酮病的发生还会引起奶牛产奶量和乳品质下降，引发产后真胃变位、子宫炎、体质下降和繁殖效率下降等潜在问题。
通过饲料添加剂来防治酮病是常用的方法，但是西药饲料添加剂尤其是抗菌药物饲料添加剂的弊端越来越显现，而中草药饲料添加剂具有无残留、生态环保等优点，成为减抗、替抗饲料添加剂的主力产品之一。例如，发明专利申请CN105663989A公开了一种用于防治奶牛消化型酮病的中药组合物及其制备方法，利用党参、当归、益母草，丹参，赤芍，熟地，砂仁，木香，苍术，厚朴，槟榔，麦芽，神曲，山楂，甘草等多种组分，针对消化型酮病患牛气血凝滞的病机特点，补血活血，降逆化浊，健脾和胃，强化新陈代谢，能够抑制酮体生成，防治奶牛消化型酮病。发明专利申请CN101822317A公开了一种防治奶牛酮病的复方饲料添加剂，利用当归、赤芍、川芎、熟地等中药组分和丙酸钠、硫酸铜、硫酸锰等无机成分相结合对酮病进行预防和治疗。
但是，上述两种饲料添加剂以及市面上常见的中药类型的饲料添加剂主要针对奶牛酮病的防治并进行研究，而对于提升新产牛生产性能和后期繁殖性能没有明显的效果，但是新产牛生产性能和后期繁殖性能均对奶牛饲养具有重要的意义，因此，将防治奶牛酮病与改善其生产性能及繁殖性能进行有效结合才更加全面的改善新产牛的各项指标，增加奶牛养殖的经济收益，且有助于实现牛场健康发展和良好经济效益。基于上述原因，期待一种既能够防治奶牛酮病同时还能够改善其生产性能及繁殖性能的多功能饲料添加剂。
发明内容
本发明的目的是提供一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，该饲料添加剂口感良好，利于吸收，不仅能够有效防治新产牛酮病，而且能全面改善新产牛代谢，同时还能提升产奶量和乳品质质量及繁殖性能，能够从多方面提升新产奶牛各项机体指标，增加奶牛养殖的经济收益。
为实现上述目的，本发明采取以下技术方案：
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，按重量计由如下组分制成：黄芪160-230份、党参40-80份、炒白术40-60份、茯苓40-60份、炙甘草40-60份、当归50-70份、茵陈80-120份、栀子20-40份、焦山楂50-70份、焦麦芽50-70份、焦神曲50-70份、枳壳40-60份、三棱20-40份、莪术10-20份、郁金10-20份、地榆10-30份、大黄10-20份。
优选的，按重量计由如下组分制成：黄芪180份、党参50份、炒白术50份、茯苓50份、炙甘草50份、当归60份、茵陈100份、栀子30份、焦山楂60份、焦麦芽60份、焦神曲60份、枳壳50份、三棱30份、莪术15份、郁金15份、地榆20份、大黄15份。
优选的，按重量计由如下组分制成：黄芪160份、党参40份、炒白术40份、茯苓40份、炙甘草40份、当归50份、茵陈80份、栀子20份、焦山楂50份、焦麦芽50份、焦神曲50份、枳壳40份、三棱20份、莪术10份、郁金10份、地榆10份、大黄10份。
优选的，按重量计由如下组分制成：黄芪230份、党参80份、炒白术60份、茯苓60份、炙甘草60份、当归70份、茵陈120份、栀子40份、焦山楂70份、焦麦芽70份、焦神曲70份、枳壳60份、三棱40份、莪术20份、郁金20份、地榆30份、大黄20份。
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂的制备方法，包括如下步骤：
S1：将所述饲料添加剂的组分研磨后充分混合，得到中药组合物；
S2：用1%质量比的酿酒酵母2*108 CFU/g、米曲霉1*105CFU/g、黑曲霉1*106 CFU/g、绿色木霉1*106 CFU/g和乳酸菌2*107 CFU/g的复合微生物和5%质量比的玉米粉做基料，对中药组合物进行厌氧发酵7天。
上述技术方案中，组方中黄芪大补脾胃元气、扶正固表，党参补中益气和胃生津，二药互补，共为主药。茯苓利水渗湿，白术健脾燥湿，当归补血活血，共为辅药，与黄芪、党参共同完成益气健脾，气血双补，固本培元，提高基础免疫力功效。茵陈清热利湿、退黄，栀子清热利湿、凉血解毒，大黄泻下攻积，清泄湿热，三药合用，清热利湿退黄，通利二便，可以改善新产牛血脂，也有助于提升乳品质；焦神曲、焦山楂消食导滞，健脾除胀，助消化，增加采食量，有助于提高新产牛营养获取水平，炙甘草和中缓急，润肺，解毒，调和诸药，共为佐药；三棱破血行气，消积祛瘀止痛；莪术破血行气，消积止痛，可以有效缓解奶牛产后可能产生的血瘀腹痛、心腹胀痛和血瘀经闭，郁金行气解郁，凉血破瘀，三药合用，对新产奶牛血瘀气滞，脾胃虚弱问题有辅助作用，兼且三药活血行气，改善微循环，可以引导诸药，达到相应脏腑、组织，强化药物对机体功能的改善作用，是为使药。诸药合剂，共凑扶正固本，补益气血消食化积，祛瘀止痛功效。有效促进新产奶牛机体机能恢复，全面提升新产牛体质，提高免疫力，促进消化机能旺盛，恢复生殖系统功能；通过改善消化机能，迅速提高奶牛采食量，减少营养负平衡，从而有效预防酮病等代谢性疾病的发生，降低发病率，减少死亡淘汰率，提高奶牛高峰日产奶量和乳品质；促进生殖系统功能恢复，减少生殖系统疾病发病率，提高下次配种受胎率，提高养殖效益。同时，本饲料添加剂使用五种复合菌株配合玉米粉基料进行发酵，这样既可以保留中药有效成分，又可以切断中药中大分子链，便于被牛体吸收，提升口感，容易被牛群接受。
具体实施方式
下面通过具体实施例，对本发明做进一步说明。
实施例1
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，按重量计由如下组分制成：黄芪180份、党参50份、炒白术50份、茯苓50份、炙甘草50份、当归60份、茵陈100份、栀子30份、焦山楂60份、焦麦芽60份、焦神曲60份、枳壳50份、三棱30份、莪术15份、郁金15份、地榆20份、大黄15份。
上述饲料添加剂的制备方法包括：
S1：将所述饲料添加剂的组分研磨后充分混合，得到中药组合物；
S2：用1%质量比的酿酒酵母2*108 CFU/g、米曲霉1*105CFU/g、黑曲霉1*106 CFU/g、绿色木霉1*106 CFU/g和乳酸菌2*107 CFU/g的复合微生物和5%质量比的玉米粉做基料，对中药组合物进行厌氧发酵7天。
实施例2
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，按重量计由如下组分制成：黄芪160份、党参40份、炒白术40份、茯苓40份、炙甘草40份、当归50份、茵陈80份、栀子20份、焦山楂50份、焦麦芽50份、焦神曲50份、枳壳40份、三棱20份、莪术10份、郁金10份、地榆10份、大黄10份。
上述饲料添加剂的制备方法包括：
S1：将所述饲料添加剂的组分研磨后充分混合，得到中药组合物；
S2：用1%质量比的酿酒酵母2*108 CFU/g、米曲霉1*105CFU/g、黑曲霉1*106 CFU/g、绿色木霉1*106 CFU/g和乳酸菌2*107 CFU/g的复合微生物和5%质量比的玉米粉做基料，对中药组合物进行厌氧发酵7天。
实施例3
一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，按重量计由如下组分制成：黄芪230份、党参80份、炒白术60份、茯苓60份、炙甘草60份、当归70份、茵陈120份、栀子40份、焦山楂70份、焦麦芽70份、焦神曲70份、枳壳60份、三棱40份、莪术20份、郁金20份、地榆30份、大黄20份。
上述饲料添加剂的制备方法包括：
S1：将所述饲料添加剂的组分研磨后充分混合，得到中药组合物；
S2：用1%质量比的酿酒酵母2*108 CFU/g、米曲霉1*105CFU/g、黑曲霉1*106 CFU/g、绿色木霉1*106 CFU/g和乳酸菌2*107 CFU/g的复合微生物和5%质量比的玉米粉做基料，对中药组合物进行厌氧发酵7天。
效果比对
实验组
选择一个2000多头规模相对较大的奶牛场，在不影响奶牛场正常生产情况下，采用完全随机区组设计，依据胎次、体况评分、上一泌乳周期总产奶量相近的原则随机选取50头新产牛作为实验组，在饲喂常规日粮的基础之上，对每头牛每天添加100g实施例1制备的饲料添加剂。饲料添加剂通过小型TMR全混合型搅拌机充分混合后，再进行饲喂。饲喂试验期为65天，从第1头牛进入新产圈到第50头牛转出新产圈。饲养管理按牛场原有程序常规进行。然后从50头牛中随机选择10头2～3胎次、体况评分在3分左右、产奶量10吨左右的新产牛作为实验组样本，进行数据采集并进行产奶量、乳指标和血清生化指标的样本测试。采食量由于TMR全混合日粮饲喂，只能测全群采食量，然后计算平均每头牛的日均采食量。
对比例1 空白对照组
选择一个2000多头规模相对较大的奶牛场，在不影响奶牛场正常生产情况下，采用完全随机区组设计，依据胎次、体况评分、上一泌乳周期总产奶量相近的原则随机选取50头新产牛作为空白对照组，饲喂常规日粮。饲喂试验期为71天，从第1头牛进入新产圈到第50头牛转出新产圈。饲养管理按牛场原有程序常规进行。然后从50头牛中随机选择10头2～3胎次、体况评分在3分左右、产奶量10吨左右的新产牛作为空白对照组样本，进行样本采集，并进行产奶量、乳指标和血清生化指标的样本测试。
对比例2 市售饲料添加剂对照组
选择一个2000多头规模相对较大的奶牛场，在不影响奶牛场正常生产情况下，采用完全随机区组设计，依据胎次、体况评分、上一泌乳周期总产奶量相近的原则随机选取50头新产牛作为市售饲料添加剂对照组，在饲喂常规日粮的基础之上，对每头牛每天添加适量的市售添加剂（市售添加剂为市面上可以通过购买获取即可，饲料饲喂量依据市售添加剂的说明书指导用量）。饲料添加剂通过小型TMR全混合型搅拌机充分混合后，再进行饲喂。饲喂试验期为60天，从第1头牛进入新产圈到第50头牛转出新产圈。饲养管理按牛场原有程序常规进行。然后从50头牛中随机选择10头2～3胎次、体况评分在3分左右、产奶量10吨左右的新产牛作为市售饲料添加剂组样本，进行样本采集，并进行产奶量、乳指标和血清生化指标的样本测试。
实验组和对比例1、对比例2的实验结果
1.1对采食量和产奶量的影响
试验结束前5天，每天称取实验组和对比例1、对比例2新产牛样本的投料量和剩料量及记录牛头数和每头牛的泌乳天数，计算每天每头牛的平均采食量，记录30头样本牛产后3～30天的产奶量，然后计算日均产奶量。结果如下表1所示：
表1采食量和产奶量检测结果（kg/头/d）
注：同行数字肩标不同小写字母表示差异显著（P<0.05），含有相同字母或者没有字母，表示异不显著（P>0.05），下同。
从表1数据得知，由于奶牛个体间差异较大，三组样本牛试验结束前5天(平均泌乳天数为产后第14天)每头牛的日均采食量差异不显著（P>0.05），但实验组高于空白对照组和市售饲料添加剂组，实验组比空白对照组这5天的日均采食量高1.98kg，比市售添加剂组高0.82kg。三组产奶量差异也不显著（P>0.05），但产奶量亦是实验组最高，比空白对照组平均高1.51kg/头/天，比市售饲料组高0.95kg/头/天。
1.2对乳品质的影响
于实验组和对比例1、对比例2中的30头样本牛，第30天转群，当天采集早、晚2 次的乳样，按1：1混合后，放入含有防腐剂的奶样收集瓶中，检测乳品质。其中包括乳脂率、乳蛋白率、乳尿素氮含量和乳体细胞数等，结果如下表2所示：
表2乳品质检测结果
从表2数据得知，各组乳脂率、乳蛋白率、体细胞数、尿素氮含量均没有显著差异（P>0.05），但实验组乳脂率、乳蛋白率均高于空白对照组和市售饲料添加剂组，体细胞数实验组、市售饲料添加剂组相对于空白对照组均降低，尿素氮实验组、市售饲料添加剂组相对于空白对照组有所提高，但均在正常范围内。因此综合而言，实验组的奶品质最高。
1.3对奶牛血液生化指标的影响
于实验组和对比例1、对比例2中的30头样本牛，第30天转群，当天晨饲前进行牛尾跟静脉采集血液10mL ,立即3500r/min离心5min后分离血清,随后立即将其带回实验室置于-20°C冰箱中,贮存待检以下指标（血液指标：葡萄糖、胰岛素、游离脂肪酸、β-羟丁酸），实验结果如下表3所示：
表3血糖血脂和胰岛素的检测结果
由表3得知，血清葡萄糖水平实验组、市售饲料添加剂组显著高于空白对照组（P<0.05），市售饲料添加剂组高于实验组，但差异不显著（P>0.05）。β-羟丁酸水平实验组显著低于空白对照组（P<0.05），低于市售饲料添加剂组，但两组差异不显著（P>0.05）；游离脂肪酸实验组、市售饲料添加剂组低于空白对照组，但各组水平差异均不显著（P>0.05）。胰岛素水平实验组低于空白对照组，市售饲料添加剂组稍微高于空白对照组，但各组水平差异均不显著（P>0.05）。综上，实验组整体测试结果较佳。
1.4对酮病发生率和繁殖性能的影响
实验组和对比例1、对比例2中，从本试验开始到这150头牛全部配种或者淘汰我们跟踪发现，在产后第7天、14天和21天我们试纸条快速检测各奶牛血酮含量时（每头牛平均检测3次）发现空白对照组有9头奶牛血清酮体含量大于1.2mmol/ L，发病率为18%；实验组有2头奶牛，发病率为4%，市售饲料添加剂组有4头奶牛，酮病发病率为8%。另从下表4可以看出，实验组和对比例1、对比例2三组的平均产后首次配种时间分别产后71天、64天、66天，妊娠配种次数分别为2.6次、1.9次、2.3次，首次情期受胎率为34.04%、42.86%、38.78%。空白对照组因乳房炎淘汰2头牛，蹄病淘汰1头牛，实验组因蹄病淘汰1头牛；市售饲料添加剂组因乳房炎淘汰1头牛。综上所述，实验组整体表现较其他两组好。
表4不同水平发酵中草药饲料添加剂对产后疾病发生和繁殖性能的影响
综上所述，实验组即在饲喂日常饲料的情况下每天添加本配方下的饲料添加剂，能够在采食量和产奶量、乳品质、血液生化指标以及酮病发生率和繁殖性能等方面具有良好效果，能够在防治奶牛酮病的同时，对新产牛的多项身体指标以及产奶量和奶品质上均有较大的提升，利于全面提升新产牛体质，提高免疫力，降低奶牛酮病等代谢性疾病的发病率，减少死亡淘汰率，提高奶牛高峰日产奶量和乳品质及后期繁殖性能，增加经济效益。
上述实施例只是对本发明构思和实现的若干说明，并非对其进行限制，在本发明构思下，未经实质变换的技术方案仍然在保护范围内。
Claims (4)
1.一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，其特征在于，按重量计由如下组分组成：黄芪160-230份、党参40-80份、炒白术40-60份、茯苓40-60份、炙甘草40-60份、当归50-70份、茵陈80-120份、栀子20-40份、焦山楂50-70份、焦麦芽50-70份、焦神曲50-70份、枳壳40-60份、三棱20-40份、莪术10-20份、郁金10-20份、地榆10-30份、大黄10-20份；
饲料添加剂的制备包括如下步骤：
S1：将所述饲料添加剂的所有组分研磨后充分混合，得到中药组合物备用；
S2：用1%质量比的酿酒酵母2×108 CFU/g、米曲霉1×105CFU/g、黑曲霉1×106 CFU/g、绿色木霉1×106 CFU/g和乳酸菌2×107 CFU/g组成的复合微生物和5%质量比的玉米粉混合后作为基料，并用所述基料对中药组合物进行厌氧发酵7天。
2.如权利要求1所述的防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，其特征在于，按重量计由如下组分组成：黄芪180份、党参50份、炒白术50份、茯苓50份、炙甘草50份、当归60份、茵陈100份、栀子30份、焦山楂60份、焦麦芽60份、焦神曲60份、枳壳50份、三棱30份、莪术15份、郁金15份、地榆20份、大黄15份。
3.如权利要求1所述的防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，其特征在于，按重量计由如下组分组成：黄芪160份、党参40份、炒白术40份、茯苓40份、炙甘草40份、当归50份、茵陈80份、栀子20份、焦山楂50份、焦麦芽50份、焦神曲50份、枳壳40份、三棱20份、莪术10份、郁金10份、地榆10份、大黄10份。
4.如权利要求1所述的防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂，其特征在于，按重量计由如下组分组成：黄芪230份、党参80份、炒白术60份、茯苓60份、炙甘草60份、当归70份、茵陈120份、栀子40份、焦山楂70份、焦麦芽70份、焦神曲70份、枳壳60份、三棱40份、莪术20份、郁金20份、地榆30份、大黄20份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210047837.6A CN114343066B (zh) | 2022-01-17 | 2022-01-17 | 一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210047837.6A CN114343066B (zh) | 2022-01-17 | 2022-01-17 | 一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114343066A CN114343066A (zh) | 2022-04-15 |
| CN114343066B true CN114343066B (zh) | 2024-02-20 |
Family
ID=81091513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210047837.6A Active CN114343066B (zh) | 2022-01-17 | 2022-01-17 | 一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114343066B (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822317A (zh) * | 2010-04-23 | 2010-09-08 | 东北农业大学 | 一种防治奶牛酮病的复方饲料添加剂及制备方法 |
| CN102247570A (zh) * | 2011-08-25 | 2011-11-23 | 格特生物制药（天津）有限公司 | 一种治疗奶牛酮病的中药组合物 |
| CN105663989A (zh) * | 2016-03-21 | 2016-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | 一种用于防治奶牛消化型酮病的中药组合物及其制备方法 |
| CN108371252A (zh) * | 2018-03-16 | 2018-08-07 | 莱阳和美华饲料有限责任公司 | 一种促进母猪产后炎症康复和催乳的中药发酵饲料添加剂及其制备方法和应用 |
| CN109315586A (zh) * | 2018-10-10 | 2019-02-12 | 湖北华大瑞尔科技有限公司 | 一种反刍动物用发酵中草药生物饲料的制备方法与应用 |
-
2022
- 2022-01-17 CN CN202210047837.6A patent/CN114343066B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822317A (zh) * | 2010-04-23 | 2010-09-08 | 东北农业大学 | 一种防治奶牛酮病的复方饲料添加剂及制备方法 |
| CN102247570A (zh) * | 2011-08-25 | 2011-11-23 | 格特生物制药（天津）有限公司 | 一种治疗奶牛酮病的中药组合物 |
| CN105663989A (zh) * | 2016-03-21 | 2016-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | 一种用于防治奶牛消化型酮病的中药组合物及其制备方法 |
| CN108371252A (zh) * | 2018-03-16 | 2018-08-07 | 莱阳和美华饲料有限责任公司 | 一种促进母猪产后炎症康复和催乳的中药发酵饲料添加剂及其制备方法和应用 |
| CN109315586A (zh) * | 2018-10-10 | 2019-02-12 | 湖北华大瑞尔科技有限公司 | 一种反刍动物用发酵中草药生物饲料的制备方法与应用 |
Non-Patent Citations (1)
| Title |
|---|
| 复方中草药添加剂对围产期奶牛泌乳性能和初乳品质的影响;何立宁;吕洁;赵兴鑫;东贤;宋瑞;王会影;;中国饲料(04);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114343066A (zh) | 2022-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103976190B (zh) | 猪饲料及其应用 | |
| CN105053637A (zh) | 一种含有猪肠粘膜蛋白的仔猪配合饲料及其制备方法 | |
| CN105994950A (zh) | 发酵豆粕及其制备方法 | |
| CN103355499A (zh) | 改善猪肉品质和提高饲料利用率的饲料添加剂及其制备 | |
| CN105166459A (zh) | 一种猪饲料 | |
| AU2020102519A4 (en) | Feed additive with the effect of promoting lactation and improving meat quality | |
| CN108887495B (zh) | 含无刺激气味天然提取组分的无抗育肥羊饲料及制备 | |
| CN108653518A (zh) | 一种益生菌发酵中药制剂及其制备方法 | |
| CN105614113A (zh) | 一种仔猪抗腹泻复合中草药饲料及其制备方法 | |
| CN107912616A (zh) | 一种用于提高肉牛育肥性能的中草药添加剂及其制备方法、使用方法及应用 | |
| CN105685476A (zh) | 一种石斑鱼饲料及其制备方法 | |
| CN105379973A (zh) | 一种山羊饲料 | |
| CN104247860A (zh) | 一种治疗奶牛泄泻的发酵中草药饲料添加剂 | |
| CN105707488A (zh) | 一种用于增强仔猪免疫力的中药微生态制剂及其制备方法 | |
| CN114343066B (zh) | 一种防治奶牛酮病并改善其生产及繁殖性能的饲料添加剂 | |
| CN112106886A (zh) | 一种饲喂家畜的鲜竹叶与药渣配合饲料的制备方法 | |
| CN102204623B (zh) | 一种中药提取剩余物饲料及其制备方法 | |
| CN114176170B (zh) | 一种功能型饲料添加剂及其制备方法和应用 | |
| CN113080335A (zh) | 一种提高蛋禽生产性能的发酵中药添加剂及其制备方法 | |
| CN112056460A (zh) | 一种含川芎成分的天然饲料 | |
| CN112043730A (zh) | 一种防治动物疫病的中药生物制剂 | |
| CN111000037A (zh) | 一种高硒辅助抗癌羊奶及其生产方法 | |
| CN110692835A (zh) | 一种提高母猪繁殖性能的植物提取物饲料添加剂 | |
| CN104256182A (zh) | 一种治疗奶牛便血的发酵中草药饲料添加剂 | |
| CN107751095A (zh) | 一种母猪的养殖方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |