CN114340608A - 一种药物组合物及其应用 - Google Patents
一种药物组合物及其应用 Download PDFInfo
- Publication number
- CN114340608A CN114340608A CN202180005272.9A CN202180005272A CN114340608A CN 114340608 A CN114340608 A CN 114340608A CN 202180005272 A CN202180005272 A CN 202180005272A CN 114340608 A CN114340608 A CN 114340608A
- Authority
- CN
- China
- Prior art keywords
- bupropion
- salt
- deuterated dextromethorphan
- mass ratio
- dextromethorphan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 45
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- 229960001058 bupropion Drugs 0.000 claims description 155
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 112
- 150000003839 salts Chemical class 0.000 claims description 110
- AKOAEVOSDHIVFX-UHFFFAOYSA-N Hydroxybupropion Chemical compound OCC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 AKOAEVOSDHIVFX-UHFFFAOYSA-N 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 29
- 229940079593 drug Drugs 0.000 claims description 18
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- 238000002360 preparation method Methods 0.000 claims description 12
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- A61P25/00—Drugs for disorders of the nervous system
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
提供了药物组合应用技术领域，具体涉及一种药物组合物及其应用。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311304808.4A CN117100750A (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010698924 | 2020-07-20 | ||
| CN2020106989249 | 2020-07-20 | ||
| CN202110799063 | 2021-07-15 | ||
| CN2021107990638 | 2021-07-15 | ||
| PCT/CN2021/106973 WO2022017300A1 (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311304808.4A Division CN117100750A (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114340608A true CN114340608A (zh) | 2022-04-12 |
| CN114340608B CN114340608B (zh) | 2023-10-31 |
Family
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| CN202311304808.4A Pending CN117100750A (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
| CN202180005272.9A Active CN114340608B (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202311304808.4A Pending CN117100750A (zh) | 2020-07-20 | 2021-07-19 | 一种药物组合物及其应用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4183391A4 (zh) |
| CN (2) | CN117100750A (zh) |
| TW (1) | TW202206075A (zh) |
| WO (1) | WO2022017300A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11969421B2 (en) | 2013-11-05 | 2024-04-30 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| CN115322150B (zh) * | 2021-05-11 | 2024-05-28 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途 |
| WO2024006853A1 (en) | 2022-06-30 | 2024-01-04 | Antecip Bioventures Ii Llc | Treatment of poor metabolizers of dextromethorphan with a combination of bupropion and dextromethorphan |
| US11844797B1 (en) * | 2023-04-20 | 2023-12-19 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
| US20240066025A1 (en) * | 2022-07-07 | 2024-02-29 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190241525A1 (en) * | 2016-07-04 | 2019-08-08 | Avanir Pharmaceuticals, Inc. | Methods for the synthesis of deuterated dextromethorphan |
| CN110279682A (zh) * | 2013-11-05 | 2019-09-27 | 安泰赛普生物风投二代有限责任公司 | 包含安非他酮或相关化合物和右美沙芬的组合物和方法 |
| CN111297860A (zh) * | 2014-11-21 | 2020-06-19 | 安泰赛普生物风投二代有限责任公司 | 使用赤式羟基安非他酮调节药物血浆水平的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015519B (zh) * | 2007-02-27 | 2012-03-21 | 重庆医药工业研究院有限责任公司 | 一种氯雷他定口服复方药物组合物 |
| AU2008247818B2 (en) | 2007-05-01 | 2011-10-20 | Sun Pharmaceutical Industries, Inc. | Morphinan compounds |
| CN101254249B (zh) * | 2008-03-20 | 2011-01-12 | 张辉 | 一种治疗咳嗽痰多症的中西药复方制剂及其生产方法 |
| US20120083487A1 (en) * | 2008-10-30 | 2012-04-05 | Amanda Thomas | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurolgical diseases, intractable and chronic pain and brain injury |
| CN104195218A (zh) * | 2014-09-03 | 2014-12-10 | 广东中西达一新药开发有限公司 | 一种细胞色素p450酶的特异性探针底物组合物及其应用 |
| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
-
2021
- 2021-07-19 CN CN202311304808.4A patent/CN117100750A/zh active Pending
- 2021-07-19 CN CN202180005272.9A patent/CN114340608B/zh active Active
- 2021-07-19 EP EP21846859.3A patent/EP4183391A4/en active Pending
- 2021-07-19 WO PCT/CN2021/106973 patent/WO2022017300A1/zh unknown
- 2021-07-19 TW TW110126404A patent/TW202206075A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279682A (zh) * | 2013-11-05 | 2019-09-27 | 安泰赛普生物风投二代有限责任公司 | 包含安非他酮或相关化合物和右美沙芬的组合物和方法 |
| CN111297860A (zh) * | 2014-11-21 | 2020-06-19 | 安泰赛普生物风投二代有限责任公司 | 使用赤式羟基安非他酮调节药物血浆水平的方法 |
| US20190241525A1 (en) * | 2016-07-04 | 2019-08-08 | Avanir Pharmaceuticals, Inc. | Methods for the synthesis of deuterated dextromethorphan |
Also Published As
| Publication number | Publication date |
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| EP4183391A4 (en) | 2024-04-17 |
| CN114340608B (zh) | 2023-10-31 |
| TW202206075A (zh) | 2022-02-16 |
| WO2022017300A1 (zh) | 2022-01-27 |
| EP4183391A1 (en) | 2023-05-24 |
| CN117100750A (zh) | 2023-11-24 |
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