CN114306308A - Nutritional supplement containing ketoesters and application thereof - Google Patents

Nutritional supplement containing ketoesters and application thereof Download PDF

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Publication number
CN114306308A
CN114306308A CN202111597532.4A CN202111597532A CN114306308A CN 114306308 A CN114306308 A CN 114306308A CN 202111597532 A CN202111597532 A CN 202111597532A CN 114306308 A CN114306308 A CN 114306308A
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China
Prior art keywords
nutritional supplement
parts
ketoesters
ketoester
combination
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Pending
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CN202111597532.4A
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Chinese (zh)
Inventor
樊继标
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Suzhou Mailun Biotechnology Co ltd
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Suzhou Mailun Biotechnology Co ltd
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Priority to CN202111597532.4A priority Critical patent/CN114306308A/en
Publication of CN114306308A publication Critical patent/CN114306308A/en
Pending legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a nutritional supplement containing ketoester and application thereof, wherein the nutritional supplement comprises the following components in parts by weight: 20-50 parts of ketoester and 150-300 parts of medicinal carrier; the nutritional supplement is in liquid form; the medicinal carrier is one or any combination of citric acid, ascorbic acid, benzoic acid and lactate. The nutritional supplement is applied to a human subject at a dose of 2-4 mg/day, and is administered to the subject at least twice a day for at least 1 month or more, and has a display effect in the aspects of improving physical quality, cognitive ability and endurance.

Description

Nutritional supplement containing ketoesters and application thereof
Technical Field
The invention relates to the technical field of chemical industry, in particular to a nutritional supplement containing ketoester and application thereof.
Background
Ketone esters, which are exogenous ketones, reach ketosis in humans soon after consumption of ketoesters. Ketosis is a state pursued by ketogenic diet, and in ketosis, a human body burns fat to generate energy, so that the human body does not feel hunger, and the cognitive ability of the human body is clearer. Ketosis is a state of nature of the human body and is often produced when ancient food is insufficient. In recent times, the body produces few cases because of the abundance of food. Meanwhile, because the carbohydrate is relatively abundant, a series of metabolic problems are generated.
In addition, several related studies using ketoesters have demonstrated that ketoesters can bring a variety of benefits: improving vascular endothelial function, improving oxidative stress and mitochondrial function, improving inflammation, promoting cardiac remodeling, and improving cardiovascular risk factors including blood pressure, body weight, blood glucose and blood lipid.
Therefore, the nutritional supplement containing the ketoester and the application thereof are provided, and the nutritional supplement has important significance for application and popularization.
Disclosure of Invention
In view of the above, the present application aims to provide a nutritional supplement containing ketoesters and its application, so as to expand the application thereof.
In order to achieve the above object, the present application provides the following technical solutions.
The first technical scheme is as follows: a nutritional supplement containing ketoesters comprises the following components in parts by weight: 20-50 parts of ketoester and 150-300 parts of medicinal carrier; the nutritional supplement is in liquid form.
Preferably, the nutritional supplement containing the ketoester comprises the following components in parts by weight: 30-40 parts of ketoester and 200-250 parts of medicinal carrier.
Preferably, the pharmaceutically acceptable carrier is one or any combination of citric acid, ascorbic acid, benzoic acid and lactate.
Preferably, the medicinal carrier is one or any combination of benzoic acid, glycerol, propylene glycol and polyethylene glycol.
Preferably, the pharmaceutically acceptable carrier is one or any combination of potassium hydroxide, sodium bicarbonate, calcium carbonate, silicon dioxide and magnesium aluminum silicate.
Preferably, the nutritional supplement further comprises an antioxidant, wherein the antioxidant is one or any combination of ellagic acid, quercetin, lipoic acid and vitamin C.
Preferably, the synthesis method of the ketoester is characterized in that the ketoester is synthesized by the enzymatic synthesis of R-3-hydroxy ethyl butyrate and (R) - (-) -1, 3-butanediol according to the proportion.
The second technical scheme is as follows: use of a nutritional supplement comprising ketoesters for improving physical fitness, cognitive performance and endurance in a human subject, said nutritional supplement being administered to said human subject at a dosage of 2-4 mg/day.
Preferably, the nutritional supplement is administered to the subject at least twice daily for at least 1 month or more.
The beneficial technical effects obtained by the invention are as follows:
the nutritional supplement comprises the following components in parts by weight: 20-50 parts of ketoester and 150-300 parts of medicinal carrier; the nutritional supplement is one of a tablet and a capsule; the nutritional supplement is administered to a human subject at a dosage of 2-4 mg/day for a period of time, and has shown effects in improving physical fitness, cognitive ability and endurance.
The foregoing description is only an overview of the technical solutions of the present application, and in order to make the technical means of the present application more clearly understood and to make the same practical in accordance with the content of the present specification, and to make the above and other objects, features, and advantages of the present application more apparent and understandable, preferred embodiments of the present application are described below in detail.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present application, but not all of the embodiments. In the following description, specific details such as specific configurations and components are provided only to help the embodiments of the present application be fully understood. Accordingly, it will be apparent to those skilled in the art that various changes and modifications may be made to the embodiments described herein without departing from the scope and spirit of the present application. In addition, descriptions of well-known functions and constructions are omitted in the embodiments for clarity and conciseness.
It should be appreciated that reference throughout this specification to "one embodiment" or "the embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present application. Thus, the appearances of the phrase "one embodiment" or "the present embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Further, the present application may repeat reference numerals and/or letters in the various examples. This repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.
The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, may mean: a exists alone, B exists alone, and A and B exist at the same time, and the term "/and" is used herein to describe another association object relationship, which means that two relationships may exist, for example, A/and B, may mean: a alone, and both a and B alone, and further, the character "/" in this document generally means that the former and latter associated objects are in an "or" relationship.
The term "at least one" herein is merely an association relationship describing an associated object, and means that there may be three relationships, for example, at least one of a and B, may mean: a exists alone, A and B exist simultaneously, and B exists alone.
It is further noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion.
Example 1
A nutritional supplement containing ketoesters comprises the following components in parts by weight: 20 parts of ketoester and 150 parts of medicinal carrier; the nutritional supplement is in liquid form.
The medicinal carrier is one or any combination of citric acid, ascorbic acid, benzoic acid and lactate.
The nutritional supplement further comprises an antioxidant, wherein the antioxidant is one or any combination of ellagic acid, quercetin, lipoic acid, and vitamin C.
The synthesis method of the ketoester is characterized in that the ketoester is synthesized by the enzyme catalysis of R-3-hydroxy ethyl butyrate and (R) - (-) -1, 3-butanediol according to the proportion.
The use of a nutritional supplement comprising ketoesters as described above in a medicament for improving physical fitness, cognitive performance and endurance, the nutritional supplement being administered to a human subject at a dosage of 2-4 mg/day.
Further, the nutritional supplement is administered to the subject at least twice daily for at least 1 month or more.
Example 2
A nutritional supplement containing ketoesters comprises the following components in parts by weight: 35 parts of ketoester and 220 parts of medicinal carrier; the nutritional supplement is in liquid form.
The medicinal carrier is one or any combination of benzoic acid, glycerol, propylene glycol and polyethylene glycol.
The nutritional supplement further comprises an antioxidant, wherein the antioxidant is one or any combination of ellagic acid, quercetin, lipoic acid, and vitamin C.
The synthesis method of the ketoester is characterized in that the ketoester is synthesized by the enzyme catalysis of R-3-hydroxy ethyl butyrate and (R) - (-) -1, 3-butanediol according to the proportion.
The use of a nutritional supplement comprising ketoesters as described above in a medicament for improving physical fitness, cognitive performance and endurance, the nutritional supplement being administered to a human subject at a dosage of 2-4 mg/day.
Further, the nutritional supplement is administered to the subject at least twice daily for at least 1 month or more.
Example 3
A nutritional supplement containing ketoesters comprises the following components in parts by weight: 50 parts of ketoester and 300 parts of medicinal carrier; the nutritional supplement is in liquid form.
The medicinal carrier is one or any combination of potassium hydroxide, sodium bicarbonate, calcium carbonate, silicon dioxide and magnesium aluminum silicate.
The nutritional supplement further comprises an antioxidant, wherein the antioxidant is one or any combination of ellagic acid, quercetin, lipoic acid, and vitamin C.
The synthesis method of the ketoester is characterized in that the ketoester is synthesized by the enzyme catalysis of R-3-hydroxy ethyl butyrate and (R) - (-) -1, 3-butanediol according to the proportion.
The use of a nutritional supplement comprising ketoesters as described above in a medicament for improving physical fitness, cognitive performance and endurance, the nutritional supplement being administered to a human subject at a dosage of 2-4 mg/day.
Further, the nutritional supplement is administered to the subject at least twice daily for at least 1 month or more.
Example 4
A nutritional supplement containing ketoesters comprises the following components in parts by weight: 30-40 parts of ketoester and 200-250 parts of medicinal carrier.
The medicinal carrier is one or any combination of citric acid, ascorbic acid, benzoic acid and lactate.
Alternatively, the pharmaceutically acceptable carrier is one or any combination of benzoic acid, glycerol, propylene glycol and polyethylene glycol.
Alternatively, the pharmaceutically acceptable carrier is one or any combination of potassium hydroxide, sodium bicarbonate, calcium carbonate, silica, and magnesium aluminum silicate.
The nutritional supplement further comprises an antioxidant, wherein the antioxidant is one or any combination of ellagic acid, quercetin, lipoic acid, and vitamin C.
The synthesis method of the ketoester is characterized in that the ketoester is synthesized by the enzyme catalysis of R-3-hydroxy ethyl butyrate and (R) - (-) -1, 3-butanediol according to the proportion.
The use of a nutritional supplement comprising ketoesters as described above in a medicament for improving physical fitness, cognitive performance and endurance, the nutritional supplement being administered to a human subject at a dosage of 2-4 mg/day.
Further, the nutritional supplement is administered to the subject at least twice daily for at least 1 month or more.
The above description is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the present invention, and it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention. Variations, modifications, substitutions, integrations and parameter changes of the embodiments may be made without departing from the principle and spirit of the invention, which may be within the spirit and principle of the invention, by conventional substitution or may realize the same function.

Claims (9)

1. A nutritional supplement containing ketoesters is characterized by comprising the following components in parts by weight: 20-50 parts of ketoester and 150-300 parts of medicinal carrier; the nutritional supplement is in liquid form.
2. The nutritional supplement containing ketoesters according to claim 1, comprising the following components in parts by weight: 30-40 parts of ketoester and 200-250 parts of medicinal carrier.
3. The nutritional supplement according to claim 1 or 2, wherein the pharmaceutically acceptable carrier is one or any combination of citric acid, ascorbic acid, benzoic acid, lactate.
4. The nutritional supplement containing ketoesters according to claim 1 or 2 wherein the pharmaceutically acceptable carrier is one or any combination of benzoic acid, glycerol, propylene glycol, polyethylene glycol.
5. The nutritional supplement of claim 1 or 2, wherein the pharmaceutically acceptable carrier is one or any combination of potassium hydroxide, sodium bicarbonate, calcium carbonate, silica, magnesium aluminum silicate.
6. A nutritional supplement containing ketoesters according to claim 1 or 2 further comprising an antioxidant which is one or any combination of ellagic acid, quercetin, lipoic acid, vitamin C.
7. The nutritional supplement according to claim 1 or 2, wherein the ketoester is synthesized by enzymatic synthesis from ethyl R-3-hydroxybutyrate and (R) - (-) -1, 3-butanediol in the ratio.
8. Use of a nutritional supplement comprising ketoesters for improving physical fitness, cognitive performance and endurance performance in a medicament according to any one of claims 1 to 7, wherein the nutritional supplement is administered to a human subject at a dose of 2 to 4 mg/day.
9. Use of a nutritional supplement containing ketoesters in a medicament for enhancing physical fitness, cognitive performance and endurance as claimed in claim 8, wherein the nutritional supplement is administered to a subject at least twice daily for at least 1 month or more.
CN202111597532.4A 2021-12-24 2021-12-24 Nutritional supplement containing ketoesters and application thereof Pending CN114306308A (en)

Priority Applications (1)

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CN202111597532.4A CN114306308A (en) 2021-12-24 2021-12-24 Nutritional supplement containing ketoesters and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111597532.4A CN114306308A (en) 2021-12-24 2021-12-24 Nutritional supplement containing ketoesters and application thereof

Publications (1)

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CN114306308A true CN114306308A (en) 2022-04-12

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105050594A (en) * 2013-03-19 2015-11-11 南佛罗里达大学 Compositions and methods for producing elevated and sustained ketosis
US20200222353A1 (en) * 2019-01-14 2020-07-16 Christopher David Thompson Ketone ester and ketone salt compositions and methods for using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105050594A (en) * 2013-03-19 2015-11-11 南佛罗里达大学 Compositions and methods for producing elevated and sustained ketosis
US20200222353A1 (en) * 2019-01-14 2020-07-16 Christopher David Thompson Ketone ester and ketone salt compositions and methods for using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王广兰等: "《运动营养学》", 华中科技大学出版社 *

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Application publication date: 20220412

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