CN114300088B - Body temperature monitoring device and system for guiding perimenopausal hormone replacement therapy - Google Patents
Body temperature monitoring device and system for guiding perimenopausal hormone replacement therapy Download PDFInfo
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Abstract
A body temperature monitoring device for guiding perimenopausal hormone replacement therapy comprises a body temperature monitor and a user intelligent mobile terminal; the body temperature monitor is a cochlear-worn electronic body temperature instrument capable of continuously measuring body temperature and comprises a temperature collector, a digital signal converter, a signal transmitter and a main controller module; the temperature collector is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basic body temperature, timing body temperature and burst hot flash body temperature, the digital signal converter converts the collected body temperature into digital signals, and the main controller module controls the signal transmitter to transmit the body temperature data to the intelligent mobile terminal of the user. Compared with the prior art, the invention obtains data through body temperature monitoring of a large sample, stores and integrates the data, obtains the optimal time point and the optimal dosage of taking hormone medicine, guides the use of clinical estrogen, maximizes the effect of HRT and simultaneously avoids harm.
Description
Technical Field
The invention relates to a body temperature monitoring device and a body temperature monitoring system, in particular to a body temperature monitoring device and a body temperature monitoring system for guiding perimenopausal hormone replacement therapy.
Background
Perimenopausal syndrome is also called climacteric syndrome, which refers to a series of syndrome mainly comprising autonomic nervous system dysfunction and accompanied by neuropsychological symptoms caused by estrogen fluctuation or decrease before and after menopause. Common symptoms in perimenopausal syndrome are low fever and hot flashes, which occur mostly between 45 and 55 years of age. Low fever is mainly caused by a decrease in estrogen levels, which causes the body to secrete excess gonadotropins. Some patients experience dysphoria and emotional instability during low fever. Hot flashes are an manifestation of unstable vasomotor function. When flushing occurs, the patient feels hot and the skin is red, and then sweats burst after burst, lasting for a few seconds to a few minutes, the frequency of the attacks is several times to tens of times per day, and the night or stress state is easy to burst. Such low heat and hot flashes can last for 1 year, sometimes as long as 5 years or more, severely affecting the quality of life and home stability of women.
At present, there are three general methods for treating perimenopausal syndrome:
psychological treatment. Through psychological consultation and interview, the living habit of the patient is changed. Such as physical and mental labor, which are of a constant strength. Can prevent muscle and joint from disuse atrophy through long-term conscious labor. By insisting on learning and thinking, the heart and chest are open, the sexuality is earthen, and the attention of vasomotor abnormality is transferred or relieved. The disadvantage is that this approach has limited therapeutic efficacy and is not a substantial treatment regimen.
The autonomic nerve function regulating medicine is taken. Patients who are not effective in psychological treatment can be assisted with autonomic nervous function regulating drugs such as oryzanol, diazepam, vitamin B6, vitamin B complex, vitamin E, vitamin A, etc. The medicine acts on nerves, is helpful for regulating autonomic nerve function and stabilizing vasomotor state. However, this method is only symptomatic and not the present treatment.
Hormone Replacement Therapy (HRT). Perimenopausal syndrome is mainly caused by ovarian function decline and estrogen reduction, and HRT is a clinical medical measure adopted for solving the problem, and belongs to the treatment.
Hormone Replacement Therapy (HRT) is an internationally recognized standard therapy for the treatment of perimenopausal syndrome. The current common mode of HRT therapy is to administer estrogens on a daily basis at regular intervals. The scientific and reasonable use of estrogen can obviously reduce the amplitude and the frequency of low fever and hectic fever of organisms and reduce the uncomfortable feeling of perimenopausal women, but has side effects such as uterine bleeding, endometrial cancer, breast cancer, liver function damage and the like. The regular and quantitative administration of estrogen every day can maintain stable blood concentration, but the use time and the use amount of estrogen are not unified standard in the medical community at present, so that the side effect cannot be effectively reduced. The beneficial effects of estrogens can only outweigh their potential hazards if they are administered scientifically, reasonably, and regularly and monitored regularly.
Existing body temperature monitoring schemes use thermometers to monitor body temperature changes, primarily when body temperature rises. However, the monitoring scheme is firstly judged by the patient according to own body temperature feeling, and then measurement and recording are carried out. Because the body temperature of the human body fluctuates every day, the human body is unscientific and incomplete by taking subjective feeling as a measurement basis.
Mature human body temperature monitoring methods have not been established in academic research for the study of perimenopausal pathogenesis and therapy. "mechanism of hot flashes and mechanism studies of estrogen replacement therapy" (Wu Xueqing et al, 11 th of the third national academy of menopause and paper assembly for study of problems related to menopause) are described herein only to address the establishment of animal models of menopausal hot flashes and remote skin temperature detection systems to investigate the neurobiological mechanisms of hot flashes. Adult female Wistar rats are subcutaneously implanted with a rat tail skin temperature sensor (T S T), then subjected to bilateral ovariectomy, preoperative and postoperative remote monitoring of T S T changes respectively (body temperature is monitored once every 3 minutes and 24 hours a day), and a body temperature change dynamic curve is drawn, so that an animal model of postmenopausal hot flashes is established and then used for experimental study.
There has been no report of continuous accurate monitoring of human body temperature data for guiding perimenopausal hormone replacement therapies. Human body temperature detection is of great significance to research on menopausal hormone replacement therapy, but the existing body temperature monitoring technology has a plurality of defects and drawbacks.
1. The common contact body temperature measuring instrument in the market at present is provided with a mercury thermometer and an electronic thermometer; the non-contact measurement has an infrared thermometer, including an ear thermometer, a forehead thermometer and an infrared imaging thermometer, but can only meet the requirement of disposable body temperature measurement. The pattern and magnitude of the body temperature changes are not currently well understood in perimenopausal women.
2. The body temperature measuring instrument commonly used in the market at present can store 5-10 times of body temperature data. In order to obtain the body temperature data of perimenopausal women as comprehensively as possible, for each individual, the basic body temperature, the body temperature every two hours and the burst hot flash body temperature are measured every day, and the monitoring is continuously carried out for at least 1 month.
3. The body temperature measuring instrument commonly used in the market at present cannot be worn for a long time.
4. The common body temperature measuring instrument in the market at present can only look up one or a few times of body temperature data, can not see long-term body temperature history fluctuation curve, can not judge the fever type, namely whether low fever is the main part or tidal fever occurs on the basis of low fever, and finally can not carry out integrated analysis on the data.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a body temperature monitoring device and a body temperature monitoring system for guiding perimenopausal hormone replacement therapy to monitor the body temperature change mode and the change amplitude of perimenopausal women. The data are obtained through body temperature monitoring of a large sample, and are stored and integrated and analyzed to obtain the optimal time point and optimal dosage of taking hormone medicine, guide the use of clinical estrogen, maximize the effect of HRT and avoid harm.
The invention adopts the following technical scheme. The invention provides a body temperature monitoring device for guiding perimenopausal hormone replacement therapy, which comprises a body temperature monitor and a user intelligent mobile terminal, wherein the body temperature monitor is used for monitoring the body temperature of a patient;
the body temperature monitor is a cochlear-worn electronic body temperature monitor capable of continuously measuring body temperature and comprises a temperature collector, a digital signal converter, a signal transmitter and a main controller module; the temperature collector is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basic body temperature, timing body temperature and burst hot flash body temperature, the digital signal converter converts the collected body temperature into digital signals, and the main controller module controls the signal transmitter to transmit the body temperature data to the intelligent mobile terminal of the user;
the intelligent mobile terminal comprises a body temperature data processing module, a hormone dosage administration recording module and a hormone dosage analysis module, wherein the body temperature data processing module stores and analyzes body temperature detection data in a set time period, and the hormone dosage administration recording module is used for recording the name, dosage and administration time of hormone medicines taken by a user in the set time period; the hormone dosage analysis module analyzes reasonable hormone dosage ranges, administration time and medicine types in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone administration record.
Preferably, the temperature collector comprises a temperature sensor and a real-time clock module, wherein the real-time clock module is used for internally timing, the main controller module controls the temperature sensor to measure the body temperature data of a user at a preset time through the real-time clock module, and when the timing reaches a preset temperature measuring time interval, the real-time clock module is awakened to drive the temperature sensor to detect the body temperature.
Preferably, the basal body temperature is measured manually through a button on an ear plug after 6 a.m. and when the basal body is naturally awake; the timing body temperature is between 8 points and 22 points, and the body temperature is automatically measured every 2 hours; the sudden tidal fever body temperature is automatically measured in real time when the body temperature is 0.5 ℃ higher than the basic body temperature.
Preferably, the signal transmitter transmits the temperature digital signal to the user smart mobile terminal through bluetooth.
Preferably, the cochlea wearable electronic thermometer adopts an ear-hook structure, wherein the ear-hook is in a C shape, one end of the ear-hook is connected with the ear-hook, a manual temperature measuring button is arranged outside the ear-hook, and when the manual temperature measuring button is touched, the temperature sensor can be driven to detect the body temperature in real time; the temperature collector, the digital signal converter, the signal transmitter and the main controller module are all arranged in the earplug;
both the earplug and the earhook are made of silica gel.
Preferably, the user intelligent mobile terminal is a mobile phone or a tablet computer.
Preferably, after receiving the body temperature data sent by the cochlear-worn electronic thermometer, the body temperature data processing module in the intelligent mobile terminal of the user draws a current day body temperature curve and calculates the current day highest body temperature and the current day average body temperature; for long-term data with the time interval of body temperature data acquisition exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature average value, a monthly regular body temperature average value, a body temperature average value and a monthly body temperature peak value average value, and drawing a body temperature curve and a table according to the data.
Preferably, the user inputs the name, the dosage and the taking time of the taken hormone medicine to the hormone dosage taking recording module through the mobile terminal;
the hormone medicine comprises Bujiale, crinite, fenmolong and tibolone;
the hormone dosage analysis module finds out the hormone medicine time point with the maximum body temperature amplitude reduction based on body temperature data acquired in four continuous months and corresponding hormone administration records;
first month body temperature data record: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when hormone medicine is not taken;
second month body temperature data record: the clinical thermometer should record the setting taking time as the basic body temperature, take the medicine immediately after measuring, and take a same hormone medicine every day, the basic body temperature, timing body temperature, burst hot flash body temperature of the user;
third month body temperature data record: the thermometer should record and set the taking time to 14 points, and when taking a hormone medicine of the same kind as the medicine of the second month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user;
fourth month body temperature data record: the thermometer should record and set the taking time to 22 points, and when taking a hormone medicine of the same kind as the medicine of the third month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user;
after receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; then comparing the monthly temperature difference K1, wherein the smaller the temperature difference K1 is, the better the hormone medicine is absorbed at the taking time point, the hot flash symptom is lightened, and the taking time point of the hormone medicine with the maximum body temperature amplitude reduction of the user is obtained;
temperature difference K1:
K1＝α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the peak average of the body temperature of the second, third or fourth month and the average of the body temperature of the current month;
b is the absolute value of the difference between the peak-to-average value of the body temperature of the second, third or fourth month and the average value of the body temperature of the month;
c is the absolute value of the difference between the peak average value of the body temperature of the second, third or fourth month and the average value of the basal body temperature of the current month;
d is the absolute value of the difference between the mean value of the burst hot flashes for the second, third or fourth month and the mean value of the timed hot flashes for the first month;
wherein α+β+γ=1, α=1.5γ, β=0.5γ;
preferably, the hormone dosage analysis module finds out the hormone medicine dosage with the maximum body temperature amplitude reduction based on the body temperature data and the corresponding hormone administration record acquired by taking one same medicine for four continuous months and taking two same medicines for three continuous months;
fifth month body temperature data record: the clinical thermometer should record the set taking time as the basic body temperature, take the medicine immediately after measuring, and take two hormone medicines of the same kind as medicine of the fourth month every day, basic body temperature, timing body temperature, burst hot flash body temperature of the user;
sixth month body temperature data record: the thermometer records and sets the taking time to be 14 points, and when two hormone medicines with the same kind as the medicines in the fifth month are taken every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of a user;
seventh month body temperature data record: the thermometer should record and set the taking time to 22 points, and when taking two hormone medicines of the same kind as the medicines of the sixth month every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of the user;
after receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; then comparing the temperature difference K2, wherein the temperature difference K2 indicates that the dosage of hormone can furthest relieve the symptoms of hectic fever, and the administration dosage and administration time point of the medicine with the maximum body temperature reduction of the user are obtained;
temperature difference K2:
K2＝ε*E+ζ*F+ν*G
e is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the average temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the average temperatures of the fifth month and the seventh month;
f is the absolute value of the difference between the second-fourth month body temperature peak average sum and the second-fourth month time body temperature average sum or the absolute value of the difference between the sum of the peak-to-average body temperature values for the fifth-seventh months and the sum of the average body temperature values for the fifth-seventh months;
g is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the base temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the base temperatures of the fifth month and the seventh month;
wherein ε+ζ+ν=1, ε=1.5ν, ζ=0.5ν.
Preferably, the body temperature monitoring system further comprises a server, wherein the server is a cloud computing background and receives body temperature data of each user in a set time period, and the name, the dosage and the taking time of hormone medicines taken by each user, which are sent by a user intelligent mobile terminal using the body temperature monitoring device;
the crowd is divided into a plurality of subgroups on the premise of no statistical difference of age, weight, menopausal time and the like after 7 months of body temperature monitoring period due to the large enough sample size:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subpopulation three: age 50-52 years, 60-70kg, menopause 1-2 years;
subpopulation four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years;
under the action of different drugs, the difference between the average monthly temperature value and the peak monthly temperature value is calculated and compared, and the smaller the difference is, the estrogen drugs can reduce the hot and tidal symptoms to the greatest extent, and the hormone drug name, the hormone drug administration time point and the drug administration dosage which are most suitable for the group of people are obtained.
The invention has the beneficial effects that:
1. the body temperature monitoring device provided by the invention is a new convenient, sustainable and accurate tool for body temperature measurement, and has the functions of easy cleaning and sanitation maintenance.
2. The body temperature monitoring device provided by the invention can automatically measure even when working and sleeping, and the earplug and the C-shaped ear hook are soft in material, so that normal life activities of people are not affected. The earhook adopts silica gel, is soft and comfortable, has strong wearability, and after the earplug is fixed in the auditory canal, the C-shaped earhook is wound to the position close to the earlobe from the rear of the auricle, so that the earhook is more stable to wear and is not easy to fall off.
3. Most of the current electronic thermometers only have a manual temperature measurement function and do not have an automatic real-time temperature measurement function. The body temperature monitoring device provided by the invention is very intelligent and convenient to start automatic temperature measurement when the real-time body temperature exceeds the basic body temperature by 0.5 ℃.
4. Most of the current electronic thermometers have limited storage space and limited stored body temperature data. The body temperature monitoring system provided by the invention uses the mobile phone as a memory, so that the memory space is large.
5. Most of the current electronic thermometers cannot perform body temperature data analysis, and therefore the application of the electronic thermometers is limited. The body temperature monitoring system provided by the invention can realize the history record and statistical analysis of body temperature data by utilizing the body temperature data processing module, and can conveniently review personal body temperature curves, data analysis results and the like through a mobile phone interface.
6. According to the body temperature monitoring system provided by the invention, the server is used for analyzing body temperature data of large samples of people, the optimal medication time point is found, and the individuation of the HRT drug treatment is finally realized.
7. According to the body temperature monitoring system provided by the invention, the hormone administration mode with the maximum body temperature amplitude reduction is found out by monitoring the body temperature when the medicine is not taken at a specific time point and the body temperature after the medicine is taken, and the best hormone medicine name, the hormone medicine taking time point and the medicine taking dosage can be found out by analyzing the body temperature data of a large sample of people through a cloud computing background, so that the maximum effect of HRT medicine treatment is finally realized, and meanwhile, the potential hazard is avoided.
8. The body temperature monitoring method established by the body temperature monitoring system provided by the invention can acquire the relationship between the body temperature and the hormone dosage of perimenopausal people and guide the perimenopausal people to carry out hormone replacement therapy; can also be used for scientific research and academic research.
Drawings
Fig. 1 is a view showing the appearance of a C-shaped ear hook of the body temperature monitoring device of the present invention;
fig. 2 is a schematic wearing view of the body temperature monitoring device of the present invention;
fig. 3 is an external view of an earplug of the body temperature monitoring device of the invention;
FIG. 4 is a diagram showing the internal structure of an earplug of the body temperature monitoring device of the present invention;
fig. 5 is a working schematic diagram of a cochlear electronic thermometer of the body temperature monitoring device of the invention;
FIG. 6 is a flow chart of signal and data processing of the body temperature monitoring system of the present invention;
fig. 7 is a flow chart of the acquisition and analysis of big data of the body temperature monitoring system of the present invention.
In the figure:
1-an earplug;
2-ear hook;
3-a temperature sensor;
a 4-digital signal converter;
a 5-signal transmitter;
6-a main controller module;
7-manual temperature measurement button.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
A body temperature monitoring device for guiding perimenopausal hormone replacement therapy comprises a body temperature monitor and a user intelligent mobile terminal;
as shown in fig. 1 to 3, the cochlear-worn electronic thermometer adopts a structure that an ear-hook 2 is connected with an ear-hook 1, the ear-hook 2 is in a C shape, one end of the ear-hook 2 is connected with the ear-hook 1, a manual temperature measuring button 7 is arranged outside the ear-hook 1, and when the manual temperature measuring button 7 is touched, a temperature sensor can be driven to detect the body temperature in real time; the temperature collector 3, the digital signal converter 4, the signal transmitter 5 and the main controller module 6 are all arranged inside the earplug; both the earplug 1 and the ear hook 2 are made of silica gel.
As shown in fig. 4, the body temperature monitor is a cochlear-worn electronic body temperature monitor capable of continuously measuring body temperature, and comprises a temperature collector 3, a digital signal converter 4, a signal transmitter 5 and a main controller module 6.
The temperature collector 3 comprises a temperature sensor and a real-time clock module, wherein the real-time clock module is used for internally timing, the main controller module controls the temperature sensor to measure the body temperature data of a user at preset time through the real-time clock module, and when timing reaches a preset temperature measuring time interval, the real-time clock module is awakened to drive the temperature sensor to detect the body temperature. The temperature collector 3 is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basic body temperature, timing body temperature and sudden tidal fever body temperature, the digital signal converter 4 converts the collected body temperature into digital signals, the main controller module 6 controls the signal transmitter 5 to transmit the body temperature data to the intelligent mobile terminal of the user, and the intelligent mobile terminal of the user is a mobile phone or a tablet computer.
The basic body temperature is measured manually through a button on the ear plug after 6 a.m. and when the user wakes up naturally; the timing body temperature is between 8 points and 22 points, and the body temperature is automatically measured every 2 hours; the sudden tidal fever body temperature is automatically measured in real time when the body temperature is 0.5 ℃ higher than the basic body temperature. The body temperature of the human body fluctuates every day, generally, the body temperature is lowest in two to four points in the early morning, and the body temperature reaches highest in two to four points in the afternoon, and then gradually drops, and the whole fluctuation is within the range of 1 ℃.
The signal transmitter 5 transmits the temperature digital signal to the user smart mobile terminal through bluetooth.
As shown in fig. 4 and 5, the intelligent mobile terminal for a user comprises a body temperature data processing module, a hormone dosage administration recording module and a hormone dosage analysis module, wherein the body temperature data processing module stores and analyzes body temperature detection data in a set time period, and the hormone dosage administration recording module is used for recording the name, dosage and administration time of hormone medicines taken by the user in the set time period; the hormone dosage analysis module analyzes the hormone medicine taking time point and the hormone medicine taking dosage of the maximum body temperature reduction in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone taking record.
After receiving body temperature data sent by a cochlear-worn electronic thermometer, a body temperature data processing module in the intelligent mobile terminal of the user draws a current day body temperature curve and calculates the highest current day body temperature and the average current day body temperature; for long-term data with the time interval of body temperature data acquisition exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature average value, a monthly regular body temperature average value, a body temperature average value and a monthly body temperature peak value average value, and drawing a body temperature curve and a table according to the data.
The user inputs the name, the dosage and the taking time of the taken hormone medicine to a hormone dosage taking recording module through the mobile terminal; hormonal drugs include Bujiale, keling Mongolian, fenmolong, tibolone;
according to the "normative diagnosis and treatment procedure of menopausal related hormone supplement data" issued by the department of obstetrics and gynecology of China (recently) in 2013 (hereinafter referred to as "procedure"), common estrogen supplement drugs include Bujiale, keling Mongolian, fenmolong, tibolone and the like, and generally, only one drug is required to be taken every day. Therefore, for patients needing to supplement estrogen, the purpose of supplementing estrogen can be achieved by taking an estrogen medicine for a long time in clinic.
The hormone dosage analysis module finds out the hormone medicine time point with the maximum body temperature amplitude reduction based on body temperature data acquired in four continuous months and corresponding hormone administration records;
first month data record: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when hormone medicine is not taken;
second month data record: the clinical thermometer should record the setting taking time as the basic body temperature, take the medicine immediately after measuring, and take a same common estrogen to supplement medicine every day, basic body temperature, timing body temperature, burst hot flash body temperature of users;
second month-taking medicine with empty stomach after measuring basal body temperature
TABLE 1
Third month data record: the thermometer should record and set the taking time to 14 points, and when taking a hormone medicine of the same kind as the medicine of the second month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user; usually, the 14 th point is 2 hours after Chinese meal, the medicine can be absorbed better, and the human body temperature is higher or the peak value of the current day is generally obtained.
Medicine for taking in March-14 th point
TABLE 2
Fourth month data record: the thermometer should record and set the taking time to 22 points, and when taking a hormone medicine of the same kind as the medicine of the third month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user;
medicine is taken at the fourth month-22 th point
TABLE 3 Table 3
After receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; and comparing the monthly temperature difference K1, wherein the smaller the temperature difference K1 is, the better the hormone medicine is absorbed at the taking time point, the hot flash symptom is relieved, and the taking time point of the hormone medicine with the maximum body temperature amplitude reduction of the user is obtained.
Temperature difference K1:
K1＝α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the peak average of the body temperature of the second, third or fourth month and the average of the body temperature of the current month;
b is the absolute value of the difference between the peak-to-average value of the body temperature of the second, third or fourth month and the average value of the body temperature of the month;
c is the absolute value of the difference between the peak average value of the body temperature of the second, third or fourth month and the average value of the basal body temperature of the current month;
d is the absolute value of the difference between the mean value of the burst hot flashes for the second, third or fourth month and the mean value of the timed hot flashes for the first month;
wherein α+β+γ=1, α=1.5γ, β=0.5γ;
for women who take one estrogen medicine in a day and still feel that the climacteric symptoms are not controlled, the same medicine can be added into two medicines (in line with the flow).
The hormone dosage analysis module finds out the hormone medicine dosage with the maximum body temperature amplitude reduction based on the body temperature data and the corresponding hormone administration record obtained by taking one same medicine for four months and taking two medicines for three months;
fifth month body temperature data record: the clinical thermometer should record the set taking time as the basic body temperature, take the medicine immediately after measuring, and take two hormone medicines of the same kind as medicine of the fourth month every day, basic body temperature, timing body temperature, burst hot flash body temperature of the user;
sixth month body temperature data record: the thermometer records and sets the taking time to be 14 points, and when two hormone medicines with the same kind as the medicines in the fifth month are taken every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of a user;
seventh month body temperature data record: the thermometer should record and set the taking time to 22 points, and when taking two hormone medicines of the same kind as the medicines of the sixth month every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of the user;
after receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; and comparing the temperature difference K2, wherein the smaller the temperature difference K2 is, the hormone dosage can reduce the hot flash symptoms to the maximum extent, and the medicine taking dosage and the taking time point with the maximum body temperature reduction of the user are obtained.
Temperature difference K2:
K2＝ε*E+ζ*F+ν*G
e is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the average temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the average temperatures of the fifth month and the seventh month;
f is the absolute value of the difference between the second-fourth month body temperature peak average sum and the second-fourth month time body temperature average sum or the absolute value of the difference between the sum of the peak-to-average body temperature values for the fifth-seventh months and the sum of the average body temperature values for the fifth-seventh months;
g is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the base temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the base temperatures of the fifth month and the seventh month;
wherein ε+ζ+ν=1, ε=1.5ν, ζ=0.5ν.
As shown in fig. 5, the body temperature monitoring system of the body temperature monitoring device further comprises a server, wherein the server is a cloud computing background and receives body temperature data, and the name, dosage and administration time of hormone medicines taken by each user in a set time period, sent by the intelligent mobile terminal of the user using the body temperature monitoring device according to claims 1-9.
For estrogen consumers in the crowd, different kinds of estrogen drugs may be selected according to factors such as medical treatment areas, drug supply, drug price and the like.
The crowd is divided into a plurality of subgroups on the premise of no statistical difference of age, weight, menopausal time and the like after 7 months of body temperature monitoring period due to the large enough sample size:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subpopulation three: age 50-52 years, 60-70kg, menopause 1-2 years;
subpopulation four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years;
under the action of different drugs, the difference between the average monthly temperature value and the peak monthly temperature value is calculated and compared, and the smaller the difference is, the estrogen drugs can reduce the hot and tidal symptoms to the greatest extent, and the hormone drug name, the hormone drug administration time point and the drug administration dosage which are most suitable for the group of people are obtained.
The invention has the beneficial effects that compared with the prior art:
1. the body temperature monitoring device provided by the invention is a new convenient, sustainable and accurate tool for body temperature measurement, and has the functions of easy cleaning and sanitation maintenance.
2. The body temperature monitoring device provided by the invention can automatically measure even when working and sleeping, and the earplug and the C-shaped ear hook are soft in material, so that normal life activities of people are not affected. The earhook adopts silica gel, is soft and comfortable, has strong wearability, and after the earplug is fixed in the auditory canal, the C-shaped earhook is wound to the position close to the earlobe from the rear of the auricle, so that the earhook is more stable to wear and is not easy to fall off.
3. Most of the current electronic thermometers only have a manual temperature measurement function and do not have an automatic real-time temperature measurement function. The body temperature monitoring device provided by the invention is very intelligent and convenient to start automatic temperature measurement when the real-time body temperature exceeds the basic body temperature by 0.5 ℃.
4. Most of the current electronic thermometers have limited storage space and limited stored body temperature data. The body temperature monitoring system provided by the invention uses the mobile phone as a memory, so that the memory space is large.
5. Most of the current electronic thermometers cannot perform body temperature data analysis, and therefore the application of the electronic thermometers is limited. The body temperature monitoring system provided by the invention can realize the history record and statistical analysis of body temperature data by utilizing the body temperature data processing module, and can conveniently review personal body temperature curves, data analysis results and the like through a mobile phone interface.
6. According to the body temperature monitoring system provided by the invention, the server is used for analyzing body temperature data of large samples of people, the optimal medication time point is found, and the individuation of the HRT drug treatment is finally realized.
7. According to the body temperature monitoring system provided by the invention, the hormone administration mode with the maximum body temperature amplitude reduction is found out by monitoring the body temperature when the medicine is not taken at a specific time point and the body temperature after the medicine is taken, and the best hormone medicine name, the hormone medicine taking time point and the medicine taking dosage can be found out by analyzing the body temperature data of a large sample of people through a cloud computing background, so that the maximum effect of HRT medicine treatment is finally realized, and meanwhile, the potential hazard is avoided.
8. The body temperature monitoring method established by the body temperature monitoring system provided by the invention can acquire the relationship between the body temperature and the hormone dosage of perimenopausal people and guide the perimenopausal people to carry out hormone replacement therapy; can also be used for scientific research and academic research.
In view of the above, the present invention provides a body temperature monitoring device and system for guiding perimenopausal hormone replacement therapy by analyzing the above problems. The system workflow is set to be that the body temperature is measured through a cochlear type thermometer (temperature sensor), the body temperature is converted into a digital signal, the digital signal is transmitted to an intelligent mobile terminal (mobile phone) through Bluetooth, the statistical analysis of individual data of a user can be carried out by body temperature data analysis APP of the mobile phone, the mobile phone data can be transmitted to a remote terminal (computer) to carry out the statistical analysis of large sample crowd data, and a basis is provided for guiding perimenopausal hormone replacement therapy, which is suitable for large-scale crowd and can also provide medication accuracy and individuation for a single user.
While the applicant has described and illustrated the embodiments of the present invention in detail with reference to the drawings, it should be understood by those skilled in the art that the above embodiments are only preferred embodiments of the present invention, and the detailed description is only for the purpose of helping the reader to better understand the spirit of the present invention, and not to limit the scope of the present invention, but any improvements or modifications based on the spirit of the present invention should fall within the scope of the present invention.
Claims (10)
1. A body temperature monitoring device for guiding perimenopausal hormone replacement therapy comprises a body temperature monitor and a user intelligent mobile terminal; the method is characterized in that:
the body temperature monitor is a cochlear-worn electronic body temperature monitor capable of continuously measuring body temperature and comprises a temperature collector (3), a digital signal converter (4), a signal transmitter (5) and a main controller module (6); the temperature collector (3) is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basic body temperature, timing body temperature and sudden hot flashes, the digital signal converter (4) converts the collected body temperature into digital signals, and the main controller module (6) controls the signal transmitter (5) to transmit the body temperature data to the intelligent mobile terminal of the user;
the intelligent mobile terminal comprises a body temperature data processing module, a hormone dosage taking recording module and a hormone dosage analysis module, wherein the body temperature data processing module receives body temperature data sent by the cochlear-worn electronic thermometer, stores and analyzes body temperature detection data in a set time period, and the hormone dosage taking recording module is used for recording the name, dosage and taking time of hormone medicines taken by a user in the set time period; the hormone dosage analysis module analyzes reasonable hormone dosage range, administration time and medicine types in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone administration record;
the user inputs the name, the dosage and the taking time of the taken hormone medicine to a hormone dosage taking recording module through the mobile terminal;
the hormone dosage analysis module finds out the hormone medicine time point with the maximum body temperature amplitude reduction based on body temperature data acquired in four continuous months and corresponding hormone administration records;
first month body temperature data record: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when hormone medicine is not taken;
second month body temperature data record: the clinical thermometer should record the setting taking time as the basic body temperature, take the medicine immediately after measuring, and take a same hormone medicine every day, the basic body temperature, timing body temperature, burst hot flash body temperature of the user;
third month body temperature data record: the thermometer should record and set the taking time to 14 points, and when taking a hormone medicine of the same kind as the medicine of the second month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user;
fourth month body temperature data record: the thermometer should record and set the taking time to 22 points, and when taking a hormone medicine of the same kind as the medicine of the third month every day, the basic body temperature, the timing body temperature and the burst hot flash body temperature of the user;
after receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; then comparing the monthly temperature difference K1, wherein the smaller the temperature difference K1 is, the better the hormone medicine is absorbed at the taking time point, the hot flash symptom is lightened, and the taking time point of the hormone medicine with the maximum body temperature amplitude reduction of the user is obtained;
temperature difference K1:
K1＝α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the peak average of the body temperature of the second, third or fourth month and the average of the body temperature of the current month;
b is the absolute value of the difference between the peak-to-average value of the body temperature of the second, third or fourth month and the average value of the body temperature of the month;
c is the absolute value of the difference between the peak average value of the body temperature of the second, third or fourth month and the average value of the basal body temperature of the current month;
d is the absolute value of the difference between the mean value of the burst hot flashes for the second, third or fourth month and the mean value of the timed hot flashes for the first month;
wherein α+β+γ=1, α=1.5γ, β=0.5γ;
2. the body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 1, wherein:
the temperature collector (3) comprises a temperature sensor and a real-time clock module, wherein the real-time clock module is used for internally timing, the main controller module controls the temperature sensor to measure the body temperature data of a user in preset time through the real-time clock module, and when timing reaches a preset temperature measuring time interval, the real-time clock module is awakened to drive the temperature sensor to detect the body temperature.
3. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 2, wherein:
the basic body temperature is measured manually through a button on the ear plug after 6 a.m. and when the user wakes up naturally; the timing body temperature is between 8 points and 22 points, and the body temperature is automatically measured every 2 hours; the sudden tidal fever body temperature is automatically measured in real time when the body temperature is 0.5 ℃ higher than the basic body temperature.
4. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 1, wherein:
the signal transmitter (5) transmits the temperature digital signal to the intelligent mobile terminal of the user through Bluetooth.
5. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 1, wherein:
the cochlea wearing type electronic thermometer adopts an earplug (1) to be connected with an ear hook (2) structure, the ear hook (2) is in a C shape, one end of the ear hook (2) is connected with the earplug (1), a manual temperature measuring button (7) is arranged outside the earplug (1), and when the manual temperature measuring button (7) is touched, a temperature sensor can be driven to detect the body temperature in real time; the temperature collector (3), the digital signal converter (4), the signal transmitter (5) and the main controller module (6) are all arranged inside the earplug;
both the earplug (1) and the earhook (2) are made of silica gel.
6. The body temperature monitoring device for use in guiding perimenopausal hormone replacement therapy according to claim 1 or 5, wherein:
the intelligent mobile terminal of the user is a mobile phone or a tablet personal computer.
7. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 1, wherein:
after receiving body temperature data sent by a cochlear-worn electronic thermometer, a body temperature data processing module in the intelligent mobile terminal of the user draws a current day body temperature curve and calculates the highest current day body temperature and the average current day body temperature; for long-term data with the time interval of body temperature data acquisition exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature average value, a monthly regular body temperature average value, a body temperature average value and a monthly body temperature peak value average value, and drawing a body temperature curve and a table according to the data.
8. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 7, wherein:
the hormone medicine comprises Bujiale, crinite, fenmolong and tibolone.
9. The body temperature monitoring device for use in directing perimenopausal hormone replacement therapy according to claim 8, wherein:
the hormone dosage analysis module finds out the hormone medicine dosage with the maximum body temperature amplitude reduction based on the body temperature data and the corresponding hormone administration record obtained by taking one same medicine for four months continuously and taking two medicines for three months continuously;
fifth month body temperature data record: the clinical thermometer should record the set taking time as the basic body temperature, take the medicine immediately after measuring, and take two hormone medicines of the same kind as medicine of the fourth month every day, basic body temperature, timing body temperature, burst hot flash body temperature of the user;
sixth month body temperature data record: the thermometer records and sets the taking time to be 14 points, and when two hormone medicines with the same kind as the medicines in the fifth month are taken every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of a user;
seventh month body temperature data record: the thermometer should record and set the taking time to 22 points, and when taking two hormone medicines of the same kind as the medicines of the sixth month every day, the basal body temperature, the timing body temperature and the burst hot flash body temperature of the user;
after receiving body temperature data sent by a thermometer, a body temperature data processing module in the intelligent mobile terminal of the user calculates a monthly basic body temperature average value, a monthly timing body temperature average value, a monthly body temperature average value and a monthly body temperature peak value average value; comparing the temperature difference K2, wherein the smaller the temperature difference K2 is, the dosage of hormone can reduce the hot flash symptom to the maximum extent, and the medicine taking dosage and the taking time point with the maximum body temperature amplitude reduction of the user are obtained;
temperature difference K2:
K2＝ε*E+ζ*F+ν*G
e is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the average temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the average temperatures of the fifth month and the seventh month;
f is the absolute value of the difference between the second-fourth month body temperature peak average sum and the second-fourth month time body temperature average sum or the absolute value of the difference between the sum of the peak-to-average body temperature values for the fifth-seventh months and the sum of the average body temperature values for the fifth-seventh months;
g is the absolute value of the difference between the sum of the peak and average temperatures of the second month and the sum of the base temperatures of the second month and the fourth month or the absolute value of the difference between the sum of the peak and average temperatures of the fifth month and the sum of the base temperatures of the fifth month and the seventh month;
wherein ε+ζ+ν=1, ε=1.5ν, ζ=0.5ν.
10. A body temperature monitoring system comprising the body temperature monitoring device of any one of claims 1-9, characterized in that:
the body temperature monitoring system further comprises a server, wherein the server is a cloud computing background and receives body temperature data, taken hormone medicine names, doses and taking time of all users in a set time period, which are sent by the intelligent mobile terminal of the user using the body temperature monitoring device according to the claims 1-9;
the population is divided into a plurality of subgroups on the premise of no statistical difference of age, weight and menopausal time after 7 months of body temperature monitoring period due to the large enough sample size:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subpopulation three: age 50-52 years, 60-70kg, menopause 1-2 years;
subpopulation four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years;
under the action of different drugs, the difference between the average monthly temperature value and the peak monthly temperature value is calculated and compared, and the smaller the difference is, the hormone drug can reduce the hot and tidal symptoms to the greatest extent, and the hormone drug name, the hormone drug administration time point and the drug administration dosage which are most suitable for the group of people are obtained.
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