CN114300088A - Body temperature monitoring device and system for guiding perimenopausal hormone replacement therapy - Google Patents
Body temperature monitoring device and system for guiding perimenopausal hormone replacement therapy Download PDFInfo
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Abstract
A body temperature monitoring device for guiding hormone replacement therapy in perimenopause comprises a body temperature monitoring instrument and a user intelligent mobile terminal; the body temperature monitor is a cochlea wearable electronic body temperature monitor capable of continuously measuring body temperature, and comprises a temperature collector, a digital signal converter, a signal emitter and a main controller module; the temperature collector is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basal body temperature, timing body temperature and burst hot body temperature, and the digital signal converter is used for controlling the signal emitter to send the body temperature data to the intelligent mobile terminal of the user by the main controller module after converting the collected body temperature into a digital signal. Compared with the prior art, the method obtains data through body temperature monitoring of a large sample, stores and integrally analyzes the data to obtain the optimal time point and optimal dosage of taking hormone medicine, guides clinical estrogen use, maximizes the HRT effect and avoids harm at the same time.
Description
Technical Field
The invention relates to a body temperature monitoring device and a body temperature monitoring system, in particular to a body temperature monitoring device and a body temperature monitoring system for guiding perimenopausal hormone replacement therapy.
Background
Perimenopausal syndrome is also called climacteric syndrome, and refers to a series of symptoms which are mainly dysfunction of autonomic nervous system and accompanied with neuropsychological symptoms caused by estrogen fluctuation or reduction before and after menopause of women. Common symptoms in perimenopausal syndrome are low grade fever and hot flashes, which occur mostly in the age of 45-55 years. Low fever is mainly caused by the decrease of estrogen level, which causes the body to secrete excessive gonadotropin. Some patients may have dysphoria and unstable mood when the fever is low. Hot flashes are a manifestation of unstable vasomotor function. When flush occurs, a patient feels burning and reddens the skin, and then the flush is followed by explosive sweating for several seconds to several minutes, the attack frequency is from several times to dozens of times every day, and the flush is easy to occur in the night or in a stress state. This low fever and hot flash phenomenon can last for 1 year, sometimes as long as 5 years or more, seriously affecting women's quality of life and home stability.
There are three common methods of treating perimenopausal syndrome:
and (4) psychotherapy. Through psychological consultation and conversation, the living habits of the patients are changed. Such as physical and mental labor to which the adherence can reach. The disuse atrophy of muscles and joints can be prevented through long-term conscious labor. Insisting on learning and thinking, the heart and chest are widened, the temperament is good, and the attention of abnormal vasomotor is transferred or relieved. The disadvantage is that the method has limited treatment effect and is not a substantial treatment scheme.
Administering an autonomic nervous function regulating agent. For patients with ineffective psychotherapy, autonomic nerve function regulating drugs such as oryzanol, diazepam, vitamin B6, vitamin B complex, vitamin E, vitamin A, etc. can be administered in adjuvant mode. The medicine acts on nerves, is helpful for regulating autonomic nerve function, and stabilizing vasomotor state. However, the method is only a symptomatic treatment and not a treatment.
Hormone Replacement Therapy (HRT). Perimenopausal syndrome is mainly caused by ovarian function decline and estrogen reduction, and HRT is a clinical medical measure adopted for solving the problem, belonging to the treatment.
Hormone Replacement Therapy (HRT) is an internationally accepted standard therapy for the treatment of perimenopausal syndrome. The current common mode of HRT therapy is the regular daily dosing of estrogen. The scientific and reasonable use of estrogen can obviously reduce the range and frequency of low fever and hot flash of the body and reduce the discomfort of perimenopausal women, but the side effects of the estrogen comprise uterine bleeding, endometrial cancer, breast cancer, liver function damage and the like. The blood concentration can be maintained to be stable by taking the estrogen regularly and quantitatively every day, but the use time and the use amount of the estrogen have no unified standard in the medical treatment world at present, so that the side effect cannot be effectively reduced. Only with scientific, rational and normative administration and regular monitoring can the beneficial effects of estrogen outweigh their potential hazards.
The existing body temperature monitoring scheme is to use a thermometer to monitor the body temperature change of the body, mainly to measure when the body temperature rises. However, in the monitoring scheme, the patient firstly judges according to the body temperature feeling of the patient and then carries out measurement and recording. Because the body temperature of a human body fluctuates every day, the body temperature is not scientific and comprehensive by taking subjective feeling as a measurement basis.
And a mature human body temperature monitoring method for researching perimenopausal pathogenesis and therapy is not established in academic research. The research on mechanism of incidence of hot flashes and estrogen replacement therapy (Wuxueqing et al, compiled in the third national menopause academic conference and menopause-related problem study treatise of Zhonghua medical society of 6-11-th-day 2011) only describes the establishment of an animal model of menopause hot flashes and a remote skin temperature detection system to discuss the neurobiological mechanism of incidence of hot flashes. The method is characterized in that a rat tail skin temperature sensor (T S T) is subcutaneously implanted into an adult female Wistar rat, bilateral oophorectomy is performed, the T S T change is remotely monitored respectively after the operation and the operation (the body temperature is monitored once every 3 minutes and is monitored for 24 hours every day), and a body temperature change dynamic curve is drawn, so that an animal model of post-menopausal hot flashes is established and then used for experimental research.
Reports of continuous and precise monitoring of human body temperature data for guidance of hormone replacement therapy in the perimenopause period are not yet available. Human body temperature detection has important significance for the research of menopausal hormone replacement therapy, but the existing body temperature monitoring technology has a plurality of defects and shortcomings.
1. The common contact type body temperature measuring instruments on the market at present comprise a mercury thermometer and an electronic thermometer; the non-contact measurement is provided with an infrared thermometer comprising an ear thermometer, a forehead thermometer and an infrared imaging thermometer, but the non-contact measurement can only meet the requirement of one-time body temperature measurement. The pattern and magnitude of body temperature changes is not currently well understood for perimenopausal women.
2. Most of the common body temperature measuring instruments on the market can store body temperature data for 5-10 times. In order to obtain the temperature data of perimenopausal women as comprehensively as possible, each individual needs to measure the basal body temperature, the body temperature every two hours and the emergent hot flash body temperature every day, and continuously monitor for at least 1 month.
3. The commonly used body temperature measuring instruments on the market can not be worn for a long time at present.
4. At present, a common body temperature measuring instrument on the market can only look up body temperature data once or a few times, cannot see a long-term historical fluctuation curve of the body temperature, and cannot judge the heat type, namely, whether low heat is dominant or hot flashes are dominant or hot flashes occur on the basis of the low heat, and finally, the data cannot be integrated and analyzed.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a body temperature monitoring device and a body temperature monitoring system for guiding the perimenopausal hormone replacement therapy, so as to monitor the body temperature change mode and the change amplitude of perimenopausal women. Data are obtained through body temperature monitoring of a large sample, and the data are stored and integrated for analysis, so that the optimal time point and the optimal dosage of taking hormone medicaments are obtained, clinical estrogen use is guided, the HRT effect is maximized, and meanwhile harm is avoided.
The invention adopts the following technical scheme. The invention provides a body temperature monitoring device for guiding a perimenopausal hormone replacement therapy, which comprises a body temperature monitoring instrument and an intelligent mobile terminal of a user;
the body temperature monitor is a cochlea wearable electronic body temperature monitor capable of continuously measuring body temperature, and comprises a temperature collector, a digital signal converter, a signal emitter and a main controller module; the temperature collector is used for measuring body temperature data of a user in a set time period, the body temperature data comprises daily basal body temperature, timing body temperature and sudden hot flash body temperature, the digital signal converter converts the collected body temperature into a digital signal and then the main controller module controls the signal emitter to send the body temperature data to the intelligent mobile terminal of the user;
the intelligent mobile terminal of the user comprises a body temperature data processing module, a hormone dosage taking recording module and a hormone dosage analyzing module, wherein the body temperature data processing module stores and analyzes body temperature detection data in a set time period, and the hormone dosage taking recording module is used for recording the name, dosage and taking time of hormone medicines taken by the user in the set time period; the hormone dosage analysis module analyzes reasonable hormone dosage range, administration time and medicine types in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone administration records.
Preferably, the temperature collector comprises a temperature sensor and a real-time clock module, the real-time clock module is used for internal timing, the main controller module controls the temperature sensor to measure the body temperature data of the user in preset time through the real-time clock module, and when the timing reaches a preset temperature measurement time interval, the real-time clock module is awakened to drive the temperature sensor to detect the body temperature.
Preferably, the basal body temperature is measured manually through a button on the earplug after 6 am and when the earplug is awake naturally; the timing body temperature is between 8 and 22 points, and the body temperature is automatically measured every 2 hours; the body temperature of the sudden hot flash is measured automatically in real time when the body temperature is 0.5 ℃ higher than the basic body temperature.
Preferably, the signal transmitter transmits the temperature digital signal to the user smart mobile terminal through bluetooth.
Preferably, the cochlear wearable electronic thermometer adopts an earplug-connected ear-hanging structure, the ear-hanging is C-shaped, one end of the ear-hanging is connected with the earplug, a manual temperature measuring button is arranged outside the earplug, and when the manual temperature measuring button is touched, the temperature sensor can be driven to carry out real-time body temperature detection; the temperature collector, the digital signal converter, the signal emitter and the main controller module are all arranged inside the earplug;
the earplugs and the ear loops are made of silica gel.
Preferably, the user intelligent mobile terminal is a mobile phone or a tablet computer.
Preferably, after receiving body temperature data sent by the cochlear wearable electronic body temperature instrument, a body temperature data processing module in the user intelligent mobile terminal draws a body temperature curve of the day, calculates the highest body temperature of the day and the average body temperature of the day; for long-term data with the body temperature data acquisition time interval exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature mean value, a monthly timing body temperature mean value, a body temperature mean value and a monthly body temperature peak mean value, and drawing a body temperature curve and a table according to the data.
Preferably, the user inputs the name, dosage and administration time of the administered hormone medicine into the hormone dosage administration recording module through the mobile terminal;
the hormone medicine comprises Bujiale, Kelingmeng, Fenmolong and tibolone;
the hormone dose analysis module finds out a hormone medicine time point with the maximum body temperature drop amplitude based on body temperature data obtained for four months and corresponding hormone administration records;
first month body temperature data recording: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot body temperature of the user when the hormone medicine is not taken;
second month temperature data recording: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when taking one same hormone medicine every day, the basal body temperature, the timing body temperature, and the sudden hot flash body temperature of the user;
third month body temperature data recording: the thermometer is used for recording the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the second month every day;
and recording body temperature data in the fourth month: the thermometer is used for recording the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the third month every day;
after a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the monthly body temperature difference K1, wherein the smaller the body temperature difference K1 is, the better the hormone medicine absorption at the taking time point is, the hot flash symptom is relieved, and the taking time point of the hormone medicine with the largest body temperature drop amplitude of the user is obtained;
body temperature gap K1:
K1=α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the mean value of the body temperature peak values of the second, third or fourth month and the mean value of the body temperature of the current month;
b is the absolute value of the difference between the mean value of the body temperature peak value of the second, third or fourth month and the mean value of the body temperature at the time of the month;
c is the absolute value of the difference between the mean value of the peak body temperature value of the second, third or fourth month and the mean value of the basal body temperature value of the current month;
d is the absolute value of the difference between the mean value of the sudden hot flash temperature of the second, third or fourth month and the mean value of the timed body temperature of the first month;
wherein α + β + γ =1, α =1.5 γ, β =0.5 γ;
preferably, the hormone dose analysis module finds out the hormone drug dose with the maximum body temperature drop amplitude based on body temperature data and corresponding hormone administration records obtained by administering one same drug for four months and administering two same drugs for three months;
fifth month body temperature data record: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when taking two hormone medicines with the same kind as the medicines in the fourth month every day, the basal body temperature, the timing body temperature and the sudden hot body temperature of the user;
recording body temperature data in the sixth month: the thermometer should record the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the fifth month every day;
and recording body temperature data in the seventh month: the thermometer should record the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the sixth month every day;
after a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the body temperature difference K2, wherein the body temperature difference K2 shows that the hormone can relieve the hot flash symptom to the maximum extent at the dose, and obtaining the medicine taking dose and the taking time point with the maximum body temperature reduction of the user;
body temperature gap K2:
K2=ε*E+ζ*F+ν*G
e is the absolute value of the difference between the total body temperature peak value mean value sum of the second month to the fourth month and the total body temperature mean value sum of the second month to the fourth month or the absolute value of the difference between the total body temperature peak value mean value sum of the fifth month to the seventh month and the total body temperature mean value sum of the fifth month to the seventh month;
f is the absolute value of the difference between the total of the body temperature peak value means of the second month to the fourth month and the total of the body temperature mean values at the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak value means of the fifth month to the seventh month and the total of the body temperature mean values at the fifth month to the seventh month;
g is the absolute value of the difference between the total of the body temperature peak values of the second month to the fourth month and the total of the body temperature peak values of the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak values of the fifth month to the seventh month and the body temperature peak values of the fifth month to the seventh month;
wherein, epsilon + zeta + nu =1, epsilon =1.5 nu, and zeta =0.5 nu.
Preferably, the body temperature monitoring system further comprises a server, wherein the server is a cloud computing background and receives body temperature data of each user in a set time period and the name, dosage and administration time of hormone medicines taken, which are sent by a user intelligent mobile terminal using the body temperature monitoring device of claims 1-9;
the population is divided into a plurality of subgroups on the premise of no statistical difference in age, weight, menopause time and the like after 7 months of body temperature monitoring period because the sample size is large enough:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subgroup three: age 50-52 years, 60-70kg, menopause 1-2 years;
subgroup four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years … …
Under the action of different medicines, the difference between the monthly body temperature mean value and the monthly body temperature peak mean value is calculated and compared, the smaller the difference is, the hot flash symptom can be reduced to the maximum extent by the estrogen medicines, and the hormone medicine name, the hormone medicine taking time point and the medicine taking dosage which are most suitable for the crowd are obtained.
The invention has the beneficial effects that:
1. the body temperature monitoring device provided by the invention is a novel convenient, sustainable and accurate body temperature measuring tool, and has the functions of being easy to clean and keeping sanitation.
2. The body temperature monitoring device provided by the invention can automatically measure even when the device works and sleeps, and the earplugs and the C-shaped ear hooks are soft in material, so that the normal life activities of people are not influenced. The ear-hang adopts silica gel, and is soft comfortable, and the wearability is strong, and after the earplug was fixed well in the duct, C type ear-hang surrounded to being close earlobe department by auricle rear, let wear more stably, be difficult for droing.
3. At present, most electronic thermometers only have a manual temperature measurement function and do not have an automatic real-time temperature measurement function. The body temperature monitoring device provided by the invention starts automatic temperature measurement when the real-time body temperature exceeds the basal body temperature by 0.5 ℃, and is very intelligent and convenient.
4. At present, most electronic thermometers have limited storage space, and the stored body temperature data is very limited. The body temperature monitoring system provided by the invention utilizes the mobile phone as a memory, and the storage space is large.
5. Most of the prior electronic thermometers can not analyze the data of the body temperature, thereby limiting the application of the electronic thermometers. The body temperature monitoring system provided by the invention can realize historical record and statistical analysis of body temperature data by using the body temperature data processing module, and can conveniently look up personal body temperature curves, data analysis results and the like through a mobile phone interface.
6. The body temperature monitoring system provided by the invention analyzes the body temperature data of a large crowd sample through the server, finds the optimal administration time point and finally realizes the individuation of HRT (high resolution transistor) drug treatment.
7. The body temperature monitoring system provided by the invention finds out the hormone administration mode with the largest body temperature reduction amplitude by monitoring the body temperature when the patient does not take the medicine at a specific time point and the body temperature after taking the medicine, and also can carry out temperature data analysis on a crowd bulk sample through a cloud computing background to find out the optimal hormone medicine name, hormone medicine taking time point and medicine taking dosage, thereby finally realizing the maximum effect of HRT medicine treatment and avoiding potential harm.
8. The body temperature monitoring method established by the body temperature monitoring system provided by the invention can acquire the relationship between the body temperature and the hormone dosage of perimenopausal people and guide the perimenopausal people to carry out hormone replacement therapy; can also be used for scientific research and academic research.
Drawings
FIG. 1 is an appearance view of a C-shaped ear-hook of the body temperature monitoring device of the present invention;
FIG. 2 is a schematic view of the wearing of the body temperature monitoring device of the present invention;
FIG. 3 is an external view of an earplug of the body temperature monitoring device of the present invention;
FIG. 4 is a view of the internal structure of an earplug of the body temperature monitoring device of the invention;
FIG. 5 is a schematic diagram of the operation of the cochlear electronic thermometer of the body temperature monitoring device according to the present invention;
FIG. 6 is a flow chart of signal and data processing of the body temperature monitoring system according to the present invention;
fig. 7 is a flow chart of big data collection and analysis of the body temperature monitoring system of the present invention.
In the figure:
1-an earplug;
2, hanging the ears;
3-a temperature sensor;
4-a digital signal converter;
5-a signal transmitter;
6-a main controller module;
7-manual temperature measuring button.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A body temperature monitoring device for guiding hormone replacement therapy in perimenopause comprises a body temperature monitoring instrument and a user intelligent mobile terminal;
as shown in fig. 1 to 3, the cochlear wearable electronic thermometer adopts a structure that an earplug 1 is connected with an ear hook 2, the ear hook 2 is in a C shape, one end of the ear hook 2 is connected with the earplug 1, a manual temperature measuring button 7 is arranged outside the earplug 1, and when the manual temperature measuring button 7 is touched, a temperature sensor can be driven to perform real-time body temperature detection; the temperature collector 3, the digital signal converter 4, the signal emitter 5 and the main controller module 6 are all arranged inside the earplug; the earplug 1 and the ear hook 2 are both made of silica gel.
As shown in fig. 4, the body temperature monitor is a cochlear wearable electronic body temperature monitor capable of continuously measuring body temperature, and includes a temperature collector 3, a digital signal converter 4, a signal emitter 5 and a main controller module 6.
The temperature collector 3 comprises a temperature sensor and a real-time clock module, the real-time clock module is used for internal timing, the main controller module controls the temperature sensor to measure body temperature data of a user in preset time through the real-time clock module, and when the timing reaches a preset temperature measurement time interval, the real-time clock module is awakened to drive the temperature sensor to carry out body temperature detection. The temperature collector 3 is used for measuring body temperature data of a user in a set time period, the body temperature data comprise daily basal body temperature, timing body temperature and sudden hot flash body temperature, the digital signal converter 4 converts the collected body temperature into a digital signal and then the main controller module 6 controls the signal emitter 5 to send the body temperature data to the intelligent mobile terminal of the user, and the intelligent mobile terminal of the user is a mobile phone or a tablet computer.
The basal body temperature is measured manually through a button on the earplug after 6 am and when the earplug is naturally awake; the timing body temperature is between 8 and 22 points, and the body temperature is automatically measured every 2 hours; the body temperature of the sudden hot flash is measured automatically in real time when the body temperature is 0.5 ℃ higher than the basic body temperature. The body temperature of a human body fluctuates every day, generally, the body temperature is lowest when the body temperature is from two points to four points in the morning, the body temperature is highest when the body temperature is from two points to four points in the afternoon, then the body temperature gradually decreases, and the whole fluctuation is within the range of 1 ℃.
The signal emitter 5 sends the temperature digital signal to the intelligent mobile terminal of the user through Bluetooth.
As shown in fig. 4 and 5, the user intelligent mobile terminal includes a body temperature data processing module, a hormone dosage administration recording module and a hormone dosage analysis module, wherein the body temperature data processing module stores and analyzes body temperature detection data in a set time period, and the hormone dosage administration recording module is used for recording the name, dosage and administration time of hormone medicines taken by a user in the set time period; the hormone dosage analysis module analyzes the hormone medicine taking time point and dosage with the maximum body temperature reduction amplitude in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone taking record.
After receiving body temperature data sent by the cochlear wearable electronic body thermometer, a body temperature data processing module in the user intelligent mobile terminal draws a body temperature curve of the current day, and calculates the highest body temperature and the average body temperature of the current day; for long-term data with the body temperature data acquisition time interval exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature mean value, a monthly timing body temperature mean value, a body temperature mean value and a monthly body temperature peak mean value, and drawing a body temperature curve and a table according to the data.
The user inputs the name, dosage and administration time of the administered hormone medicine into the hormone dosage administration recording module through the mobile terminal; the hormone medicine comprises Bujiale, Kerimg, Fenmoletong and tibolone;
according to the 'standard diagnosis and treatment process for hormone supplement data related to menopause' (hereinafter referred to as 'process') published by the university medical society, gynaecological and obstetrical scientific society and academy group in 2013 (recently), the commonly used estrogen supplement medicines comprise Bujiale, Kelingmeng, Fenmoltong, tibolone and the like, and generally only one medicine needs to be taken every day. Therefore, for patients needing to be supplemented with estrogen, the purpose of supplementing estrogen can be achieved by taking an estrogen medicament for a long time in clinic.
The hormone dose analysis module finds out a hormone medicine time point with the maximum body temperature drop amplitude based on body temperature data obtained for four months and corresponding hormone administration records;
first month data record: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot body temperature of the user when the hormone medicine is not taken;
second month data record: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when the same estrogen supplement medicine is taken every day, the basal body temperature, the timing body temperature and the sudden hot body temperature of the user;
february-basal body temperature measurement and fasting administration
TABLE 1
Third month data record: the thermometer is used for recording the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the second month every day; generally, the 14 o' clock is 2 hours after a Chinese meal, the medicine can be better absorbed, and the body temperature of the human body is higher or peak in the day generally.
The medicine is taken at the point from March-14
TABLE 2
Fourth month data record: the thermometer is used for recording the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the third month every day;
the medicine is taken at the point of the fourth month-22
TABLE 3
After a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the monthly body temperature difference K1, the smaller the body temperature difference K1 is, the better the absorption of hormone medicine is at the taking time point, the hot flash symptom is relieved, and the taking time point of hormone medicine with the largest body temperature drop of the user is obtained.
Body temperature gap K1:
K1=α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the mean value of the body temperature peak values of the second, third or fourth month and the mean value of the body temperature of the current month;
b is the absolute value of the difference between the mean value of the body temperature peak value of the second, third or fourth month and the mean value of the body temperature at the time of the month;
c is the absolute value of the difference between the mean value of the peak body temperature value of the second, third or fourth month and the mean value of the basal body temperature value of the current month;
d is the absolute value of the difference between the mean value of the sudden hot flash temperature of the second, third or fourth month and the mean value of the timed body temperature of the first month;
wherein α + β + γ =1, α =1.5 γ, β =0.5 γ;
for women who still feel uncontrolled climacteric symptoms after taking one estrogen medicament a day, the same medicament can be added to two (follow the procedure).
The hormone dose analysis module finds out the hormone drug dose with the maximum body temperature drop amplitude based on body temperature data and corresponding hormone administration records obtained by administering one same drug for four months and administering two same drugs for three months;
fifth month body temperature data record: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when taking two hormone medicines with the same kind as the medicines in the fourth month every day, the basal body temperature, the timing body temperature and the sudden hot body temperature of the user;
recording body temperature data in the sixth month: the thermometer should record the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the fifth month every day;
and recording body temperature data in the seventh month: the thermometer should record the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the sixth month every day;
after a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the body temperature difference K2, the smaller the body temperature difference K2 is, the more the hormone can reduce the hot flash symptom to the maximum extent at the dose, and the maximum medicine taking dose and taking time point of the body temperature of the user can be obtained.
Body temperature gap K2:
K2=ε*E+ζ*F+ν*G
e is the absolute value of the difference between the total body temperature peak value mean value sum of the second month to the fourth month and the total body temperature mean value sum of the second month to the fourth month or the absolute value of the difference between the total body temperature peak value mean value sum of the fifth month to the seventh month and the total body temperature mean value sum of the fifth month to the seventh month;
f is the absolute value of the difference between the total of the body temperature peak value means of the second month to the fourth month and the total of the body temperature mean values at the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak value means of the fifth month to the seventh month and the total of the body temperature mean values at the fifth month to the seventh month;
g is the absolute value of the difference between the total of the body temperature peak values of the second month to the fourth month and the total of the body temperature peak values of the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak values of the fifth month to the seventh month and the body temperature peak values of the fifth month to the seventh month;
wherein, epsilon + zeta + nu =1, epsilon =1.5 nu, and zeta =0.5 nu.
As shown in fig. 5, the body temperature monitoring system of the body temperature monitoring device further includes a server, which is a cloud computing background and receives body temperature data of each user in a set time period and names, dosages and administration times of hormone drugs that are sent by the user intelligent mobile terminal using the body temperature monitoring device according to claims 1 to 9.
For estrogen users in a population, different types of estrogen drugs may be selected due to different factors such as medical areas, drug supply, drug price, and the like.
The population is divided into a plurality of subgroups on the premise of no statistical difference in age, weight, menopause time and the like after 7 months of body temperature monitoring period because the sample size is large enough:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subgroup three: age 50-52 years, 60-70kg, menopause 1-2 years;
subgroup four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years … …
Under the action of different medicines, the difference between the monthly body temperature mean value and the monthly body temperature peak mean value is calculated and compared, the smaller the difference is, the hot flash symptom can be reduced to the maximum extent by the estrogen medicines, and the hormone medicine name, the hormone medicine taking time point and the medicine taking dosage which are most suitable for the crowd are obtained.
Compared with the prior art, the invention has the beneficial effects that:
1. the body temperature monitoring device provided by the invention is a novel convenient, sustainable and accurate body temperature measuring tool, and has the functions of being easy to clean and keeping sanitation.
2. The body temperature monitoring device provided by the invention can automatically measure even when the device works and sleeps, and the earplugs and the C-shaped ear hooks are soft in material, so that the normal life activities of people are not influenced. The ear-hang adopts silica gel, and is soft comfortable, and the wearability is strong, and after the earplug was fixed well in the duct, C type ear-hang surrounded to being close earlobe department by auricle rear, let wear more stably, be difficult for droing.
3. At present, most electronic thermometers only have a manual temperature measurement function and do not have an automatic real-time temperature measurement function. The body temperature monitoring device provided by the invention starts automatic temperature measurement when the real-time body temperature exceeds the basal body temperature by 0.5 ℃, and is very intelligent and convenient.
4. At present, most electronic thermometers have limited storage space, and the stored body temperature data is very limited. The body temperature monitoring system provided by the invention utilizes the mobile phone as a memory, and the storage space is large.
5. Most of the prior electronic thermometers can not analyze the data of the body temperature, thereby limiting the application of the electronic thermometers. The body temperature monitoring system provided by the invention can realize historical record and statistical analysis of body temperature data by using the body temperature data processing module, and can conveniently look up personal body temperature curves, data analysis results and the like through a mobile phone interface.
6. The body temperature monitoring system provided by the invention analyzes the body temperature data of a large crowd sample through the server, finds the optimal administration time point and finally realizes the individuation of HRT (high resolution transistor) drug treatment.
7. The body temperature monitoring system provided by the invention finds out the hormone administration mode with the largest body temperature reduction amplitude by monitoring the body temperature when the patient does not take the medicine at a specific time point and the body temperature after taking the medicine, and also can carry out temperature data analysis on a crowd bulk sample through a cloud computing background to find out the optimal hormone medicine name, hormone medicine taking time point and medicine taking dosage, thereby finally realizing the maximum effect of HRT medicine treatment and avoiding potential harm.
8. The body temperature monitoring method established by the body temperature monitoring system provided by the invention can acquire the relationship between the body temperature and the hormone dosage of perimenopausal people and guide the perimenopausal people to carry out hormone replacement therapy; can also be used for scientific research and academic research.
In summary, through the analysis of the above problems, the present invention provides a body temperature monitoring device and system for guiding hormone replacement therapy during perimenopause. The system work flow is set to measure the body temperature through the cochlear thermometer (temperature sensor) and convert the body temperature into digital signals, the digital signals are transmitted to the intelligent mobile terminal (mobile phone) through Bluetooth, the body temperature data analysis APP of the mobile phone can carry out the statistical analysis of individual data of a user, the mobile phone data can also be sent to the remote terminal (computer) to carry out the statistical analysis of large-sample crowd data, and the basis is provided for guiding hormone replacement therapy in the perimenopause period, so that the system is suitable for large-scale crowds, and can also provide the basis for the medication accuracy and individuation of a single user.
The present applicant has described and illustrated embodiments of the present invention in detail with reference to the accompanying drawings, but it should be understood by those skilled in the art that the above embodiments are merely preferred embodiments of the present invention, and the detailed description is only for the purpose of helping the reader to better understand the spirit of the present invention, and not for limiting the scope of the present invention, and on the contrary, any improvement or modification made based on the spirit of the present invention should fall within the scope of the present invention.
Claims (10)
1. A body temperature monitoring device for guiding hormone replacement therapy in perimenopause comprises a body temperature monitoring instrument and a user intelligent mobile terminal; the method is characterized in that:
the body temperature monitor is a cochlea wearable electronic body temperature monitor capable of continuously measuring body temperature, and comprises a temperature collector (3), a digital signal converter (4), a signal emitter (5) and a main controller module (6); the temperature collector (3) is used for measuring body temperature data of a user in a set time period, the body temperature data comprises daily basal body temperature, timing body temperature and sudden hot flash body temperature, the digital signal converter (4) converts the collected body temperature into a digital signal, and then the main controller module (6) controls the signal emitter (5) to send the body temperature data to the intelligent mobile terminal of the user;
the intelligent mobile terminal of the user comprises a body temperature data processing module, a hormone dosage taking recording module and a hormone dosage analyzing module, wherein the body temperature data processing module stores and analyzes body temperature detection data in a set time period, and the hormone dosage taking recording module is used for recording the name, dosage and taking time of hormone medicines taken by the user in the set time period; the hormone dosage analysis module analyzes reasonable hormone dosage range, administration time and medicine types in the hormone replacement therapy of the user based on the body temperature detection data and the corresponding hormone administration records.
2. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 1, wherein:
the temperature collector (3) comprises a temperature sensor and a real-time clock module, the real-time clock module is used for internal timing, the main controller module controls the temperature sensor to measure body temperature data of a user at preset time through the real-time clock module, and when the timing reaches a preset temperature measurement time interval, the real-time clock module is awakened to drive the temperature sensor to carry out body temperature detection.
3. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 2, wherein:
the basal body temperature is measured manually through a button on the earplug after 6 am and when the earplug is naturally waken; the timing body temperature is between 8 and 22 points, and the body temperature is automatically measured every 2 hours; the body temperature of the sudden hot flash is measured automatically in real time when the body temperature is 0.5 ℃ higher than the basic body temperature.
4. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 1, wherein:
and the signal emitter (5) sends the temperature digital signal to the intelligent mobile terminal of the user through Bluetooth.
5. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 1, wherein:
the cochlea-worn electronic thermometer adopts a structure that an earplug (1) is connected with an ear hook (2), the ear hook (2) is C-shaped, one end of the ear hook (2) is connected with the earplug (1), a manual temperature measurement button (7) is arranged outside the earplug (1), and when the manual temperature measurement button (7) is touched, a temperature sensor can be driven to carry out real-time body temperature detection; the temperature collector (3), the digital signal converter (4), the signal emitter (5) and the main controller module (6) are all arranged inside the earplug;
the earplug (1) and the ear hook (2) are both made of silica gel.
6. Body temperature monitoring device for guiding perimenopausal hormone replacement therapy according to claim 1 or 5, characterized in that:
the user intelligent mobile terminal is a mobile phone or a tablet computer.
7. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 1, wherein:
after receiving body temperature data sent by the cochlear wearable electronic body thermometer, a body temperature data processing module in the user intelligent mobile terminal draws a body temperature curve of the current day, and calculates the highest body temperature and the average body temperature of the current day; for long-term data with the body temperature data acquisition time interval exceeding 1 month, the body temperature data processing module is used for calculating a monthly basal body temperature mean value, a monthly timing body temperature mean value, a body temperature mean value and a monthly body temperature peak mean value, and drawing a body temperature curve and a table according to the data.
8. A body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 7, wherein:
the user inputs the name, dosage and administration time of the administered hormone medicine into the hormone dosage administration recording module through the mobile terminal;
the hormone medicine comprises Bujiale, Kelingmeng, Fenmolong and tibolone;
the hormone dose analysis module finds out a hormone medicine time point with the maximum body temperature drop amplitude based on body temperature data obtained for four months and corresponding hormone administration records;
first month body temperature data recording: the thermometer should record the basal body temperature, the timing body temperature and the sudden hot body temperature of the user when the hormone medicine is not taken;
second month temperature data recording: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when taking one same hormone medicine every day, the basal body temperature, the timing body temperature, and the sudden hot flash body temperature of the user;
third month body temperature data recording: the thermometer is used for recording the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the second month every day;
and recording body temperature data in the fourth month: the thermometer is used for recording the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of a user when taking one hormone medicine with the same kind as the medicine in the third month every day;
after a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the monthly body temperature difference K1, wherein the smaller the body temperature difference K1 is, the better the hormone medicine absorption at the taking time point is, the hot flash symptom is relieved, and the taking time point of the hormone medicine with the largest body temperature drop amplitude of the user is obtained;
body temperature gap K1:
K1=α*A+β*B+γ*C-δ*D
a is the absolute value of the difference between the mean value of the body temperature peak values of the second, third or fourth month and the mean value of the body temperature of the current month;
b is the absolute value of the difference between the mean value of the body temperature peak value of the second, third or fourth month and the mean value of the body temperature at the time of the month;
c is the absolute value of the difference between the mean value of the peak body temperature value of the second, third or fourth month and the mean value of the basal body temperature value of the current month;
d is the absolute value of the difference between the mean value of the sudden hot flash temperature of the second, third or fourth month and the mean value of the timed body temperature of the first month;
wherein α + β + γ =1, α =1.5 γ, β =0.5 γ;
9. a body temperature monitoring device for guidance of perimenopausal hormone replacement therapy according to claim 8, wherein:
the hormone dose analysis module finds out the hormone drug dose with the maximum body temperature drop amplitude based on body temperature data and corresponding hormone administration records obtained by administering one same drug for four months and administering two same drugs for three months;
fifth month body temperature data record: the thermometer should record the set administration time as the basal body temperature, and take the medicine immediately on an empty stomach, and when taking two hormone medicines with the same kind as the medicines in the fourth month every day, the basal body temperature, the timing body temperature and the sudden hot body temperature of the user;
recording body temperature data in the sixth month: the thermometer should record the set medicine taking time as 14 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the fifth month every day;
and recording body temperature data in the seventh month: the thermometer should record the set medicine taking time as 22 points, and the basal body temperature, the timing body temperature and the sudden hot flash body temperature of the user when taking two hormone medicines with the same kind as the medicines in the sixth month every day;
after a body temperature data processing module in the user intelligent mobile terminal receives body temperature data sent by a body temperature instrument, calculating a monthly basic body temperature mean value, a monthly timing body temperature mean value, a monthly body temperature mean value and a monthly body temperature peak value mean value; then comparing the body temperature difference K2, wherein the smaller the body temperature difference K2 is, the more the hot flash symptom can be relieved by the hormone in the dose, and the medicine taking dose and the taking time point with the largest body temperature reduction range of the user are obtained;
body temperature gap K2:
K2=ε*E+ζ*F+ν*G
e is the absolute value of the difference between the total body temperature peak value mean value sum of the second month to the fourth month and the total body temperature mean value sum of the second month to the fourth month or the absolute value of the difference between the total body temperature peak value mean value sum of the fifth month to the seventh month and the total body temperature mean value sum of the fifth month to the seventh month;
f is the absolute value of the difference between the total of the body temperature peak value means of the second month to the fourth month and the total of the body temperature mean values at the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak value means of the fifth month to the seventh month and the total of the body temperature mean values at the fifth month to the seventh month;
g is the absolute value of the difference between the total of the body temperature peak values of the second month to the fourth month and the total of the body temperature peak values of the second month to the fourth month or the absolute value of the difference between the total of the body temperature peak values of the fifth month to the seventh month and the body temperature peak values of the fifth month to the seventh month;
wherein, epsilon + zeta + nu =1, epsilon =1.5 nu, and zeta =0.5 nu.
10. A body temperature monitoring system comprising a body temperature monitoring device according to any one of claims 1 to 9, wherein:
the body temperature monitoring system further comprises a server which is a cloud computing background and is used for receiving body temperature data of each user in a set time period and names, dosage and taking time of hormone medicines taken, wherein the body temperature data is sent by an intelligent mobile terminal of the user using the body temperature monitoring device according to claims 1-9;
the population is divided into a plurality of subgroups on the premise of no statistical difference in age, weight, menopause time and the like after 7 months of body temperature monitoring period because the sample size is large enough:
subgroup one: age 50-52 years, 50-60kg, menopause 1-2 years;
subgroup two: age 50-52 years, 50-60kg, menopause 3-5 years;
subgroup three: age 50-52 years, 60-70kg, menopause 1-2 years;
subgroup four: age 50-52 years, 60-70kg, menopause 3-5 years;
subgroup five: age 50-52 years, 70-80kg, menopause 1-2 years;
subgroup six: age 50-52 years, 70-80kg, menopause 3-5 years … …
Under the action of different medicines, the difference between the monthly body temperature mean value and the monthly body temperature peak mean value is calculated and compared, the smaller the difference is, the hot flash symptom can be reduced to the maximum extent by the estrogen medicines, and the hormone medicine name, the hormone medicine taking time point and the medicine taking dosage which are most suitable for the crowd are obtained.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030004146A1 (en) * | 2000-03-29 | 2003-01-02 | Joseph Levy | Compositions for preventing hormone induced adverse effects |
| CN103550484A (en) * | 2013-10-30 | 2014-02-05 | 天津中医药大学 | Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof |
| CN204971237U (en) * | 2015-09-02 | 2016-01-20 | 热映光电股份有限公司 | Hard of hearing temperature sensing apparatus and hard of hearing temperature monitoring system |
| CN105938020A (en) * | 2015-03-06 | 2016-09-14 | 精工爱普生株式会社 | Temperature measurement apparatus and temperature measurement method |
| TW201707643A (en) * | 2015-08-17 | 2017-03-01 | 熱映光電股份有限公司 | Behind ear temperature monitoring apparatus, system thereof and a method for monitoring temperature |
| CN109141677A (en) * | 2018-10-18 | 2019-01-04 | 安徽汉诺医疗科技有限公司 | A kind of internet Mobile medical system based on temperature taking |
| CN112133397A (en) * | 2020-08-14 | 2020-12-25 | 浙江中医药大学 | Dynamic management method and device for patient medicine taking and storage medium |
| CN212592089U (en) * | 2020-03-11 | 2021-02-26 | 广州波通通信有限公司 | Ear-wearing type body temperature monitor |
-
2021
- 2021-12-15 CN CN202111532448.4A patent/CN114300088B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030004146A1 (en) * | 2000-03-29 | 2003-01-02 | Joseph Levy | Compositions for preventing hormone induced adverse effects |
| CN103550484A (en) * | 2013-10-30 | 2014-02-05 | 天津中医药大学 | Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof |
| CN105938020A (en) * | 2015-03-06 | 2016-09-14 | 精工爱普生株式会社 | Temperature measurement apparatus and temperature measurement method |
| TW201707643A (en) * | 2015-08-17 | 2017-03-01 | 熱映光電股份有限公司 | Behind ear temperature monitoring apparatus, system thereof and a method for monitoring temperature |
| CN204971237U (en) * | 2015-09-02 | 2016-01-20 | 热映光电股份有限公司 | Hard of hearing temperature sensing apparatus and hard of hearing temperature monitoring system |
| CN109141677A (en) * | 2018-10-18 | 2019-01-04 | 安徽汉诺医疗科技有限公司 | A kind of internet Mobile medical system based on temperature taking |
| CN212592089U (en) * | 2020-03-11 | 2021-02-26 | 广州波通通信有限公司 | Ear-wearing type body temperature monitor |
| CN112133397A (en) * | 2020-08-14 | 2020-12-25 | 浙江中医药大学 | Dynamic management method and device for patient medicine taking and storage medium |
Non-Patent Citations (1)
| Title |
|---|
| 邱华: "围绝经期妇女社区护理干预的研究概况", 《中外医学研究》, vol. 12, no. 15, pages 161 - 163 * |
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