CN114292737A - Microbial cell wall breaking machine for biological medicine - Google Patents
Microbial cell wall breaking machine for biological medicine Download PDFInfo
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- CN114292737A CN114292737A CN202210015237.1A CN202210015237A CN114292737A CN 114292737 A CN114292737 A CN 114292737A CN 202210015237 A CN202210015237 A CN 202210015237A CN 114292737 A CN114292737 A CN 114292737A
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- 230000000813 microbial effect Effects 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 54
- 238000001816 cooling Methods 0.000 claims description 37
- 230000000903 blocking effect Effects 0.000 claims description 17
- 238000005086 pumping Methods 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 8
- 238000009833 condensation Methods 0.000 claims description 6
- 230000005494 condensation Effects 0.000 claims description 6
- 238000007790 scraping Methods 0.000 claims description 4
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- 238000005192 partition Methods 0.000 claims description 3
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- 210000004027 cell Anatomy 0.000 abstract description 55
- 239000012530 fluid Substances 0.000 abstract description 39
- 238000000926 separation method Methods 0.000 abstract description 2
- 239000011325 microbead Substances 0.000 description 18
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- 229910001220 stainless steel Inorganic materials 0.000 description 7
- 229910000975 Carbon steel Inorganic materials 0.000 description 6
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Abstract
The invention provides a microbial cell wall breaking machine for biomedicine, and relates to the technical field of biomedicine. This kind of broken wall machine uses through the cooperation of rotary rod and scraper blade, can prevent that the microballon from blockking up the filter screen in the stirring, uses through the cooperation of electromagnetism piece, magnetic path, separation piece and ring channel, can prevent that cell fluid from entering into the discharge tube in advance, ensures the completion degree of cell fluid broken wall.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a microbial cell wall breaking machine for biological medicines.
Background
The biomedical industry is a comprehensive technical system which is formed by combining the biotechnology industry and the medicine industry, wherein the biotechnology is based on the modern life science theory and provides goods and service means for society by utilizing organisms and the cellular, subcellular and molecular components thereof.
With the development of science and technology, people find that microorganisms can produce a lot of bioactive substances with unique functions, such as fat, polysaccharide, protein, carotenoid and the like, and have important development values in the fields of medicine, food, aquaculture and the like, so that people need to perform various biomedical experiments on cells of the microorganisms, find and extract substances beneficial to human phyla, and at the moment, the microbial cells need to be subjected to wall breaking treatment so as to extract the contents in the microbial cells, and therefore, a cell wall breaking machine is needed to be used for wall breaking operation.
When the existing wall breaking machine breaks the wall of cells, a bead grinding and crushing method is generally adopted, the microbeads and the cell fluid needing wall breaking are injected into the wall breaking machine together, then the wall breaking machine is started, the microbeads in the wall breaking machine move in various forms along with the rotation of the stirring rod, collision and shearing force are generated between the beads and the cells, the cell walls are broken to release inclusion, and the broken cell fluid and the microbeads are separated through the filter screen.
And current broken wall machine is when discharge cell fluid, because broken incasement portion leaves a large amount of microballons for the microballon sinks, stops in filter screen department, causes the filter screen to block up, influences the discharge velocity of cell fluid, and current broken wall machine when carrying out the broken wall, and partial cell fluid can enter into the discharge tube through the filter screen in advance, makes partial cell fluid not participate in the broken wall operation, influences the completion degree of cell fluid broken wall.
Disclosure of Invention
The invention aims to solve the defects in the background technology and provides a microbial cell wall breaking machine for biomedicine, wherein through the matching use of a rotating rod and a scraping plate, microbeads can be prevented from blocking a filter screen while stirring, and through the matching use of an electromagnetic block, a magnetic block, a blocking block and an annular groove, cell fluid can be prevented from entering a discharge pipe in advance, so that the completion degree of cell fluid wall breaking is ensured.
In order to achieve the purpose, the invention provides the following technical scheme that the microbial cell wall breaking machine for the biological medicine comprises a box body, a crushing box, a cooling box and a cooling component, wherein the cooling component is arranged between the box body and the cooling box and used for cooling the crushing box;
the front side of the box body is fixedly provided with a control panel, the top of the box body is fixedly provided with an equipment box, the interior of the box body is fixedly provided with a crushing box, one side of the box body is fixedly provided with a cooling box, and the inner wall of the bottom of the crushing box is fixedly provided with a fixing plate in a disc shape;
the cooling assembly comprises a water pump, a water pumping pipe, a condensation pipe and a return pipe, the water pump is fixedly arranged inside the cooling box, the water pumping pipe is fixedly connected to one side of the water pump, the condensation pipe of the serpentine structure is arranged on the outer side of the crushing box, and the return pipe is fixedly connected to one side of the cooling box.
Further, the water pump is connected with control panel electric connection, the one end of back flow runs through the box and is connected with the condenser pipe top, the one end of drinking-water pipe runs through the box and is connected with the condenser pipe bottom.
Furthermore, one side of the cooling box is fixedly connected with a water inlet pipe and a water outlet pipe, and the water inlet pipe is positioned above the water outlet pipe.
Further, broken roof portion fixedly connected with inlet pipe, just inlet pipe top protrusion in box upper surface, broken bottom of the case portion fixedly connected with discharging pipe, be provided with a plurality of semicircular lugs on the broken incasement wall, the row's of box one side fixedly connected with material pipe, just it is connected with broken case to arrange the material pipe.
Further, the inside fixed mounting of equipment box has the baffle, baffle top fixed mounting has servo motor, servo motor and control panel electric connection, servo motor bottom drive is connected with the rotary rod, just the rotary rod bottom runs through box and broken case and is connected with the fixed plate through the bearing.
Further, many puddlers of the equal fixedly connected with in rotary rod both sides, and many the puddler is the align to grid distribution in the vertical direction, the scraper blade of the equal fixedly connected with arc structure in rotary rod both sides, just the fixed plate outside is hugged closely to the scraper blade.
Further, a cavity is formed in the crushing box, an electromagnet is fixedly mounted in the cavity, a magnetic block of a circular ring-shaped structure is arranged at the top of the electromagnet, a plurality of reset springs are fixedly connected to the top of the magnetic block, and the top ends of the reset springs are connected with the inner wall of the cavity.
Furthermore, the fixed plate bottom has been seted up the fluting, just a plurality of through-holes have been seted up in the fixed plate outside, just the inside filter screen that is provided with of through-hole, the ring channel has been seted up to the fixed plate bottom.
Furthermore, an annular blocking groove is formed in the inner wall of the bottom of the crushing box, the cavity is communicated with the groove through the blocking groove, and the top of the magnetic block is fixedly connected with a blocking block of an annular structure.
The invention provides a microbial cell wall breaking machine for biological medicine, which has the following beneficial effects:
1. the invention has the advantages that through the filter screen, the rotary rod and the scraper, when the crushed cell fluid is discharged, the microbeads are separated from the cell fluid through the filter screen, the separated microbeads stay on the outer side of the filter screen, and the microbeads staying on the filter screen are scraped away through the scraper, so that the circulation of the filter screen is ensured, and the filter screen is prevented from being blocked due to the fact that a large number of microbeads stay on the outer side of the filter screen.
2. Secondly, through battery iron, magnetic path, barrier block and ring channel for the barrier block blocks the filter screen completely, makes in the cell fluid can't enter into the discharging tube through the filter screen, ensures that the cell fluid stops the inside broken wall operation that carries out of broken case completely, improves the completion degree of the broken wall of cell fluid.
3. Then, through water pump, drinking-water pipe, condenser pipe and back flow, can let the water in the condenser pipe carry out the heat exchange to broken case when carrying out the broken wall operation to reduce broken case's temperature, avoid broken case's high temperature, lead to cell fluid deactivation or even die, the water after the cooling flows back to the cooling tank again in, realizes water circulative cooling's effect.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is a sectional view of the overall structure of the present invention.
Fig. 3 is a top sectional view of the crushing box structure of the present invention.
Fig. 4 is a schematic view of the scraper structure of the present invention.
Fig. 5 is a schematic structural view of a fixing plate according to the present invention.
Fig. 6 is a schematic view of a structure of a condenser tube according to the present invention.
FIG. 7 is a cross-sectional view of a magnetic block structure of the present invention.
FIG. 8 is a top view of a magnetic block structure of the present invention.
Fig. 9 is a bottom view of the fixing plate structure of the present invention.
Fig. 10 is an enlarged view of the invention at a in fig. 2.
In FIGS. 1-10: 1. a box body; 101. a control panel; 102. a feed pipe; 103. a crushing box; 104. a bump; 105. a discharge pipe; 106. a discharge pipe; 107. a cavity; 2. an equipment box; 201. a partition plate; 202. a servo motor; 203. rotating the rod; 204. a stirring rod; 205. a squeegee; 3. a fixing plate; 301. filtering with a screen; 302. an annular groove; 4. an electromagnet; 401. a magnetic block; 402. a return spring; 403. a barrier block; 404. a blocking groove; 5. a cooling tank; 501. a water inlet pipe; 502. a water outlet pipe; 503. a water pump; 504. a water pumping pipe; 505. a condenser tube; 506. a return pipe.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example (b):
referring to FIGS. 1-10 of the drawings,
the microbial cell wall breaking machine for the biological medicine provided by the embodiment comprises a box body 1, a crushing box 103, a cooling box 5 and a cooling assembly arranged between the box body 1 and the cooling box 5 and used for cooling the crushing box 103;
the front surface of the box body 1 is fixedly provided with a control panel 101, the top of the box body 1 is fixedly provided with an equipment box 2, a crushing box 103 for breaking cell walls is fixedly arranged in the box body 1, one side of the box body 1 is fixedly provided with a cooling box 5 for storing cooling liquid, and the inner wall of the bottom of the crushing box 103 is fixedly provided with a disc-shaped fixing plate 3;
the cooling assembly comprises a water pump 503, a water pumping pipe 504, a condensing pipe 505 and a return pipe 506, the water pump 503 is fixedly installed inside the cooling box 5, the water pumping pipe 504 is fixedly connected to one side of the water pump 503, the condensing pipe 505 of the serpentine structure is arranged on the outer side of the crushing box 103, and the return pipe 506 is fixedly connected to one side of the cooling box 5.
The crushing box 103 is made of stainless steel materials, and the stainless steel materials have the characteristics of high melting point and good toughness, so that when wall breaking operation is performed in the crushing box 103, a large amount of heat generated by friction between microbeads and the inner wall of the crushing box 103 can be resisted, the crushing box 103 is prevented from deforming due to excessive heating and influencing crushing efficiency, and meanwhile, the crushing box 103 has the characteristics of good toughness, can bear a certain impact force, and can be prevented from being broken after the crushing box 103 is subjected to large impact, so that cell fluid leakage is avoided;
Further, water pump 503 and control panel 101 electric connection, the one end of back flow pipe 506 runs through box 1 and is connected with condenser pipe 505 top, the one end of drinking-water pipe 504 runs through box 1 and is connected with condenser pipe 505 bottom, when carrying out the broken wall operation to the cell, microballon and broken case 103 inner wall friction produce a large amount of heats, start water pump 503 through control panel 101 this moment, make water pump 503 with 5 water-logging in cooler bin through the suction pipe 504 suction to condenser pipe 505, make the water in the condenser pipe 505 carry out the heat exchange with broken case 103, let the temperature in broken case 103 descend, avoid the high temperature to lead to the cell deactivation or even die, then the water after the heat exchange flows back to 5 in through back flow pipe 506 again, realize the function of circulating water cooling.
Further, cooler 5 one side fixedly connected with inlet tube 501 and outlet pipe 502, and inlet tube 501 is located outlet pipe 502 top, after the water in cooler 5 cools off the operation for a long time, produce a large amount of incrustations easily, need change the water in cooler 5, discharge through outlet pipe 502 this moment with water, then pour into the cooler 5 with water again through inlet tube 501 in, avoid the incrustation scale too much by the suction to condenser pipe 505 in, cause condenser pipe 505 to block up, influence the cooling effect of condenser pipe 505.
Further, broken case 103 top fixedly connected with inlet pipe 102, and inlet pipe 102 top protrusion in 1 upper surface of box, broken case 103 bottom fixedly connected with discharging pipe 106, be provided with a plurality of semicircular lugs 104 on the broken case 103 inner wall, material pipe 105 is arranged to 1 one side fixedly connected with of box, and it is connected with broken case 103 to arrange material pipe 105, pour the microballon that the broken wall needs to use into broken case 103 through inlet pipe 102, then in the cell fluid that will carry out the broken wall pours into broken case 103 into, when carrying out the broken wall operation, the cell fluid is driven by puddler 204 and is rotated, make the cell fluid hug closely broken case 103 inner wall and rotate under the effect of centrifugal force, can increase the cell through a plurality of lugs 104 this moment and receive the shearing force, improve broken effect.
Further, the inside fixed mounting of equipment box 2 has baffle 201, baffle 201 top fixed mounting has servo motor 202, servo motor 202 and control panel 101 electric connection, servo motor 202 bottom drive is connected with rotary rod 203, and the rotary rod 203 bottom runs through box 1 and broken case 103 and is connected with fixed plate 3 through the bearing, when carrying out the broken wall operation, start servo motor 202 through control panel 101, make servo motor 202 drive rotary rod 203 rotate, make rotary rod 203 drive many puddlers 204, make the interior microballon of broken case 103 carry out the motion of various forms along with the rotation of puddler 204, thereby make between microballon and the cell shear and collide each other, make the cell breakage, release the inclusion.
Further, many puddlers 204 of the equal fixedly connected with in rotary rod 203 both sides, and many puddlers 204 are align to grid and distribute in the vertical direction, the scraper blade 205 of the equal fixedly connected with arc structure in rotary rod 203 both sides, and scraper blade 205 hugs closely the fixed plate 3 outside, then when the cell fluid after the discharge breakage, rotary rod 203 drives scraper blade 205 and rotates, make scraper blade 205 scrape away the microballon in the filter screen 301 outside, avoid the microballon to stop in filter screen 301 department, cause filter screen 301 to block up, influence the discharge velocity of cell fluid.
Further, broken case 103 is inside to be seted up cavity 107, the inside fixed mounting of cavity 107 has electro- magnet 4, 4 tops of electro-magnet are provided with circle ring structure's magnetic path 401, a plurality of reset spring 402 of magnetic path 401 top fixedly connected with, and reset spring 402 top is connected with cavity 107 inner wall, before carrying out broken wall operation chamber, energize electro-magnet 4 through control panel 101, electro-magnet 4 produces the same magnetic pole with magnetic path 401, make magnetic path 401 rebound under the effect of magnetic force, reset spring 402 receives the extrusion of magnetic path 401 to take place elastic deformation and produces elasticity this moment.
Further, the fluting has been seted up to fixed plate 3 bottom, and a plurality of through-holes have been seted up in the fixed plate 3 outside, and the inside filter screen 301 that is provided with of through-hole, annular groove 302 has been seted up to fixed plate 3 bottom, after broken, stop to the circular telegram of electro-magnet 4 through control panel 101, make magnetic path 401 kick-back under the effect of reset spring 402 elasticity, make barrier block 403 and annular groove 302 separate, make the cell fluid in broken case 103 can enter into discharging pipe 106 through the filter screen in, and discharge through discharging pipe 106, through filter screen 301 with microballon and cell fluid separation.
Furthermore, an annular blocking groove 404 is formed in the inner wall of the bottom of the crushing box 103, the cavity 107 is communicated with the groove through the blocking groove 404, and the top of the magnetic block 401 is fixedly connected with the blocking block 403 with the annular structure, so that the magnetic block 401 drives the blocking block 403 to move upwards, the blocking block 403 is inserted into the annular groove 302, cell fluid cannot enter the groove through the filter screen 301, and partial cell fluid is prevented from entering the groove and not being crushed.
When the cell breaking device is used, the electromagnet 4 is electrified through the control panel 101, the electromagnet 4 generates the same magnetic pole as the magnetic block 401, the magnetic block 401 moves upwards under the action of magnetic force, the magnetic block 401 drives the blocking block 403 to move upwards, the blocking block 403 is inserted into the annular groove 302, cell fluid cannot enter a groove through the filter screen 301, partial cell fluid is prevented from entering the groove and not being broken, at the moment, the reset spring 402 is extruded by the magnetic block 401 to generate elastic force, then, microbeads required to be used for breaking walls and the cell fluid required to be broken walls are respectively injected into the breaking box 103 through the feeding pipe 102, then, the servo motor 202 is started through the control panel 101, the servo motor 202 drives the rotating rod 203 to rotate, the rotating rod 203 drives the stirring rods 204, and the microspheres in the breaking box 103 move in various forms along with the rotation of the stirring rods 204, therefore, the microbeads and the cells are mutually sheared and collided to break the cells and release inclusion, meanwhile, the cell fluid is driven by the stirring rod 204 to rotate, so that the cell fluid is tightly attached to the inner wall of the breaking box 103 to rotate under the action of centrifugal force, the shearing force on the cells can be increased through the plurality of bumps 104 at the moment, the breaking effect is improved, then when the cells are broken, the microbeads and the inner wall of the breaking box 103 rub to generate a large amount of heat, at the moment, the water pump 503 is started through the control panel 101, so that the water in the cooling box 5 is pumped into the condensing pipe 505 through the water pumping pipe 504 by the water pump 503, the water in the condensing pipe 505 exchanges heat with the breaking box 103, the temperature in the breaking box 103 is reduced, the cells are prevented from being inactivated and even dead due to overhigh temperature, and then the water after heat exchange flows back into the cooling box 5 through the return pipe 506 again, so as to realize the function of circulating water cooling, after the crushing is finished, the control panel 101 stops energizing the electromagnet 4, so that the magnetic block 401 rebounds under the action of the elastic force of the reset spring 402, the blocking block 403 is separated from the annular groove 302, the microbeads are separated from the cell fluid through the filter screen 301, the cell fluid in the crushing box 103 can enter the discharge pipe 106 through the filter screen 301 and be discharged through the discharge pipe 106, at the moment, the rotating rod 203 continues to rotate, the cell fluid and the microbeads in the crushing box 103 rotate, the microbeads move towards the inner wall direction of the crushing box 103 under the action of centrifugal force, the microbeads and the cell fluid are conveniently separated, meanwhile, the rotating rod 203 drives the scraping plate 205 to rotate, the scraping plate 205 scrapes off the microbeads outside the filter screen 301, the situation that the microbeads stay at the filter screen 301 to cause the blockage of the filter screen 301 and influence the discharge speed of the cell fluid is avoided, then the discharge pipe 105 is opened after the discharge of the cell fluid is finished, make the microballon scrape under scraper blade 205's effect to broken case 103 outside, make the microballon discharge through arranging material pipe 105, after the water in cooler bin 5 cools off the operation for a long time, produce a large amount of incrustations easily, need change the water in cooler bin 5, discharge through outlet pipe 502 with water this moment, then pour into water into cooler bin 5 again through inlet tube 501, avoid the incrustation scale too much by the suction in condenser pipe 505, cause condenser pipe 505 to block up, influence the cooling effect of condenser pipe 505, can prevent that the microballon from blockking up filter screen 301 in the stirring through above structure, and prevent that partial cell fluid from not participating in the broken wall, improve the degree of completion of broken wall.
The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, it is possible to make several variations and modifications without departing from the concept of the present invention, and these should be considered as the protection scope of the present invention, which will not affect the effect of the implementation of the present invention and the utility of the patent.
Claims (9)
1. A microbial cell wall breaking machine for biomedicine is characterized by comprising a box body, a crushing box, a cooling box and a cooling assembly arranged between the box body and the cooling box and used for cooling the crushing box;
the front side of the box body is fixedly provided with a control panel, the top of the box body is fixedly provided with an equipment box, the interior of the box body is fixedly provided with a crushing box, one side of the box body is fixedly provided with a cooling box, and the inner wall of the bottom of the crushing box is fixedly provided with a fixing plate in a disc shape;
the cooling assembly comprises a water pump, a water pumping pipe, a condensation pipe and a return pipe, the water pump is fixedly arranged inside the cooling box, the water pumping pipe is fixedly connected to one side of the water pump, the condensation pipe of the serpentine structure is arranged on the outer side of the crushing box, and the return pipe is fixedly connected to one side of the cooling box.
2. The microbial cell wall breaking machine for the biopharmaceutical according to claim 1, wherein the water pump is electrically connected with the control panel, one end of the return pipe penetrates through the box body to be connected with the top end of the condensation pipe, and one end of the pumping pipe penetrates through the box body to be connected with the bottom end of the condensation pipe.
3. The microbial cell wall breaking machine for the biomedicine according to claim 1, characterized in that one side of the cooling tank is fixedly connected with a water inlet pipe and a water outlet pipe, and the water inlet pipe is positioned above the water outlet pipe.
4. A microbial cell wall breaking machine for biomedicine according to claim 1, characterized in that the top of the crushing box is fixedly connected with a feeding pipe, the top end of the feeding pipe protrudes out of the upper surface of the box body, the bottom of the crushing box is fixedly connected with a discharging pipe, a plurality of semicircular convex blocks are arranged on the inner wall of the crushing box, a discharging pipe is fixedly connected to one side of the box body, and the discharging pipe is connected with the crushing box.
5. The microbial cell wall breaking machine for the biopharmaceutical according to claim 1, wherein a partition plate is fixedly installed inside the equipment box, a servo motor is fixedly installed at the top of the partition plate, the servo motor is electrically connected with a control panel, a rotating rod is connected to the bottom of the servo motor in a driving manner, and the bottom end of the rotating rod penetrates through the box body and the crushing box and is connected with the fixing plate through a bearing.
6. The microbial cell wall breaking machine for the biopharmaceutical according to claim 5, wherein a plurality of stirring rods are fixedly connected to both sides of the rotating rod, and are uniformly arranged and distributed in a vertical direction, and scraping plates having an arc structure are fixedly connected to both sides of the rotating rod, and are tightly attached to the outer side of the fixing plate.
7. The microbial cell wall breaking machine for the biomedicine according to claim 1, characterized in that a cavity is formed inside the crushing box, an electromagnet is fixedly installed inside the cavity, a magnet with a circular ring-shaped structure is arranged at the top of the electromagnet, a plurality of return springs are fixedly connected to the top of the magnet, and the top ends of the return springs are connected with the inner wall of the cavity.
8. The microbial cell wall breaking machine for the biomedicine according to claim 1, characterized in that the bottom of the fixing plate is provided with a slot, the outer side of the fixing plate is provided with a plurality of through holes, a filter screen is arranged in each through hole, and the bottom of the fixing plate is provided with an annular groove.
9. The microbial cell wall breaking machine for the biopharmaceutical of claim 7, wherein the inner wall of the bottom of the crushing box is provided with a blocking groove of an annular structure, the cavity is communicated with the groove through the blocking groove, and the top of the magnetic block is fixedly connected with a blocking block of an annular structure.
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| CN202210015237.1A CN114292737B (en) | 2022-01-07 | 2022-01-07 | Microbial cell wall breaking machine for biological medicine |
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| CN202210015237.1A CN114292737B (en) | 2022-01-07 | 2022-01-07 | Microbial cell wall breaking machine for biological medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108102882A (en) * | 2018-02-06 | 2018-06-01 | 江苏阿拉丁环保科技有限公司 | Microbial cell wall-breaking machine |
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