CN114286681A - Nad+和/或nad+抑制剂和/或nad+激动剂的用途及其联合制剂 - Google Patents
Nad+和/或nad+抑制剂和/或nad+激动剂的用途及其联合制剂 Download PDFInfo
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Abstract
NAD+和/或NAD+激动剂和/或NAD+抑制剂在制备制剂或试剂盒中的用途，以及包含T细胞和NAD+和/或NAD+激动剂和/或NAD+抑制剂的联合制剂。所述制剂或试剂盒用于调节T细胞活性、调节T细胞表面的CD69表达水平、调节T细胞内的磷酸化水平和/或治疗与T细胞活性相关的疾病。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2019/090022 WO2020243911A1 (zh) | 2019-06-04 | 2019-06-04 | Nad+和/或nad+抑制剂和/或nad+激动剂的用途及其联合制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114286681A true CN114286681A (zh) | 2022-04-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980097190.4A Pending CN114286681A (zh) | 2019-06-04 | 2019-06-04 | Nad+和/或nad+抑制剂和/或nad+激动剂的用途及其联合制剂 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220401465A1 (zh) |
| JP (1) | JP7432624B2 (zh) |
| CN (1) | CN114286681A (zh) |
| WO (1) | WO2020243911A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114939169A (zh) * | 2022-06-15 | 2022-08-26 | 申川 | 一种烟酰胺磷酸核糖转移酶抑制剂的新用途 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2912729T3 (es) | 2015-11-03 | 2022-05-27 | Janssen Biotech Inc | Formulaciones subcutáneas de anticuerpos anti-CD38 y sus usos |
| US20220275090A1 (en) * | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
| CN114306366B (zh) * | 2021-11-30 | 2023-01-06 | 合肥康诺生物制药有限公司 | 含nad和cd38抑制剂的药物组合物及其用途 |
| CN115414375B (zh) * | 2022-11-03 | 2023-03-24 | 卡瑞济(北京)生命科技有限公司 | 烟酰胺单核苷酸延长car-t细胞寿命的用途 |
| WO2024092629A1 (zh) * | 2022-11-03 | 2024-05-10 | 卡瑞济(北京)生命科技有限公司 | 烟酰胺单核苷酸增强car-t细胞寿命的用途 |
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| US20060079510A1 (en) * | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| US20160067272A1 (en) * | 2013-04-09 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Methods for treating immune diseases |
| CN107375934A (zh) * | 2017-08-10 | 2017-11-24 | 浙江大学 | 含有果糖‑1，6‑二磷酸的组合物在制备抗肿瘤药物中的应用 |
| CN107964012A (zh) * | 2016-10-19 | 2018-04-27 | 广州丹康医药生物有限公司 | 作为parp抑制剂的化合物及其用途 |
| US20180353526A1 (en) * | 2015-12-03 | 2018-12-13 | Temple University--of the Commonwealth System of Higher Education | Modulation of nad+ metabolic pathways for treatment of disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019234D0 (en) * | 2000-08-04 | 2000-09-27 | Univ Bath | Therapeutics |
| CN113164408A (zh) | 2018-12-07 | 2021-07-23 | 科济生物医药（上海）有限公司 | 肿瘤联合免疫治疗 |
-
2019
- 2019-06-04 US US17/616,200 patent/US20220401465A1/en active Pending
- 2019-06-04 JP JP2021572023A patent/JP7432624B2/ja active Active
- 2019-06-04 CN CN201980097190.4A patent/CN114286681A/zh active Pending
- 2019-06-04 WO PCT/CN2019/090022 patent/WO2020243911A1/zh active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079510A1 (en) * | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| US20160067272A1 (en) * | 2013-04-09 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Methods for treating immune diseases |
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