CN114272177B - Illite talcum powder and preparation method thereof - Google Patents
Illite talcum powder and preparation method thereof Download PDFInfo
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- CN114272177B CN114272177B CN202111645997.2A CN202111645997A CN114272177B CN 114272177 B CN114272177 B CN 114272177B CN 202111645997 A CN202111645997 A CN 202111645997A CN 114272177 B CN114272177 B CN 114272177B
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Abstract
The invention provides illite talcum powder, which comprises the following components: 40-95 parts by mass of modified tapioca starch; 5-55 parts by mass of illite powder; 0.01 to 10 parts by mass of honeysuckle extract; 0.1 to 10 parts by mass of small molecule hyaluronic acid. The invention also provides a preparation method of the illite talcum powder. The talcum powder is prepared from the modified tapioca starch, illite powder, honeysuckle extract and small-molecule hyaluronic acid, and has the advantages of definite efficacy, simple components, high safety coefficient and fresh skin feel. Experimental results show that the talcum powder provided by the invention has good moisture absorption performance, good dispersion performance, good skin friction improving performance and anti-inflammatory effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to illite talcum powder and a preparation method thereof.
Background
With the vigorous development of the skin care field and the improvement of skin care requirements of people, the safety of products is more and more valued by consumers. The demand for products has gradually shifted from price and efficacy considerations to safety and quality. Prickly heat is a superficial and inflammatory skin disease that is common in summer or in a hot environment. Because a large amount of sweat is not easy to evaporate under the high-temperature sultry environment, the stratum corneum is immersed and swelled, sweat gland ducts are narrowed or blocked, sweat is retained, and the sweat is extravasated into surrounding tissues to form papules, blisters or pustules, which are well developed at the fold positions.
The talcum powder is a skin care product capable of absorbing sweat and smoothing skin, and has the action principle that talcum powder in the product has lubricating and covering capabilities, can be adhered to skin, absorbs sweat secreted by the skin and keeps the skin dry, thereby preventing and treating miliaria. However, with the exposure of various drawbacks and problems of talc, especially its possible presence of oncogenic asbestos and the inseparable heavy metal lead, this material is abandoned by more and more people. The most used substitutes are biomass powder at present, and the biomass powder comprises starch substances such as corn starch, sweet potato starch, tapioca starch, rice starch and the like. The starch has the characteristics of wide source, high safety, low cost and the like, and is relatively simple and easy to obtain. However, with the replacement and use of biomass powder, the problems of moisture absorption, agglomeration and the like can occur in the use process, so that the skin feel of the use is not smooth as that of the traditional talcum powder, and even other skin problems can occur due to the fact that agglomerated small particles are hidden in skin wrinkles. Therefore, the development of the talcum powder which has good safety performance, can ensure smooth skin feel during use and is assisted with a certain effect is particularly urgent.
Disclosure of Invention
Accordingly, the invention aims to provide illite talcum powder and a preparation method thereof, and the illite talcum powder provided by the application does not contain carcinogenic components and has good smooth skin feel
Prickly heat is a superficial and inflammatory skin disease that is common in summer or in a hot environment. Because a large amount of sweat is not easy to evaporate under the high-temperature sultry environment, the stratum corneum is immersed and swelled, sweat gland ducts are narrowed or blocked, sweat is retained, and the sweat is extravasated into surrounding tissues to form papules, blisters or pustules, which are well developed at the fold positions. Bacteria multiply and produce toxins which further exacerbate the inflammatory response.
According to the difference of sweat gland duct injury and sweat overflow parts, the following types are clinically classified:
1. crystalline form of miliaria
Also known as miliaria, is caused by sweat spilling out of sweat ducts within or below the stratum corneum. Is common in Gao Reda patients who are sweating, bedridden for a long period of time, and excessively debilitating. Skin injury is a superficial small blister from the needle point to the needle head, has thin wall, is clear, has no red halo around, is easy to break by light rubbing, and leaves fine scales after drying. There is self-limitation and there is generally no subjective symptom.
2. Red milia
Also known as miliaria, is caused by sweat spilling out of sweat ducts at the stratum spinosum. Acute onset, skin lesions are dense pimples or papules with a round and sharp needle size in batches with a slight redness surrounding them. There was mild desquamation after the skin lesions resolved. Light burning sensation and itching sensation are felt by oneself.
3. Pustular milia
Also known as miliaria pustularis. Most of them develop from red milia. The skin lesions are dense papules with needle-sized superficial pustules on top. Within the pustules are often sterile or nonpathogenic cocci.
4. Deep milia castanopsis
Also known as deep miliaria, is often found in patients with severe and recurrent red miliaria due to sweat tube spillage at the upper dermis, particularly at the dermis-epidermis interface. The skin damage is dense skin-color small blisters, the content is clear and clear, the skin is not easy to scratch, the skin damage is increased during sweating, and the skin damage is reduced during sweating. When rash is generalized, the whole body skin sweats are reduced or no sweats exist, the compensatory sweats of the face, armpits and hands and feet can be increased, tropical sweat closed failure or heat failure can be caused, and the whole body symptoms such as weakness, drowsiness, dizziness, headache and the like can appear on patients.
The invention provides illite talcum powder, which comprises the following components:
40-95 parts by mass of modified tapioca starch;
5-55 parts by mass of illite powder;
0.01 to 10 parts by mass of honeysuckle extract;
0.1 to 10 parts by mass of small molecule hyaluronic acid.
According to the root cause of prickly heat formation, the illite talcum powder provided by the invention can prevent and treat prickly heat from two dimensions of moisture absorption and sweat dissipation and inflammation elimination.
Referring to fig. 1, fig. 1 is a diagram showing an action mechanism of the illite talcum powder provided in the embodiment of the present application for preventing and treating miliaria. In the aspect of moisture absorption and sweat dispersion, the modified tapioca starch absorbs sweat, keeps skin dry, the illite powder with high specific surface area increases volatilization of sweat, and meanwhile, the slippery feel of the illite powder can improve skin feel of the powder. In the aspect of anti-inflammation, the honeysuckle extract can inhibit the production of pro-inflammatory factors TNF-alpha and IL-1 and increase the production of anti-inflammatory factors IL-10, and can remarkably reduce inflammatory response. Whereas small molecule HA is capable of inhibiting the secretion of the pro-inflammatory cytokines TNF- α, IL-1 α and IL-6, thereby inhibiting the production of inflammation. Experimental results show that the illite talcum powder provided by the invention not only has proper moisture absorption performance, dispersity and skin friction improving capability, but also has good anti-inflammatory effect.
The modified tapioca starch is used as the main component of the talcum powder instead of talcum powder, has certain moisture absorption performance, can absorb sweat secreted by skin, keeps the skin dry and comfortable, and does not cause moisture absorption and agglomeration per se, thereby affecting use.
In the invention, the modified tapioca starch is prepared according to the following method:
mixing tapioca starch with water to obtain a starch solution with a solid content of 1-50%;
and homogenizing the starch solution under high pressure, and spray-drying to obtain the modified tapioca starch.
The high-pressure homogenization can lead the material in suspension state to flow through the containing cavity (high-pressure homogenization cavity) with special internal structure at high speed under the action of ultrahigh pressure, so that the material is subjected to physical modification modes of a series of changes of physical, chemical, structural properties and the like. The high-pressure homogenizing treatment of the tapioca starch is to make the starch receive mechanical actions such as high-speed shearing, high-frequency oscillation, convection impact and the like and corresponding thermal effects in a short time by utilizing a high-pressure homogenizer, and the mechanical force and chemical effects caused by the mechanical actions can induce the physical structure property of the starch macromolecules to change, so that the starch macromolecules have the characteristics different from the original starch. The modified tapioca starch is modified by adopting a high-pressure homogenizing method, and the obtained modified tapioca starch has proper moisture absorption performance, can absorb sweat on skin, is not easy to absorb moisture and agglomerate, and is not beneficial to use.
Specifically, the application firstly mixes tapioca starch and water, and prepares the tapioca starch into a starch solution with the solid content of 1-50%. In one embodiment, the starch solution has a solids content of 5 to 40%. In one embodiment, the starch solution has a solids content of 10 to 30%.
And (3) carrying out high-pressure homogenization on the starch solution in a high-pressure homogenizer, wherein the pressure of the high-pressure homogenization is 100-2000 Bar. In one embodiment, the high pressure homogenization is at a pressure of 500 to 1500Bar. In one embodiment, the high pressure homogenization is at a pressure of 1000 to 1200Bar. In one embodiment, the high pressure homogenization cycle is performed 3 times.
And (3) after high-pressure homogenization, carrying out spray drying on the obtained starch solution to obtain the modified tapioca starch. In one embodiment, after spray drying, further comprising passing the modified tapioca starch through a 100 mesh molecular sieve. In one embodiment, after spray drying, further comprising passing the modified tapioca starch through a 200 mesh molecular sieve.
In one embodiment, the modified tapioca starch is used in an amount of 40 to 95 parts by mass. In one embodiment, the modified tapioca starch is used in an amount of 50 to 90 parts by mass. In one embodiment, the modified tapioca starch is used in an amount of 60 to 80 parts by mass.
The illite talcum powder provided by the invention comprises illite powder. The i Li Danchang is produced by the weathering of muscovite and potash feldspar and is produced in argillite or by the alteration of other minerals, often intermediate transition minerals forming other clay minerals. The illite mineral has the characteristics of simple components, no toxicity and no odor, soft and smooth quality, silk luster, good dispersibility, strong adhesive force, stable chemical property and the like. The illite mineral contains iron, silicon, calcium, sodium and other elements beneficial to human skin, and the pH value is between 6 and 7 and is close to that of human body.
However, industrial illite has a poor skin adhesion ability compared with mica powder, silica powder, etc., and is unfavorable for sweat volatilization. The invention preferably adopts refined illite powder which has a good scaly structure and is compounded with modified tapioca starch to ensure that the obtained talcum powder has certain hygroscopicity. The refined illite powder also has micron particle size and high specific surface area, so that the refined illite powder not only has finer and smoother skin feel, but also can promote the volatilization of sweat and maintain the dryness of skin due to the high specific surface area.
In one embodiment, the illite powder is prepared as follows:
mixing illite with water according to mineral powder, ball milling and cyclone separation to obtain primary suspension;
carrying out primary sedimentation on the primary suspension, and separating to obtain a secondary suspension;
and (3) homogenizing the secondary suspension at high pressure, and separating after secondary sedimentation to obtain illite powder.
Specifically, the illite purity of illite raw ore can be improved from 30% -40% to about 90% and up to 94% after nine steps of ore dressing, impurity removal, ball milling and crushing, cyclone separation, primary sedimentation, high-pressure homogenizing and crushing, secondary sedimentation, moisture drying, grinding and screening and sealing preservation.
In one embodiment, the illite powder is used in an amount of 5 to 55 parts by mass. In one embodiment, the illite powder is used in an amount of 10 to 50 parts by mass. In one embodiment, the illite powder is used in an amount of 20 to 40 parts by mass. In one embodiment, the illite powder has a particle size of less than 100 mesh. In one embodiment, the illite powder has a particle size of less than 200 mesh.
The illite talcum powder provided by the invention also comprises honeysuckle extract. The flos Lonicerae (Lonicera japonica) is dried flower bud or flower with primary opening of Lonicera japonica of Caprifoliaceae and its congeneric plant. In one embodiment, the honeysuckle extract is a honeysuckle aqueous extract.
In one embodiment, the honeysuckle extract is prepared according to the following method:
pulverizing dry honeysuckle powder, adding 10-20 times of water, uniformly mixing, leaching at 60 ℃ for 80-100 min, filtering, adding 5-10 times of water, leaching at 60 ℃ for 30-60 min, mixing the two extracts, centrifuging at 9000r/min for 15min, collecting supernatant, and concentrating by rotary evaporation to obtain the honeysuckle extract.
In one embodiment, the honeysuckle extract is a honeysuckle extract freeze-dried powder, and the honeysuckle extract obtained above is freeze-dried. The honeysuckle extract freeze-dried powder is added into talcum powder in the form of powder, so that the preparation process is simplified.
In one embodiment, the honeysuckle extract is used in an amount of 0.01 to 10 parts by mass. In one embodiment, the honeysuckle extract is used in an amount of 0.1 to 8 parts by mass. In one embodiment, the honeysuckle extract is used in an amount of 0.5 to 5 parts by mass.
The illite talcum powder provided by the invention also comprises small-molecule hyaluronic acid. Hyaluronic Acid (HA) is also known as hyaluronic acid, and HAs the molecular formula (C) 14 H 21 NO 11 ) n Is disaccharide unit glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid has high viscoelasticity, plasticity, super water-holding capacity, permeability and good biological absorbability, and has wide application in the fields of cosmetics, medicine, food and the like. The biological activity and the effect of use of HA are directly related to their relative molecular weights, so that they show different effects and actions according to their differences in molecular weights. For example high molecular weight (Mr > 2X 10) 6 ) HAs better viscoelasticity, moisture retention, inflammatory reaction inhibition and the like; and has a molecular weight of 1 to 2X 10 6 HAs good moisture retention, lubrication and drug slow release effects; the Low Molecular Weight HA (LMWHA) HAs the functions of resisting tumor, promoting wound healing, promoting bone and angiogenesis, regulating immunity, etc.
The invention takes the micromolecular hyaluronic acid as one of the raw materials, the micromolecular hyaluronic acid is the hydrolyzed hyaluronic acid with ultrahigh biological activity, which is obtained by adopting a professional enzyme cutting process and a spray drying/freeze drying technology, and has the characteristics of being capable of rapidly penetrating epidermis, reaching dermis, scavenging free radicals, reducing inflammatory factor activity, inhibiting inflammatory reaction, repairing damaged cells, resisting skin inflammation and sensitivity caused by various stimuli, and the like. In particular, in inhibiting inflammatory response, it can inhibit the release of inflammatory factors TNF-alpha, IL-1 alpha and IL-6, thereby effecting inhibition of inflammation.
In one embodiment, the molecular weight of the small molecule hyaluronic acid is 600-1500 Da.
In one embodiment, the small molecule hyaluronic acid is used in an amount of 0.1 to 10 parts by mass. In one embodiment, the small molecule hyaluronic acid is used in an amount of 0.5 to 8 parts by mass. In one embodiment, the small molecule hyaluronic acid is used in an amount of 1 to 5 parts by mass.
In one embodiment, the illite talcum powder comprises:
40-95 parts by mass of modified tapioca starch;
10-50 parts by mass of illite powder;
0.1 to 5 parts by mass of honeysuckle extract;
0.5 to 5 parts by mass of small molecule hyaluronic acid. .
In one embodiment, the illite talcum powder comprises:
65-80 parts by mass of modified tapioca starch;
20-30 parts by mass of illite powder;
0.5 to 2 parts by mass of honeysuckle extract;
1 to 3 parts by mass of small molecule hyaluronic acid.
The invention also provides a preparation method of the illite talcum powder, which comprises the following steps:
mixing the modified tapioca starch and illite powder to obtain talcum powder matrix powder;
mixing the talcum powder matrix powder with the honeysuckle extract and the micromolecular hyaluronic acid to obtain the illite talcum powder.
The illite talcum powder provided by the invention comprises the following components: 40-95 parts by mass of modified tapioca starch; 5-55 parts by mass of illite powder; 0.01 to 10 parts by mass of honeysuckle extract; 0.1 to 10 parts by mass of small molecule hyaluronic acid. The talcum powder is prepared from the modified tapioca starch, illite powder, honeysuckle extract and small-molecule hyaluronic acid, and has the advantages of definite efficacy, simple components, high safety coefficient and fresh skin feel. Experimental results show that the talcum powder provided by the invention has good moisture absorption performance, good dispersion performance, good skin friction improving performance and anti-inflammatory effect.
Specifically, the talcum powder provided by the invention has the effects of absorbing moisture and removing sweat and eliminating inflammation, wherein the modified tapioca starch can absorb skin sweat and keep skin dry, and the illite powder is used for increasing the smoothness of matrix powder, promoting the volatilization of sweat and ensuring the skin feel and the function of the matrix powder; the honeysuckle extract is selected to inhibit the production of pro-inflammatory factors TNF-alpha and IL-1 and increase the production of anti-inflammatory factor IL-10, so that the inflammatory response can be obviously reduced. Whereas small molecule HA is capable of inhibiting the secretion of the pro-inflammatory cytokines TNF- α, IL-1 α and IL-6, thereby inhibiting the production of inflammation. The talcum powder provided by the invention only contains four components, not only has extremely high biological safety, but also has the practical and useful effects due to the addition of each component, and has the advantages of simple composition components, clear effects, high safety coefficient, fresh skin feel and wide application prospect.
Drawings
Fig. 1 is a diagram showing the mechanism of action of the illite talcum powder provided in the examples of the present application for preventing and treating miliaria;
fig. 2 is a graph showing the results of the moisture absorption performance test of the toilet powder according to the examples and comparative examples of the present invention;
fig. 3 is a result of a dispersion test of the talcum powder provided in the examples and comparative examples of the present invention;
fig. 4 is a view showing the skin friction improving effect of the talcum powder provided in the examples and comparative examples of the present invention;
fig. 5 shows the anti-inflammatory results of the toilet powders provided in the examples and comparative examples of the present invention.
Detailed Description
Examples 1 to 5
A talcum powder was prepared according to the formulation shown in table 1 according to the following method:
table 1 the formulation of the talcum powder provided in the examples and comparative examples of the present invention
Mixing tapioca starch with water to obtain a starch solution with the solid content of 25%, homogenizing the starch solution under 1500Bar pressure by using a high-pressure homogenizer, circulating for 3 times, and then spray-drying the obtained starch solution and sieving the starch solution by using a 200-mesh molecular sieve to obtain the modified tapioca starch.
Primary crushing illite raw ore by adopting a jaw crusher, mixing 800g of primary crushed illite raw ore powder with 200g of water, ball milling for 8 hours by adopting a wet ball mill, and performing cyclone separation on the obtained mixture by adopting a cyclone separator to obtain primary suspension; carrying out primary sedimentation on the primary suspension, layering the suspension, and sucking out upper liquid in the suspension by negative pressure suction to obtain a secondary suspension; homogenizing the secondary suspension at 200Bar pressure in a high-pressure homogenizer, performing cyclic treatment for three times, performing secondary precipitation, sucking supernatant of the suspension, performing evaporation treatment to keep the water content of the obtained product at about 30-40%, sterilizing, and sieving with a 200-mesh molecular sieve to obtain refined illite.
The molecular weight of the micromolecular hyaluronic acid freeze-dried powder is 600-1500 Da
The preparation method of the honeysuckle extract freeze-dried powder comprises the following steps:
pulverizing flos Lonicerae dry powder, adding 15 times of water, mixing, extracting at 60deg.C for 90min, filtering residues, adding 10 times of water, extracting at 60deg.C for 60min, mixing the two extractive solutions, centrifuging at 9000r/min for 15min, collecting supernatant, rotary evaporating, concentrating, and lyophilizing to obtain lyophilized powder of flos Lonicerae extract.
Mixing refined illite and modified tapioca starch to obtain talcum powder matrix powder, adding micromolecular hyaluronic acid and honeysuckle extract freeze-dried powder, and uniformly mixing to obtain the talcum powder.
The preparation of the comparative example was the same as the procedure described above.
Example 6 Talcum powder Performance and efficacy testing
2.1 moisture absorption Properties of Talcum powder
1) Principle of testing
And placing a certain amount of talcum powder in a closed container with the relative humidity controlled within a certain range, and weighing again after a plurality of hours, wherein the weight gain of the powder material is the water content absorbed by the powder material from the ambient air with the temperature and the relative humidity within a certain range in the time. The ratio of the absorbed moisture content to the mass of the dry dust is the moisture absorption rate of the powder material, and represents the moisture absorption of the powder material.
2) Test method
-test environment: the test environment temperature is 35+/-1 ℃, the relative humidity is 90+/-5%, and real-time dynamic detection is carried out;
-a testing step: removing large granular substances in the talcum powder through a 100-target standard sieve, then placing the material in a 45 ℃ environment for drying for 24 hours, accurately weighing a certain amount of talcum powder in a weighing bottle after the material is naturally cooled, and placing the weighing bottle in a constant temperature and humidity environment with the environment temperature of 35+/-1 ℃ and the relative humidity of 90+/-5% for a hygroscopicity experiment. The sample and the weight of the weighing bottle were recorded every 6 hours until the weighing bottle was constant and the end point of the experiment was reached.
3) Test results
The formula for calculating the moisture absorption rate of the talcum powder is as follows: w (W) i ＝(m i -m s )/(m s -m 0 )×100％
W in the formula i The moisture absorption rate of the talcum powder is%;
m i g, the total mass of the talcum powder and the weighing bottle at the ith moment;
m s g is the total mass of the talcum powder dry powder and the weighing bottle;
m 0 the quality of the weighing bottle is clean and dry, and g.
Results referring to table 2 and fig. 2, table 2 shows the results of the moisture absorption performance test of the talcum powder provided in the examples and comparative examples according to the present invention, and fig. 2 shows the results of the moisture absorption performance test of the talcum powder provided in the examples and comparative examples according to the present invention.
TABLE 2 results of moisture absorption test of Talcum powder provided in examples and comparative examples of the present invention
As can be seen from fig. 2 and table 2, the talcum powder provided by the embodiment of the invention has a low moisture absorption rate, and is less prone to moisture absorption, agglomeration and caking. The comparative example provided a talcum powder having a relatively high moisture absorption rate, which is at risk of moisture absorption and agglomeration, and in particular comparative example 4, which is comparable to the modified tapioca starch. In examples 1 to 5, example 2 had the lowest moisture absorption rate.
2.2 degree of dispersion of Talcum powder
1) Principle of testing
The dispersion degree of the talcum powder is that of the talcum powder in the air. And (3) freely falling a certain amount of the dried talcum powder from 0.3m high altitude, receiving the talcum powder by a receiving tray, measuring the weight of a sample in the receiving tray, and calculating the ratio of the weight in the sample tray to the total weight of the dried talcum powder to obtain the dispersity of the talcum powder. The more the talcum powder disperses in the air, i.e. the less the talcum powder in the receiving tray, the higher the substrate dispersion degree of the talcum powder in the air, the more the possibility of dust emission.
2) Test method
-test environment: the test environment temperature is 25+/-1 ℃, the relative humidity is 50+/-5%, and real-time dynamic detection is carried out;
-a testing step: the receiving tray is cleaned, weighed and placed on the experiment table stably. 10g of talcum powder is weighed and put into a dry volumetric flask, and the volumetric flask is taken to the air with the height of 0.3m above a receiving tray. Pouring the volumetric flask to enable the talcum powder to fall freely, taking the receiving tray away after the talcum powder in the air falls completely, weighing, and calculating the dispersity.
3) Test results
The formula for calculating the dispersion degree of the talcum powder is as follows: d (D) s ＝(m 0 -m 1 )/(m 0 )×100％
D in s The dispersion degree of the talcum powder is%;
M 1 g, the total mass of talcum powder in the receiving tray after free falling;
m 0 g is the total mass of the talcum powder before free falling.
Results referring to table 3 and fig. 3, table 3 shows the results of the dispersion test of the talcum powder provided in the examples and comparative examples of the present invention, and fig. 3 shows the results of the dispersion test of the talcum powder provided in the examples and comparative examples of the present invention.
TABLE 3 dispersity test results of the toilet powders provided in the examples and comparative examples of the present invention
From fig. 3 and table 3, it can be seen that the dispersion degree of the talcum powder provided in the embodiment of the present application is below 3, so that the dust emission problem can be effectively reduced. The talcum powder provided by the comparative example has a dispersity of 3 or more, and the talcum powder provided by the comparative example 4 even has a dispersity of 6.85, which may cause problems such as increase of inhaled particles. In addition, the dispersion degree of the talcum powder provided in example 2 was the lowest.
2.3 skin roughness changes
1) Principle of testing
The present invention employs CK german skin friction tester FR700 to test skin friction. The friction of the skin depends on factors such as dryness, smoothness, roughness, etc., and can reflect the current roughness and smoothness of the skin. The change in friction before and after the use of the talcum powder sample can represent the effect of the talcum powder on the smoothness and roughness of the skin. The invention is used for measuring the improvement condition of the talcum powder on the surface roughness of the skin.
2) Test method
-test environment: the test environment temperature is 22+/-1 ℃, the humidity is 50+/-5%, and real-time dynamic detection is carried out;
-test volunteers: ages between 16 and 60 years (except pregnant or lactating women); patients with no serious systemic disease, no immunodeficiency or autoimmune disease; the prior skin care cosmetics have no serious allergic history; hormonal drugs and immunosuppressants have not been used for a month; those who did not participate in other clinical trials; the tested medicines are used according to the regulations and the data are complete; all volunteers should fill in informed consent prior to testing.
-a testing step:
preparation before testing: no product (cosmetic or topical medicine) can be used 2-3 days before the test site. Before the test, the sample application areas were drawn on the inner sides of the arm bends of the testers, respectively, and evaluated by the skin friction tester FR 700.
-a testing procedure: after the subject was allowed to sit still in the constant temperature and humidity room for 30 minutes, the skin friction force in the region where the arm was bent was measured as an original value. Then, the same amount of experimental samples were applied to the test areas of the subjects for the same time and force, and the subjects were allowed to sit still for 30 minutes after the extra powder on the skin surface was blown off with an ear-washing ball. The skin angle friction force measurement is carried out by the measuring staff on the test area respectively, and the test of the same volunteer is completed by the same measuring staff.
3) Test results
The calculation formula of the skin friction force change rate is as follows: f% = (F 1 -F 2 )/F 1 *100％
Note that: f is the moisture content increase rate,%;
F 2 skin friction after 30min for the sample;
F 1 the original value of skin friction force before using the sample.
Results referring to table 4 and fig. 4, table 4 shows the skin friction improving effect of the talcum powder provided in the examples and comparative examples according to the present invention, and fig. 4 shows the skin friction improving effect of the talcum powder provided in the examples and comparative examples according to the present invention.
TABLE 4 skin Friction improving Effect of Talcum powders provided by examples and comparative examples of the present invention
As can be seen from fig. 4 and table 4, the talcum powder provided in the examples of the present application can effectively improve skin friction, the improvement rate is about 20% or even more, and especially the improvement rate of the talcum powder provided in example 2 is as high as 23%; the talcum powder provided in comparative example has low improvement rate of skin friction force, and is especially in comparative example 3 and comparative example 5
2.4 anti-inflammatory efficacy
1) Principle of testing
The macrophage produces inflammatory factors under the stimulation of lipopolysaccharide, and then different test samples are added to observe the inhibition condition of the inflammatory factors, so that the method is one of experiments for simulating inflammatory response in vitro. IL-6 is an important pro-inflammatory factor that is rapidly produced upon stimulation by infectious agents and tissue damage and exacerbates the inflammatory response by modulating intracellular signaling, and is considered an important marker of inflammation in vivo. The effect of the samples on IL-6 secretion in inflammatory response of macrophages was examined by ELISA and its anti-inflammatory effect was evaluated.
2) Test method
A. Dissolving different samples with the same amount of culture medium, oscillating in an oscillator for 30min, centrifuging, and collecting supernatant.
B. Cell inoculation: ana-1 cells were seeded at 4000 cells/well in 96-well plates at 37℃in 5% CO 2 Culturing in an incubator for 24 hours;
C. LPS induces an inflammatory response: diluting 1mg/ml LPS solution to 3 μg/ml, adding the same amount of culture medium into a 50 μl/Kong Jiazhi well plate, placing at 37deg.C, and 5% CO 2 Culturing in an incubator for 4 hours;
D. diluting and adding a sample to be tested: preparing 0.4% sample working solution according to sample test concentration table by using complete culture medium as diluent, adding into cells, 100 μl/well, adding equivalent complete culture medium into negative control group, placing at 37deg.C, 5% CO 2 Culturing in an incubator for 24 hours;
E. IL-6 content was measured by ELISA and the results were counted.
3) Test results
The inhibition rate of IL-6 was calculated as: x= (L) Yang (Yang) -L i )/(L Yang (Yang) -L Yin type vagina )*100％
Wherein Li is the level of interleukin-6 (IL-6), pg/ml, of the ith sample;
in which L Yang (Yang) Levels of interleukin-6 (IL-6), pg/ml, as positive control samples;
in which L Yin type vagina Levels of interleukin-6 (IL-6), pg/ml, as negative control samples;
results referring to table 5 and fig. 5, table 5 shows the anti-inflammatory results of the talcum powder provided in the examples and comparative examples of the present invention, and fig. 5 shows the anti-inflammatory results of the talcum powder provided in the examples and comparative examples of the present invention.
TABLE 5 anti-inflammatory results of the toilet powders provided in examples and comparative examples of the present invention
As can be seen from table 5 and fig. 5, the talcum powder provided in the examples of the present application has a higher IL-6 inhibition rate, i.e., has a good anti-inflammatory effect. The talcum powder IL-6 provided by the comparative example has lower inhibition rate and poor anti-inflammatory effect.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (4)
1. An illite talcum powder comprising:
72 parts by mass of modified tapioca starch,
25 parts by mass of illite powder,
1 part by mass of honeysuckle extract freeze-dried powder,
2 parts by mass of small molecule hyaluronic acid;
the modified tapioca starch is prepared according to the following method:
mixing tapioca starch with water to obtain a starch solution with a solid content of 1-50%;
homogenizing the starch solution under high pressure, and spray-drying to obtain modified tapioca starch;
the illite powder is prepared according to the following method:
mixing illite mineral powder with water, ball milling and cyclone separation to obtain primary suspension;
carrying out primary sedimentation on the primary suspension, and separating to obtain a secondary suspension;
homogenizing the secondary suspension at high pressure, and separating after secondary sedimentation to obtain illite powder;
the molecular weight of the small-molecule hyaluronic acid is 600-1500 Da;
the honeysuckle extract freeze-dried powder is prepared according to the following method: pulverizing flos Lonicerae dry powder, adding 15 times of water, mixing, extracting at 60deg.C for 90min, filtering residues, adding 10 times of water, extracting at 60deg.C for 60min, mixing the two extractive solutions, centrifuging at 9000r/min for 15min, collecting supernatant, rotary evaporating, concentrating, and lyophilizing to obtain lyophilized powder of flos Lonicerae extract.
2. The illite talcum powder according to claim 1, characterized in that the high-pressure homogenizing pressure is 100-2000 bar and the homogenizing is circulated 3 times.
3. The illite talcum powder according to any one of claims 1-2, characterized in that the particle size of the modified tapioca starch and illite powder is less than 100 mesh.
4. A method for producing illite talcum powder as claimed in any one of claims 1 to 3, comprising the steps of:
mixing the modified tapioca starch and illite powder to obtain talcum powder matrix powder;
and mixing the talcum powder matrix powder with the honeysuckle extract freeze-dried powder and the micromolecular hyaluronic acid to obtain the illite talcum powder.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108473484A (en) * | 2015-10-01 | 2018-08-31 | 赛诺米克斯公司 | It can be used as the compound of TRPM8 conditioning agents |
| CN110742844A (en) * | 2019-11-26 | 2020-02-04 | 苏州东方之宝生物药业有限公司 | Multi-effect talcum powder and preparation method thereof |
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| US20170087199A1 (en) * | 2016-02-10 | 2017-03-30 | Senomyx, Inc. | Compositions for delivering a cooling sensation |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108473484A (en) * | 2015-10-01 | 2018-08-31 | 赛诺米克斯公司 | It can be used as the compound of TRPM8 conditioning agents |
| CN110742844A (en) * | 2019-11-26 | 2020-02-04 | 苏州东方之宝生物药业有限公司 | Multi-effect talcum powder and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| bionanocomposites of cassava starch and synthetic clay;Gustavo F;《journal of carbohydrate chemistry》;第483-501页 * |
| 膨润土的改性及其在润肤乳液中的应用;雷东升等;《化工矿物与加工》;第29-31页 * |
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