CN114259518A

CN114259518A - A preparation for improving prostate calcification spot and prostate chronic inflammation

Info

Publication number: CN114259518A
Application number: CN202210028845.6A
Authority: CN
Inventors: 孟庆雄
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-01-11
Filing date: 2022-01-11
Publication date: 2022-04-01
Also published as: WO2023133982A1

Abstract

The invention discloses a formula capable of improving chronic inflammation of prostate and calcification spots of prostate. The formula has no toxic or side effect, no drug dependence, simple formula, convenient administration, low cost and good curative effect. The formula is a health-care product consisting of an African carbine extract, arginine, a black maca extract, Cannabidiol (CBD) full spectrum oil, an echinacea purpurea extract and a kudzu root extract. The echinacea purpurea extract can play roles in immune stimulation, tissue regeneration, infection resistance, bacteria resistance and virus resistance, reaches the focus of prostate and has certain effects on prostate calcification and chronic inflammation. While african carbene extracts, black maca extracts and arginine can improve male performance, Cannabidiol (CBD) whole spectrum oil and kudzu root extracts in this formulation act to deliver beneficial ingredients to the lesions and coordinate the neutralizing effect. The invention can improve male hypofunction caused by the chronic inflammation and the calcification spots of the prostate while treating the chronic inflammation and the calcification spots of the prostate, and has wide application prospect.

Description

A preparation for improving prostate calcification spot and prostate chronic inflammation

Technical Field

The invention relates to the technical field of health care products, in particular to a preparation of a functional product for improving prostate calcification spots and chronic inflammation of prostate.

Background

Prostatitis, especially chronic prostatitis, is a common disease of adult men, accounts for about 25% of patients in outpatients of urology surgery, is a frequently encountered disease and an intractable disease, has complex and changeable clinical manifestations and different causes of diseases, and has repeated attacks as the characteristic of the disease. Not only is chronic prostatitis painful for the patient, but also psychologically poses a major threat, causing calcification spots in the prostate, and giving sufficient attention to patients with combined sexual dysfunction and infertility.

The treatment of patients with chronic prostatitis is difficult, incurable, and often frustrating to physicians and patients, which is why treatment cycles are long, and a variety of treatments are available. The invention takes the method as the starting point, and achieves the purpose of treatment by a method for treating inflammation and calcified plaque and improving male functions simultaneously.

Disclosure of Invention

The invention aims to develop a formula aiming at the symptoms that the treatment of chronic inflammation of prostate and calcified plaque of prostate is difficult and male hypofunction can be caused. To solve the above problems, the present invention provides a method for treatment. African carbene extract, arginine, black maca extract, Cannabidiol (CBD) full spectrum oil, echinacea purpurea extract and kudzu root extract.

The components of the invention mainly have the following functions:

african carbene extract: the carbene extract is extracted from the bark of a tree called Pausinystalia macrocera, and has good pharmacological action. Can act on male hypophysis to stimulate the secretion of self-hormone, and improve various physiological functions of male comprehensively. Can also be used for treating arteriosclerosis, rheumatism and other diseases in clinic. The carbene extract is also an adrenergic receptor blocker, and can selectively block alpha₂Adrenergic receptors, which dilate vascular smooth muscle, increase peripheral parasympathetic tone, and decrease sympathetic tone, can produce beneficial effects on erectile function through central effects. The extract is obtained by drying, crushing and supercritical extraction.

Arginine: arginine is an essential amino acid in the human body and can be found in many foods. Has effects in promoting wound healing, treating cardiovascular diseases, improving immunity, and improving male function. The natural small arginine peptides are purchased from external companies.

Black maca extract: the maca rhizome contains various chemical components with biological activity, wherein alkaloid and polysaccharide, macamide, macaene, beta-sitosterol, brassicasterol and the like are mainly contained in the maca rhizome. The black maca has the effects of reinforcing kidney and tonifying yang, contains macamide, macaene and other components, has the effect of improving sexual function, and can improve sexual dysfunction, male sperm motility, sperm quantity reduction, male and female fertility reduction, female menstrual disorder, climacteric syndrome and the like. The maca contains rich nutrients such as protein, iron element, amino acid, zinc element and the like, can provide energy for human bodies, relieve fatigue, promote sleep, enhance the immunity of the organisms and improve the disease resistance of the bodies.

Cannabidiol (CBD) whole spectrum oil: is a pure natural component extracted from a cannabis plant. Cannabidiol has the functions of blocking the adverse effect of some polyphenol on human nervous system, blocking breast cancer metastasis, treating epilepsy, resisting rheumatoid arthritis, resisting insomnia, resisting depression and other physiological activities, and has good effect of treating multiple sclerosis. The Cannabidiol (CBD) full spectrum oil is obtained by drying, crushing and supercritical extraction.

Echinacea extract: echinacea is a perennial wild plant of the North American grassland and is widely used by the Western world for improving immunity, treating cold and influenza, combating infection, accelerating wound healing and reducing inflammation. The extract is obtained by drying, crushing and supercritical extraction.

Kudzu root extract: dried root of Pueraria lobata Ohwi of Leguminosae family. It is commonly indicated for exterior syndrome with fever, strong pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency.

The invention is realized by the following technical scheme:

the formula of the product comprises the following combined raw materials: african carbene extract, arginine, black maca extract, Cannabidiol (CBD) full spectrum oil, echinacea purpurea extract and kudzu root extract.

The preferable components are as follows: 20-30g of African carbine extract, 8-16g of arginine, 10-15g of black maca extract, 15-20g of Cannabidiol (CBD) full spectrum oil, 10-16g of echinacea extract and 12-16g of kudzu root extract.

Further preferred compositions are: 27g of African carbine extract, 12g of arginine, 13g of black maca extract, 18g of Cannabidiol (CBD) full spectrum oil, 15g of echinacea extract and 15g of kudzu root extract.

The invention has the beneficial effects that: the treatment and improvement of chronic inflammation of prostate and calcified plaque of prostate are difficult, often cause the treatment cycle long, cause male dysfunction, the treatment means is different difficult problem. Can also solve the problem of poor effect of other medicines. In the product, the echinacea extract can achieve good anti-inflammatory, antibacterial and antiviral effects, and can also improve human immunity and promote tissue regeneration. And Cannabidiol (CBD) has good antibacterial, anti-inflammatory and analgesic effects, and can also play a role in efficient drug delivery. The maca has the effects of reinforcing the kidney and tonifying yang, and is combined with arginine and African carbene extract for use, so that other effective components can quickly reach a focus, the effects of resisting inflammation and bacteria, improving prostate calcification spots and improving and enhancing male functions can be achieved. The product of the invention is extracted from all natural plants, has no toxic or side effect and drug dependence, and has simple formula, convenient medication, low cost and good curative effect.

Detailed Description

The invention is further illustrated by the following examples. It should be understood that the examples of the present invention are for the purpose of illustration and not limitation. Modifications of the invention in light of the above teachings are within the scope of the invention as claimed.

Example one

Examples capsules of the invention.

The arginine of the present invention is purchased from an external company. The African carbene extract, black maca extract, Cannabidiol (CBD) whole spectrum oil, echinacea extract and kudzu root extract are processed.

Collecting the African carbene bark, black maca, industrial hemp, purple coneflower and radix Puerariae, cleaning, oven drying to obtain dry product, and micronizing.

The drying temperature of the African carbine tree bark, the black maca, the industrial hemp, the echinacea and the kudzu root is 50-80 ℃, and the drying time is 4-6 hours.

The African carbine tree bark, the black maca, the industrial hemp, the echinacea and the kudzu root are dried and then crushed into 60-80 meshes.

The African carbine tree bark powder is put into an extraction tank of a supercritical carbon dioxide extraction device, supercritical carbon dioxide is used as a solvent, 60-80% ethanol is used as an entrainer, and extraction is carried out under the conditions that the pressure is 15-25MPa and the temperature is 40-60 ℃, wherein the extraction time is 2 hours. Putting the African carbene tree bark powder into an extraction tank, adding 60-80% ethanol as an entrainer, and soaking for 10-12 h at room temperature. Through a series of single-factor tests and response surface test optimization, the optimal extraction process for extracting the African carbene extract is determined as follows: the dosage of the extraction entrainer is 2.1mL/g, and the extraction pressure is 40 MPa. The pressure of the first-stage decompression separation in the separation tank is 5-10MPa, and the temperature is 40-60 ℃; the secondary decompression separation pressure is 5-7MPa, and the temperature is 30-50 ℃. The temperature of the African carbene tree bark powder sample separation kettle I is 75 ℃, the pressure is 5.4MPa, and the temperature of the separation kettle II is 70 ℃, and the pressure is 5.4 MPa.

The maca powder is put into an extraction tank of a supercritical carbon dioxide extraction device, supercritical carbon dioxide is used as a solvent, 60-80% ethanol is used as an entrainer, and extraction is carried out under the conditions that the pressure is 15-25MPa and the temperature is 40-60 ℃, wherein the extraction time is 2 hours. Putting the maca powder into an extraction tank, adding 60-80% ethanol as an entrainer, and soaking for 10-12 h at room temperature. Through a series of single-factor tests and response surface test optimization, the optimal extraction process for extracting the black maca extract is determined as follows: the dosage of the extraction entrainer is 2.0mL/g, and the extraction pressure is 45 MPa. The pressure of the first-stage decompression separation in the separation tank is 5-10MPa, and the temperature is 40-60 ℃; the secondary decompression separation pressure is 5-7MPa, and the temperature is 30-50 ℃. The temperature of the first separation kettle of the black maca powder sample is 75 ℃, the pressure is 5.4MPa, and the temperature of the second separation kettle is 70 ℃, and the pressure is 5.4 MPa.

The industrial hemp powder is put into an extraction tank of a supercritical carbon dioxide extraction device, extracted under the conditions of 15-25MPa of pressure and 40-60 ℃ of temperature for 2 hours by using supercritical carbon dioxide as a solvent and 60-80% ethanol as an entrainer. Putting industrial hemp powder into an extraction tank, adding 60-80% ethanol as an entrainer, and soaking for 10-12 h at room temperature. Through a series of single-factor tests and response surface test optimization, the optimal extraction process for extracting the cannabidiol is determined as follows: the dosage of the extraction entrainer is 2.1mL/g, and the extraction pressure is 40 MPa. The pressure of the first-stage decompression separation in the separation tank is 5-10MPa, and the temperature is 40-60 ℃; the secondary decompression separation pressure is 5-7MPa, and the temperature is 30-50 ℃. The temperature of the industrial hemp powder sample separation kettle I is 75 ℃, the pressure is 5.2MPa, and the temperature of the separation kettle II is 70 ℃, and the pressure is 5.2 MPa.

The echinacea purpurea powder is put into an extraction tank of a supercritical carbon dioxide extraction device, extracted under the conditions of 15-25MPa of pressure and 40-60 ℃ of temperature for 2 hours by using supercritical carbon dioxide as a solvent and 60-80% ethanol as an entrainer. Putting the echinacea purpurea powder into an extraction tank, adding 60-80% ethanol as an entrainer, and soaking for 10-12 h at room temperature. Through a series of single-factor tests and response surface test optimization, the optimal extraction process for extracting the echinacea purpurea extract is determined as follows: the dosage of the extraction entrainer is 2.1mL/g, and the extraction pressure is 40 MPa. The pressure of the first-stage decompression separation in the separation tank is 5-10MPa, and the temperature is 40-60 ℃; the secondary decompression separation pressure is 5-7MPa, and the temperature is 30-50 ℃. The temperature of the echinacea purpurea powder sample separation kettle I is 75 ℃, the pressure is 5.3MPa, and the temperature of the separation kettle II is 70 ℃, and the pressure is 5.3 MPa.

The non-pueraria powder is put into an extraction tank of a supercritical carbon dioxide extraction device, supercritical carbon dioxide is used as a solvent, 60-80% ethanol is used as an entrainer, and extraction is carried out under the conditions that the pressure is 15-25MPa and the temperature is 40-60 ℃, and the extraction time is 2 hours. And putting the kudzu root powder into an extraction tank, adding 60-80% ethanol serving as an entrainer, and soaking for 10-12 hours at room temperature. Through a series of single-factor tests and response surface test optimization, the optimal extraction process for extracting the radix puerariae extract is determined as follows: the dosage of the extraction entrainer is 2.3mL/g, and the extraction pressure is 45 MPa. The pressure of the first-stage decompression separation in the separation tank is 5-10MPa, and the temperature is 40-60 ℃; the secondary decompression separation pressure is 5-7MPa, and the temperature is 30-50 ℃. The temperature of the kudzu root powder sample separation kettle I is 75 ℃, the pressure is 5.2MPa, and the temperature of the separation kettle II is 70 ℃, and the pressure is 5.2 MPa.

Mixing the six components according to 27g of African carbine extract, 12g of arginine, 13g of black maca extract, 18g of Cannabidiol (CBD) full spectrum oil, 15g of echinacea purpurea extract and 15g of kudzu root extract, and drying in a dryer to prepare dry powder.

And (6) subpackaging into capsules.

Example two

The medicine of the formula is taken out, and is dissolved in drinking water for intragastric administration. The effect on carrageenan-induced footpad swelling in rats was tested as follows: grouping 1:

experimental group 1: blank control group: 500ml/kg of drinking water;

experimental group 2: the formula group of the invention is as follows: 500 mg/kg.

Experimental group 3: the Qianliekang group and the formula are as follows: 500mg/kg +250 mg/kg.

Experimental group 4: prostate recovery group: 1000 mg/kg;

2 Experimental animals and feeds

Experimental animals: SD rats, male, four week old, SPF grade fed.

Basic feed: 20g of flour, 10g of rice flour, 20g of corn, 25g of bran, 20g of bean material, 2g of bone meal, 2g of fish meal, 0.9g of salt and 0.1g of vitamin.

3 feeding and administration mode

After purchasing the experimental animals, the basic feed is normally and adaptively fed for one week (SPF feeding, namely feeding the animals in animal rooms with the temperature of 23 +/-2 ℃, the humidity of 40-50 g, artificial illumination and light and dark of 12 hours respectively). Then randomly divided into: blank control group, the formula group of the invention, prostate recovery group, the formula group and the prostate recovery group, wherein each group comprises 10 animals. The medicine is administered by intragastric administration after dissolving according to the dosage.

4 observation index and measuring method

The volume of the right hind footpad was measured 1, 3 and 5 hours after the injection of 0.1ml of a sterilized 1% carrageenan physiological saline solution subcutaneously for each rat, and the difference from the volume of the footpad before the injection of carrageenan was used as a swelling indication, and the results are shown in Table 1.

5 statistical treatment

The data obtained were statistically processed by means of the mean. + -. standard deviation

Indicating that the significance of the difference was judged by t-test. The calculation method of the P value comprises the following steps: comparing the model control group with the blank control group, and comparing the experimental administration group with the model control group (P)<0.01 is a very significant difference, P<0.05 is a significant difference).

TABLE 1 Effect of functional products of the present formulation on carrageenan-induced footpad swelling in rats

(. P < 0.05. P <0.01, compared to control group)

6 results and comparative analysis

As can be seen from Table 1: test results show that the formula group and the prostate health group have obvious inhibition effect on the foot sole swelling of rats (P is less than 0.05) at 1, 3 and 5 hours after carrageenan injection; however, the formula of the invention has very obvious inhibition effect on the plantar swelling of rats at 1, 3 and 5 hours when being used with the prostate rehabilitation group (P < 0.01).

The raw materials and the mixture of the formula set of the invention have no obvious toxic effect on various observation indexes of female and male rats through safety toxicology tests, so the invention is safe to take and does not cause toxic reaction.

EXAMPLE III

Preparation example 1:

a formula composition for improving chronic inflammation of prostate and calcification spots of prostate comprises: 25g of African carbine extract, 14g of arginine, 12g of black maca extract, 19g of Cannabidiol (CBD) full spectrum oil, 14g of echinacea extract and 16g of kudzu root extract.

The preparation method comprises the following steps: cleaning African carbene bark, black maca, industrial hemp whole plant, Echinacea whole plant and radix Puerariae, oven drying, micronizing, sieving with 60-80 mesh sieve, performing supercritical extraction to obtain extract, mixing with purchased natural arginine small peptide, drying to obtain mixture, and vacuum packaging.

Preparation example 2:

a formula composition for improving chronic inflammation of prostate and calcification spots of prostate comprises: 27g of African carbine extract, 12g of arginine, 13g of black maca extract, 18g of Cannabidiol (CBD) full spectrum oil, 15g of echinacea extract and 15g of kudzu root extract.

Preparation example 3:

a formula composition for improving chronic inflammation of prostate and calcification spots of prostate comprises: 27g of African carbine extract, 11g of arginine, 14g of black maca extract, 16g of Cannabidiol (CBD) full spectrum oil, 16g of echinacea extract and 16g of kudzu root extract.

Preparation example 4:

a formula composition for improving chronic inflammation of prostate and calcification spots of prostate comprises: 25g of African carbine extract, 13g of arginine, 14g of black maca extract, 14g of Cannabidiol (CBD) full spectrum oil, 17g of echinacea extract and 17g of kudzu root extract.

Preparation example 5:

a formula composition for improving chronic inflammation of prostate and calcification spots of prostate comprises: 26g of African carbine extract, 13g of arginine, 14g of black maca extract, 17g of Cannabidiol (CBD) full spectrum oil, 14g of echinacea extract and 16g of kudzu root extract.

The foregoing is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that modifications and equivalents of the above embodiment may be made without departing from the spirit of the invention, and are within the scope of the invention.

Claims

1. A preparation for improving chronic inflammation of prostate and calcification of prostate is provided.

2. A formulation according to claim 1, comprising african carbene extract, arginine, black maca extract, Cannabidiol (CBD) whole spectrum oil, echinacea extract, kudzu root extract.

3. A formulation according to claim 2, comprising: 20-30g of African carbine extract, 8-16g of arginine, 10-15g of black maca extract, 15-20g of Cannabidiol (CBD) full spectrum oil, 10-16g of echinacea extract and 12-16g of kudzu root extract.

4. A formulation according to claim 3, further preferably the pharmaceutical composition is: 27g of African carbine extract, 12g of arginine, 13g of black maca extract, 18g of Cannabidiol (CBD) full spectrum oil, 15g of echinacea extract and 15g of kudzu root extract.

5. The preparation according to claims 1 to 4, wherein the improvement of the symptoms of chronic inflammation of prostate and calcification of prostate is an inhibition effect on the inflammation of prostate, and has antibacterial and antiviral effects, and has good effect on improving the chronic inflammation of prostate.

6. The preparation according to claims 1 to 4, which is capable of improving male hypofunction due to prostate problems, improving male function, and achieving a healthy state.

7. The formulation of claims 3-6, wherein the pharmaceutical formulation consists essentially of an oral formulation.

8. The formulation of claims 3-6, wherein the pharmaceutical formulation comprises capsules, tablets, granules, capsules, and the like.