CN114251755B - Reagent library of biochemical analyzer, control method, and storage medium - Google Patents

Reagent library of biochemical analyzer, control method, and storage medium Download PDF

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Publication number
CN114251755B
CN114251755B CN202011000222.5A CN202011000222A CN114251755B CN 114251755 B CN114251755 B CN 114251755B CN 202011000222 A CN202011000222 A CN 202011000222A CN 114251755 B CN114251755 B CN 114251755B
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reagent
water
storage device
water storage
humidity
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CN114251755A (en
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杨彦志
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Canon Medical Systems Corp
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Canon Medical Systems Corp
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F6/00Air-humidification, e.g. cooling by humidification
    • F24F6/12Air-humidification, e.g. cooling by humidification by forming water dispersions in the air
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/62Control or safety arrangements characterised by the type of control or by internal processing, e.g. using fuzzy logic, adaptive control or estimation of values
    • F24F11/63Electronic processing
    • F24F11/64Electronic processing using pre-stored data
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/88Electrical aspects, e.g. circuits
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/89Arrangement or mounting of control or safety devices
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F13/00Details common to, or for air-conditioning, air-humidification, ventilation or use of air currents for screening
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F2110/00Control inputs relating to air properties
    • F24F2110/20Humidity

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Signal Processing (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
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  • Medicinal Chemistry (AREA)
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  • General Physics & Mathematics (AREA)
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  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention provides a reagent kit capable of controlling the interior of the reagent kit to be at a proper humidity, avoiding drying in the reagent kit and avoiding dew generated in the reagent kit from falling into a reagent bottle, a biochemical analysis device with the reagent kit, a control method when the reagent kit is used, and a storage medium. A reagent library of a biochemical analyzer of the present invention comprises: a reagent bottle for accommodating the reagent bottle; the water storage device is arranged at the bottom of the reagent cylinder and used for storing moisture used for humidifying the inside of the reagent cylinder; and the outer cover is used for keeping cold in the reagent cylinder.

Description

Reagent library of biochemical analyzer, control method, and storage medium
Technical Field
The present invention relates to a reagent library for storing reagents in biochemical analysis for analyzing reagents, a biochemical analysis apparatus using the reagent library, a control method for the use of the reagent library, and a storage medium.
Background
Conventionally, biochemical analyzers such as automatic biochemical analyzers and full-automatic biochemical analyzers that analyze reagents have been known to have a reagent library that stores reagents, the reagent library including: the reagent bottle is used for storing a reagent for detection; a rotatable table (also referred to as a reagent table) for carrying reagent bottles; and a cover of the reagent cylinder is provided with a reagent dispensing opening. During reagent dispensing, the workbench is driven to rotate, so that the reagent bottle to be dispensed is rotated to the bottle mouth to be exposed from the reagent dispensing opening, and then reagent is dispensed into the reagent bottle through the reagent dispensing opening by using the reagent needle.
In such a reagent reservoir, for example, in the case of air-drying in winter, the evaporation amount of the reagent in the reagent bottle becomes large, and static electricity is easily generated due to a decrease in humidity, so that the liquid surface detection of the reagent becomes ineffective (false detection). Specifically, if the humidity of the air is 30% or less, static electricity is extremely likely to occur. In order to reduce the occurrence of static electricity, humidity control in the reagent chamber is required.
In contrast, for example, patent document 1 describes an automatic analyzer provided with a humidifier, which, when it is detected by a humidity sensor that the humidity in a chamber 62 of an evaporation protection chamber is equal to or lower than a predetermined value, causes a fan 39 provided in the humidifier 36 to operate, and blows high-humidity air into the chamber 62, thereby preventing evaporation of various reagents and cleaning solutions held by various containers on a container standby tray 5.
Prior art literature
Patent literature
Patent document 1: japanese patent application laid-open No. 2010-204129
Disclosure of Invention
However, the humidifier releases a large amount of water vapor during humidification, and the large amount of water vapor is likely to condense at the reagent bottle mouth to form dew water, and finally flows into the reagent bottle. If dew water enters the reagent bottle, this can have an adverse effect on the reagent. In particular, because the reagent reservoir of some devices is also provided with a circulating fan (rendt), a large amount of water vapor is blown upwards to form more dew and more easily fall into the reagent bottle.
The object of the present invention is to provide a reagent kit capable of controlling the interior of the reagent kit to an appropriate humidity, preventing the interior of the reagent kit from drying, and preventing dew condensation water generated in the reagent kit from falling into reagent bottles, a biochemical analysis device provided with the reagent kit, a control method when the reagent kit is used, and a storage medium.
A reagent library of a biochemical analyzer according to an embodiment of the present invention includes: a reagent bottle for accommodating the reagent bottle; the water storage device is arranged at the bottom of the reagent cylinder and used for storing moisture used for humidifying the inside of the reagent cylinder; and the outer cover is used for keeping cold in the reagent cylinder.
The water storage device may be provided with a humidifying unit for atomizing water stored in the water storage device to humidify the inside of the reagent cylinder.
The reagent container of the biochemical analyzer may further include an inner cover having an opening into which at least a mouth of the reagent bottle is fitted, and a portion of a lower surface of the inner cover other than the opening may separate the mouth of the reagent bottle from a space in the reagent bottle below the mouth, thereby suppressing the flow of the water vapor in the reagent bottle to the mouth of the reagent bottle.
The reagent vessel may further include a rotatable reagent table for placing a reagent bottle thereon, the inner cover may include a rotating portion, the opening may be provided in the rotating portion, and the rotating portion may be rotated together with the reagent bottle placed on the reagent table when the reagent table is rotated.
The outer periphery of the inner cover may further include a fixing portion, the rotating portion may be located at an inner periphery of the inner cover, and the fixing portion and the rotating portion may be detachably connected to each other through a bearing.
The reagent table may be provided with an opening, and dew water generated by the water vapor may flow into the water storage device through the opening.
The outer cover and the inner cover may be connected to each other.
The bottom surface of the reagent vessel may be inclined so as to be lower toward the water storage device, or a water guide may be provided so as to guide the condensed water generated when the temperature of the dew condensation water in the reagent vessel is low into the water storage device.
The humidifying unit may be a piezoelectric ceramic.
The reagent container may further include a humidity detection unit that detects humidity in the reagent cylinder, and the reagent container may further include a control unit that controls the humidification unit based on humidity information detected by the humidity detection unit.
The water storage device may be provided with a liquid level sensor for detecting whether or not the amount of water in the water storage device reaches a predetermined amount.
The water storage device may be provided with a water inlet pipe and a water discharge pipe, and the water storage device may be filled with water via the water inlet pipe when the amount of water in the water storage device does not reach a predetermined amount, and the water discharge pipe may be used to discharge water when the amount of water in the water storage device exceeds the predetermined amount, based on the detection result of the liquid level sensor.
The biochemical analyzer according to an embodiment of the present invention includes the reagent library. The control method for using the reagent library according to one embodiment of the present invention comprises the steps of: a humidity detection step of detecting the humidity in the reagent cylinder; a humidifying step of humidifying the reagent cylinder until the humidity in the reagent cylinder reaches 40% without sucking the reagent when the humidity in the reagent cylinder is less than 30%; and a reagent sucking step of sucking a reagent when the humidity in the reagent cylinder is 30% or higher.
In the humidifying step, the amount of water in the water storage device may be detected by the liquid level sensor, and when the amount of water in the water storage device does not reach a predetermined amount based on the detection result of the liquid level sensor, water may be injected into the water storage device until the amount of water in the water storage device is detected to reach the predetermined amount, and then the inside of the reagent vessel may be humidified.
An embodiment of the present invention is a computer-readable storage medium storing a program for causing a computer to execute the above-described control method.
Thus, the inside of the reagent chamber can be controlled to have an appropriate humidity, and the generation of static electricity due to the too small humidity can be reduced, thereby avoiding the influence on the detection of the liquid surface and reducing the evaporation of the reagent. Meanwhile, dew generated when the humidity in the reagent warehouse is too high can be prevented from falling into the reagent bottle.
Drawings
FIG. 1 is a schematic sectional view showing the structure of a reagent library in a biochemical analyzer according to the present invention.
Fig. 2 (a) is a plan view and a side view of an inner cover of a reagent reservoir in the biochemical analyzer of the present invention, and fig. 2 (b) is a plan view of an outer cover of the reagent reservoir in the biochemical analyzer of the present invention.
FIG. 3 is a view showing a path along which water vapor generated by humidification of the reagent reservoir is blocked by the cover and then forms dew condensation water to fall.
Fig. 4 is a diagram for explaining a control flow when the reagent library is used.
Description of the reference numerals
1, a reagent cylinder; 2, a test bottle; 3, a reagent table; 4, a cover; 41, an outer cover; 411, reagent dispensing port; 412, a handle; 42, inner cover; 421, a fixing portion; 422, a rotating part; 422a, openings; 43, a bearing; 5, a water accumulation tank; 51, a water inlet pipe; 512, solenoid valve; 52, a drain pipe; 53, a humidifier; 54, a liquid level sensor; and 6, a humidity sensor.
Detailed Description
Hereinafter, embodiments of the present invention will be described with reference to the drawings. In the following embodiments, the same or equivalent portions are given the same reference numerals, and description is given.
FIG. 1 is a schematic sectional view showing the structure of a reagent library in a biochemical analyzer according to the present invention. As shown in fig. 1, the reagent kit includes:
a reagent cylinder (band) 1 having a plurality of reagent bottles 2 to be detected therein;
a plurality of reagent bottles (bottles) 2 each containing a reagent to be detected;
a reagent table (table) 3 for mounting a plurality of reagent bottles 2, the reagent table 3 preferably being provided with an opening (not shown) so that dew condensation water formed in the reagent bottle 1 leaks down from the opening to flow into a water accumulation tank 5 described later, and the reagent table 3 being rotatably provided so as to perform reagent dispensing operation described later;
a cover (cover) 4 of the reagent vessel 1;
a water accumulation tank 5 provided at the bottom of the reagent vessel 1 and storing a proper amount of water for humidifying the inside of the reagent vessel 1;
the humidity sensor 6 is used for detecting or monitoring the humidity in the reagent cylinder 1 and is connected with a reagent library control substrate (control unit) outside the reagent cylinder 1.
Among them, a humidifier 53 is provided at a proper position (preferably, a bottom portion) of the water storage tank 5, and the humidifier 53 is preferably a widely used piezoelectric ceramic capable of atomizing water to humidify, and the humidifier 53 humidifies the inside of the reagent chamber as needed, thereby ensuring the humidity inside the reagent chamber. For example, if the humidity in the reagent reservoir is monitored to be lower than 30% by the humidity sensor, the piezoelectric ceramic as the humidifier 53 is activated to atomize the water in the water reservoir, thereby increasing the humidity in the reagent reservoir. If the humidity is monitored to be too high (for example, higher than 40%) by the humidity sensor, the piezoelectric ceramic as the humidifier 53 is stopped. Thus, the humidity of the reagent vessel 1 is always controlled to be between 30% and 40%.
Preferably, the water accumulation tank 5 is further provided with a well-known liquid level sensor 54 for detecting the liquid level in the water accumulation tank 5, and the liquid level sensor 54 may be a float switch, a float, or the like, for example, when the water in the water accumulation tank 5 is insufficient, the float switch is automatically opened. Based on the detection result of the liquid level sensor 54, it is possible to determine whether or not the amount of water in the water accumulation tank 5 is appropriate.
Preferably, the water accumulation tank 5 is further connected to a water inlet pipe 51 and a water outlet pipe 52, and solenoid valves (only a solenoid valve 512 provided in the water inlet pipe 51 is shown in the figure) are provided in the water inlet pipe 51 and the water outlet pipe 52, respectively, for example, when the liquid level is lower than a predetermined height, the solenoid valve 512 is opened, water is injected into the water accumulation tank 5 through the water inlet pipe 51, and when the liquid level reaches the predetermined height, the solenoid valve 512 is closed to stop water injection. Similarly, when the liquid level exceeds a predetermined level, the solenoid valve provided in the drain pipe 52 is opened to drain excess water from the drain pipe 52, and when the liquid level reaches the predetermined level, the solenoid valve is closed to stop the drainage. The drain pipe 52 may be connected to a predetermined height of the side wall of the water accumulation tank 5, and when the water amount in the water accumulation tank 5 exceeds the predetermined height, the water is automatically drained from the drain pipe 52 by using the communicating vessel principle, and in this case, the liquid level sensor 54 may be omitted.
Further, the water accumulation groove 5 stores not only an appropriate amount of water for humidifying the inside of the reagent vessel 1, but also receives dew (or condensed water) when the dew (or condensed water) is generated in the reagent vessel 1, and for this purpose, it is more preferable that a water guide channel (not shown) is provided at the bottom of the reagent vessel 1, or the bottom surface of the reagent vessel 1 is provided so as to be inclined toward the water accumulation groove 5, so that the dew is preferably discharged into the water accumulation groove 5 along the bottom surface of the reagent vessel 1, and the dew flowing into the water accumulation groove 5 can supplement the water amount of the water accumulation groove.
As the humidity sensor 6, a known humidity sensor can be used, and the control requirements of the present invention can be satisfied as long as the detection accuracy in the low-medium humidity range (0 to 80% rh) reaches ±2% rh. More preferably, the humidity sensor 6 always monitors the humidity in the reagent reservoir, and when it detects that the humidity in the reagent reservoir is lower than 30%, the control board to which it is connected controls to activate the humidifier 53 to atomize the water in the water accumulation tank 5, thereby increasing the humidity in the reagent reservoir. When the humidity in the reagent chamber is detected to be too high (for example, 40% or more), the control board stops the operation of the humidifier 53. Thus, the humidity in the reagent reservoir is controlled to be between 30% and 40%.
The cover 4, which is a feature of the present invention, will be described in detail below.
As shown in fig. 1 and 2, the cover 4 includes an outer cover 41 and an inner cover 42, wherein the outer cover 41 is positioned at the upper side in fig. 1, and is also a cover of a conventional reagent cylinder for maintaining humidity and temperature (usually 2-10 ℃) of the interior environment of the reagent container, and is made of heat insulation materials, so that the function of keeping cold can be achieved. The reagent dispensing device is provided with a handle 412 for holding and a reagent dispensing port 411, and can suck the reagent from the reagent bottle 2 in the reagent cylinder 1 through the reagent dispensing port 411 at the time of reagent dispensing. Although the reagent dispensing ports 411 are shown as being circular and two, the number and shape thereof are not limited.
The inner cap 42 is located inside the reagent vessel 1 with respect to the outer cap 41, and is not particularly limited in material so as to block water vapor flowing into the mouth of the reagent bottle 2 in the reagent vessel 1 and to fit each reagent bottle 2 therein. As shown in a plan view of the inner cover 42 above (a) of fig. 2, the inner cover 42 is provided with a plurality of openings 422a through which at least the mouth portions of the reagent bottles 2 are inserted, and preferably, the inner cover 42 is composed of an outer peripheral fixed portion 421 and an inner peripheral rotating portion 422, and as shown in a side view of the inner cover 42 below (a) of fig. 2, the fixed portion 421 and the rotating portion 422 are connected by a bearing (bearing) 43 or the like, the plurality of openings 422a are provided in the rotating portion 422, and a portion of the inner cover 42 where the openings 422a are not formed separates at least the mouth portions of the reagent bottles 2 from a space below for blocking water vapor flowing to the mouth portions of the reagent bottles 2 in the reagent bottles 1 (described later in detail), the mouth portions of the reagent bottles 2 are fitted in the openings 422a and protrude from the openings 422a, and the lower ends of the reagent bottles 2 are mounted on the rotatable reagent table 3, and each time the reagent table 3 rotates accordingly, thereby driving all the reagent bottles 2 and the rotatable reagent table 422 to be fitted in the fixed portion 421. Then, the mouth of the reagent bottle 2 to be dispensed is rotated to a position overlapping the reagent dispensing port 411 of the outside cap 41, and is exposed from the reagent dispensing port 411, whereby reagent dispensing can be performed from the reagent bottle 2 through the reagent dispensing port 411 by using the reagent needle. After the reagent dispensing of the reagent bottle 2 is completed, the reagent table 3 is driven to continue to rotate, and the mouth of the next reagent bottle 2 to be dispensed is driven to a position overlapping the reagent dispensing opening 411 of the outer cap 41.
Here, the number and shape of the openings 422a are not limited as long as they are set according to the number and shape of the reagent bottles to be tested, and in fig. 2 (a), a plurality of openings 422a are shown surrounding two circles, and therefore, although only two reagent bottles 2 are shown in fig. 1, in practice, the number of reagent bottles 2 of the openings 422a can be accommodated at most in the reagent cylinder 1.
As a connection method between the outer cover 41 and the inner cover 42, it is preferable to detachably fix the outer peripheral portion of the outer cover 41 to the fixing portion 421 of the inner cover 42, but the connection method is not limited thereto, and the outer cover 41 and the fixing portion 421 may be integrally formed using the same material. Although the inner cover 42 may be provided separately from each other, for example, by being directly engaged with the inner wall of the reagent vessel 1, it is not preferable to remove the outer cover 41 and the inner cover 42 together to replace the reagent at the time of reagent replacement.
With such a cap 4, the water vapor in the reagent vessel 1 is blocked from flowing upward into the mouth of the reagent bottle 2 when it is excessive, so that the water vapor is prevented from forming dew and falling into the reagent bottle 2. The principle of operation of the cover 4 will be described in detail below with reference to fig. 3.
Fig. 3 shows a path in which water vapor generated by humidification of the reagent reservoir is blocked by the cover 4 and then forms dew condensation water to fall.
First, when the insufficient amount of water in the water tank 5 is detected by the liquid level sensor, the electromagnetic valve 512 is opened, and water is injected from the water inlet pipe 51 into the water tank 5. Then, the piezoelectric ceramic 53 generates water vapor or air with water droplets, which rises to the inner cover 42 as indicated by an upward arrow, is blocked by a portion of the lower surface of the inner cover 42 where no opening is provided, and then condenses into dew water, which falls down, and flows back into the water accumulation tank as indicated by a downward arrow along the inner wall of the reagent vessel 1, the surface of the reagent vessel interior, or via the opening in the reagent table 3, and the dew water flowing into the water accumulation tank can continue to be used for humidification. In addition, if condensed water is generated due to a low temperature on the inner wall of the reagent vessel 1 or the like, the condensed water may flow back into the water accumulation tank through the same path.
In this way, the inside cap 42 keeps the water vapor (including the circulating air blown together when the circulating fan is provided) under the mouth of the test vial, and the mouth of the test vial extends above the inside cap 42, so that dew condensation water formed by condensation of the water vapor does not adhere to the bottle. Therefore, the humidity in the reagent reservoir is increased, and the phenomenon that a large amount of dew is condensed on the bottle mouth of the reagent bottle and flows into the bottle is avoided. In addition, the air flow at the bottle mouth is controlled, so that the evaporation of the reagent can be reduced.
Here, although the mouth of the reagent bottle is positioned above the inner cover 42, the bottle mouth of the reagent bottle is positioned in a high humidity environment, and the reagent bottle is integrated, so that the humidity of the entire reagent bottle is ensured, and a large amount of static electricity is not generated.
The control flow when using the reagent library will be described below with reference to fig. 4.
First, the system control switch is activated (powered on), and thus the humidity sensor 6 starts to operate, automatically monitoring or detecting the humidity in the reagent reservoir.
Next, when the humidity sensor 6 detects that the humidity in the reagent reservoir is 30% or more, the control unit to which it is connected controls the reagent arm (arm) for reagent dispensing to allow the reagent to be sucked. When the humidity sensor 6 detects that the humidity in the reagent reservoir is less than 30%, the control unit controls the reagent arm for reagent dispensing not to be allowed to suck the reagent. This is because if the humidity is 30% or less, the liquid surface is too dry, and if the liquid surface is detected, false detection due to static electricity may occur.
When the humidity sensor 6 detects that the humidity in the reagent reservoir is less than 30%, the liquid level detector (float switch) in the water storage tank 5 starts to operate, and detects whether or not the water amount in the water storage tank 5 reaches a predetermined amount. If the predetermined amount is not reached, the electromagnetic valve 512 is opened, and water is injected into the water accumulation tank 5 through the water inlet pipe 51.
When it is detected that the amount of water in the water accumulation tank 5 reaches a predetermined amount, the electromagnetic valve 512 is closed (the electromagnetic valve is kept in the closed state, if it is originally), and then the piezoelectric ceramic as the humidifier 53 is operated to humidify the reagent chamber, and the suction of the reagent is not allowed until the humidity sensor 6 detects that the humidity in the reagent chamber is 30% or more.
Next, when the humidity sensor 6 detects that the humidity in the reagent chamber is 40% or more, the humidifier 53 stops humidification so as to prevent excessive dew condensation water from being generated in the reagent chamber due to excessive humidity. Of course, even when the humidity is 40% or more, the suction of the reagent is allowed because excessive dew condensation water can be blocked by the cap 4 with the inner cap 42 of the present invention, and thus the condition that dew condensation water flows into the reagent bottle is avoided, so that the reagent is not affected and reagent dispensing can be performed.
In this way, the humidity sensor 6 and the humidifier 53 always control the humidity inside the reagent chamber to 30% to 40%, and the reagent table 3 is rotated continuously at this humidity to suck the reagent.
While the preferred embodiment of the present invention has been described above, the configuration of the reagent kit of the present invention is not limited to this.
For example, the rotation portion 422 may not be circular throughout the inner periphery of the fixed portion 421, but may be a sector shape in which an arc-shaped portion of the outer periphery fits into a portion of the inner periphery of the fixed portion 421. The rotating part 422 may be formed by splicing a plurality of sectors, and different types of reagents may be placed in each sector area.
In the case where the outer cap 41 and the inner cap 42 are separated from each other and the inner cap 42 is directly engaged with the inner wall of the reagent vessel 1, the fixing portion 421 may be omitted as long as the inner cap 42 can be rotated together with the plurality of reagent vessels 2 in accordance with the rotation of the reagent table 3.
Although the example in which the reagent table 3 has an opening so that dew condensation water flows down through the opening has been described above, the reagent table 3 may not have an opening as long as a path for dew condensation water to flow into the water accumulation groove 5 is ensured.
The water accumulation groove 5 may be provided on the bottom surface of the reagent vessel 1, or may be provided at a corner of the bottom surface of the reagent vessel 1.
In addition, although the above-described example in which the cover 4 has two covers, that is, the outer cover 41 and the inner cover 42, is described, the number thereof is not limited to two, as long as the functions can be realized. For example, in the case where the reagent bottle is long, two inner covers 42 of the same structure may be provided so as to more stably support the reagent bottle in the longitudinal direction.
Although one embodiment of the present invention has been described above, this embodiment is presented as an example and is not intended to limit the scope of the invention. These novel embodiments can be implemented in various other modes, and various omissions, substitutions, and changes can be made without departing from the spirit of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the scope of the invention described in the claims and equivalents thereof.

Claims (15)

1. A reagent library of a biochemical analyzer is characterized by comprising:
a reagent bottle for accommodating the reagent bottle;
the water storage device is arranged at the bottom of the reagent cylinder and used for storing moisture used for humidifying the inside of the reagent cylinder; and
an outer cover for cooling the inside of the reagent cylinder,
the reagent reservoir of the biochemical analyzer further comprises an inner cover provided with an opening for being fitted into at least the mouth of the reagent bottle, and a portion of the lower surface of the inner cover other than the opening separates the mouth of the reagent bottle from a space in the reagent cylinder below the mouth, thereby suppressing the flow of the water vapor in the reagent cylinder to the mouth of the reagent bottle.
2. The reagent library of the biochemical analysis device according to claim 1, wherein,
a humidifying unit is arranged in the water storage device and is used for atomizing water stored in the water storage device to humidify the inside of the reagent cylinder.
3. The reagent library of the biochemical analysis device according to claim 1, wherein,
the reagent cylinder is also provided with a rotatable reagent table for placing the reagent bottle,
the inner cover has a rotation part, the opening is provided on the rotation part, and the rotation part rotates together with the reagent bottle placed on the reagent table when the reagent table rotates.
4. A reagent library of a biochemical analysis device according to claim 3, wherein,
the outer periphery of the inner cover is also provided with a fixing part, the rotating part is positioned at the inner periphery of the inner cover, and the fixing part and the rotating part are detachably connected through a bearing.
5. A reagent library of a biochemical analysis device according to claim 3, wherein,
the reagent table is provided with an opening, and dew water generated by water vapor flows into the water storage device through the opening.
6. The reagent library of the biochemical analysis device according to claim 1, wherein,
the outer cover and the inner cover are connected to each other.
7. A reagent kit for a biochemical analyzer according to claim 1 or 2,
the bottom surface of the reagent vessel is inclined so as to be lowered toward the water storage device, or a water guide channel is provided so as to guide dew water generated by the water vapor in the reagent vessel or condensed water generated when the temperature is low into the water storage device.
8. The reagent library of the biochemical analysis device according to claim 2, wherein,
the humidifying unit is made of piezoelectric ceramics.
9. The reagent library of the biochemical analysis device according to claim 2, wherein,
a humidity detection unit for detecting the humidity in the reagent cylinder is also arranged in the reagent warehouse,
and a control unit is further arranged in the reagent library and is used for controlling the humidifying unit according to the humidity information detected by the humidity detection unit.
10. A reagent kit for a biochemical analyzer according to claim 1 or 2,
a level sensor is provided in the water storage device for detecting whether the amount of water in the water storage device reaches a prescribed amount.
11. The reagent library of the biochemical analysis device according to claim 10, wherein,
the water storage device is provided with a water inlet pipe and a water outlet pipe, and water is injected into the water storage device through the water inlet pipe when the water amount in the water storage device does not reach a prescribed amount according to the detection result of the liquid level sensor, and water is discharged through the water outlet pipe when the water amount in the water storage device exceeds the prescribed amount.
12. A biochemical analyzer comprising the reagent kit according to any one of claims 1 to 11.
13. A control method when using a reagent kit, characterized in that the reagent kit is the reagent kit according to claim 9, comprising the steps of:
a humidity detection step of detecting the humidity in the reagent cylinder;
a humidifying step of humidifying the reagent cylinder until the humidity in the reagent cylinder reaches 40% without sucking the reagent when the humidity in the reagent cylinder is less than 30%; and
and a reagent sucking step of sucking the reagent when the humidity in the reagent cylinder is 30% or more.
14. The control method according to claim 13, characterized in that,
in the humidifying step, the water amount in the water storage device is detected by a liquid level sensor, and when the water amount in the water storage device does not reach a predetermined amount based on the detection result of the liquid level sensor, water is injected into the water storage device until the water amount in the water storage device is detected to reach the predetermined amount, and then the inside of the reagent cylinder is humidified, wherein the liquid level sensor is provided in the water storage device and is used for detecting whether the water amount in the water storage device reaches the predetermined amount.
15. A computer-readable storage medium storing a program for causing a computer to execute the control method according to claim 13 or 14.
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Citations (5)

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Publication number Priority date Publication date Assignee Title
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JPH08262030A (en) * 1995-03-23 1996-10-11 Hitachi Ltd Autoanalyzer
JP2016205938A (en) * 2015-04-20 2016-12-08 東芝メディカルシステムズ株式会社 Automatic analyzer and sampler
JP2018080953A (en) * 2016-11-15 2018-05-24 キヤノンメディカルシステムズ株式会社 Automatic analyzer and reagent storage
CN109458669A (en) * 2018-11-01 2019-03-12 珠海格力电器股份有限公司 A kind of humidification control device, air-conditioning system and its humidifying controlling method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043143A (en) * 1990-03-28 1991-08-27 Eastman Kodak Company Analyzer having humidity control apparatus
JPH08262030A (en) * 1995-03-23 1996-10-11 Hitachi Ltd Autoanalyzer
JP2016205938A (en) * 2015-04-20 2016-12-08 東芝メディカルシステムズ株式会社 Automatic analyzer and sampler
JP2018080953A (en) * 2016-11-15 2018-05-24 キヤノンメディカルシステムズ株式会社 Automatic analyzer and reagent storage
CN109458669A (en) * 2018-11-01 2019-03-12 珠海格力电器股份有限公司 A kind of humidification control device, air-conditioning system and its humidifying controlling method

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