CN114224977A - Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof - Google Patents

Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof Download PDF

Info

Publication number
CN114224977A
CN114224977A CN202210034121.2A CN202210034121A CN114224977A CN 114224977 A CN114224977 A CN 114224977A CN 202210034121 A CN202210034121 A CN 202210034121A CN 114224977 A CN114224977 A CN 114224977A
Authority
CN
China
Prior art keywords
parts
hyperglycemia
hyperlipidemia
traditional chinese
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210034121.2A
Other languages
Chinese (zh)
Inventor
李望
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN202210034121.2A priority Critical patent/CN114224977A/en
Publication of CN114224977A publication Critical patent/CN114224977A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a traditional Chinese medicine for regulating hypertension, hyperlipidemia and hyperglycemia and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following components in parts by weight: 20-40 parts of inonotus obliquus, 20-40 parts of cordyceps militaris, 15-25 parts of pine cone, 15-25 parts of lithospermum, 15-25 parts of sea buckthorn, 10-20 parts of fructus momordicae, 10-25 parts of radix puerariae, 10-18 parts of elecampane, 10-15 parts of wolfberry fruit, 8-15 parts of rhizoma polygonati, 5-10 parts of hawthorn and 5-10 parts of Chinese yam. The components of the invention have different particle sizes, can be slowly and hierarchically released, has good curative effect on patients with hypertension, hyperglycemia and hyperlipidemia, can reduce the load on internal organs of a human body, and can be widely used for preventing and treating hypertension, hyperlipidemia and hyperglycemia.

Description

Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia and a preparation method thereof.
Background
Hyperlipidemia, hypertension and hyperglycemia; the main causes of the three high diseases are due to long-time diet problems, such as excessive lipid and excessive alcohol in the diet, and the lipid alcohol substances in the body are gradually increased because reasonable exercise is not performed to promote the metabolism of the lipid alcohol; the substances are mixed in blood to block capillary vessels, and the lipid-alcohol substances are easily combined with free mineral ions in the body to form thrombus with the lapse of time; thrombus is easy to accumulate and calcify at the corners or the bottle necks of the blood vessels; meanwhile, the thrombus is more and more, so that the diameter of the blood vessel is reduced; in order to maintain a sufficient blood supply to the heart, the blood pressure is increased, causing hypertensive diseases; it may also be caused by excessive smoking or excessive drinking, impairment of the spleen and stomach, dysfunction of the spleen in transportation, and failure of the diet to normalize.
Although there are many drugs for treating diabetes and hypertension, these drugs are only used for stabilizing the disease or relieving the symptoms, and most of them require patients to take drugs for a long time. This not only increases the economic burden on the patient, but also easily causes damage to internal organs due to long-term administration. Therefore, the research of the medicine for treating the hypertension, the hyperglycemia and the hyperlipidemia with small side effect and better curative effect on the hypertension, the hyperglycemia and the hyperlipidemia has great economic and social effects.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia, which has good curative effect on patients with hypertension, hyperglycemia and hyperlipidemia and can reduce the load on internal organs of a human body.
Another object of the present invention is to provide a method for preparing a Chinese medicine for regulating hypertension, hyperlipidemia and hyperglycemia, which can slowly and gradually release the drug properties of the Chinese medicine.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia, which comprises the following components in parts by weight: 20-40 parts of inonotus obliquus, 20-40 parts of cordyceps militaris, 15-25 parts of pine cone, 15-25 parts of lithospermum, 15-25 parts of sea buckthorn, 10-20 parts of fructus momordicae, 10-25 parts of radix puerariae, 10-18 parts of elecampane, 10-15 parts of wolfberry fruit, 8-15 parts of rhizoma polygonati, 5-10 parts of hawthorn and 5-10 parts of Chinese yam.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine for regulating hypertension, hyperlipidemia and hyperglycemia, which comprises the following steps: crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, extracting with water for 2-3 times, combining extracting solutions, purifying by using macroporous adsorption resin, concentrating, drying and granulating the purified extracts, and sieving by using a 30-50-mesh sieve to obtain a material a; extracting elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam with water for 2-4 times, concentrating, drying and granulating, and sieving with a sieve of 70-100 meshes to obtain a material b; mixing the material a, the material b, the slow release auxiliary agent and the filler to prepare the slow release medicament.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the raw materials of the invention adopt the inonotus obliquus, the cordyceps militaris, the pine cone, the lithospermum, the sea buckthorn, the six-axis seed, the kudzuvine root, the elecampane, the medlar, the rhizoma polygonati, the hawthorn and the Chinese yam, and the effects of warming interior and calming liver, regulating qi and strengthening body resistance, and regulating the blood pressure, blood fat and blood sugar of a human body are achieved. The traditional Chinese medicinal materials and the sustained-release auxiliary agent are combined, so that the release time of the traditional Chinese medicinal materials can be prolonged, the drug effect of a patient after taking the medicine is quickly released, and the damage to the liver is reduced. The slow release auxiliary agent is added into the traditional Chinese medicine, so that the product can be used for preventing hypertension, hyperlipidemia and hyperglycemia.
According to the invention, the elecampane inula root, the wolfberry fruit, the rhizoma polygonati, the hawthorn and the Chinese yam are extracted by water and prepared into finer materials, so that the effect of relatively quick release is exerted in the medicine, the effects of tonifying spleen and kidney, helping digestion and nourishing stomach and liver and kidney are achieved, and the damage to the liver is further reduced; the active molecules are further extracted by carrying out water extraction and macroporous resin adsorption on the inonotus obliquus, the cordyceps militaris, the pine cone, the lithospermum, the sea buckthorn, the six-axle seed and the kudzuvine root, and the active molecules are prepared into a material with larger relative granularity, so that the effect of slow release is achieved.
In conclusion, the preparation method of the invention can slowly and hierarchically release the medicine, has good curative effect on patients with hypertension, hyperglycemia and hyperlipidemia, can reduce the load on internal organs of a human body, and can be widely used for preventing and treating hypertension, hyperlipidemia and hyperglycemia.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following components in parts by weight: 20-40 parts of inonotus obliquus, 20-40 parts of cordyceps militaris, 15-25 parts of pine cone, 15-25 parts of lithospermum, 15-25 parts of sea buckthorn, 10-20 parts of fructus momordicae, 10-25 parts of radix puerariae, 10-18 parts of elecampane, 10-15 parts of wolfberry fruit, 8-15 parts of rhizoma polygonati, 5-10 parts of hawthorn and 5-10 parts of Chinese yam.
In some embodiments of the invention, the traditional Chinese medicine comprises the following components in parts by weight: 30-35 parts of inonotus obliquus, 25-35 parts of cordyceps militaris, 20-25 parts of pine cone, 20-25 parts of lithospermum, 15-20 parts of sea buckthorn, 10-15 parts of fructus momordicae, 12-20 parts of radix puerariae, 12-15 parts of elecampane, 12-15 parts of wolfberry fruit, 10-15 parts of rhizoma polygonati, 5-8 parts of hawthorn and 5-8 parts of Chinese yam.
In some embodiments of the invention, the traditional Chinese medicine comprises the following components in parts by weight: 32 parts of inonotus obliquus, 30 parts of cordyceps militaris, 20 parts of pine cone, 22 parts of lithospermum, 18 parts of sea-buckthorn, 12 parts of six-axis seed, 15 parts of kudzu root, 13 parts of elecampane, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 5 parts of hawthorn and 6 parts of Chinese yam.
In some embodiments of the present invention, the traditional Chinese medicine further comprises a slow release auxiliary agent and a filler.
In some embodiments of the present invention, the slow release auxiliary agent comprises 5 to 8 parts of chitosan, 2 to 5 parts of dimethylformamide, 2 to 5 parts of spirulina, 3 to 6 parts of soybean lecithin, 5 to 10 parts of polylactic glycolic acid solution and 6 to 12 parts of ethanol gel solution.
In some embodiments of the present invention, the filler includes one or more of dextrin, starch, sorbitol and microcrystalline cellulose, and the weight part of the filler is 5 to 20 parts.
A preparation method of a traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia comprises the following steps:
crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, extracting with water for 2-3 times, combining extracting solutions, purifying by using macroporous adsorption resin, concentrating, drying and granulating the purified extracts, and sieving by using a 30-50-mesh sieve to obtain a material a;
extracting elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam with water for 2-4 times, concentrating, drying and granulating, and sieving with a sieve of 70-100 meshes to obtain a material b;
mixing the material a, the material b, the slow release auxiliary agent and the filler to prepare the slow release medicament.
In some embodiments of the present invention, the ratio of the water extract of the material a to the water extract of the material b is 1: (10-15), and the water content after drying is less than or equal to 5%.
In some embodiments of the invention, the type of the macroporous adsorption resin is S-8, the flow rate is 2-2.5 BV/h, and hydrochloric acid solution can be used for elution after the macroporous adsorption resin is adsorbed.
In some embodiments of the present invention, the sustained release agent includes sustained release tablets, sustained release capsules and sustained release granules, which are convenient for different people to eat.
In addition, the raw materials of the invention can be used as tea bags only after being cleaned, dried, crushed and bagged, and the tea bags can be used as daily drinking tea for patients with hypertension, hyperlipidemia and hyperglycemia, and are beneficial to preventing and treating hypertension, hyperlipidemia and hyperglycemia.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 320g of inonotus obliquus, 300g of cordyceps militaris, 200g of pine nut, 220g of lithospermum, 180g of sea-buckthorn, 120g of six-axis seed, 150g of kudzuvine root, 130g of elecampane, 150g of medlar, 120g of rhizoma polygonati, 50g of hawthorn and 60g of Chinese yam; slow release auxiliary agent: 60g of chitosan, 30g of dimethylformamide, 50g of spirulina, 30g of soybean lecithin, 70g of polylactic glycolic acid solution and 120g of ethanol gel solution; filling: 40g of starch and 60g of dextrin.
The preparation method comprises the following steps: heating chitosan and dimethylformamide to 120 ℃ in nitrogen atmosphere, preserving heat for 5 hours, cooling to room temperature, filtering, vacuum drying, adding spirulina and soybean lecithin, stirring at the rotating speed of 1200r/min for 20 minutes, adding a polylactic glycolic acid solution and an ethanol gel solution, continuously stirring for 2 hours, then centrifugally collecting at the rotating speed of 12000r/min, washing with water, and freeze-drying to obtain a slow-release auxiliary agent; crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, adding water with the mass being 12 times that of the particles, boiling the particles with big fire to turn the particles to small fire, decocting the particles for 2 hours, collecting an extracting solution, adding water with the mass being 13 times that of the particles into filter residues, continuously extracting the water, collecting and combining the extracting solutions of the two times, adsorbing and purifying the extracting solutions by S-8 type macroporous adsorption resin, enabling the flow rate of the extracting solutions in the macroporous adsorption resin to be 2BV/h, concentrating and drying the purified extracts, reducing the water content to be below 5%, granulating the obtained product, and sieving the obtained product by a 30-mesh sieve to obtain a material a; crushing elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam into granules, mixing, adding 13 times of water by mass, extracting for 4 times, combining extracting solutions, concentrating, drying and granulating, and sieving with a 80-mesh sieve to obtain a material b, wherein the water content in the material b is lower than 5%; and mixing the material a, the material b, the slow release auxiliary agent and the filler, and pressing into tablets to prepare the slow release tablets.
Example 2
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 320g of inonotus obliquus, 350g of cordyceps militaris, 250g of pine nut, 250g of lithospermum, 150g of sea-buckthorn, 100g of six-axis seed, 120g of kudzuvine root, 120g of elecampane, 120g of medlar, 100g of rhizoma polygonati, 50g of hawthorn and 50g of Chinese yam; slow release auxiliary agent: 80g of chitosan, 50g of dimethylformamide, 30g of spirulina, 60g of soybean lecithin, 100g of polylactic glycolic acid solution and 60g of ethanol gel solution; filling: 20g of starch and 30g of dextrin.
The preparation method comprises the following steps: heating chitosan and dimethylformamide to 130 ℃ in nitrogen atmosphere, preserving heat for 6 hours, cooling to room temperature, filtering, vacuum drying, adding spirulina and soybean lecithin, stirring at the rotating speed of 1300r/min for 15 minutes, adding a polylactic glycolic acid solution and an ethanol gel solution, continuously stirring for 2 hours, then centrifugally collecting at the rotating speed of 12000r/min, washing with water, and freeze-drying to obtain a slow-release auxiliary agent; crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, adding 15 times of water by mass, boiling with strong fire to turn to small fire, decocting for 2 hours, collecting an extracting solution, adding 12 times of water by mass into filter residues, continuously extracting water, collecting and combining the extracting solution obtained in two times, adsorbing and purifying the extracting solution by using S-8 type macroporous adsorption resin, enabling the flow rate of the extracting solution in the macroporous adsorption resin to be 2BV/h, concentrating and drying the purified extract, reducing the water content to be below 5%, granulating again, and sieving by using a 50-mesh sieve to obtain a material a; crushing elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam into granules, mixing, adding 10 times of water by mass, carrying out water extraction for 4 times, combining extract, concentrating, drying and granulating, and sieving with a 100-mesh sieve to obtain a material b, wherein the water content in the material b is also lower than 5%; mixing the material a, the material b, the sustained-release auxiliary agent and the filler, coating, and filling into hollow medicinal capsules to prepare the sustained-release capsules.
Example 3
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 350g of inonotus obliquus, 250g of cordyceps militaris, 200g of pine nut, 200g of lithospermum, 200g of sea-buckthorn, 150g of six-axis seed, 200g of kudzuvine root, 150g of elecampane, 150g of medlar, 150g of rhizoma polygonati, 80g of hawthorn and 80g of Chinese yam; slow release auxiliary agent: 50g of chitosan, 20g of dimethylformamide, 20g of spirulina, 30g of soybean lecithin, 50g of polylactic glycolic acid solution and 120g of ethanol gel solution; filling: 30g of sorbitol and 120g of microcrystalline cellulose.
The preparation method comprises the following steps: heating chitosan and dimethylformamide to 125 ℃ in nitrogen atmosphere, preserving heat for 5 hours, cooling to room temperature, filtering, vacuum drying, adding spirulina and soybean lecithin, stirring for 20 minutes at the rotating speed of 1250r/min, adding a polylactic glycolic acid solution and an ethanol gel solution, continuously stirring for 2 hours, then centrifugally collecting at the rotating speed of 10000r/min, washing with water, and freeze-drying to obtain a slow-release auxiliary agent; crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, adding 13 times of water by mass, boiling with big fire to turn to small fire, decocting for 3 hours, collecting an extracting solution, repeating the same steps for 3 times, collecting and combining the extracting solution for three times, adsorbing and purifying the extracting solution by using S-8 type macroporous adsorption resin, wherein the flow rate of the extracting solution in the macroporous adsorption resin is 2BV/h, concentrating and drying the purified extract, reducing the water content to below 5%, granulating, and sieving by using a 40-mesh sieve to obtain a material a; crushing elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam into granules, mixing, adding 10 times of water by mass, carrying out water extraction for 4 times, combining extract, concentrating, drying and granulating, and sieving with a 80-mesh sieve to obtain a material b, wherein the water content in the material b is also lower than 5%; mixing the material a, the material b, the slow release auxiliary agent and the filler, and preparing into slow release pills by a granulator.
Example 4
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 400g of inonotus obliquus, 200g of cordyceps militaris, 250g of pine cone, 250g of lithospermum, 150g of sea-buckthorn, 100g of six-axis seed, 250g of kudzuvine root, 100g of elecampane, 150g of medlar, 80g of rhizoma polygonati, 50g of hawthorn and 50g of Chinese yam; slow release auxiliary agent: 80g of chitosan, 50g of dimethylformamide, 20g of spirulina, 40g of soybean lecithin, 100g of polylactic glycolic acid solution and 80g of ethanol gel solution; filling: 30g of starch, 40g of dextrin, 30g of sorbitol and 100g of microcrystalline cellulose.
The preparation method comprises the following steps: heating chitosan and dimethylformamide to 120 ℃ in nitrogen atmosphere, preserving heat for 6 hours, cooling to room temperature, filtering, vacuum drying, adding spirulina and soybean lecithin, stirring for 30 minutes at the rotating speed of 1250r/min, adding a polylactic glycolic acid solution and an ethanol gel solution, continuously stirring for 3 hours, then centrifugally collecting at the rotating speed of 8000r/min, washing with water, and freeze-drying to obtain a slow-release auxiliary agent; crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, adding 10 times of water by mass, boiling with strong fire to turn to small fire, decocting for 2 hours, collecting an extracting solution, repeating the same steps for 3 times, collecting and combining the extracting solution for three times, adsorbing and purifying the extracting solution by using S-8 type macroporous adsorption resin, wherein the flow rate of the extracting solution in the macroporous adsorption resin is 2BV/h, concentrating and drying the purified extract, reducing the water content to below 5%, granulating, and sieving by using a 30-mesh sieve to obtain a material a; crushing elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam into granules, mixing, adding water with the mass being 12 times that of the granules for water extraction, performing water extraction for 3 times, combining extracting solutions for carrying out concentration, drying and granulation, and sieving the extracting solutions with a 90-mesh sieve to obtain a material b, wherein the water content in the material b is also lower than 5%; mixing the material a, the material b, the slow release auxiliary agent and the filler, and preparing into slow release pills by a granulator.
Example 5
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 200g of inonotus obliquus, 400g of cordyceps militaris, 150g of pine cone, 150g of lithospermum, 250g of sea-buckthorn, 200g of six-axis seed, 100g of kudzuvine root, 180g of elecampane, 100g of medlar, 150g of rhizoma polygonati, 100g of hawthorn and 100g of Chinese yam; slow release auxiliary agent: 70g of chitosan, 25g of dimethylformamide, 25g of spirulina, 50g of soybean lecithin, 80g of polylactic glycolic acid solution and 80g of ethanol gel solution; filling: 30g of starch, 80g of dextrin and 20g of microcrystalline cellulose.
The preparation method comprises the following steps: heating chitosan and dimethylformamide to 120 ℃ in nitrogen atmosphere, preserving heat for 6 hours, cooling to room temperature, filtering, vacuum drying, adding spirulina and soybean lecithin, stirring at the rotating speed of 1250r/min for 25 minutes, adding a polylactic glycolic acid solution and an ethanol gel solution, continuously stirring for 2.5 hours, then centrifugally collecting at the rotating speed of 9000r/min, washing with water, and freeze-drying to obtain a slow-release auxiliary agent; crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, adding 10 times of water by mass, boiling with strong fire to turn to small fire, decocting for 2 hours, collecting an extracting solution, repeating the same steps for 3 times, collecting and combining the extracting solution for three times, adsorbing and purifying the extracting solution by using S-8 type macroporous adsorption resin, wherein the flow rate of the extracting solution in the macroporous adsorption resin is 2BV/h, concentrating and drying the purified extract, reducing the water content to below 5%, granulating, and sieving by using a 40-mesh sieve to obtain a material a; crushing elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam into granules, mixing, adding 13 times of water by mass, carrying out water extraction for 3 times, combining extract, concentrating, drying and granulating, and sieving by a 90-mesh sieve to obtain a material b, wherein the water content in the material b is also lower than 5%; mixing the material a, the material b, the sustained-release auxiliary agent and the filler, coating, and filling into hollow medicinal capsules to prepare the sustained-release capsules.
Example 6
A traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia comprises the following traditional Chinese medicines: 200g of inonotus obliquus, 400g of cordyceps militaris, 150g of pine cone, 150g of lithospermum, 250g of sea-buckthorn, 200g of six-axis seed, 100g of kudzuvine root, 180g of elecampane, 100g of medlar, 150g of rhizoma polygonati, 100g of hawthorn and 100g of Chinese yam.
The preparation method comprises the following steps: crushing the raw materials into particles, adding 12 times of water by mass, boiling with strong fire, turning to small fire, decocting for 2h, pouring out the filtrate, adding 10 times of water by mass into the filter residue, boiling with strong fire, turning to small fire, decocting for 2h, and pouring out the filtrate; mixing the two filtrates, concentrating, drying, and granulating to obtain Chinese medicinal granule with water content of less than 5%.
Example 7
The difference between the embodiment and the embodiment 1 is that the processing method of elecampane inula root, medlar, rhizoma polygonati, hawthorn and Chinese yam in the embodiment is the same as that of inonotus obliquus, cordyceps militaris, pine nut, lithospermum, sea buckthorn, six-axis seed and kudzuvine root, and the size of the granules is also the same.
Experimental example 1
In examples 1 to 7, 1 drug was taken and the in vitro release rate was measured by the first basket method apparatus in the XD release rate measurement method in appendix II of the 2005 edition of Chinese pharmacopoeia. 900mL of simulated gastric juice with pH of 1.2 is used as a release medium, the simulated gastric juice is placed in a rotary basket of a dissolution apparatus with the temperature of 37 ℃ and the rotating speed of 100r/min, 5mL of simulated gastric juice is sampled at fixed time, and the release medium with the same temperature and volume is supplemented. The sample is filtered by a 0.45 mu m microporous membrane, the concentration of the Inonotus obliquus and the Inula helenium is measured by a high performance liquid chromatograph, the accumulated release amount is calculated, and the test result is shown in tables 1 and 2, wherein the table 1 is the release amount of the Inonotus obliquus, and the table 2 is the release amount of the Inula helenium.
TABLE 1
Figure BDA0003467458040000101
Figure BDA0003467458040000111
TABLE 2
Figure BDA0003467458040000112
Figure BDA0003467458040000121
As can be seen from tables 1 and 2, the medicines in examples 1 to 5 release the material b with small particles at a fast speed, and release the material a with larger particles at a slow speed, and the material b can achieve the effects of invigorating stomach and spleen, and reduce the damage of the traditional Chinese medicine to the internal organs.
Since 2012 till now, the effective rate of the sustained-release preparation of embodiments 1 to 5 of the present invention reaches more than 98% for patients with hypertension, hyperglycemia and hyperlipidemia.
In summary, the traditional Chinese medicine for regulating hypertension, hyperlipidemia and hyperglycemia and the preparation method thereof provided by the embodiments of the present invention are provided.
The raw materials of the invention adopt the inonotus obliquus, the cordyceps militaris, the pine cone, the lithospermum, the sea buckthorn, the six-axis seed, the kudzuvine root, the elecampane, the medlar, the rhizoma polygonati, the hawthorn and the Chinese yam, and the effects of warming interior and calming liver, regulating qi and strengthening body resistance, and regulating the blood pressure, blood fat and blood sugar of a human body are achieved. The traditional Chinese medicinal materials and the sustained-release auxiliary agent are combined, so that the release time of the traditional Chinese medicinal materials can be prolonged, the drug effect of a patient after taking the medicine is quickly released, and the damage to the liver is reduced. The slow release auxiliary agent is added into the traditional Chinese medicine, so that the product can be used for preventing hypertension, hyperlipidemia and hyperglycemia.
According to the invention, the elecampane inula root, the wolfberry fruit, the rhizoma polygonati, the hawthorn and the Chinese yam are extracted by water and prepared into finer materials, so that the effect of relatively quick release is exerted in the medicine, the effects of tonifying spleen and kidney, helping digestion and nourishing stomach and liver and kidney are achieved, and the damage to the liver is further reduced; the active molecules are further extracted by carrying out water extraction and macroporous resin adsorption on the inonotus obliquus, the cordyceps militaris, the pine cone, the lithospermum, the sea buckthorn, the six-axle seed and the kudzuvine root, and the active molecules are prepared into a material with larger relative granularity, so that the effect of slow release is achieved.
In conclusion, the preparation method of the invention can slowly and hierarchically release the medicine, has good curative effect on patients with hypertension, hyperglycemia and hyperlipidemia, can reduce the load on internal organs of a human body, and can be widely used for preventing and treating hypertension, hyperlipidemia and hyperglycemia.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia is characterized by comprising the following components in parts by weight: 20-40 parts of inonotus obliquus, 20-40 parts of cordyceps militaris, 15-25 parts of pine cone, 15-25 parts of lithospermum, 15-25 parts of sea buckthorn, 10-20 parts of fructus momordicae, 10-25 parts of radix puerariae, 10-18 parts of elecampane, 10-15 parts of wolfberry fruit, 8-15 parts of rhizoma polygonati, 5-10 parts of hawthorn and 5-10 parts of Chinese yam.
2. The traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia as claimed in claim 1 is characterized by comprising the following components in parts by weight: 30-35 parts of inonotus obliquus, 25-35 parts of cordyceps militaris, 20-25 parts of pine cone, 20-25 parts of lithospermum, 15-20 parts of sea buckthorn, 10-15 parts of fructus momordicae, 12-20 parts of radix puerariae, 12-15 parts of elecampane, 12-15 parts of wolfberry fruit, 10-15 parts of rhizoma polygonati, 5-8 parts of hawthorn and 5-8 parts of Chinese yam.
3. The traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia as claimed in claim 2 is characterized by comprising the following components in parts by weight: 32 parts of inonotus obliquus, 30 parts of cordyceps militaris, 20 parts of pine cone, 22 parts of lithospermum, 18 parts of sea-buckthorn, 12 parts of six-axis seed, 15 parts of kudzu root, 13 parts of elecampane, 15 parts of wolfberry fruit, 12 parts of rhizoma polygonati, 5 parts of hawthorn and 6 parts of Chinese yam.
4. The traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia according to claim 1, which is characterized by further comprising a slow release auxiliary and a filler.
5. The traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia as claimed in claim 4, wherein the slow release auxiliary comprises 5-8 parts of chitosan, 2-5 parts of dimethylformamide, 2-5 parts of spirulina, 3-6 parts of soybean lecithin, 5-10 parts of polylactic glycolic acid solution and 6-12 parts of ethanol gel solution.
6. The traditional Chinese medicine for conditioning hypertension, hyperglycemia and hyperlipidemia as claimed in claim 4, wherein the filler comprises one or more of dextrin, starch, sorbitol and microcrystalline cellulose, and the weight part of the filler is 5-20 parts.
7. The preparation method of the traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia as claimed in any one of claims 1 to 6, which is characterized by comprising the following steps:
crushing inonotus obliquus, cordyceps militaris, pine cone, lithospermum, sea buckthorn, fructus momordicae and radix puerariae into particles, extracting with water for 2-3 times, combining extracting solutions, purifying by using macroporous adsorption resin, concentrating, drying and granulating the purified extracts, and sieving by using a 30-50-mesh sieve to obtain a material a;
extracting elecampane, wolfberry fruit, rhizoma polygonati, hawthorn and Chinese yam with water for 2-4 times, concentrating, drying and granulating, and sieving with a sieve of 70-100 meshes to obtain a material b;
mixing the material a, the material b, the slow release auxiliary agent and the filler to prepare the slow release medicament.
8. The method for preparing a traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia according to claim 7, wherein the material-to-liquid ratio in the water extraction step of the material a and the material b is 1: (10-15), and the water content after drying is less than or equal to 5%.
9. The preparation method of the traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia according to claim 7, wherein the type of the macroporous adsorption resin is S-8, the flow rate is 2-2.5 BV/h, and hydrochloric acid solution is adopted for elution after the macroporous adsorption resin is adsorbed.
10. The method for preparing a traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia according to claim 7, wherein the sustained-release agent comprises sustained-release tablets, sustained-release capsules and sustained-release granules.
CN202210034121.2A 2022-01-12 2022-01-12 Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof Pending CN114224977A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210034121.2A CN114224977A (en) 2022-01-12 2022-01-12 Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210034121.2A CN114224977A (en) 2022-01-12 2022-01-12 Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof

Publications (1)

Publication Number Publication Date
CN114224977A true CN114224977A (en) 2022-03-25

Family

ID=80746325

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210034121.2A Pending CN114224977A (en) 2022-01-12 2022-01-12 Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof

Country Status (1)

Country Link
CN (1) CN114224977A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101274078A (en) * 2007-03-30 2008-10-01 南京万舜源生物科技有限公司 Natural plant extract and preparing method and application of the same
CN102172385A (en) * 2011-01-12 2011-09-07 涂传荣 Chinese medicinal preparation with effects of enhancing immunity, lowering blood sugar and lowering blood fat
CN105852127A (en) * 2016-05-05 2016-08-17 张艳艳 Hypoglycemic hypolipidemic health-care product and production method
CN107136357A (en) * 2017-06-01 2017-09-08 吴天明 A kind of CHAGA health beverages and preparation method
CN107637722A (en) * 2017-10-25 2018-01-30 明光市兴渔克氏原螯虾良种繁育中心 Feed that a kind of Procambius clarkii nurturing period is digested with promotion and preparation method thereof
CN111543526A (en) * 2020-05-06 2020-08-18 通化大医菌方健康科技有限公司 Inonotus obliquus and cordyceps sinensis health-care tea capable of tonifying liver, tonifying kidney and dispelling wind

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101274078A (en) * 2007-03-30 2008-10-01 南京万舜源生物科技有限公司 Natural plant extract and preparing method and application of the same
CN102172385A (en) * 2011-01-12 2011-09-07 涂传荣 Chinese medicinal preparation with effects of enhancing immunity, lowering blood sugar and lowering blood fat
CN105852127A (en) * 2016-05-05 2016-08-17 张艳艳 Hypoglycemic hypolipidemic health-care product and production method
CN107136357A (en) * 2017-06-01 2017-09-08 吴天明 A kind of CHAGA health beverages and preparation method
CN107637722A (en) * 2017-10-25 2018-01-30 明光市兴渔克氏原螯虾良种繁育中心 Feed that a kind of Procambius clarkii nurturing period is digested with promotion and preparation method thereof
CN111543526A (en) * 2020-05-06 2020-08-18 通化大医菌方健康科技有限公司 Inonotus obliquus and cordyceps sinensis health-care tea capable of tonifying liver, tonifying kidney and dispelling wind

Similar Documents

Publication Publication Date Title
CN101822697B (en) Preparation method of traditional Chinese medicine ultrafine formula particles
CN102423352B (en) Preparation method of Chinese medicinal granules for treating cardio-cerebrovascular diseases
CN103520577A (en) Medicine-and-food dual-purpose preparation for treating pneumoconiosis, clearing away lung-heat and nourishing heart and preparation method for medicine-and-food dual-purpose preparation
CN105707874A (en) Horseradish tree leaf tablets and preparation method thereof
CN101007071A (en) Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology
CN100469377C (en) Nankang soft capsule for treating prostatitis
CN114028514A (en) Wolfberry fruit medicinal and edible dual-purpose composition with memory improving effect and preparation method and application thereof
CN111870627A (en) Sobering-up preparation and its preparing method and use
CN115531463B (en) Traditional Chinese medicine for treating hyperlipidemia
CN104225206A (en) Sugar-free Changchun longevity granules and preparation method thereof
CN114224977A (en) Traditional Chinese medicine for regulating hypertension, hyperglycemia and hyperlipidemia and preparation method thereof
CN101190250B (en) Chewable tablets for preventing and controlling high-altitude disease and preparation method thereof
CN110881555A (en) Dispersible candy tablet with dual-effect of lowering blood pressure
CN106309809B (en) Qingxin Shenan granule and preparation method thereof
CN115137770A (en) Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure
CN100420471C (en) Oral taking preparation of Chinese traditional medicine for nourishing the kidney and the lung
CN108578578B (en) Pharmaceutical composition with blood fat reducing effect and preparation method thereof
CN112914010A (en) Phlegm-dampness constitution health-care solid beverage and preparation method thereof
CN107997170B (en) Composition with blood fat reducing function and preparation method thereof
CN113018404A (en) Blood stasis constitution health-care solid beverage and preparation method thereof
CN116262126B (en) Antioxidant traditional Chinese medicine granule and preparation method thereof
CN109078115A (en) A kind of Chinese materia medica preparation and preparation method thereof for hemorrhage of digestive tract
CN103494916A (en) Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof
CN113318085B (en) Fructus amomi tablet for improving vomiting of pregnancy reaction and preparation method thereof
CN106994142A (en) A kind of loquat extract and its hypoglycemic loquat black tea extract buccal tablet of preparation

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20220325