CN114222755B - Glp-1和gip受体双重激动剂化合物及其应用 - Google Patents

Glp-1和gip受体双重激动剂化合物及其应用 Download PDF

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Publication number
CN114222755B
CN114222755B CN202180004912.4A CN202180004912A CN114222755B CN 114222755 B CN114222755 B CN 114222755B CN 202180004912 A CN202180004912 A CN 202180004912A CN 114222755 B CN114222755 B CN 114222755B
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amino acid
glp
acid residues
ala
ile
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Chinese (zh)
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CN114222755A (zh
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吴方舟
王雷
黄旭超
吴然
刘仁志
花海清
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Beijing Tuojie Biomedical Technology Co ltd
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Beijing Tuojie Biomedical Technology Co ltd
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Priority to CN202410666887.1A priority patent/CN118754965A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180004912.4A 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用 Active CN114222755B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202410663771.2A CN118530333A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用
CN202410666887.1A CN118754965A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2020104725778 2020-05-29
CN202010472577 2020-05-29
CN202110335100 2021-03-29
CN202110335100X 2021-03-29
PCT/CN2021/096568 WO2021239082A1 (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

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CN202410663771.2A Division CN118530333A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用
CN202410666887.1A Division CN118754965A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

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CN114222755A CN114222755A (zh) 2022-03-22
CN114222755B true CN114222755B (zh) 2024-06-11

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CN202180004912.4A Active CN114222755B (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用
CN202410666887.1A Pending CN118754965A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用
CN202410663771.2A Pending CN118530333A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

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CN202410666887.1A Pending CN118754965A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用
CN202410663771.2A Pending CN118530333A (zh) 2020-05-29 2021-05-28 Glp-1和gip受体双重激动剂化合物及其应用

Country Status (11)

Country Link
US (1) US20230190879A1 (https=)
EP (1) EP4159750A4 (https=)
JP (1) JP2023526973A (https=)
KR (1) KR20230018395A (https=)
CN (3) CN114222755B (https=)
AU (1) AU2021278157A1 (https=)
BR (1) BR112022023834A2 (https=)
CA (1) CA3180215A1 (https=)
MX (1) MX2022014368A (https=)
TW (1) TWI910174B (https=)
WO (1) WO2021239082A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
US20250115654A1 (en) * 2021-11-12 2025-04-10 Fujian Shengdi Pharmaceutical Co., Ltd. Pharmaceutical composition of glp-1 receptor and gip receptor dual agonist, and use thereof
WO2023207106A1 (zh) * 2022-04-29 2023-11-02 苏州星洲生物科技有限公司 Glp-1/gip受体共激动剂、包含其的药物组合物及其用途
EP4556487A1 (en) * 2022-07-13 2025-05-21 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Glp-1/gip dual agonist, and preparation method therefor and use thereof
CN115806593B (zh) * 2022-09-23 2023-09-05 成都普康生物科技有限公司 一种脂肪酸链修饰的双受体激动剂及其用途
CN116120425A (zh) * 2022-12-27 2023-05-16 南京赛诺生物技术有限公司 一种glp-1/gip受体双重激动剂及其应用
CN118056839B (zh) * 2023-01-17 2024-11-29 广东众生睿创生物科技有限公司 带有修饰结构的多肽及其应用
CN118684758A (zh) * 2023-03-23 2024-09-24 上海民为生物技术有限公司 肠促胰岛素类似物及其应用
CN116496361B (zh) * 2023-06-25 2023-09-15 北京科翔中升医药科技有限公司 氘代模拟肽gip和glp-1双受体激动剂药物及用途
TW202529797A (zh) * 2023-12-12 2025-08-01 大陸商江蘇恆瑞醫藥股份有限公司 Ｇｌｐ－１類似物治療代謝疾病的方法及醫藥用途
WO2025242218A1 (zh) * 2024-05-24 2025-11-27 上海翰森生物医药科技有限公司 一种多肽激动剂，其制备方法及医药用途
CN120081924A (zh) * 2024-07-11 2025-06-03 中国药科大学 Glp-1r受体激动多肽化合物及其用途
CN119390784A (zh) * 2024-07-11 2025-02-07 中国药科大学 一种双激动多肽化合物及其医药用途

Citations (2)

* Cited by examiner, † Cited by third party
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CN103764673A (zh) * 2011-06-10 2014-04-30 北京韩美药品有限公司 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用
CN107108715A (zh) * 2014-10-24 2017-08-29 默沙东公司 胰高血糖素和glp‑1受体的共激动剂

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JP6006118B2 (ja) * 2009-12-16 2016-10-12 ノヴォ ノルディスク アー／エス Ｇｌｐ−１アナログ及び誘導体
CN104583232B (zh) * 2012-06-21 2018-04-13 印第安纳大学研究及科技有限公司 展现gip受体活性的胰高血糖素类似物
AU2013366692B2 (en) * 2012-12-21 2017-11-23 Sanofi Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
CN108271356A (zh) * 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
WO2016131893A1 (en) * 2015-02-18 2016-08-25 Medimmune Limited Incretin fusion polypeptides
US10946074B2 (en) * 2016-03-03 2021-03-16 Novo Nordisk A/S GLP-1 derivatives and uses thereof
CN112351994B (zh) * 2019-04-11 2024-06-07 江苏豪森药业集团有限公司 一种多受体激动剂及其医药用途
CN111825758B (zh) * 2019-04-19 2024-11-22 上海翰森生物医药科技有限公司 Glp-1和gip共激动剂化合物

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CN103764673A (zh) * 2011-06-10 2014-04-30 北京韩美药品有限公司 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用
CN107108715A (zh) * 2014-10-24 2017-08-29 默沙东公司 胰高血糖素和glp‑1受体的共激动剂

Non-Patent Citations (1)

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Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide;Jesper Lau等;J. Med. Chem.;第58卷;7370-7380 *

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Publication number Publication date
CN118530333A (zh) 2024-08-23
MX2022014368A (es) 2022-12-15
EP4159750A1 (en) 2023-04-05
JP2023526973A (ja) 2023-06-26
TW202144393A (zh) 2021-12-01
AU2021278157A1 (en) 2022-11-24
WO2021239082A1 (zh) 2021-12-02
US20230190879A1 (en) 2023-06-22
CN118754965A (zh) 2024-10-11
CN114222755A (zh) 2022-03-22
BR112022023834A2 (pt) 2022-12-27
CA3180215A1 (en) 2021-12-02
TWI910174B (zh) 2026-01-01
EP4159750A4 (en) 2023-10-18
KR20230018395A (ko) 2023-02-07

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