CN114206918A - 嵌合抗原受体的替代细胞内信号传导结构域 - Google Patents
嵌合抗原受体的替代细胞内信号传导结构域 Download PDFInfo
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- CN114206918A CN114206918A CN202080035754.4A CN202080035754A CN114206918A CN 114206918 A CN114206918 A CN 114206918A CN 202080035754 A CN202080035754 A CN 202080035754A CN 114206918 A CN114206918 A CN 114206918A
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K2317/55—Fab or Fab'
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2019107136A RU2742000C2 (ru) | 2019-03-13 | 2019-03-13 | Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор |
| RU2019107136 | 2019-03-13 | ||
| PCT/RU2020/000136 WO2020185121A2 (ru) | 2019-03-13 | 2020-03-13 | Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114206918A true CN114206918A (zh) | 2022-03-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080035754.4A Pending CN114206918A (zh) | 2019-03-13 | 2020-03-13 | 嵌合抗原受体的替代细胞内信号传导结构域 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12540169B2 (https=) |
| EP (1) | EP3974444A4 (https=) |
| JP (1) | JP7735186B2 (https=) |
| KR (1) | KR20220157861A (https=) |
| CN (1) | CN114206918A (https=) |
| RU (1) | RU2742000C2 (https=) |
| WO (1) | WO2020185121A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111315402A (zh) * | 2017-08-15 | 2020-06-19 | 艾达普特免疫有限公司 | T细胞修饰 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| WO2022081486A1 (en) * | 2020-10-12 | 2022-04-21 | Sorrento Therapeutics, Inc. | Cd19-directed chimeric antigen receptor constructs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170107286A1 (en) * | 2014-06-02 | 2017-04-20 | The United States Of America, As Represented By The Secretary | Chimeric antigen receptors targeting cd-19 |
| WO2018132506A1 (en) * | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
| CN109069597A (zh) * | 2015-12-22 | 2018-12-21 | 诺华股份有限公司 | 间皮素嵌合抗原受体(car)和抗pd-l1抗体抑制剂联用于抗癌治疗 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| WO2014153114A1 (en) * | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| PL3546572T3 (pl) * | 2013-05-13 | 2024-07-22 | Cellectis | Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania |
| WO2015069922A2 (en) * | 2013-11-06 | 2015-05-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alk antibodies, conjugates, and chimeric antigen receptors, and their use |
-
2019
- 2019-03-13 RU RU2019107136A patent/RU2742000C2/ru active
-
2020
- 2020-03-13 KR KR1020217032967A patent/KR20220157861A/ko not_active Ceased
- 2020-03-13 US US17/438,398 patent/US12540169B2/en active Active
- 2020-03-13 EP EP20770459.4A patent/EP3974444A4/en active Pending
- 2020-03-13 CN CN202080035754.4A patent/CN114206918A/zh active Pending
- 2020-03-13 WO PCT/RU2020/000136 patent/WO2020185121A2/ru not_active Ceased
- 2020-03-13 JP JP2021555415A patent/JP7735186B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170107286A1 (en) * | 2014-06-02 | 2017-04-20 | The United States Of America, As Represented By The Secretary | Chimeric antigen receptors targeting cd-19 |
| CN109069597A (zh) * | 2015-12-22 | 2018-12-21 | 诺华股份有限公司 | 间皮素嵌合抗原受体(car)和抗pd-l1抗体抑制剂联用于抗癌治疗 |
| WO2018132506A1 (en) * | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
Non-Patent Citations (3)
| Title |
|---|
| DARREN G WOODSIDE ET AL.: "The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains", J BIOL CHEM, vol. 277, no. 42, 8 August 2002 (2002-08-08), pages 39401 - 39408, XP002505110, DOI: 10.1074/JBC.M207657200 * |
| HARRY: "CAR-T细胞疗法中CAR设计的新思路_医谷网", pages 1 - 8, Retrieved from the Internet <URL:https://m.medvalley.cn/article/223-0-54264> * |
| 周静;高丽枫;: "嵌合体抗原受体修饰T细胞的肿瘤免疫治疗", 赤峰学院学报(自然科学版), no. 02, 25 January 2017 (2017-01-25), pages 128 - 132 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111315402A (zh) * | 2017-08-15 | 2020-06-19 | 艾达普特免疫有限公司 | T细胞修饰 |
| CN111315402B (zh) * | 2017-08-15 | 2024-05-07 | 艾达普特免疫有限公司 | T细胞修饰 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7735186B2 (ja) | 2025-09-08 |
| WO2020185121A3 (ru) | 2020-11-05 |
| WO2020185121A2 (ru) | 2020-09-17 |
| EP3974444A2 (en) | 2022-03-30 |
| KR20220157861A (ko) | 2022-11-29 |
| RU2019107136A (ru) | 2020-09-14 |
| JP2022526720A (ja) | 2022-05-26 |
| US20220127329A1 (en) | 2022-04-28 |
| EP3974444A4 (en) | 2023-04-19 |
| RU2019107136A3 (https=) | 2020-09-14 |
| US12540169B2 (en) | 2026-02-03 |
| RU2742000C2 (ru) | 2021-02-01 |
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