RU2742000C2 - Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор - Google Patents

Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор Download PDF

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RU2742000C2
RU2742000C2 RU2019107136A RU2019107136A RU2742000C2 RU 2742000 C2 RU2742000 C2 RU 2742000C2 RU 2019107136 A RU2019107136 A RU 2019107136A RU 2019107136 A RU2019107136 A RU 2019107136A RU 2742000 C2 RU2742000 C2 RU 2742000C2
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Павел Михайлович Гершович
Александр Владимирович Карабельский
Андрей Борисович Улитин
Дмитрий Александрович Мадера
Роман Алексеевич Иванов
Дмитрий Валентинович Морозов
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Общество С Ограниченной Ответственностью "Анабион"
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Priority to RU2019107136A priority Critical patent/RU2742000C2/ru
Priority to JP2021555415A priority patent/JP7735186B2/ja
Priority to EP20770459.4A priority patent/EP3974444A4/en
Priority to PCT/RU2020/000136 priority patent/WO2020185121A2/ru
Priority to CN202080035754.4A priority patent/CN114206918A/zh
Priority to US17/438,398 priority patent/US12540169B2/en
Priority to KR1020217032967A priority patent/KR20220157861A/ko
Publication of RU2019107136A publication Critical patent/RU2019107136A/ru
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RU2019107136A 2019-03-13 2019-03-13 Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор RU2742000C2 (ru)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU2019107136A RU2742000C2 (ru) 2019-03-13 2019-03-13 Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор
JP2021555415A JP7735186B2 (ja) 2019-03-13 2020-03-13 キメラ抗原受容体の代替の細胞内シグナル伝達ドメイン
EP20770459.4A EP3974444A4 (en) 2019-03-13 2020-03-13 ALTERNATIVE INTRACELLULAR SIGNALING DOMAIN OF A CHIMERIC ANTIGEN RECEPTOR
PCT/RU2020/000136 WO2020185121A2 (ru) 2019-03-13 2020-03-13 Выделенный альтернативный внутриклеточный сигнальный домен химерного антигенного рецептора и включающий его химерный антигенный рецептор
CN202080035754.4A CN114206918A (zh) 2019-03-13 2020-03-13 嵌合抗原受体的替代细胞内信号传导结构域
US17/438,398 US12540169B2 (en) 2019-03-13 2020-03-13 Alternative intracellular signalling domain of a chimeric antigen receptor
KR1020217032967A KR20220157861A (ko) 2019-03-13 2020-03-13 키메라 항원 수용체의 얼터너티브 세포내 신호전달 도메인

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US (1) US12540169B2 (https=)
EP (1) EP3974444A4 (https=)
JP (1) JP7735186B2 (https=)
KR (1) KR20220157861A (https=)
CN (1) CN114206918A (https=)
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WO (1) WO2020185121A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201713078D0 (en) * 2017-08-15 2017-09-27 Adaptimmune Ltd T Cell Modification
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2022081486A1 (en) * 2020-10-12 2022-04-21 Sorrento Therapeutics, Inc. Cd19-directed chimeric antigen receptor constructs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015187528A1 (en) * 2014-06-02 2015-12-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting cd-19
RU2015153250A (ru) * 2013-05-13 2017-06-19 Селлектис Cd19-специфический химерный антигенный рецептор и его применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
CA2386270A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
WO2014153114A1 (en) * 2013-03-14 2014-09-25 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
WO2015069922A2 (en) * 2013-11-06 2015-05-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Alk antibodies, conjugates, and chimeric antigen receptors, and their use
EP3393504B1 (en) * 2015-12-22 2025-09-24 Novartis AG Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy
WO2018132506A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Chimeric antigen receptors based on alternative signal 1 domains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015153250A (ru) * 2013-05-13 2017-06-19 Селлектис Cd19-специфический химерный антигенный рецептор и его применения
WO2015187528A1 (en) * 2014-06-02 2015-12-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting cd-19

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
BURNS W. R. et al., A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas, Cancer research, 2010, V. 70, N. 8, p.3027-3033. *
CHEN X. et al., Fusion protein linkers: property, design and functionality, Advanced drug delivery reviews, 2013, V. 65, N. 10, p.1357-1369. *
CHEN Y. P. et al., Ser-752--> Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia, Proceedings of the National Academy of Sciences, 1992, V. 89, N. 21, p.10169-10173. *
DOLEZAL O. et al., ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in VL to VH orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers, Protein engineering, 2000, V. 13, N. 8, p.565-574. *
FRANKEL A.E. et al., Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor, Protein engineering, 2000, V. 13, N. 8, p.575-581. *
FRANKEL A.E. et al., Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor, Protein engineering, 2000, V. 13, N. 8, p.575-581. PAKULA A.A. et al., Genetic analysis of protein stability and function, Annual review of genetics, 1989, V. 23, N. 1, p.289-310. RIEUX-LAUCAT F. et al., Inherited and somatic CD3 ζ mutations in a patient with T-cell deficiency, New England Journal of Medicine, 2006, V. 354, N. 18, p.1913-1921. MAUS M. V. et al., T cells expressing chimeric antigen receptors can cause anaphylaxis in humans, Cancer immunology research, 2013, V. 1, N. 1, p.26-31. TURTLE C. J. et al., CD19 CAR-T cells of defined CD4+: CD8+ composition in adult B cell ALL patients, The Journal of clinical investigation, 2016, V. 126, N. 6, p.2123-2138. BURNS W. R. et al., A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas, Cancer research, 2010, V. 70, N. 8, p.3027-3033. RICHMAN *
GUEDAN S. et al., Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation, JCI insight, 2018, V. 3, N. 1, e96976. GUHA P. et al., Frontline Science: Functionally impaired geriatric CAR‐T cells rescued by increased α5β1 integrin expression, Journal of leukocyte biology, 2017, V. 102, N. 2, p.201-208. *
HEGE K. M. et al., Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer, Journal for immunotherapy of cancer, 2017, V. 5, N. 1, p.1-14. *
HUDECEK M. et al., The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity, Cancer immunology research, 2015, V. 3, N. 2, p.125-135. *
KUMAR C. S. et al., Cloning and Characterization of a Novel Integrin β3Subunit, Journal of Biological Chemistry, 1997, V. 272, N. 26, p.16390-16397. *
LONG A. H. et al., 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors, Nature Medicine, 2015, V. 21, N. 6, p.581-590. *
MAEDA Y. et al., Engineering of functional chimeric protein G-VargulaLuciferase, Analytical biochemistry, 1997, V. 249, N. 2, p.147-152. *
MAUS M. V. et al., T cells expressing chimeric antigen receptors can cause anaphylaxis in humans, Cancer immunology research, 2013, V. 1, N. 1, p.26-31. *
MIYASHITA N. et al., A novel heterozygous ITGB3 p. T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction, Annals of hematology, 2018, V. 97, N. 4, p.629-640. *
PAKULA A.A. et al., Genetic analysis of protein stability and function, Annual review of genetics, 1989, V. 23, N. 1, p.289-310. *
RICHMAN S. A. et al., High-affinity GD2-specific CAR T cells induce fatal encephalitis in a preclinical neuroblastoma model, Cancer immunology research, 2018, V. 6, N. 1, p.36-46. *
RIEUX-LAUCAT F. et al., Inherited and somatic CD3 ζ mutations in a patient with T-cell deficiency, New England Journal of Medicine, 2006, V. 354, N. 18, p.1913-1921. *
SRIVASTAVA S. et al., Engineering CAR-T cells: design concepts, Trends in immunology, 2015, V. 36, N. 8, p.494-502. *
TEPLYAKOV A. et al., Antibody modeling assessment II. Structures and models, Proteins: Structure, Function, and Bioinformatics, 2014, V. 82, N. 8, p.1563-1582. *
TURTLE C. J. et al., CD19 CAR-T cells of defined CD4+: CD8+ composition in adult B cell ALL patients, The Journal of clinical investigation, 2016, V. 126, N. 6, p.2123-2138. *
VAN KUPPEVELT T. H. et al., An alternative cytoplasmic domain of the integrin beta 3 subunit, Proceedings of the National Academy of Sciences, 1989, V. 86, N. 14, p.5415-5418. *
VAN KUPPEVELT T. H. et al., An alternative cytoplasmic domain of the integrin beta 3 subunit, Proceedings of the National Academy of Sciences, 1989, V. 86, N. 14, p.5415-5418. KUMAR C. S. et al., Cloning and Characterization of a Novel Integrin β3Subunit, Journal of Biological Chemistry, 1997, V. 272, N. 26, p.16390-16397. CHEN Y. P. et al., Ser-752--> Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia, Proceedings of the National Academy of Sciences, 1992, V. 89, N. 21, p.10169-10173. MIYASHITA N. et al., A novel heterozygous ITGB3 p. T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction, Annals of hematology, 2018, V. 97, N. 4, p.629-640. *

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