CN114177241A

CN114177241A - Production process of hawthorn extract for tonifying spleen and stomach

Info

Publication number: CN114177241A
Application number: CN202111680981.5A
Authority: CN
Inventors: 郑军峰
Original assignee: XI'AN RENREN PHARMACEUTICAL CO Ltd
Current assignee: XI'AN RENREN PHARMACEUTICAL CO Ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2022-03-15

Abstract

The application relates to the field of preparation methods of traditional Chinese medicine preparations, in particular to a production process of a hawthorn extract for tonifying spleen and stomach. The process comprises the following steps: decocting fructus crataegi with water for at least two times to obtain extractive solution, and sieving with 100-150 mesh sieve; concentrating the extracting solution to obtain a hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 90-95 ℃, and the concentration of the hawthorn concentrated solution is 1.1g/cm³‑1.3g/cm³Tremella, rhizoma Dioscoreae and PoriaRespectively crushing and drying, adding salt and mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder by a sieve of 80 meshes to 100 meshes; and adding the mixed medicinal powder, sucrose powder, citric acid and lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract. The effectiveness of active substances in the hawthorn can be effectively ensured, the mixed medicinal powder is suspended in the hawthorn concentrated solution, the medicinal effect is improved, and the agglomeration amount is reduced; the obtained fructus crataegi extract has effects of invigorating spleen, benefiting stomach, promoting growth, and enhancing resistance.

Description

Production process of hawthorn extract for tonifying spleen and stomach

Technical Field

The application relates to the field of preparation methods of traditional Chinese medicine preparations, in particular to a production process of a hawthorn extract for tonifying spleen and stomach.

Background

Flos Lonicerae, flos Chrysanthemi, fructus forsythiae, semen Armeniacae amarum, pericarpium Citri Tangerinae, citric acid, simple syrup and benzoic acid can be added into conventional fructus crataegi extract to make fructus crataegi extract have effects of invigorating spleen, benefiting stomach, clearing away heat and toxic materials, eliminating phlegm and relieving cough.

CN 106361860A: a liquid for clearing away heat and toxic materials for children is prepared from flos Lonicerae, flos Chrysanthemi, fructus forsythiae, fructus crataegi, semen Armeniacae amarum, pericarpium Citri Tangerinae, citric acid, simple syrup and benzoic acid by cleaning flos Lonicerae, flos Chrysanthemi, fructus forsythiae and semen Armeniacae amarum, air drying, pulverizing, sieving, distilling with water, and extracting aromatic water; extracting fructus crataegi with ethanol under heating twice, concentrating to obtain extract, and dissolving in water; pulverizing pericarpium Citri Tangerinae, percolating with ethanol; mixing the fructus crataegi extractive solution, pericarpium Citri Tangerinae percolate and aromatic water, adding citric acid, simple syrup and benzoic acid, adding water to desired volume, mixing, and filtering.

The existing process adopts ethanol extraction and concentration, so that the cost is high, and when other added traditional Chinese medicines are mixed with the hawthorn extract, the problems of uneven mixing, uneven concentration of the traditional Chinese medicines, uneven drug effect and the like caused by adhesion of active substances in the traditional Chinese medicines are solved.

Disclosure of Invention

The application provides a production process of a hawthorn extract for tonifying spleen and reinforcing stomach, which aims to solve the technical problem of low concentration of active substances in the existing hawthorn extract.

In a first aspect, the application provides a process for producing hawthorn extract for tonifying spleen and stomach, which comprises the following steps:

decocting fructus crataegi with water for at least two times to obtain extractive solution, and sieving with 100-150 mesh sieve;

concentrating the extracting solution to obtain a hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 90-95 ℃, and the concentration of the hawthorn concentrated solution is 1.1g/cm³-1.3g/cm³；

Respectively crushing and drying tremella, Chinese yam and poria cocos, adding salt and mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder with a sieve of 80-100 meshes;

and adding the mixed medicinal powder, sucrose powder, citric acid and lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract.

Optionally, the drying temperature is 75-80 ℃, and the drying time is more than or equal to 4 hours.

Optionally, the decoction temperature is 97-100 ℃, and the steam pressure of the decoction is less than 0.2 MPa.

Optionally, the vacuum degree of the concentration is-0.06 MPa-0 MPa; the temperature of the concentration is 60-95 ℃.

Optionally, the vacuum degree of the concentration is-0.06 MPa-0.08 MPa; the temperature of the concentration is 70-85 ℃.

Optionally, the pulverization is ultrafine pulverization.

Optionally, the mixed medicinal powder, sucrose powder, citric acid and lysine are added into the hawthorn concentrated solution and stirred to obtain hawthorn extract, which specifically comprises the following steps:

adding the mixed medicinal powder, sucrose powder, citric acid and lysine into the hawthorn concentrated solution, and stirring to obtain mixed slurry;

and cooling the mixed slurry to 40-50 ℃, kneading into a dough, and cooling to room temperature by a conveyor to obtain the hawthorn extract, wherein the water content in the hawthorn extract is 10-25%.

Optionally, the stirring speed is 1000-.

In a second aspect, the present application provides a method for preparing a Chinese medicinal granule, the method comprising the steps of:

And putting the hawthorn extract into a granulator to obtain traditional Chinese medicine granules, wherein the particle size of the traditional Chinese medicine granules is 10-60 meshes.

Optionally, the premixing time of the granulator is 10-15 minutes; in the granulator, the frequency of a fan is 20-30Hz, and the air inlet temperature is 60-70 ℃.

Compared with the prior art, the technical scheme provided by the embodiment of the application has the following advantages:

according to the method provided by the embodiment of the application, the hawthorn is decocted by adding water for at least two times to obtain the extracting solution, the hawthorn concentrated solution is obtained, the temperature of the hawthorn concentrated solution is controlled to be 90-95 ℃, the effectiveness of active substances in the hawthorn can be effectively ensured, and the concentration of the hawthorn concentrated solution is 1.1g/cm³-1.3g/cm³The mixed powder can be suspended in the hawthorn concentrated solution, so that active substances in the hawthorn concentrated solution are dissolved out more, the drug effect is improved, and the agglomeration amount is reduced; the obtained fructus crataegi extract has effects of invigorating spleen, benefiting stomach, promoting growth, and enhancing resistance.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.

In order to more clearly illustrate the embodiments or technical solutions in the prior art of the present invention, the drawings used in the description of the embodiments or prior art will be briefly described below, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.

Fig. 1 is a schematic flow chart of a production process of a hawthorn extract for invigorating spleen and benefiting stomach provided by the embodiment of the application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

In a first aspect, the present application provides a process for producing hawthorn extract with spleen and stomach invigorating functions, as shown in fig. 1, the process comprises the following steps:

s1, adding water into hawthorn, decocting the hawthorn for at least two times to obtain an extracting solution, and sieving the extracting solution with a 100-150-mesh sieve;

s2, concentrating the extracting solution to obtain a hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 90-95 ℃, and the concentration of the hawthorn concentrated solution is 1.1g/cm³-1.3g/cm³；

S3, respectively crushing and drying tremella, Chinese yam and poria cocos, adding salt and mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder through a sieve of 80-100 meshes;

and S4, adding the mixed medicinal powder, sucrose powder, citric acid and lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract.

Specifically, the process may comprise the steps of:

s1, adding 450-550 parts by weight of hawthorn into water, decocting at least two times to obtain an extracting solution, and sieving the extracting solution with a 100-150-mesh sieve;

specifically, the pure medicinal materials or decoction pieces of hawthorn can be decocted twice by adding water, the water adding amount is 5000L and 4000L in sequence, the decoction is about 3 hours each time, and the extracting solution is filtered by a 100-mesh screen.

S2, concentrating the extracting solution to obtain 375 to 425 parts of hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 90 to 95 ℃, and the concentration of the hawthorn concentrated solution is 1.1g/cm³-1.3g/cm³；

In the embodiment of the application, the concentration of the hawthorn concentrated solution has certain influence on the positions and the solubilities of the tremella, the Chinese yam and the poria cocos in the extract, and if the tremella, the Chinese yam and the poria cocos are suspended in the hawthorn extract, the dissolution of active substances in the tremella, the Chinese yam and the poria cocos can be improved, and the tremella, the Chinese yam and the poria cocos are prevented from sinking to the bottom.

S3, respectively crushing and drying 45-55 parts of tremella, 180-210 parts of Chinese yam and 180-210 parts of poria cocos, adding 6-8 parts of salt, and mixing to obtain mixed medicinal powder, wherein the mixed medicinal powder is sieved by a sieve of 80-100 meshes;

s4, adding the mixed medicinal powder, 40-60 parts of sucrose powder, 10-15 parts of citric acid and 200-250 parts of lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract.

The fructus crataegi has effects of resolving food stagnation, invigorating stomach, activating qi-flowing, and reducing blood lipid. The hawthorn has three main effects: the food has the effects of promoting digestion and invigorating stomach, and can be used for treating food stagnation and gastric distention. Secondly, promoting qi circulation and removing blood stasis, and is used for treating diarrhea and dysentery, blood stasis and amenorrhea,

rhizoma Dioscoreae has effects of invigorating lung and kidney, and saponin and mucus contained therein have effects of lubricating and moistening, benefiting lung qi, nourishing lung yin, and adjuvant treating lung deficiency, phlegm cough, and chronic cough; in addition, the yam also has the effects of replenishing essence and reinforcing kidney, and arresting seminal emission and has certain effects on treating kidney deficiency, nocturnal emission, premature ejaculation and other diseases.

Tremella fuciformis is neutral in nature, sweet in taste and quite rich in nutritional ingredients, such as protein, various amino acids, fat, minerals, glycogen and the like, and is a high-grade tonic. Has effects in stimulating appetite, invigorating spleen, improving sleep, nourishing brain, invigorating qi, clearing intestine, clearing away heat, and nourishing yin.

Poria cocos is sweet and bland in taste and neutral in nature, and has the functions of promoting diuresis, excreting dampness, benefiting spleen, harmonizing stomach, calming heart and tranquilizing mind when being used as a medicine. Modern medical research: poria can enhance immunity, and pachyman has obvious effects of resisting tumor and protecting liver.

In the application, the hawthorn is added with tremella, Chinese yam, poria cocos, hawthorn and lysine, so that the hawthorn has the effects of tonifying spleen and stomach, promoting growth and enhancing resistance. Can be used for treating anorexia, dysplasia, and weakness after illness.

In some embodiments, the temperature of the drying is 75-80 ℃, and the time of the drying is more than or equal to 4 hours.

The drying temperature is controlled to be 75-80 ℃, so that the moisture can be effectively removed, and the active components are not consumed.

In some embodiments, the temperature of the decoction is 97 ℃ to 100 ℃, and the steam pressure of the decoction is < 0.2 MPa.

The steam pressure of the decoction is controlled to be less than 0.2MPa, the decoction time can be saved, the decoction temperature is controlled to be 97-100 ℃, the decoction time can be accelerated while the active substances in the hawthorn are kept, and the active substances in the hawthorn are dissolved in the solution.

In some embodiments, the vacuum of the concentration is from-0.06 MPa to 08 MPa; the temperature of the concentration is 60-95 ℃.

In some embodiments, the vacuum of the concentration is from-0.06 MPa to 0.08 MPa; the temperature of the concentration is 70-85 ℃.

Controlling the vacuum degree of concentration to raise the boiling point of the extracting solution of the hawthorn, reducing the effective temperature difference between heating steam and the extracting solution, reducing the heat transfer quantity, reducing the evaporation rate, being beneficial to slowing down the evaporation of water, realizing the re-extraction and dissolution of active substances in the hawthorn, ensuring the vacuum degree to be-0.06 MPa-0.08 MPa, keeping the effectiveness of the active substances of the hawthorn at the temperature of 60-95 ℃, avoiding the excessive denaturation of the active substances, and controlling the vacuum degree of concentration to be-0.06 MPa-0.08 MPa; the concentration temperature is 60-95 ℃, and the quality of the hawthorn extracting solution is directly ensured.

In some embodiments, the pulverization is a micronization.

In the embodiment of the application, the astringent tastes of the components such as tremella, Chinese yam, poria cocos and the like can be reduced by carrying out superfine grinding, the dissolution rate of effective components is improved, the palatability of hawthorn is improved, and the mouthfeel is improved.

The crushing degree is controlled, and meanwhile, the salt is added after the tremella, the Chinese yam and the poria cocos are crushed, so that the tremella, the Chinese yam and the poria cocos are prevented from agglomerating at a low temperature, the tremella, the Chinese yam and the poria cocos are prevented from being mixed unevenly in the hawthorn concentrate, the powder suspension rate and the dissolution rate of effective components are improved, the loss of mixed medicinal powder is reduced, and the utilization efficiency is improved.

Generally, the drying is carried out firstly and then the crushing is carried out, so that the drying efficiency and the drying degree can be improved.

In some embodiments, the mixing powder, sucrose powder, citric acid and lysine are added to the hawthorn concentrate and stirred to obtain hawthorn extract, which specifically comprises:

The water content in the hawthorn extract is controlled to be 10-25%, so that the situation that the hawthorn extract is adhered to a conveyor to cause that the subsequent process cannot be carried out can be avoided, and the realization of batch production is ensured.

In some embodiments, the stirring speed is 1000-.

The stirring speed is controlled to be 1000-.

In some embodiments, the granulator is pre-blended for a time of 10 to 15 minutes; in the granulator, the frequency of a fan is 20-30Hz, and the air inlet temperature is 60-70 ℃.

The process of the present invention will be described in detail below with reference to examples, comparative examples and experimental data.

Example 1

The embodiment of the application provides a production process of a hawthorn extract for tonifying spleen and reinforcing stomach, which comprises the following steps:

s1, adding 460 parts of hawthorn into water, decocting at least two times by weight to obtain an extracting solution, and sieving the extracting solution with a 120-mesh sieve; the decoction temperature is 98 ℃ and 8 ℃, and the decoction steam pressure is 0.1 MPa.

S2, concentrating the extracting solution to obtain 380 parts of hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 91 ℃, and the concentration of the hawthorn concentrated solution is 1.12g/cm^3；The vacuum degree of the concentration is-0.065 MPa; the temperature of the concentration was 65 ℃.

S3, respectively crushing and drying 46 parts of tremella, 182 parts of Chinese yam and 184 parts of Chinese yam, adding 6.5 parts of salt, and mixing to obtain mixed powder, wherein the mixed powder is sieved by a 90-mesh 9-mesh sieve; the drying temperature is 76 ℃, and the drying time is 5 hours; the crushing is ultramicro crushing;

s4, adding the mixed medicinal powder, 45 parts of sucrose powder, 12 parts of citric acid and 210 parts of lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract; the stirring speed is 1050 revolutions per minute, and the rotating speed of the cutter in stirring is 2550 revolutions per minute.

A preparation method of traditional Chinese medicine granules comprises putting the hawthorn extract into a granulator to obtain traditional Chinese medicine granules, wherein the particle size of the traditional Chinese medicine granules is 10-60 meshes.

Example 2

s1, adding 540 parts of hawthorn into water, decocting for 4 times to obtain an extracting solution, and sieving the extracting solution with a 140-mesh sieve; the decoction temperature is 98.5 ℃, and the decoction steam pressure is 0.18 MPa.

S2, concentrating the extracting solution to obtain 420 parts of hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 94 ℃, and the concentration of the hawthorn concentrated solution is 1.23g/cm^3；The vacuum degree of the concentration is 0.078 MPa; the temperature of the concentration was 90 ℃.

S3, respectively crushing and drying 50 parts of tremella, 200 parts of Chinese yam and 200 parts of poria cocos, adding 7 parts of table salt, mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder through a 90-mesh sieve; the drying temperature is 78 ℃, and the drying time is 6 hours; the crushing is ultramicro crushing;

s4, adding the mixed medicinal powder, 55 parts of sucrose powder, 13.5 parts of citric acid and 245 parts of lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract; the stirring speed is 1450 revolutions per minute, and the rotating speed of the cutter in the stirring is 2800 revolutions per minute.

Example 3

s1, adding water into 500 parts of hawthorn by weight, decocting at least two times to obtain an extracting solution, and sieving the extracting solution with a 135-mesh sieve; the decoction temperature is 98 ℃, and the steam pressure of the decoction is 0.05 MPa.

S2, concentrating the extracting solution to obtain 400 parts of hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 92 ℃, and the concentration of the hawthorn concentrated solution is 1.15g/cm^3；The vacuum degree of the concentration is-0.07 MPa; the temperature of the concentration was 80 ℃.

S3, respectively crushing and drying 50 parts of tremella, 195 parts of Chinese yam and 195 parts of poria cocos, adding 7 parts of salt, mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder through a 90-mesh sieve; the drying temperature is 77 ℃, and the drying time is 5 hours; the crushing is ultramicro crushing; s4, adding the mixed medicinal powder, 50 parts of sucrose powder, 12.5 parts of citric acid and 225 parts of lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract; the stirring speed is 1250 revolutions per minute, and the rotating speed of the cutter in stirring is 2750 revolutions per minute.

Example 4

This comparative example differs from example 3 in that: the pulverization is conventional pulverization. The hawthorn extract prepared in this example had an astringent taste, which was inferior to the hawthorn extracts prepared in examples 1 to 3.

Comparative example 1

This comparative example differs from example 3 in that: in S3, salt is not added, 50 parts of tremella, 195 parts of Chinese yam and 195 parts of poria cocos are respectively crushed and dried, and are directly mixed to obtain mixed powder, and 7 parts of salt is added into the extracting solution of S2.

Comparative example 2

This comparative example differs from example 3 in that: the crushing is conventional crushing and 80-mesh sieving.

Comparative example 3

This comparative example differs from example 3 in that: the vacuum degree of the concentration is-0.2 MPa

Comparative example 4

This comparative example differs from example 3 in that: the vacuum degree of the concentration is 1 MPa.

Comparative example 5

This comparative example differs from example 3 in that: the temperature of the concentration was 105 ℃.

Comparative example 6

This comparative example differs from example 3 in that: the temperature of the concentration was 50 ℃.

Test examples

The processes and hawthorn extracts in the examples and comparative examples were compared and tested, and the results are shown in table 1.

Collecting and weighing residual materials in the crushing device and the mixed powder conveying device in each batch of examples and comparative examples, fully inspecting hawthorn extractum in each batch, wherein 200-300 parts of hawthorn extractum in each batch are detected, and the number of the lumps with the particle size of 3-6mm is detected;

30-60g of the hawthorn extract obtained in the examples and the comparative examples are taken every time, 1-2 parts of the hawthorn extract are taken every day, and 2 weeks are a treatment course after drinking in one day. The curative effect experiment:

180 sub-healthy patients with stomach are selected for treatment, the patients have irregular daily diet, have symptoms of fullness in chest and abdomen, anorexia, sallow complexion and nausea and eructation and nausea, are classified into 9 groups according to the traditional Chinese medicine syndrome differentiation diagnosis, and take the hawthorn extractum obtained in the examples 1-3 and the comparative examples 1-6 in sequence. Wherein, 120 cases of men and 60 cases of women are aged 30-45 years, and 2 weeks is a treatment course. After a course of treatment, the patients in the groups of examples 1-3 cured 40 cases, had 17 cases of significant effect, 1 case of effect and 2 cases of no effect; the results of the comparative example groups are shown in table 1, and the patients of the comparative example groups were cured by 58 cases, 1 case was significant, 35 cases were significant, and 1 case was not significant after continued to take 1 course of treatment.

The treatment effect judgment criteria adopted by the statistics are as follows:

firstly, healing: the symptoms of fullness and distention of chest and abdomen, sallow complexion, belching and nausea disappear;

secondly, effect is displayed: the chest and abdomen are full of flatulence, sallow complexion, nausea and vomiting or the main symptoms are eliminated;

③ effective: the symptoms of fullness and distention of chest and abdomen, sallow complexion, eructation and nausea basically disappear;

fourthly, invalidation: fullness and distention of chest and abdomen, sallow complexion, belching and nausea, and no change before treatment or more serious illness.

Table 1 comparative process and hawthorn extract tables in examples and comparative examples.

The statistical data show that the salt is added in the process for mixing, then the mixed medicinal powder is transported, and meanwhile, the superfine grinding is carried out, so that the utilization rate of the raw materials can be improved, the loss is reduced, and individual larger traditional Chinese medicine particles in the hawthorn extract are reduced, so that the agglomeration amount is reduced, the dissolution rate of the traditional Chinese medicine is improved, the astringent taste is reduced, and the quality of the hawthorn extract is improved.

It is noted that, in this document, relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The foregoing are merely exemplary embodiments of the present invention, which enable those skilled in the art to understand or practice the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A production process of hawthorn extract for tonifying spleen and reinforcing stomach is characterized by comprising the following steps:

2. The process as claimed in claim 1, wherein the drying temperature is 75-80 ℃ and the drying time is not less than 4 hours.

3. The process according to claim 1, wherein the temperature of the decoction is 97 ℃ to 100 ℃ and the steam pressure of the decoction is < 0.2 MPa.

4. The process of claim 1, wherein the vacuum of the concentration is-0.06 MPa-0 MPa; the temperature of the concentration is 60-95 ℃.

5. The process of claim 1, wherein the vacuum of the concentration is-0.06 MPa-0.08 MPa; the temperature of the concentration is 70-85 ℃.

6. The process of claim 1, wherein the comminution is micronization.

7. The process of claim 1, wherein the mixing powder, sucrose powder, citric acid and lysine are added to the hawthorn concentrate and stirred to obtain hawthorn extract, and the process specifically comprises the following steps:

8. The process as claimed in claim 1, wherein the stirring speed is 1000-1500 rpm, and the rotating speed of the cutter during stirring is 2500-3000 rpm.

9. A preparation method of traditional Chinese medicine granules is characterized by comprising the following steps:

concentrating the extracting solution to obtain a hawthorn concentrated solution, wherein the temperature of the hawthorn concentrated solution is 90-95 ℃, and the concentration of the hawthorn concentrated solution is about 1g/cm³-1.3g/cm³；

Respectively crushing tremella, Chinese yam and poria cocos, adding salt and mixing to obtain mixed medicinal powder, and sieving the mixed medicinal powder through a sieve of 80-100 meshes;

adding the mixed medicinal powder, sucrose powder, citric acid and lysine into the hawthorn concentrated solution, and stirring to obtain hawthorn extract;

10. The method according to claim 9, wherein the granulator is pre-mixed for a time of 10-15 minutes; in the granulator, the frequency of a fan is 20-30Hz, and the air inlet temperature is 60-70 ℃.