CN114177099A - Whitening and freckle removing combination, whitening milk containing whitening and freckle removing combination and preparation method of whitening and freckle removing combination - Google Patents
Whitening and freckle removing combination, whitening milk containing whitening and freckle removing combination and preparation method of whitening and freckle removing combination Download PDFInfo
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- CN114177099A CN114177099A CN202210009540.0A CN202210009540A CN114177099A CN 114177099 A CN114177099 A CN 114177099A CN 202210009540 A CN202210009540 A CN 202210009540A CN 114177099 A CN114177099 A CN 114177099A
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- stearate
- carnosine
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 69
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 30
- 239000008267 milk Substances 0.000 title claims abstract description 28
- 210000004080 milk Anatomy 0.000 title claims abstract description 28
- 235000013336 milk Nutrition 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 69
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 46
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims abstract description 33
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 32
- 108010087806 Carnosine Proteins 0.000 claims abstract description 32
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims abstract description 32
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 claims abstract description 32
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 32
- 229940044199 carnosine Drugs 0.000 claims abstract description 32
- -1 PEG-100 stearate Chemical compound 0.000 claims abstract description 30
- 229940114496 olive leaf extract Drugs 0.000 claims abstract description 26
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 23
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 23
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract description 23
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 23
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229940100460 peg-100 stearate Drugs 0.000 claims abstract description 23
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 23
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims abstract description 23
- 235000010262 sodium metabisulphite Nutrition 0.000 claims abstract description 23
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 23
- 239000000230 xanthan gum Substances 0.000 claims abstract description 23
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 23
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 23
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 18
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 18
- 229940001584 sodium metabisulfite Drugs 0.000 claims abstract description 17
- 241001071795 Gentiana Species 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 229940075529 glyceryl stearate Drugs 0.000 claims abstract description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 23
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 22
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 22
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 22
- 229940104261 taurate Drugs 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 12
- 238000004945 emulsification Methods 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 6
- 229960001484 edetic acid Drugs 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 229940082862 olea europaea leaf extract Drugs 0.000 claims description 6
- 238000005086 pumping Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 208000012641 Pigmentation disease Diseases 0.000 abstract description 3
- 102000003425 Tyrosinase Human genes 0.000 abstract description 3
- 108060008724 Tyrosinase Proteins 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 206010008570 Chloasma Diseases 0.000 abstract description 2
- 238000005562 fading Methods 0.000 abstract description 2
- 230000019612 pigmentation Effects 0.000 abstract description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 7
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000005282 brightening Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a whitening and freckle-removing combination, whitening milk containing the same and a preparation method thereof, wherein the whitening milk of the whitening and freckle-removing combination comprises the following components: deionized water, 4-butylresorcinol, gentian root extract, olive leaf extract, ascorbyl tetraisopalmitate, carnosine, glycerol, butylene glycol, PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, xanthan gum, ammonium polyacryloyldimethyltaurate, sodium metabisulfite, disodium EDTA, hydrogenated lecithin, 1, 2-hexanediol, p-hydroxyacetophenone. 4-butyl resorcinol, radix gentianae extract, olive leaf extract, ascorbyl tetraisopalmitate and carnosine have a synergistic effect, and have remarkable effects of resisting oxidation, fading chloasma, inhibiting activity of tyrosinase, and inhibiting inflammation and pigmentation induced by ultraviolet rays.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a whitening and freckle removing composition, a whitening milk containing the whitening and freckle removing composition and a preparation method of the whitening milk.
Background
Whitening is a constant pursuit of oriental women. In the declaration of Asian new products on the market, the brightening/brightening and whitening account for 48 percent of the total proportion.
People have no pause in exploring whitening raw materials, and consumers pay more attention to whitening ingredients which can quickly whiten skin and are safer and low in irritation. Most of the whitening products in the current market have single whitening strategy and no obvious effect.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing combination, a whitening milk containing the same and a preparation method thereof, which can enhance the whitening effect and cover more people. 4-butyl resorcinol, vitamin C derivatives and natural efficacy plants are compounded, so that the safety is high, the effect is good, the stimulation to the skin can be reduced, and the problems in the background art can be solved.
In order to achieve the purpose, the invention provides the following technical scheme:
the whitening and freckle-removing composition comprises the following components in parts by mass:
0.5-2 parts of 4-butyl resorcinol, 1-5 parts of gentian root extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate and 0.1-0.5 part of carnosine.
Further, the components in parts by mass also comprise: 0.8-1.5 parts of 4-butyl resorcinol, 2-4 parts of gentian root extract, 0.4-0.8 part of olive leaf extract, 1.2-2.8 parts of ascorbyl tetraisopalmitate and 0.2-0.4 part of carnosine.
Further, the components in parts by mass also comprise: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate and 0.3 part of carnosine.
The invention provides another technical scheme that: the whitening milk containing the whitening and freckle removing composition comprises the following components in parts by mass: 0.5-2 parts of 4-butyl resorcinol, 1-5 parts of radix gentianae extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate, 0.1-0.5 part of carnosine, 3-10 parts of glycerol, 3-7 parts of butanediol, 1-2 parts of PEG-100 stearate, 1-2 parts of glycerol stearate, 1-4 parts of polydimethylsiloxane, 2-3 parts of caprylic/capric triglyceride, 0.1-0.3 part of xanthan gum, 0.3-0.8 part of ammonium polyacryloyl dimethyl taurate, 0.1-0.3 part of sodium metabisulfite, 0.05-0.10 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.3-0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
Further, the feed comprises the following components in parts by mass: 0.8-1.5 parts of 4-butylresorcinol, 2-4 parts of radix gentianae extract, 0.4-0.8 part of olive leaf extract, 1.2-2.8 parts of ascorbyl tetraisopalmitate, 0.2-0.4 part of carnosine, 5-8 parts of glycerol, 4-6 parts of butanediol, 1.2-1.8 parts of PEG-100 stearate, 1.2-1.8 parts of glycerol stearate, 2-3 parts of polydimethylsiloxane, 2.2-2.8 parts of caprylic/capric triglyceride, 0.12-0.28 part of xanthan gum, 0.4-0.7 part of ammonium polyacryloyldimethyltaurate, 0.12-0.28 part of sodium metabisulfite, 0.06-0.09 part of disodium EDTA (EDTA), 0.35-0.45 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to 100 parts.
Further, the feed comprises the following components in parts by mass: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.3 part of carnosine, 6 parts of glycerol, 5 parts of butanediol, 1.5 parts of PEG-100 stearate, 1.5 parts of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.2 part of xanthan gum, 0.5 part of ammonium polyacryloyl dimethyl taurate, 0.2 part of sodium metabisulfite, 0.075 part of disodium EDTA, 0.4 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
The invention also provides another technical scheme: the preparation method of the whitening milk containing the whitening and freckle removing combination comprises the following steps:
step 1: preparing raw materials according to the following components by weight: 0.5-2 parts of 4-butylresorcinol, 1-5 parts of radix gentianae extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate, 0.1-0.5 part of carnosine, 3-10 parts of glycerol, 3-7 parts of butanediol, 1-2 parts of PEG-100 stearate, 1-2 parts of glycerol stearate, 1-4 parts of polydimethylsiloxane, 2-3 parts of caprylic/capric triglyceride, 0.1-0.3 part of xanthan gum, 0.3-0.8 part of ammonium polyacryloyldimethyl taurate, 0.1-0.3 part of sodium metabisulfite, 0.05-0.10 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.3-0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to be supplemented to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 80-85 deg.C, adding sodium pyrosulfite, disodium EDTA, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and making into water phase material, and keeping the temperature at 80-85 deg.C;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 80-85 deg.C, dissolving completely to obtain oil phase material, and keeping the temperature at 80-85 deg.C for use;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 80-85 deg.C, vacuum pumping into the oil phase, introducing into the emulsification tank, homogenizing for 10min, and cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
Compared with the prior art, the invention has the beneficial effects that:
the whitening milk disclosed by the invention adopts 4-butyl resorcinol, a gentian root extract, an olive leaf extract, ascorbyl tetraisopalmitate and carnosine as main components, wherein the 4-butyl resorcinol effectively inhibits the activity of the tyrosinase; the radix Gentianae extract can inhibit cyclooxygenase activity, reduce irritation, and inhibit skin pigmentation due to inflammatory reaction caused by ultraviolet; the olive leaf extract can remove free radicals and resist oxidation; the ascorbyl tetraisopalmitate is efficient, mild, whitening and antioxidant; carnosine scavenges reactive oxygen radicals and is resistant to glycation. The combined whitening product has mild texture and has the obvious effects of resisting oxidation, fading chloasma, inhibiting activity of tyrosinase and inhibiting inflammation and pigmentation induced by ultraviolet rays.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The whitening milk containing the whitening and freckle removing composition comprises the following components in parts by mass: 0.5 part of 4-butyl resorcinol, 5 parts of radix gentianae extract, 0.1 part of olive leaf extract, 3 parts of ascorbyl tetraisopalmitate, 0.1 part of carnosine, 3 parts of glycerol, 3 parts of butanediol, 2 parts of PEG-100 stearate, 2 parts of glycerol stearate, 4 parts of polydimethylsiloxane, 2 parts of caprylic/capric triglyceride, 0.3 part of xanthan gum, 0.3 part of ammonium polyacryloyldimethyl taurate, 0.1 part of sodium metabisulfite, 0.10 part of disodium EDTA, 0.3 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which is supplemented to 100 parts.
The preparation method of the whitening milk containing the whitening and freckle removing combination comprises the following steps:
step 1: preparing raw materials according to the following components by weight: 0.5 part of 4-butyl resorcinol, 5 parts of radix gentianae extract, 0.1 part of olive leaf extract, 3 parts of ascorbyl tetraisopalmitate, 0.1 part of carnosine, 3 parts of glycerol, 3 parts of butanediol, 2 parts of PEG-100 stearate, 2 parts of glycerol stearate, 4 parts of polydimethylsiloxane, 2 parts of caprylic/capric triglyceride, 0.3 part of xanthan gum, 0.3 part of ammonium polyacryloyldimethyl taurate, 0.1 part of sodium metabisulfite, 0.10 part of disodium EDTA, 0.3 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 85 deg.C, adding sodium pyrosulfite, disodium EDTA, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and making into water phase material, and keeping the temperature at 80 deg.C;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 82 deg.C, dissolving completely to obtain oil phase material, and keeping at 85 deg.C;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 80 ℃, pumping the oil phase into the emulsification tank in vacuum, keeping the temperature and homogenizing for 10min, and then cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
Example 2
The whitening milk containing the whitening and freckle removing composition comprises the following components in parts by mass: 2 parts of 4-butyl resorcinol, 1 part of gentian root extract, 1 part of olive leaf extract, 1 part of ascorbyl tetraisopalmitate, 0.5 part of carnosine, 10 parts of glycerol, 7 parts of butanediol, 1 part of PEG-100 stearate, 1 part of glycerol stearate, 1 part of polydimethylsiloxane, 3 parts of caprylic/capric triglyceride, 0.1 part of xanthan gum, 0.8 part of ammonium polyacryloyldimethyl taurate, 0.3 part of sodium metabisulfite, 0.05 part of EDTA disodium, 0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
The preparation method of the whitening milk containing the whitening and freckle removing combination comprises the following steps:
step 1: preparing raw materials according to the following components by weight: 2 parts of 4-butyl resorcinol, 1 part of radix gentianae extract, 1 part of olive leaf extract, 1 part of ascorbyl tetraisopalmitate, 0.5 part of carnosine, 10 parts of glycerol, 7 parts of butanediol, 1 part of PEG-100 stearate, 1 part of glycerol stearate, 1 part of polydimethylsiloxane, 3 parts of caprylic/capric triglyceride, 0.1 part of xanthan gum, 0.8 part of ammonium polyacryloyldimethyl taurate, 0.3 part of sodium metabisulfite, 0.05 part of EDTA disodium, 0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 80 ℃, adding sodium pyrosulfite, EDTA disodium, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and preparing a water phase material, and keeping the temperature at 85 ℃ for later use;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 80 deg.C, dissolving completely to obtain oil phase material, and keeping the temperature at 80 deg.C;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 85 ℃, pumping the oil phase into the emulsification tank in vacuum, keeping the temperature and homogenizing for 10min, and then cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
Example 3
The whitening milk containing the whitening and freckle removing composition comprises the following components in parts by mass: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.3 part of carnosine, 6 parts of glycerol, 5 parts of butanediol, 1.5 parts of PEG-100 stearate, 1.5 parts of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.2 part of xanthan gum, 0.5 part of ammonium polyacryloyl dimethyl taurate, 0.2 part of sodium metabisulfite, 0.075 part of disodium EDTA, 0.4 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
The preparation method of the whitening milk containing the whitening and freckle removing combination comprises the following steps:
step 1: preparing raw materials according to the following components by weight: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.3 part of carnosine, 6 parts of glycerol, 5 parts of butanediol, 1.5 parts of PEG-100 stearate, 1.5 parts of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.2 part of xanthan gum, 0.5 part of ammonium polyacryloyl dimethyl taurate, 0.2 part of sodium metabisulfite, 0.075 part of disodium EDTA, 0.4 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 82 ℃, adding sodium pyrosulfite, EDTA disodium, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and preparing a water phase material, and keeping the temperature at 83 ℃ for later use;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 85 deg.C, dissolving completely to obtain oil phase material, and keeping the temperature at 80 deg.C for use;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 84 ℃, pumping the oil phase into the emulsification tank in vacuum, keeping the temperature and homogenizing for 10min, and then cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
Example 4
The whitening milk containing the whitening and freckle removing composition comprises the following components in parts by mass: 1 part of 4-butyl resorcinol, 2 parts of gentian root extract, 0.2 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.2 part of carnosine, 3 parts of glycerol, 4 parts of butanediol, 2 parts of PEG-100 stearate, 1 part of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.15 part of xanthan gum, 0.4 part of ammonium polyacryloyldimethyltaurate, 0.15 part of sodium metabisulfite, 0.05 part of disodium EDTA, 0.3 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to 100 parts.
The preparation method of the whitening milk containing the whitening and freckle removing combination comprises the following steps:
step 1: preparing raw materials according to the following components by weight: 1 part of 4-butyl resorcinol, 2 parts of radix gentianae extract, 0.2 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.2 part of carnosine, 3 parts of glycerol, 4 parts of butanediol, 2 parts of PEG-100 stearate, 1 part of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.15 part of xanthan gum, 0.4 part of ammonium polyacryloyldimethyltaurate, 0.15 part of sodium metabisulfite, 0.05 part of disodium EDTA, 0.3 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 82 ℃, adding sodium pyrosulfite, EDTA disodium, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and preparing a water phase material, and keeping the temperature at 81 ℃ for later use;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 80 deg.C, dissolving completely to obtain oil phase material, and keeping at 82 deg.C;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 85 ℃, pumping the oil phase into the emulsification tank in vacuum, keeping the temperature and homogenizing for 10min, and then cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
Comparative example: the whitening essence milk is sold in the market.
Experiment: whitening and spot-lightening essence milk efficacy test
In order to verify the efficacy of the present invention in whitening and spot-lightening, the following experiments were performed.
Experiment one (control experiment):
summary of the experimental methods:
75 volunteers were selected for the study, and the age was between 30 and 45 years and divided into A, B, C, D groups and E groups, wherein the group A used the whitening essence milk of example 1, the group B used the whitening essence milk of example 2, the group C used the whitening essence milk of example 3, the group D used the whitening essence milk of example 4, the group E used the commercially available whitening essence milk, the test part was the face, and the test time was 8 weeks after 1 application in the morning and evening. During the test period, no other essence is used, and the rest skin care products are consistent.
And (3) testing results:
1. luminance change test
Subjects' facial brightness changes after 8 weeks were tested using the VISIA skin color analysis system
Table one: test results of luminance variation
2. Subjective feedback from subjects
Table two: subjective evaluation results of the subjects
3. Spot sticker safety test
Selecting qualified patch material, sucking 0.025ml of the substance to be tested and blank control distilled water by a liquid-moving machine, respectively dripping on a filter paper sheet, applying the patch device with whitening essence emulsion on the curved side of the forearm of the subject, lightly pressing with palm to uniformly apply the patch on the skin, and keeping for 24 h. The patch was removed and the skin reaction was observed. All 75 subjects had negative reactions and no adverse reactions.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.
Claims (7)
1. The whitening and freckle-removing composition is characterized by comprising the following components in parts by mass:
0.5-2 parts of 4-butyl resorcinol, 1-5 parts of gentian root extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate and 0.1-0.5 part of carnosine.
2. The whitening and freckle-removing combination according to claim 1, further comprising the following components in parts by mass: 0.8-1.5 parts of 4-butyl resorcinol, 2-4 parts of gentian root extract, 0.4-0.8 part of olive leaf extract, 1.2-2.8 parts of ascorbyl tetraisopalmitate and 0.2-0.4 part of carnosine.
3. The whitening and freckle-removing combination according to claim 1, further comprising the following components in parts by mass: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate and 0.3 part of carnosine.
4. The whitening milk containing the whitening and freckle-removing combination according to claim 1 is characterized by comprising the following components in parts by mass: 0.5-2 parts of 4-butyl resorcinol, 1-5 parts of radix gentianae extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate, 0.1-0.5 part of carnosine, 3-10 parts of glycerol, 3-7 parts of butanediol, 1-2 parts of PEG-100 stearate, 1-2 parts of glycerol stearate, 1-4 parts of polydimethylsiloxane, 2-3 parts of caprylic/capric triglyceride, 0.1-0.3 part of xanthan gum, 0.3-0.8 part of ammonium polyacryloyl dimethyl taurate, 0.1-0.3 part of sodium metabisulfite, 0.05-0.10 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.3-0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
5. The whitening milk containing the whitening and freckle-removing combination according to claim 4 is characterized by comprising the following components in parts by mass: 0.8-1.5 parts of 4-butylresorcinol, 2-4 parts of radix gentianae extract, 0.4-0.8 part of olive leaf extract, 1.2-2.8 parts of ascorbyl tetraisopalmitate, 0.2-0.4 part of carnosine, 5-8 parts of glycerol, 4-6 parts of butanediol, 1.2-1.8 parts of PEG-100 stearate, 1.2-1.8 parts of glycerol stearate, 2-3 parts of polydimethylsiloxane, 2.2-2.8 parts of caprylic/capric triglyceride, 0.12-0.28 part of xanthan gum, 0.4-0.7 part of ammonium polyacryloyldimethyltaurate, 0.12-0.28 part of sodium metabisulfite, 0.06-0.09 part of disodium EDTA (EDTA), 0.35-0.45 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to 100 parts.
6. The whitening milk containing the whitening and freckle-removing combination according to claim 5 is characterized by comprising the following components in parts by mass: 1.2 parts of 4-butyl resorcinol, 3 parts of gentian root extract, 0.6 part of olive leaf extract, 2 parts of ascorbyl tetraisopalmitate, 0.3 part of carnosine, 6 parts of glycerol, 5 parts of butanediol, 1.5 parts of PEG-100 stearate, 1.5 parts of glycerol stearate, 2.5 parts of polydimethylsiloxane, 2.5 parts of caprylic/capric triglyceride, 0.2 part of xanthan gum, 0.5 part of ammonium polyacryloyl dimethyl taurate, 0.2 part of sodium metabisulfite, 0.075 part of disodium EDTA, 0.4 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water which are supplemented to 100 parts.
7. The method of preparing a whitening lotion containing a combination of whitening and spot removing according to claim 4, comprising the steps of:
step 1: preparing raw materials according to the following components by weight: 0.5-2 parts of 4-butylresorcinol, 1-5 parts of radix gentianae extract, 0.1-1 part of olive leaf extract, 1-3 parts of ascorbyl tetraisopalmitate, 0.1-0.5 part of carnosine, 3-10 parts of glycerol, 3-7 parts of butanediol, 1-2 parts of PEG-100 stearate, 1-2 parts of glycerol stearate, 1-4 parts of polydimethylsiloxane, 2-3 parts of caprylic/capric triglyceride, 0.1-0.3 part of xanthan gum, 0.3-0.8 part of ammonium polyacryloyldimethyl taurate, 0.1-0.3 part of sodium metabisulfite, 0.05-0.10 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.3-0.5 part of hydrogenated lecithin, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and water to be supplemented to 100 parts;
step 2: dispersing xanthan gum and ammonium polyacryloyldimethyl taurate in glycerol uniformly, adding deionized water, heating to 80-85 deg.C, adding sodium pyrosulfite, disodium EDTA, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and making into water phase material, and keeping the temperature at 80-85 deg.C;
and step 3: adding PEG-100 stearate, glyceryl stearate, polydimethylsiloxane, caprylic/capric triglyceride, and ascorbyl tetraisopalmitate into an oil pan, heating to 80-85 deg.C, dissolving completely to obtain oil phase material, and keeping the temperature at 80-85 deg.C for use;
and 4, step 4: adding the water phase into an emulsification tank, maintaining the temperature at 80-85 deg.C, vacuum pumping into the oil phase, introducing into the emulsification tank, homogenizing for 10min, and cooling;
and 5: cooling to below 40 deg.C, adding 4-butylresorcinol, radix Gentianae extract, Olea europaea leaf extract, and carnosine which are completely dissolved in butanediol, stirring for 10min, mixing, and discharging.
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| CN202210009540.0A CN114177099A (en) | 2022-01-06 | 2022-01-06 | Whitening and freckle removing combination, whitening milk containing whitening and freckle removing combination and preparation method of whitening and freckle removing combination |
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| CN105687046A (en) * | 2016-03-16 | 2016-06-22 | 烟台新时代健康产业日化有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method of whitening and freckle-removing cream |
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| CN111603428A (en) * | 2020-06-04 | 2020-09-01 | 陶兴仲 | Whitening and freckle-removing plant type essence, preparation method and use method |
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| CN105687046A (en) * | 2016-03-16 | 2016-06-22 | 烟台新时代健康产业日化有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method of whitening and freckle-removing cream |
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| CN111603428A (en) * | 2020-06-04 | 2020-09-01 | 陶兴仲 | Whitening and freckle-removing plant type essence, preparation method and use method |
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