CN114176085A - Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil - Google Patents
Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil Download PDFInfo
- Publication number
- CN114176085A CN114176085A CN202111430125.4A CN202111430125A CN114176085A CN 114176085 A CN114176085 A CN 114176085A CN 202111430125 A CN202111430125 A CN 202111430125A CN 114176085 A CN114176085 A CN 114176085A
- Authority
- CN
- China
- Prior art keywords
- nitrouracil
- spirodiclofen
- shearing
- agent
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005664 Spirodiclofen Substances 0.000 title claims abstract description 59
- DTDSAWVUFPGDMX-UHFFFAOYSA-N spirodiclofen Chemical compound CCC(C)(C)C(=O)OC1=C(C=2C(=CC(Cl)=CC=2)Cl)C(=O)OC11CCCCC1 DTDSAWVUFPGDMX-UHFFFAOYSA-N 0.000 title claims abstract description 59
- TUARVSWVPPVUGS-UHFFFAOYSA-N 5-nitrouracil Chemical compound [O-][N+](=O)C1=CNC(=O)NC1=O TUARVSWVPPVUGS-UHFFFAOYSA-N 0.000 title claims abstract description 53
- 239000007900 aqueous suspension Substances 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000375 suspending agent Substances 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 241001454295 Tetranychidae Species 0.000 claims abstract description 11
- 239000002518 antifoaming agent Substances 0.000 claims abstract description 9
- 239000002270 dispersing agent Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000002335 preservative effect Effects 0.000 claims abstract description 5
- 238000009736 wetting Methods 0.000 claims abstract description 5
- 238000010008 shearing Methods 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 21
- 238000005303 weighing Methods 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 12
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 12
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 8
- 239000000084 colloidal system Substances 0.000 claims description 7
- 239000002612 dispersion medium Substances 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 7
- 239000004576 sand Substances 0.000 claims description 7
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 5
- 239000004299 sodium benzoate Substances 0.000 claims description 5
- 235000010234 sodium benzoate Nutrition 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 239000006229 carbon black Substances 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920005682 EO-PO block copolymer Polymers 0.000 claims description 3
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000000440 bentonite Substances 0.000 claims description 3
- 229910000278 bentonite Inorganic materials 0.000 claims description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 3
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 3
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- DNIKXCUKOGVNIO-UHFFFAOYSA-N formaldehyde;phenol;styrene Chemical compound O=C.OC1=CC=CC=C1.C=CC1=CC=CC=C1 DNIKXCUKOGVNIO-UHFFFAOYSA-N 0.000 claims description 3
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 claims description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 3
- 229920001568 phenolic resin Polymers 0.000 claims description 3
- 229920005646 polycarboxylate Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 150000004756 silanes Chemical class 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 239000003973 paint Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 36
- 230000000895 acaricidal effect Effects 0.000 abstract description 15
- 241000488583 Panonychus ulmi Species 0.000 abstract description 13
- 241000238876 Acari Species 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 8
- 229920000742 Cotton Polymers 0.000 abstract description 5
- 230000007246 mechanism Effects 0.000 abstract description 5
- 230000002045 lasting effect Effects 0.000 abstract description 3
- 235000005979 Citrus limon Nutrition 0.000 abstract description 2
- 244000131522 Citrus pyriformis Species 0.000 abstract description 2
- 244000141359 Malus pumila Species 0.000 abstract description 2
- 235000021016 apples Nutrition 0.000 abstract description 2
- 230000009466 transformation Effects 0.000 abstract description 2
- 239000000843 powder Substances 0.000 description 15
- 238000011282 treatment Methods 0.000 description 10
- 235000013305 food Nutrition 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- 241001454293 Tetranychus urticae Species 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 241000238631 Hexapoda Species 0.000 description 6
- 239000000642 acaricide Substances 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000000857 drug effect Effects 0.000 description 4
- 239000004482 other powder Substances 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 238000005338 heat storage Methods 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- WFJFGMLKAISFOZ-UHFFFAOYSA-N 1-amino-3-iminourea Chemical compound NN=C(O)N=N WFJFGMLKAISFOZ-UHFFFAOYSA-N 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- 241000488581 Panonychus citri Species 0.000 description 2
- 241000344246 Tetranychus cinnabarinus Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 poly (oxypropylene) Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GJUABKCEXOMRPQ-UHFFFAOYSA-N 1-[(2,5-dimethoxyphenyl)diazenyl]naphthalen-2-ol Chemical compound COC1=CC=C(OC)C(N=NC=2C3=CC=CC=C3C=CC=2O)=C1 GJUABKCEXOMRPQ-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 241000239290 Araneae Species 0.000 description 1
- 241001486393 Cacopsylla chinensis Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- STUSTWKEFDQFFZ-UHFFFAOYSA-N Chlordimeform Chemical compound CN(C)C=NC1=CC=C(Cl)C=C1C STUSTWKEFDQFFZ-UHFFFAOYSA-N 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000051366 Glycosyltransferases Human genes 0.000 description 1
- 108700023372 Glycosyltransferases Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000497192 Phyllocoptruta oleivora Species 0.000 description 1
- 241000758706 Piperaceae Species 0.000 description 1
- 241000952063 Polyphagotarsonemus latus Species 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- XCCTYIAWTASOJW-XVFCMESISA-N Uridine-5'-Diphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-XVFCMESISA-N 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- UOAMTSKGCBMZTC-UHFFFAOYSA-N dicofol Chemical compound C=1C=C(Cl)C=CC=1C(C(Cl)(Cl)Cl)(O)C1=CC=C(Cl)C=C1 UOAMTSKGCBMZTC-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a water suspending agent containing spirodiclofen and 5-nitrouracil, which comprises the following components in parts by weight: 10-30 parts of spirodiclofen; 1-10 parts of 5-nitrouracil; 2-8 parts of a wetting dispersant; 1-6 parts of an antifreezing agent; 0.5-2 parts of a suspending agent; 0.1-1 part of preservative; 0.1-0.3 part of defoaming agent; 0.1-0.2 part of tackifier; the acaricidal composition disclosed by the invention is good in quick-acting property, rain-wash-resistant, long in lasting period, safe to crops and natural enemies, unique in acaricidal action mechanism, good in control effect and remarkable in yield increase effect, solves the resistance problem of the spirodiclofen single agent, can be applied to crops such as cotton, oranges, apples or lemons, especially has a special effect on controlling harmful mites such as red spiders and spider mites, and is suitable for transformation, popularization and application.
Description
Technical Field
The invention belongs to the field of pesticide chemical industry, relates to a pesticide preparation technology, and particularly relates to a preparation method and application of a water suspending agent containing spirodiclofen and 5-nitrouracil.
Background
The spirodiclofen is a chemical substance with a brand new structure and a unique action mechanism, has white powder appearance, no special smell, contact action and no systemic property. The miticide has good killing effect on eggs, young mites and nymphs of harmful mites, is ineffective on adult mites, and has the effect of inhibiting the hatching rate of eggs of female mites. In addition, the spirodiclofen has good control effect on red spider, yellow spider, phyllocoptruta oleivora, yellow tea mite, tetranychus cinnabarinus, tetranychus urticae koch and the like, and can be used for controlling mite damage of fruit trees such as oranges and grapes and solanaceae crops such as eggplants, peppers, tomatoes and the like. Meanwhile, the pesticide composition has a good effect of treating pests such as psylla chinensis, elm shuriococci, leafhopper and the like. The acaricide has the characteristics of wide acaricidal spectrum, strong adaptability, killing of eggs and young, long lasting period, low toxicity, low residue, good safety, no mutual resistance with most pesticides and the like, and is sought by people in recent years.
The 5-nitrouracil is a pharmaceutical biochemical intermediate, is a specific inhibitor of uridine diphosphate glycosyltransferase (UGTs), can enhance the lethal effect of tetranychus cinnabarinus, has a unique acaricidal action mechanism, and is considered to be compounded with spirodiclofen for use to enhance the acaricidal effect.
At present, some old acaricides (such as dicofol and chlordimeform, etc.) in China are prohibited from being used due to the safety and resistance problems, but acaricides products with relatively high safety and better control effect are increasingly highlighted due to long-term use. In recent years, although new acaricides are developed and produced, because mites are easy to generate resistance and the control effect is poor after long-term use, the acaricides with different action mechanisms are required to be alternately used. At present, the most applied product in the market is a 24% spirodiclofen water suspending agent, but the spirodiclofen water suspending agent has long application time and obvious resistance, and has undesirable effect on preventing and controlling red spiders and spider mites.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a preparation method and application of an aqueous suspension containing spirodiclofen and 5-nitrouracil, which can effectively prevent and treat agricultural pest mites, solve the problem of drug resistance, reduce the dosage of spirodiclofen raw drug, reduce the cost, improve the prevention effect and have obvious yield-increasing effect.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
an aqueous suspension containing spirodiclofen and 5-nitrouracil comprises the following components in parts by weight:
the wetting dispersant comprises one or a combination of two or more of nonionic comb copolymer, EO-PO block copolymer, nonylphenol polyoxyethylene ether, alkylaryl polyoxyethylene ether phosphate, sodium dodecyl benzene sulfonate, sodium methylene dinaphthalene sulfonate, calcium lignosulfonate, alkylaryl polychloropropene polyoxyethylene ether, polycarboxylate and styrene phenol formaldehyde resin polyoxyethylene ether phosphate;
the antifreezing agent comprises one or the combination of two or more of urea, ethylene glycol, propylene glycol and glycerol;
the suspending agent comprises white carbon black, organic bentonite or magnesium aluminum silicate;
the preservative comprises sodium benzoate or cason;
the defoaming agent comprises an organic silicon defoaming agent AF-9903, a modified silane AF-1501 defoaming agent or fatty acids;
the viscosity increaser comprises xanthan gum, polyvinyl alcohol or sodium alginate.
A preparation method of an aqueous suspension containing spirodiclofen and 5-nitrouracil comprises the following steps:
(1) pouring the spirodiclofen original drug, the 5-nitrouracil and the suspending agent into a prepared pulverizer, and pulverizing until the particle size is controlled below 75 microns for later use;
(2) adding the wetting dispersant into dispersion medium water, stirring uniformly, adding the crushed spirodiclofen original drug, 5-nitrouracil and a suspending agent while shearing and stirring, finally putting the antifreezing agent, the preservative and the defoaming agent into a shearing tank, shearing uniformly, and feeding into a sand mill for sanding after a colloid mill;
(3) weighing the tackifier and the antifreezing agent, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
An aqueous suspension containing spirodiclofen and 5-nitrouracil has excellent effect in preventing and treating red spider mites and spider mites.
The invention has the advantages and positive effects that:
1. compared with other formulations, the spirodiclofen and 5-nitrouracil containing the spirodiclofen and the 5-nitrouracil are safer and more environment-friendly in preparation process and more convenient to apply. The two active ingredients in the acaricidal composition have a synergistic effect, so that the dosage can be effectively reduced, the cost is reduced, the problem of pesticide residue in soil and agricultural products is solved, and the acaricidal composition is safer to environment and human health.
2. The invention has scientific and reasonable design, optimizes the process in the preparation processing process, greatly improves the sanding efficiency, and greatly shortens the preparation time, thereby reducing the production cost.
3. The acaricidal composition disclosed by the invention is good in quick-acting property, rain-wash-resistant, long in lasting period, safe to crops and natural enemies, unique in acaricidal action mechanism, good in control effect and remarkable in yield increase effect, solves the resistance problem of the spirodiclofen single agent, can be applied to crops such as cotton, oranges, apples or lemons, especially has a special effect on controlling harmful mites such as red spiders and spider mites, and is suitable for transformation, popularization and application.
Drawings
FIG. 1 is a diagram of the manufacturing process of the present invention.
Detailed Description
The present invention is further illustrated by the following specific examples, which are intended to be illustrative, not limiting and are not intended to limit the scope of the invention.
Example 1
An aqueous suspension containing spirodiclofen and 5-nitrouracil is prepared from the following components in parts by weight:
the preparation method of the water suspending agent containing the spirodiclofen and the 5-nitrouracil comprises the following steps:
(1) weighing the raw spirodiclofen, 5-nitrouracil, magnesium aluminum silicate and other powder according to weight, pouring the powder into a prepared crusher, and crushing the powder until the particle size is controlled below 75 microns for later use.
(2) Weighing the nonionic comb copolymer and the EO-PO block copolymer according to the weight, adding the weighed dispersion medium water, uniformly stirring, adding the spirodiclofen original drug, the 5-nitrouracil and the magnesium aluminum silicate while shearing and stirring, finally putting the sodium benzoate and the AF-9903 into a shearing tank, uniformly shearing, and sanding in a sand mill after colloid milling;
(3) weighing xanthan gum powder and ethylene glycol according to weight, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
In addition, the water suspension containing the spirodiclofen and the 5-nitrouracil has higher control effect on red spiders, spider mites and the like.
Example 2
An aqueous suspension containing spirodiclofen and 5-nitrouracil is prepared from the following components in parts by weight:
the preparation method of the water suspending agent containing the spirodiclofen and the 5-nitrouracil comprises the following steps:
(1) weighing the raw spirodiclofen, 5-nitrouracil, white carbon black and other powder according to weight, pouring the powder into a prepared crusher, crushing the powder until the particle size is controlled below 75 microns for later use.
(2) Weighing nonylphenol polyoxyethylene ether according to weight, adding the weighed dispersion medium water, uniformly stirring, adding the spirodiclofen original drug, 5-nitrouracil and white carbon black while shearing and stirring, finally putting sodium benzoate and AF-1501 into a shearing tank, uniformly shearing, and feeding into a sand mill for sanding after a colloid mill;
(3) weighing polyvinyl alcohol and propylene glycol by weight, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
In addition, the acaricidal synergistic aqueous suspension containing the spirodiclofen and the 5-nitrouracil has higher control effect on red spiders, spider mites and the like.
Example 3
An aqueous suspension containing spirodiclofen and 5-nitrouracil is prepared from the following components in parts by weight:
the preparation method of the water suspending agent containing the spirodiclofen and the 5-nitrouracil comprises the following steps:
(1) weighing the powder of the spirodiclofen original drug, the 5-nitrouracil, the organic bentonite and the like according to the weight, pouring the powder into a prepared crusher, and crushing the powder until the particle size is controlled below 75 microns for later use.
(2) Weighing alkyl aryl polyoxyethylene ether phosphate and sodium dodecyl benzene sulfonate according to weight, adding the weighed dispersion medium into water, uniformly stirring, adding the spirodiclofen original drug, 5-nitrouracil and organobentonite while shearing and stirring, finally putting the carbazone and the fatty acid into a shearing tank, uniformly shearing, and grinding in a sand mill after a colloid mill;
(3) weighing sodium alginate and glycerol by weight, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
In addition, the water suspension containing the spirodiclofen and the 5-nitrouracil has higher control effect on red spiders, spider mites and the like.
Example 4
An aqueous suspension containing spirodiclofen and 5-nitrouracil is prepared from the following components in parts by weight:
the preparation method of the water suspending agent containing the spirodiclofen and the 5-nitrouracil comprises the following steps:
(1) weighing the raw spirodiclofen, 5-nitrouracil, magnesium aluminum silicate and other powder according to weight, pouring the powder into a prepared crusher, and crushing the powder until the particle size is controlled below 75 microns for later use.
(2) Weighing sodium methylene dinaphthalene sulfonate, calcium lignosulfonate and alkylaryl poly (oxypropylene) polyoxyethylene ether according to weight, adding the weighed dispersion medium water, uniformly stirring, adding spirodiclofen technical, 5-nitrouracil and magnesium aluminum silicate while shearing and stirring, finally adding urea, sodium benzoate and AF-9903 into a shearing tank, uniformly shearing, and sanding in a sand mill after a colloid mill;
(3) weighing xanthan powder and glycerol by weight, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
In addition, the water suspension containing the spirodiclofen and the 5-nitrouracil has higher control effect on red spiders, spider mites and the like.
Example 5
An aqueous suspension containing spirodiclofen and 5-nitrouracil is prepared from the following components in parts by weight:
the preparation method of the water suspending agent containing the spirodiclofen and the 5-nitrouracil comprises the following steps:
(1) weighing the raw spirodiclofen, 5-nitrouracil, magnesium aluminum silicate and other powder according to weight, pouring the powder into a prepared crusher, and crushing the powder until the particle size is controlled below 75 microns for later use.
(2) Weighing polycarboxylate and styrene phenol formaldehyde resin polyoxyethylene ether phosphate ester according to weight, adding the weighed dispersion medium water, uniformly stirring, adding spirodiclofen original drug, 5-nitrouracil and magnesium aluminum silicate while shearing and stirring, finally putting the carbazone and AF-9903 into a shearing tank, uniformly shearing, and grinding in a sand mill after a colloid mill;
(3) weighing xanthan gum powder and ethylene glycol according to weight, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
In addition, the water suspension containing the spirodiclofen and the 5-nitrouracil has higher control effect on red spiders, spider mites and the like.
And (3) product performance detection:
the results of the performance tests of the above 5 examples are as follows:
product quality inspection data for 5 examples
| Treatment of | Stability at Normal temperature | Stability in Heat storage | Stability in Cold storage | Freeze thaw stability |
| Example 1 | Superior food | Good wine | Good wine | Good wine |
| Example 2 | Superior food | Superior food | Superior food | Good wine |
| Example 3 | Superior food | Superior food | Good wine | Good wine |
| Example 4 | Superior food | Good wine | Good wine | In |
| Example 5 | Superior food | Good wine | In | In |
From the above table, it can be seen that the above 5 examples are excellent in the normal temperature state, wherein the samples of example 1, example 2 and example 3 are good in the hot storage, cold storage and freeze-thaw stability; the sample in the example 4 has good stability in hot storage and cold storage and is slightly poor in freeze-thaw state; the sample of example 5 has good heat storage stability and slightly poor cold storage and freeze-thaw state; the sample in the embodiment 2 has good cold storage stability and heat storage stability, good fluidity and good freeze-thaw stability.
1. The results of the drug effects of the above 5 examples and the control drug on the prevention and treatment of citrus red mite are as follows:
the invention was set up with 7 treatments, examples 1-5 of the invention, a control agent of 24% spirodiclofen aqueous suspension (Beijing, New Ruifeng technology) and a blank control.
The test site is a new meeting area of Jiangmen City in Guangdong province, the medicine is applied at the initial prosperity stage of the citrus, the application time is 3, 8 and 3 months in 2020, and the medicine is applied once. Before and during the test without any bactericide or insecticide applied, each treatment was repeated 3 times, the cells were randomly arranged, and the area of each cell was 20m2The manual knapsack sprayer is used for conventional spraying, the medicine is required to be uniformly and meticulously used, and the specific result is as follows:
the investigation method comprises the following steps: at least 4 red spider citrus plants are selected in each cell, and the number of red spiders on the front and back sides of each leaf is marked by each brand.
The drug effect calculation method comprises the following steps:
oral cavity decline rate (%) [ (predrug number-predrug number)/predrug number ] × 100
Control effect (%) < 1- (number of insects before application in the blank area x number of insects after application in the treatment area)/number of insects after application in the blank area x number of insects before application in the treatment area) ] × 100
Field pesticide effect result for preventing and controlling citrus red spiders
As can be seen from the above table, the control effect of the agent of the example on citrus red mites is significantly better than that of the control agent, and the control effect of the agent of the example 2 is the best. From the aspect of quick action, the control effect of the embodiment is improved by 9.67 percent compared with that of a control medicament one day after the control medicament is applied, the medicament effect is in an ascending trend along with the prolonging of time, and the control effect is higher than that of the control medicament. When the content of the active ingredients is the same, the higher the content of the 5-nitrouracil is, the better the prevention and treatment effect is; when the content of the spirodiclofen is the same, the higher the content of the 5-nitrouracil is, the better the effect is, but the difference of the control effect is not obvious.
2. The results of the drug effects of the above 5 examples and the control drug on controlling two-spotted spider mite of cotton are as follows:
the invention was set up with a total of 7 treatments, examples 1-5 in the invention; a contrast agent, 24% spirodiclofen aqueous suspension (Beijing, New Ruifeng science); and a clear water control.
The test site is Anyang city yellow county in Henan province, and the pesticide is applied at the initial stage of the cotton tetranychus urticae, wherein the pesticide application time is 7 months and 25 days in 2019, and the pesticide application time is once. Before and during the test without any bactericide or insecticide applied, each treatment was repeated 3 times, the cells were randomly arranged, and the area of each cell was 30m2The backpack electric sprayer is adopted for conventional spraying, the medicine is required to be uniformly and meticulously taken, and the specific result is as follows:
the investigation method comprises the following steps: 5 spots per cell, 2 plants per spot, and 10 plants in total were investigated. Fixing 3, 4 and 3 leaves of each plant according to the upper, middle and lower 3 layers, respectively, investigating the number of live insects on the leaves, and calculating the reduction rate of insect population and the prevention and treatment effect.
Field pesticide effect result for preventing and controlling two-spotted spider mite of cotton
As can be seen from the table above, the effect of the embodiment on controlling tetranychus urticae koch is obviously superior to that of a control medicament, and the control effect is obvious no matter the quick-acting effect or the lasting period exists, which shows that the 5-nitrouracil has the synergistic effect. Compared with the example 3, the control effect is best when the 5-nitrouracil is used at 6% under the condition that the content of the spirodiclofen is the same; as can be seen from examples 1 and 4, the increase in the amount of 5-nitrouracil (10%) was insignificant for improving the drug effect (compared with example 3). Therefore, the mixing control effect of the spirodiclofen and the 5-nitrouracil is obviously higher than that of a single agent.
Yield increase results for the above 5 examples and the control
As can be seen from the above table, the yield increasing effect of the examples and the control samples is significant compared to the blank control, and the yield increasing effect of the examples is significantly higher than that of the control sample, wherein the yield increasing rate of the example 2 is the highest. When the dosage of the embodiment is consistent with that of the control sample (No. 6), the yield increase rate of the embodiment is obviously higher than that of the control sample, and the synergistic effect of the spirodiclofen and the 5-nitrouracil is obvious; when the content of the spirodiclofen is consistent, the higher the content of the 5-nitrouracil is, the higher the yield increasing effect is.
The spirodiclofen and 5-nitrouracil suspension concentrate developed by the invention has obviously better control effect than a reference medicament, good quick action, long lasting period, obvious synergism and better yield increasing effect. Compared with other formulations, the preparation process is simpler, the raw material sources are safer, the pesticide effect is obvious, the product stability is better, and the pesticide composition can be used for preventing and controlling crop pests such as red spider, tetranychus urticae and the like.
Although the embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the invention and the appended claims, and therefore the scope of the invention is not limited to the embodiments disclosed.
Claims (3)
1. An aqueous suspension containing spirodiclofen and 5-nitrouracil, which is characterized in that: the paint comprises the following components in parts by weight:
the wetting dispersant comprises one or a combination of two or more of nonionic comb copolymer, EO-PO block copolymer, nonylphenol polyoxyethylene ether, alkylaryl polyoxyethylene ether phosphate, sodium dodecyl benzene sulfonate, sodium methylene dinaphthalene sulfonate, calcium lignosulfonate, alkylaryl polychloropropene polyoxyethylene ether, polycarboxylate and styrene phenol formaldehyde resin polyoxyethylene ether phosphate;
the antifreezing agent comprises one or the combination of two or more of urea, ethylene glycol, propylene glycol and glycerol;
the suspending agent comprises white carbon black, organic bentonite or magnesium aluminum silicate;
the preservative comprises sodium benzoate or cason;
the defoaming agent comprises an organic silicon defoaming agent AF-9903, a modified silane AF-1501 defoaming agent or fatty acids;
the viscosity increaser comprises xanthan gum, polyvinyl alcohol or sodium alginate.
2. A preparation method of an aqueous suspension containing spirodiclofen and 5-nitrouracil is characterized in that: the method comprises the following steps:
(1) pouring the spirodiclofen original drug, the 5-nitrouracil and the suspending agent into a prepared pulverizer, and pulverizing until the particle size is controlled below 75 microns for later use;
(2) adding the wetting dispersant into dispersion medium water, stirring uniformly, adding the crushed spirodiclofen original drug, 5-nitrouracil and a suspending agent while shearing and stirring, finally putting the antifreezing agent, the preservative and the defoaming agent into a shearing tank, shearing uniformly, and feeding into a sand mill for sanding after a colloid mill;
(3) weighing the tackifier and the antifreezing agent, and uniformly shearing for later use;
(4) and (3) finishing sanding, adding the (2) into a sanding tank after the particle size is qualified, shearing and stirring uniformly, sampling, detecting, and obtaining a qualified finished product.
3. The use of an aqueous suspension containing spirodiclofen and 5-nitrouracil according to claim 1 or 2 for controlling spider mites and spider mites.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111430125.4A CN114176085A (en) | 2021-11-29 | 2021-11-29 | Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111430125.4A CN114176085A (en) | 2021-11-29 | 2021-11-29 | Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114176085A true CN114176085A (en) | 2022-03-15 |
Family
ID=80602864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111430125.4A Pending CN114176085A (en) | 2021-11-29 | 2021-11-29 | Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114176085A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104396961A (en) * | 2014-10-28 | 2015-03-11 | 江苏安邦电化有限公司 | Suspending agent comprising spirodiclofen |
| CN110150283A (en) * | 2019-05-27 | 2019-08-23 | 中农立华生物科技股份有限公司 | A kind of Envidor suspending agent and preparation method thereof |
-
2021
- 2021-11-29 CN CN202111430125.4A patent/CN114176085A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104396961A (en) * | 2014-10-28 | 2015-03-11 | 江苏安邦电化有限公司 | Suspending agent comprising spirodiclofen |
| CN110150283A (en) * | 2019-05-27 | 2019-08-23 | 中农立华生物科技股份有限公司 | A kind of Envidor suspending agent and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102124574B1 (en) | Method for producing natural complex composition having prevention of pests, offensive odor removal of barn, and sterilization effect | |
| CN101999356A (en) | Sterilization composition containing fluopicolide and metalaxyl and application thereof | |
| CN104277935A (en) | Fruit/vegetable cleaning solution | |
| CN111557305A (en) | Dispersible oil suspending agent containing acetamiprid and flonicamid, and preparation method and application thereof | |
| CN104542618A (en) | Synergetic acaricidal composition containing cyenopyrafen and etoxazole | |
| CN104082300B (en) | Insecticide acaricide composition containing pyriproxyfen and spirodiclofen | |
| CN103493831A (en) | Insecticide composition with insecticides of pyriminostrobin and tetronic acid | |
| CN106577699A (en) | Ternary herbicidal composition containing pyraclonil and benzobicylon | |
| CN114176085A (en) | Preparation method and application of water suspension containing spirodiclofen and 5-nitrouracil | |
| CN105165880A (en) | Pesticide composition and application thereof | |
| CN101653140B (en) | Compound bactericidal composition containing boscalid | |
| CN104430401A (en) | Pesticide suspension preparation for preventing and treating rice insect pests and preparation method thereof | |
| CN101218922A (en) | High-efficiency and low-toxin seed-treating agent | |
| CN111084191B (en) | Clothianidin and efficient cyfluthrin suspending agent and preparation method thereof | |
| CN113100241A (en) | Synergistic pesticide composition containing paeoniflorin and alginate oligosaccharides | |
| CN104286010B (en) | Composition pesticide containing sulfur-phosphor and Bifenazate | |
| CN107926951B (en) | Bactericidal composition containing terpene alcohol and trifloxystrobin and application thereof | |
| CN103931621B (en) | A kind of containing Tolfenpyrad with the composition pesticide of cyflumetofen | |
| CN102224831B (en) | Control method of tetranychus cinnabarinus based on tomato extracts | |
| CN102484992A (en) | Synergetic pesticide composition of nimbin and tea saponin | |
| CN105309441B (en) | Composition pesticide containing nitrile pyrrole mite ester and its purposes in prevention and treatment harmful mite | |
| CN110326623A (en) | A kind of plant pesticide composition and preparation method thereof | |
| CN112772651A (en) | Oligogalacturonic acid and kasugamycin combined bactericide and application thereof | |
| CN101755780A (en) | Pesticidal composition containing tebuconazole and propineb and application thereof | |
| CN103931642B (en) | A kind of containing indoxacarb with the composition pesticide of cyflumetofen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220315 |