CN104396961A - Suspending agent comprising spirodiclofen - Google Patents
Suspending agent comprising spirodiclofen Download PDFInfo
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- CN104396961A CN104396961A CN201410588917.8A CN201410588917A CN104396961A CN 104396961 A CN104396961 A CN 104396961A CN 201410588917 A CN201410588917 A CN 201410588917A CN 104396961 A CN104396961 A CN 104396961A
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Abstract
The invention discloses a suspending agent comprising spirodiclofen. The suspending agent is composed of the following substances, by weight: 5-35% of spirodiclofen, 1-40% of an active substance A, 2-6% of a dispersing agent, 1-3% of a wetting agent, 0.1-3% of a synergist, 0.1-0.5% of a defoaming agent, 0.1-1% of a thickening agent, 0.1-0.5% of a preservative, 4-6% of an antifreeze agent and balance of water. According to the invention, during the suspending agent preparation process, another active substance and the synergist are added. With the other active substance, a significant synergistic effect is provided for the pesticide activity and miticidal and insecticidal effects. The suspending agent is fast-acting, and has long effect duration. With the suspending agent, drug resistance can be effectively retarded. With the synergist, the deposition amount of the active components on targets (plant or insect) is substantially improved, active component loss is reduced, active component utilization rate is improved, and product dose is reduced.
Description
Technical field
The present invention relates to a kind of agricultural chemical composition for disinsection, relate to a kind of suspending agent containing spiral shell mite ester being used for preventing and treating insect agriculturally, harmful mite particularly.
Background technology
The algebraically that evil mite occurred in 1 year is many, population growth ability is strong, often want dispenser can control its harm for several times in 1 year, thus harmful mite more easily develops immunity to drugs, adding in recent years, single drug and not scientific and reasonable medication, the pesticide resistance of evil mite to old kind agricultural chemicals increases more greatly, and successful is deteriorated.
Spiral shell mite esterification formal name used at school is called: 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro [4, the 5]-last of the ten Heavenly stems-3-alkene 4-base-2,2-dimethyl butyrate acid esters, is New-type spiro tetronic acid insecticides and the miticide of Bayer A.G's exploitation.Spiral shell mite ester is the miticide with brand-new mechanism of action, its killing mechanism is different from existing various miticide completely, by suppressing the Fatty synthesis in evil mite body, destroy the energy metabolism activity of acarid, finally kill harmful mite, it be a kind of completely newly, efficient non-internal-absorting leaf surface treatment miticide, cross resistance problem is there is not with other existing miticide, fine preventive effect and outstanding lasting effect is all had to the different mite classes of various crop, not only ovicidal but also kill young mite, is particularly suitable for preventing and treating the pest mite class existing miticide being produced to resistance.Spiral shell mite ester low toxicity, low-residual, safety are good, very safe to crop under different temperature condition, to person poultry safety, are applicable to non-harmful product and produce.Because the speed of action of spiral shell mite ester is comparatively slow, neither be very good to one-tenth mite effect, and spiral shell mite ester is without transreactance, so with existing miticide mixture, mite can be killed into fast, the quantity of evil acarid mouth can be controlled again for a long time, also be conducive to evil mite resistance management.
But, usually different defects is there is in the miticide only containing a kind of active component in control of insect, the single miticide of Long-Time Service not only easily causes drug-fast generation, and the miticide of one-component all can not have good result to each worm phase of evil mite in the process of preventing and treating, and generally can not hold concurrently anti-to different classes of acarid, aphid etc., therefore need often to spray different classes of agricultural chemicals with for can not insect, not only Aggravate peasant's burden, and along with the continuous increase of formulation rate, the harm of environment is also significantly increased.Simultaneously, the dispersion medium of suspending agent is water, have on surface on the blade face of wax coat, often can not well extend and permeate, droplet cannot stop on blade face, and cause a large amount of losses of active ingredient, the availability of active ingredient is lower, not only increase peasant's use cost, and larger harm is also caused to environment.
Summary of the invention
Goal of the invention: for solving the technical problem existed in prior art; the present invention proposes a kind of suspending agent containing spiral shell mite ester; this suspending agent adds a certain amount of synergist especially; and effect mutually auxiliary with other active insecticidal components; effectively improve the deposition of active ingredient on target, reduce the loss of active ingredient, increase operation rate; reduce use cost, protection of the environment.
Technical scheme: for realizing above-mentioned technical purpose, suspending agent containing spiral shell mite ester of the present invention comprises the component of following mass percent: spiral shell mite ester 5% ~ 35%, active substance A 1 ~ 40%, dispersant 2% ~ 6%, wetting agent 1% ~ 3%, synergist 0.1% ~ 3%, defoamer 0.1 ~ 0.5%, thickener 0.1% ~ 1%, preservative 0.1% ~ 0.5%, the water of antifreezing agent 3% ~ 6% and surplus.
Wherein, described synergist is any one or a few in silicone based, natural oil lipid non-ionic surface active agent, maleic diethylester and propyl isome, and preferably, the mass percent shared by described synergist is 1% ~ 2%.
Wherein, described active substance A can be in second worm nitrile, single carbonamidine, Amitraz, Hexythiazox and dicofol any one.
Preferably, when described active substance is dicofol, the mass percent shared by it is preferably 5% ~ 25%; When described active substance is Hexythiazox, the mass percent shared by it is preferably 10% ~ 40%; When described active substance is second worm nitrile, the mass percent shared by it is preferably 1% ~ 20%; When described active substance is single carbonamidine, the mass percent shared by it is preferably 1% ~ 15%; When described active substance is Amitraz, the mass percent shared by it is preferably 1% ~ 15%.
Wherein, for dispersant is any one or a few in polycarboxylic acid salt's dispersant, Sulfonates dispersant, Sulfates dispersant, quaternary ammonium salt dispersant, fatty acid ethylene oxide addition product and aliphatic alcohols APEO, the mass percent that described dispersant accounts for total preparation is 2% ~ 6%.Preferably, when described dispersant is fatty acid ethylene oxide addition product, the mass percent shared by it is preferably 3% ~ 5%; When described dispersant is polycarboxylic acid salt, the mass percent shared by it is preferably 4% ~ 5%; When described dispersant is Sulfonates, the mass percent shared by it is preferably 3% ~ 4%.
Particularly, described polycarboxylic acid salt's dispersant is any one in the acid of loose ester soap, acrylic acid-acrylic ester-sulfonate, maleic-acrylic acid sodium salt etc.; Described Sulfonates dispersant is any one in benzyl naphthalene sulfonic formaldehyde condensation compound, neopelex, sodium butylnaphthalenesulfonate, diisopropyl sodium naphthalene sulfonate, petroleum sodium sulfonate, dihexyl succinic acid sodium sulfonate, dihexyl succinic acid sodium sulfonate, methyl naphthalene sulfonate formaldehyde condensate etc.; Described Sulfates dispersant is spermaceti alcohol radical sodium sulphate, OPEO sulphate, sulfated castor oil, secondary alcohol groups sodium sulphate, any one in ethoxylated dodecyl alcohol sodium sulphate etc.; Described quaternary ammonium salt dispersant be in hexadecyltrimethylammonium chloride, Dodecyl trimethyl ammonium chloride, OTAC, dodecyl benzyl dimethyl ammonium chloride any one etc.; Described fatty acid ethylene oxide addition product class dispersant is any one in polyoxyethylene oleic acid ester, polyoxyethylene stearic acid ester, polyoxylethylene abietate etc.; Described aliphatic alcohols polyethenoxy ether class dispersant is ethoxylated dodecyl alcohol, iso-octyl APEO, octadecane alcohol radical APEO, any one in different tridecanol polyoxyethylene ether etc.
Wherein, described wetting agent is any one or a few in lauryl sodium sulfate, neopelex, polyacrylate, acrylate copolymer, fatty alcohol and ethylene oxide condensate and Fluhyzon Barbiturates, and the mass percent that described wetting agent accounts for total preparation is 1% ~ 3%.Preferably, when described wetting agent is acrylate copolymer, the mass percent shared by it is preferably 1% ~ 2%; Preferably, when described wetting agent is polyacrylate, the mass percent shared by it is preferably 1% ~ 2%.
Wherein, described thickener is any one or a few in xanthans, aluminium-magnesium silicate, bentonite and white carbon, and the mass percent that described thickener accounts for total preparation is 0.1% ~ 1%.Preferably, when described thickener is xanthans, the mass percent shared by it is preferably 0.1% ~ 0.3%; When described thickener be aluminium-magnesium silicate time, the mass percent shared by it is preferably 0.1% ~ 0.5%.
Wherein, described antifreezing agent is any one or a few in ethylene glycol, propane diols and glycerine, and the mass percent that described antifreezing agent accounts for total preparation is 3% ~ 6%.Preferably, when described thickener is ethylene glycol, the mass percent shared by it is preferably 4% ~ 5%; When described thickener is glycerine, the mass percent shared by it is preferably 4% ~ 5%.
Wherein.Described preservative is any one or a few in Sodium Benzoate, Kathon CG, and the mass percent that described preservative accounts for total preparation is 0.1% ~ 0.5%.Preferably, when described preservative is Sodium Benzoate, the mass percent shared by it is preferably 0.2% ~ 0.3%.
Wherein, described defoamer is organosilicon ketone, and the mass percent that described defoamer accounts for total preparation is 0.1% ~ 0.5%, is preferably 0.3% ~ 0.5%.
Present invention further proposes the preparation method of the above-mentioned suspending agent containing spiral shell mite ester, adopt wet pulverizing method, comprise the steps: previously prepared for the thickener of formula ratio mass concentration to be that the aqueous solution of 2 ~ 4wt% is as stabilizing solution; The dispersant of formula ratio, wetting agent, synergist, defoamer, preservative and antifreezing agent are dissolved in remaining water, after stirring, add spiral shell mite ester and the active substance A of formula two, then under high speed shear condition, form uniform suspension; Scattered suspension is transferred in sand mill and carries out the average grain diameter of wet grinding to spiral shell mite ester particle at 2 ~ 3 microns; Previously prepared good stabilizing solution is joined also homogenize in ground sand milling liquid.
Dicofol chemical name is: 1,1-bis-(rubigan)-2,2,2-ethapon.Dicofol belongs to organochlorine acaricide, kills mite spectrum extensively, active high, to crop safety.This medicine belongs to never poison, has stronger action of contace poison to evil mite, and without interior absorption, if all have very strong toxic action to one-tenth mite and ovum, and lethal effect is rapid, and the longevity of residure is long, uses for many years and easily produces resistance.This medicine is low to people, animal toxicity, to mite class natural enemy and crop all safer, effectively can prevent and treat multiple harmful mite in fruit tree, flowers and other crops.
Hexythiazox chemical name is: 5-(4-chlorphenyl)-3-(N-cyclohexyl carboxyamide)-4-first bright base thiazolidine-2-one.Hexythiazox is thiazolidine ketone miticide, if having strong ovicidal to various plants evil mite, kill the characteristic of children mite, invalid to one-tenth mite, but the ovum that the female adult pest touching liquid produces is had to the effect suppressing hatching.Good to tetranychid preventive effect, poor to rust mite, goitre mite preventive effect.Can be mixed with the Multiple Pesticides such as bordeaux mixture, lime sulfur.Mechanism of action, based on action of contace poison, has good permeability to plant tissue, without interior absorption effect.To people, animal low toxicity, there is minimal irritation effect to eye, to birds low toxicity, to honeybee non-toxic reaction under constant, very little on natural enemy impact, poisonous to fish.Environmental temperature height does not affect result of use, and within after general dispenser 10 days, just can demonstrate good preventive effect, the lasting period can keep about 50 days.
Second worm nitrilation formal name used at school is called: 1-(2,6-dichlor-4-trifluoromethyl phenyl)-3-cyano group-4-ethylsulfinyl-5-amino-pyrazol, is the Insecticidal and acaricidal agent developed by rhone-poulenc discovery, Beyer Co., Ltd.Second worm nitrile belongs to benzene pyrazoles broad spectrum pesticide; its mechanism of action disturbs chloride channel by an aminobutyric acid (GABA); thus destroy central nervous system (CNS) normal activity; make insect lethal; its mode of action is contact; not absorption in tool, to various crop do kind of chewing type and sucking pest all has control efficiency.The lasting period of this medicine can reach about 14 days, to crop safety under recommended dose, has no poisoning and produces, on predator substantially without impact.
Single carbonamidine chemical name is: N-2,4-dimethyl benzene-N-methylrnethwirnidamide.Single carbonamidine belongs to medium malicious miticide, harmful mite on the crops such as energy effectively preventing citrus, apple, tealeaves, cotton and vegetables and ectozoa of domestic animals, all there is good effect to each worm phase of mite and resistant mite, doublely can also control the insects such as ceroplastes rubens 1 ~ 2 age, arrowhead scales 1-2 instar larvae, cotton bollworm and aphid simultaneously.Formamidine agricultural chemicals is safer to natural enemy (except Predatory Mites), is the favourable agents of integrated control.
Amitraz chemical name is: two (2, the 4-dimethylbenzene iminomethyl) amine of N-methyl.Amitraz system broad spectrum acaricides, is medium malicious miticide, mainly suppresses the activity of monoamine oxidase.There is multiple poisoning mechanism, have tag, food refusal, repellent action, also have certain stomach toxicity, stifling and systemic action, be applicable to the harmful mite of all kinds of crop, also have good preventive effect to homoptera pest.Amitraz uses drug effect high when high temperature becomes a fine day, in recommendation concentration range, to cotton, oranges and tangerines, tea tree and apple without poisoning, to natural enemy and honeybee safer.
Beneficial effect: for the preparation of suspending agent, key issue is the selection of various assistant types and the proportioning of content.Only have and select suitable assistant types and suitable ratio, just can produce the suspending agent of stability and high efficiency.The present invention is by selecting suitable auxiliary material, spiral shell mite ester and a certain amount of active component that other have insecticidal activity also carry out composite by synergist, obtained suspending agent outward appearance is Uniform Flow phase suspension, through quality testing, every quality index all meets the requirements, heat storage, cold storage all meets the requirements, and by increasing another active substance and synergist in suspending agent manufacturing process, significantly expand desinsection, kill mite spectrum, effective raising control efficiency, increase the deposition of active ingredient on target (plant or insect), avoid a large amount of losses of active ingredient, improve the availability of active ingredient, reduce field rotating medicine amount, the pesticide resistance contributing to overcoming or postponing evil mite produces, effective minimizing environmental pollution and residue of pesticide.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, the following specific embodiment of the present invention is described, but the present invention is limited to absolutely not these examples.The following stated is only the good embodiment of the present invention, only for explaining the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with appended claims.
Embodiment 1
In the beaker of 250ml, add 88.2 grams of water, slowly add 1.8 grams of xanthans, fully stir and soak, preparation stabilizing solution.24 grams of polyoxyethylene oleic acid esters (fatty acid ethylene oxide addition product class dispersant) are added in 1L beaker, 12 grams of EEA (ethylene-ethyl acrylate copolymer), 9 grams of RH-208 (silicone based), 3 grams of organic silicone defoamers, 24 grams of ethylene glycol, 1.8 grams of Sodium Benzoates, 157.9 grams of water.After stirring, add the spiral shell mite ester of 183.6 gram 98%, the dicofol of 94.7 gram 95%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 97.2%, suspensibility 94.6% after heat storage, suspensibility 96.3% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces RH-208 and dicofol to prepare; 1b is called with the suspending agent that the water of equal weight replaces RH-208 to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 1 ~ table 3.
Citrus red mite field trial prevented and treated by table 1
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 64.8 | 75.7 | 84.8 |
| 1b | 80.1 | 90.7 | 91.9 |
| 1c | 84.5 | 93.8 | 95.4 |
Phyllocoptruta oleivora field trial prevented and treated by table 2
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 73.3 | 79.1 | 84.8 |
| 1b | 80.4 | 87.3 | 90.7 |
| 1c | 84.2 | 94.1 | 97.4 |
Panonychus citri field trial prevented and treated by table 3
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 58.8 | 71.9 | 83.3 |
| 1b | 78.6 | 88.1 | 92.5 |
| 1c | 86.2 | 93.7 | 96.9 |
As can be seen from result of the test, the synergistic effect of active substance dicofol and synergist (RH-208) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 2
In the beaker of 250ml, add 88.2 grams of water, slowly add 1.8 grams of xanthans, fully stir and soak, preparation stabilizing solution.36 grams of loose esters acid soap (polycarboxylic acid salt's dispersant) are added, 15 grams of nekals, 15 grams of maleic diethylesters, 2.4 grams of organic silicone defoamers, 30 grams of ethylene glycol, 1.8 gram calorie pines, 164.9 grams of water in 1L beaker.After stirring, add the spiral shell mite ester of 153.1 gram 98%, the Hexythiazox of 91.8 gram 98%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 95.5%, suspensibility 93.6% after heat storage, suspensibility 94.1% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces maleic diethylester and Hexythiazox to prepare; 1b is called with the suspending agent that the water of equal weight replaces maleic diethylester to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 4 ~ table 6.
Citrus red mite field trial prevented and treated by table 4
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 65.7 | 77.3 | 84.6 |
| 1b | 71.4 | 82.1 | 91.8 |
| 1c | 76.7 | 89.1 | 94.6 |
Phyllocoptruta oleivora field trial prevented and treated by table 5
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 72.6 | 79.3 | 85.2 |
| 1b | 79.4 | 89.8 | 91.3 |
| 1c | 85.1 | 93.3 | 94.7 |
Panonychus citri field trial prevented and treated by table 6
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 55.6 | 71.4 | 82.3 |
| 1b | 74.1 | 86.5 | 91.4 |
| 1c | 81.1 | 88.6 | 93.8 |
As can be seen from result of the test, the synergistic effect of active substance Hexythiazox and synergist (maleic diethylester) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 3
In the beaker of 250ml, add 88.2 grams of water, slowly add 1.8 grams of xanthans, fully stir and soak, preparation stabilizing solution.30 grams of hexadecyltrimethylammonium chlorides (quaternary ammonium salt dispersant) are added, 15 grams of lauryl sodium sulfate, 12 grams of maleic diethylesters, 1.8 grams of organic silicone defoamers, 24 grams of propane diols, 1.8 grams of Sodium Benzoates, 240.4 grams of water in 1L beaker.After stirring, add the spiral shell mite ester of 122.5 gram 98%, the second worm nitrile of 62.5 gram 96%, puts into high-speed shearing machine and shears, after forming even suspension, to pour in 1L use for laboratory vertical grinding machine sand milling into 2 hours, obtain sand milling liquid, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 94.4%, suspensibility 91.7% after heat storage, suspensibility 93.8% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces maleic diethylester and second worm nitrile to prepare; 1b is called with the suspending agent that the water of equal weight replaces maleic diethylester to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 7 ~ table 9.
Citrus red mite field trial prevented and treated by table 7
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 61.4 | 76.8 | 85.3 |
| 1b | 77.8 | 85.5 | 93.5 |
| 1c | 80.3 | 91.7 | 96.0 |
Phyllocoptruta oleivora field trial prevented and treated by table 8
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 71.9 | 75.6 | 81.3 |
| 1b | 76.5 | 84.9 | 90.5 |
| 1c | 83.7 | 89.4 | 95.1 |
Panonychus citri field trial prevented and treated by table 9
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 59.1 | 72.7 | 83.0 |
| 1b | 77.4 | 85.9 | 93.9 |
| 1c | 84.6 | 90.4 | 95.3 |
As can be seen from result of the test, the synergistic effect of active substance second worm nitrile and synergist (maleic diethylester) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 4
In the beaker of 250ml, add 147 grams of water, slowly add 3 grams of aluminium-magnesium silicates, fully stir and soak, preparation stabilizing solution.18 grams of diisooctyl succinate sulfonate (Sulfonates dispersant) are added, 12 grams of neopelexes, 12 grams of propyl isomes, 1.8 grams of organic silicone defoamers, 24 grams of glycerine, 1.8 gram calorie pines, 225.4 grams of water in 1L beaker.After stirring, add the spiral shell mite ester of 91.8 gram 98%, single carbonamidine of 63.2 gram 95%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 96.8%, suspensibility 95.7% after heat storage, suspensibility 96.1% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces propyl isome and single carbonamidine to prepare; 1b is called with the suspending agent that the water of equal weight replaces propyl isome to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 10 ~ table 12.
Citrus red mite field trial prevented and treated by table 10
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 59.8 | 74.4 | 82.1 |
| 1b | 78.5 | 88.3 | 89.9 |
| 1c | 81.7 | 91.4 | 93.8 |
Phyllocoptruta oleivora field trial prevented and treated by table 11
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 70.3 | 76.6 | 83.5 |
| 1b | 75.7 | 87.2 | 92.4 |
| 1c | 82.8 | 91.4 | 95.6 |
Panonychus citri field trial prevented and treated by table 12
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 59.4 | 70.1 | 84.7 |
| 1b | 77.3 | 86.8 | 93.3 |
| 1c | 82.5 | 92.1 | 96.9 |
As can be seen from result of the test, the synergistic effect of active substance list carbonamidine and synergist (propyl isome) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 5
In the beaker of 250ml, add 147 grams of water, slowly add 3 grams of aluminium-magnesium silicates, fully stir and soak, preparation stabilizing solution.24 grams of spermaceti alcohol radical sodium sulphate (Sulfates dispersant) are added, 9 grams of Sodium Polyacrylates, 18 grams of NHS (natural oil lipid non-ionic surface active agent) in 1L beaker, 1.8 grams of organic silicone defoamers, 1.5 gram calorie pines, 30 grams of propane diols, 181 grams of water.After stirring, add the spiral shell mite ester of 153.1 gram 98%, the Amitraz of 31.6 gram 95%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 1.5 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 94.2%, suspensibility 91.6% after heat storage, suspensibility 93.9% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces NHS and Amitraz to prepare; 1b is called with the suspending agent that the water of equal weight replaces NHS to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 13 ~ table 15.
Citrus red mite field trial prevented and treated by table 13
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 59.8 | 74.4 | 82.1 |
| 1b | 78.5 | 88.3 | 89.9 |
| 1c | 81.7 | 91.4 | 95.8 |
Phyllocoptruta oleivora field trial prevented and treated by table 14
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 74.8 | 80.1 | 84.7 |
| 1b | 77.6 | 88.7 | 91.4 |
| 1c | 84.1 | 90.9 | 95.7 |
Panonychus citri field trial prevented and treated by table 15
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 61.7 | 72.1 | 82.4 |
| 1b | 73.7 | 85.9 | 94.1 |
| 1c | 82.3 | 92.6 | 95.5 |
As can be seen from result of the test, the synergistic effect of active substance Amitraz and synergist (NHS) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 6
In the beaker of 250ml, add 88.2 grams of water, slowly add 1.8 grams of xanthans, fully stir and soak, preparation stabilizing solution.30 grams of OPEO sulphate (Sulfates dispersant) are added in 1L beaker, 12 grams of AEO-3 (fatty alcohol and ethylene oxide condensate), 15 grams of NHS (natural oil lipid non-ionic surface active agent), 1.8 grams of organic silicone defoamers, 30 grams of ethylene glycol, 1.5 grams of Sodium Benzoates, 170 grams of water.After stirring, add the spiral shell mite ester of 91.8 gram 98%, the dicofol of 157.9 gram 95%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 93.1%, suspensibility 91.5% after heat storage, suspensibility 93.0% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces NHS and dicofol to prepare; 1b is called with the suspending agent that the water of equal weight replaces NHS to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 16 ~ table 18.
Citrus red mite field trial prevented and treated by table 16
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 60.4 | 71.8 | 79.7 |
| 1b | 82.2 | 91.5 | 90.1 |
| 1c | 85.1 | 93.5 | 94.6 |
Phyllocoptruta oleivora field trial prevented and treated by table 17
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 69.9 | 74.1 | 80.1 |
| 1b | 83.4 | 85.8 | 91.1 |
| 1c | 83.7 | 92.1 | 95.2 |
Panonychus citri field trial prevented and treated by table 18
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 55.4 | 69.7 | 78.1 |
| 1b | 79.3 | 87.3 | 91.8 |
| 1c | 88.1 | 92.6 | 96.4 |
As can be seen from result of the test, the synergistic effect of active substance dicofol and synergist (NHS) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 7
In the beaker of 250ml, add 88.2 grams of water, slowly add 1.8 grams of xanthans, fully stir and soak, preparation stabilizing solution.36 grams of ethoxylated dodecyl alcohols (aliphatic alcohols polyethenoxy ether class dispersant) are added, 12 grams of nekals, 15 grams of RH-208 (silicone based) in 1L beaker, 2.4 grams of organic silicone defoamers, 24 grams of ethylene glycol, 1.8 grams of Sodium Benzoates, 112.7 grams of water.After stirring, add the spiral shell mite ester of 91.8 gram 98%, the Hexythiazox of 214.3 gram 98%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 95.2%, suspensibility 93.8% after heat storage, suspensibility 94.5% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 1a with the suspending agent that the water of equal weight replaces RH-208 and Hexythiazox to prepare; 1b is called with the suspending agent that the water of equal weight replaces RH-208 to prepare; The suspending agent prepared according to above-mentioned preparation process is called 1c.Experimental result is for shown in table 19 ~ table 21.
Citrus red mite field trial prevented and treated by table 19
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 63.8 | 75.6 | 85.1 |
| 1b | 72.2 | 81.9 | 90.5 |
| 1c | 74.1 | 88.4 | 95.1 |
Phyllocoptruta oleivora field trial prevented and treated by table 20
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 66.1 | 78.8 | 83.9 |
| 1b | 78.5 | 86.3 | 91.5 |
| 1c | 82.7 | 92.9 | 93.5 |
Panonychus citri field trial prevented and treated by table 21
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 50.2 | 65.8 | 76.9 |
| 1b | 73.1 | 85.4 | 90.4 |
| 1c | 79.9 | 89.1 | 93.3 |
As can be seen from result of the test, the synergistic effect of active substance Hexythiazox and synergist (RH-208) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
Embodiment 8
In the beaker of 250ml, add 147 grams of water, slowly add 1.5 grams of white carbons and 1.5 grams of bentonites, fully stir and soak, preparation stabilizing solution.24 grams of benzyl naphthalene sulfonic formaldehyde condensation compounds (Sulfonates) are added, 9 grams of Sodium Polyacrylates, 9 grams of NHS (natural oil lipid non-ionic surface active agent) in 1L beaker, 1.8 grams of organic silicone defoamers, 30 grams of ethylene glycol, 1.8 gram calorie pines, 188.2 grams of water.After stirring, add the spiral shell mite ester of 61.2 gram 98%, the second worm nitrile of 125 gram 96%, put into high-speed shearing machine to shear, after forming even suspension, pour sand milling in 1L use for laboratory vertical grinding machine into and obtain sand milling liquid in 2 hours, then the stabilizing solution configured is joined ground sand milling liquid, obtained suspending agent normal temperature suspensibility 93.9%, suspensibility 92.7% after heat storage, suspensibility 93.5% after cold storage.
The comparative test of drug effect: in above-mentioned preparation process, is called 8a with the suspending agent that the water of equal weight replaces NHS and second worm nitrile to prepare; 8b is called with the suspending agent that the water of equal weight replaces NHS to prepare; The suspending agent prepared according to above-mentioned preparation process is called 8c.Experimental result is for shown in table 22 ~ table 24.
Citrus red mite field trial prevented and treated by table 22
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 56.5 | 70.1 | 79.7 |
| 1b | 76.1 | 84.1 | 89.9 |
| 1c | 79.4 | 84.2 | 91.4 |
Phyllocoptruta oleivora field trial prevented and treated by table 23
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 60.5 | 68.7 | 76.2 |
| 1b | 72.4 | 80.8 | 87.6 |
| 1c | 79.8 | 85.2 | 91.6 |
Panonychus citri field trial prevented and treated by table 24
| Medicament | 1 day Revision insect recluced rate (%) | 7 days Revision insect recluced rate (%) | 15 days Revision insect recluced rate (%) |
| 1a | 53.4 | 67.7 | 78.9 |
| 1b | 70.3 | 78.4 | 87.1 |
| 1c | 80.5 | 84.9 | 90.9 |
As can be seen from result of the test, the synergistic effect of active substance second worm nitrile and synergist (NHS) is obvious, is all significantly improved to the quick-acting of control citrus red mite, phyllocoptruta oleivora and panonychus citri and lasting effect.
As can be seen from above-mentioned data, adding of another active substance and synergist, Revision insect recluced rate is significantly improved, illustrates that the drug effect of invention formulation has obvious raising.
Invention formulation has good preventive effect to two spotted spider mite, yellow spider, Xiu Pi lice, yellow tea mite, Tetranychus cinnabarinus, Panonychus citri and Tetranychus urticae etc., higher to ovum, larva, adult preventive effect, has good quick-acting and lasting effect.
The present invention adds another active substance and Novel synergistic agent in suspending agent manufacturing process, the adding of another active substance make the activity of agricultural chemicals and kill mite, insecticidal effect has significant synergistic effect, quick-acting is high, lasting effect is long, can effectively slow down drug-fast generation, synergist then makes the deposition of active ingredient on target (plant or insect) significantly improve, reduce the loss of active ingredient, improve the availability of active ingredient, reduce the usage amount of product.
Claims (10)
1. the suspending agent containing spiral shell mite ester, it is characterized in that, described suspending agent comprises the component of following mass percent: spiral shell mite ester 5% ~ 35%, active substance A 1 ~ 40%, dispersant 2% ~ 6%, wetting agent 1% ~ 3%, synergist 0.1% ~ 3%, defoamer 0.1 ~ 0.5%, thickener 0.1% ~ 1%, preservative 0.1% ~ 0.5%, the water of antifreezing agent 3% ~ 6% and surplus.
2. the suspending agent of spiral shell mite ester according to claim 1, is characterized in that, described synergist is any one or a few in silicone based, natural oil lipid non-ionic surface active agent, maleic diethylester and propyl isome.
3. the suspending agent of spiral shell mite ester according to claim 1, is characterized in that, described active substance A is any one in dicofol, Hexythiazox, second worm nitrile, single carbonamidine and Amitraz.
4. the suspending agent containing spiral shell mite ester according to claim 1, it is characterized in that, described dispersant is any one or a few in polycarboxylic acid salt's dispersant, Sulfonates dispersant, Sulfates dispersant, quaternary ammonium salt dispersant, fatty acid ethylene oxide addition product and aliphatic alcohols APEO.
5. the suspending agent containing spiral shell mite ester according to claim 1, it is characterized in that, described wetting agent is any one or a few in lauryl sodium sulfate, neopelex, polyacrylate, acrylate copolymer, fatty alcohol and ethylene oxide condensate and Fluhyzon Barbiturates.
6. the suspending agent containing spiral shell mite ester according to claim 1, is characterized in that, described thickener is any one or a few in xanthans, aluminium-magnesium silicate, bentonite and white carbon.
7. the suspending agent containing spiral shell mite ester according to claim 1, is characterized in that, described antifreezing agent is any one or a few in ethylene glycol, propane diols and glycerine.
8. the suspending agent containing spiral shell mite ester according to claim 1, it is characterized in that, described defoamer is organic silicone defoamer.
9. the suspending agent containing spiral shell mite ester according to claim 1, is characterized in that, described preservative is any one or a few in Sodium Benzoate, Kathon CG.
10. contain the preparation method of the suspending agent of spiral shell mite ester described in claim 1, it is characterized in that, comprise the steps: previously prepared for the thickener of formula ratio one-tenth mass concentration to be that the aqueous solution of 2 ~ 4wt% is as stabilizing solution; The dispersant of formula ratio, wetting agent, synergist, defoamer, preservative and antifreezing agent are dissolved in remaining water, after stirring, add spiral shell mite ester and the active substance A of formula ratio, then under high speed shear condition, form uniform suspension; Scattered suspension is transferred in sand mill and carries out the average grain diameter of wet grinding to spiral shell mite ester particle at 2 ~ 3 microns; Previously prepared good stabilizing solution is joined also homogenize in ground sand milling liquid.
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Application publication date: 20150311 |