CN114159383A - External traditional Chinese medicine for treating chronic refractory wound and preparation method thereof - Google Patents

External traditional Chinese medicine for treating chronic refractory wound and preparation method thereof Download PDF

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CN114159383A
CN114159383A CN202210029756.3A CN202210029756A CN114159383A CN 114159383 A CN114159383 A CN 114159383A CN 202210029756 A CN202210029756 A CN 202210029756A CN 114159383 A CN114159383 A CN 114159383A
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chinese medicine
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calamine
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王小平
王元君
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12Magnesium silicate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

The invention relates to an external traditional Chinese medicine for treating chronic refractory wound and a preparation method thereof, wherein the external traditional Chinese medicine is prepared from the following raw materials in parts by weight: 25-50 parts of gypsum, 3-7 parts of borneol, 20-35 parts of calamine, 15-25 parts of angelica dahurica, 10-15 parts of talcum, 5-15 parts of dandelion and 5-15 parts of herba scutellariae barbatae. Calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment. The invention has the effects of clearing away heat and toxic material, resisting bacteria and diminishing inflammation, removing necrosis and promoting granulation, astringing dampness and healing sore, and reducing swelling and relieving pain, and has good treatment effect on various burn wounds, diabetic feet, pressure sore and various surgical chronic intractable sores and ulcers.

Description

External traditional Chinese medicine for treating chronic refractory wound and preparation method thereof
Technical Field
The invention relates to the field of medicines for treating refractory wounds, in particular to an external traditional Chinese medicine for treating chronic refractory wounds and a preparation method thereof.
Background
With the rapid development of socioeconomic, the disease spectrum is greatly changed, and the types of common diseases are increased. The proportion of people suffering from various difficult-to-heal wound diseases is getting larger and larger. The number of patients with wounds caused by various diseases is increasing, and particularly the difficult-to-heal wounds caused by burns, wounds, neurotrophic ulcers, postoperative wound infections, diabetic feet, bedsores, sinus tracts and the like are rising year by year, so that the life quality of the patients is reduced, and great pain is brought to the mind and body of the patients. However, the kinds of wound surfaces caused by the diseases are various, the treatment difficulty is large, no effective solution exists, and the wound surface patients cannot be effectively treated, which becomes an urgent problem in the medical field.
At present, various therapeutic drugs are available on the market, but the drugs have the problems of poor curative effect and great side effect. The medicines for treating chronic intractable wound surfaces sold in the market often have anaphylactic reaction, and the treatment effect is not obvious and slow.
Therefore, an external traditional Chinese medicine for treating chronic refractory wound and a preparation method thereof become technical problems to be urgently solved by technical personnel in the field.
Disclosure of Invention
Aiming at the defects of the existing products, the invention provides the external traditional Chinese medicine for treating chronic refractory wound surfaces, which can effectively reduce anaphylactic reaction, is easy to absorb and promote healing, so as to relieve infection and early healing, promote skin growth and effectively avoid canceration.
In order to achieve the purpose, the invention adopts the following technical scheme: an external traditional Chinese medicine for treating chronic refractory wounds and a preparation method thereof comprise, by weight, 25-50 parts of gypsum, 3-7 parts of borneol, 20-35 parts of calamine, 15-25 parts of radix angelicae, 10-15 parts of talc, 5-15 parts of dandelion and 5-15 parts of herba scutellariae barbatae.
The health-care wine further comprises the following components, by weight, 25 parts of gypsum, 3 parts of borneol, 20 parts of calamine, 15 parts of angelica dahurica, 10 parts of talc, 5 parts of dandelion and 5 parts of herba scutellariae barbatae.
The health-care wine further comprises the following components, by weight, 35 parts of gypsum, 5 parts of borneol, 25 parts of calamine, 20 parts of angelica dahurica, 12 parts of talc, 10 parts of dandelion and 10 parts of herba scutellariae barbatae.
Further comprises the following components, by weight, 50 parts of gypsum, 7 parts of borneol, 35 parts of calamine, 25 parts of angelica dahurica, 15 parts of talcum, 15 parts of dandelion and 15 parts of herba scutellariae barbatae.
Further, the preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment.
Further, the traditional Chinese medicine in the step (2) is ground into powder which is obtained by sieving through a 100-200-mesh sieve.
Compared with the prior art, the invention has the advantages that: the invention is based on the secret prescription handed down from ancestors for treating the pyocutaneous disease, takes the theory of traditional Chinese medicine as basic guidance and is improved by combining years of clinical experience. The ointment has the function of promoting wound healing and has good treatment effect on various burn wounds, diabetic feet, pressure sores and various surgical chronic refractory sores and ulcers. Experiments prove that the ointment has remarkable curative effects of inhibiting bacteria, diminishing inflammation, promoting tissue regeneration and healing wound on chronic refractory wound surfaces and can effectively promote wound healing. Low cost, convenient preparation and no toxic or side effect. The effective rate is more than 95% after more than 20 years of clinical verification. The combined ointment has the advantages of wide raw material sources, strict formula and definite curative effect.
The invention adopts pure traditional Chinese medicine support, has small toxic and side effects, treats both principal and secondary aspects of diseases, is safe and effective, has obvious curative effect and obviously improves clinical symptoms.
Detailed Description
The present invention is described in further detail below.
The invention provides an external traditional Chinese medicine for treating chronic refractory wound surfaces and a preparation method thereof in specific implementation, and the external traditional Chinese medicine comprises, by weight, 25-50 parts of gypsum, 3-7 parts of borneol, 20-35 parts of calamine, 15-25 parts of angelica dahurica, 10-15 parts of talc, 5-15 parts of dandelion and 5-15 parts of herba scutellariae barbatae.
The first embodiment is as follows: an external traditional Chinese medicine for treating chronic refractory wound comprises, by weight, 25 parts of gypsum, 3 parts of borneol, 20 parts of calamine, 15 parts of angelica dahurica, 10 parts of talc, 5 parts of dandelion and 5 parts of herba scutellariae barbatae.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment.
Example two: an external traditional Chinese medicine for treating chronic refractory wound comprises, by weight, 35 parts of gypsum, 5 parts of borneol, 25 parts of calamine, 20 parts of angelica dahurica, 12 parts of talc, 10 parts of dandelion and 10 parts of herba scutellariae barbatae.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment.
Example three: an external traditional Chinese medicine for treating chronic refractory wound comprises, by weight, 50 parts of gypsum, 7 parts of borneol, 35 parts of calamine, 25 parts of angelica dahurica, 15 parts of talc, 15 parts of dandelion and 15 parts of herba scutellariae barbatae.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment.
As a further elaboration of the invention, the traditional Chinese medicine in the step (2) is crushed into powder which is sieved by a sieve of 100-200 meshes.
As further elaboration of the invention, the formula of the invention has been used in clinical thousands of cases, which proves that the invention has definite curative effect, and the raw materials used in the formula are rich in medicine sources and easy to obtain. The attributes and effects of the Chinese herbal medicine raw materials in the formula are as follows:
gypsum: clear heat and remove toxicity, and then calcined to generate muscles and heal wound.
Borneol: relieving swelling and pain.
Calamine: astringe dampness and heal wound, it is indicated for unhealing ulcer.
Radix angelicae: clear heat and remove toxicity, resolve swelling and expel pus, treat sore and ulcer with swelling and pain.
Talc: it is used for treating skin wet rot.
Dandelion: has effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, relieving inflammation, and relieving itching.
Barbed skullcap herb: clearing away heat and toxic material, promoting blood circulation, relieving pain, eliminating swelling, and relieving itching.
The components are refined and compact; monarch, minister, assistant and guide, complement each other. The monarch drug gypsum has the efficacies of clearing away heat and toxic material, promoting granulation and healing sore, and is the main drug of the recipe for treating various diseases. The ministerial drug borneol has good effects of relieving swelling and pain, and enhancing the effect of the monarch drug in clearing heat and promoting granulation, and the calamine and the talc have the effects of astringing dampness and healing sore and are used for treating skin damp and ulcer. The angelica dahurica, the dandelion and the barbed skullcap herb have the effects of clearing away heat and toxic materials, inhibiting bacteria, diminishing inflammation, reducing swelling and relieving itching, and are used as adjuvant drugs for helping monarch drugs to heal sores and promote granulation. Vaseline is used as a carrier of each monarch drug, can continuously act, promotes the absorption of the drugs and is used as a conductant drug. The medicines are compatible, the curative effect is obvious, and the traditional Chinese medicine is a good prescription for treating burns and scalds and various chronic refractory wounds.
The pure traditional Chinese medicine external ointment developed and developed by more than twenty years of clinical practice can successively cure thousands of diseases such as burns, scalds, electric injuries, chemical burns, frostbite, trauma, unhealed operation incision, various acute and chronic ulcers, bedsores, diabetes mellitus complicated with skin soft tissue ulceration, furuncle pyogenic infections and the like, has the advantages of less pain, no need of skin grafting, short treatment course, good healing effect, no toxic or side effect, low treatment cost and the like, and particularly has obvious curative effect on the diseases such as burn and scald residual wound surfaces, bedsores, diabetes mellitus complicated with skin soft tissue ulceration and various chronic ulcers which are not suitable for operation treatment but do not have special effect medicines clinically at present. Has obvious and reliable curative effect on the aspects of relieving pain and diminishing inflammation of wound surfaces, preventing and eliminating infection, removing necrotic tissues, regenerating new tissues, preventing and reducing the formation of scar tissues and the like. Is a safe and effective good medicine for creating a good wound healing environment, preventing wound infection, easing pain, diminishing inflammation and promoting wound healing.
The characteristics of the medicine are as follows:
1. has good analgesic effect, quick action, and long lasting time.
2. Good anti-inflammatory effect of the wound surface and obvious reduction of exudation of the wound surface.
3. Effectively preventing and eliminating wound infection and eliminating wound necrotic tissue.
4. Effectively improves the microenvironment of the wound surface, promotes the regeneration of the new tissue of the wound surface and obviously shortens the healing time of the wound surface.
5. The wound surface is smooth and the scar is slightly hyperplastic.
6. The ointment is soft, has no irritation, and does not stick to wound surface.
7. The use is simple and convenient, and is not limited by treatment environment.
The invention and its embodiments have been described above, without this being limitative. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (6)

1. An external traditional Chinese medicine for treating chronic refractory wound surfaces is characterized in that: the external wall decoration material comprises, by weight, 25-50 parts of gypsum, 3-7 parts of borneol, 20-35 parts of calamine, 15-25 parts of radix angelicae, 10-15 parts of talc, 5-15 parts of dandelion and 5-15 parts of herba scutellariae barbatae.
2. The external traditional Chinese medicine for treating chronic refractory wounds as claimed in claim 1, is characterized in that: the external plaster comprises, by weight, 25 parts of gypsum, 3 parts of borneol, 20 parts of calamine, 15 parts of angelica dahurica, 10 parts of talc, 5 parts of dandelion and 5 parts of herba scutellariae barbatae.
3. The external traditional Chinese medicine for treating chronic refractory wounds as claimed in claim 1, is characterized in that: the traditional Chinese medicine composition comprises, by weight, 35 parts of gypsum, 5 parts of borneol, 25 parts of calamine, 20 parts of angelica dahurica, 12 parts of talc, 10 parts of dandelion and 10 parts of herba scutellariae barbatae.
4. The external traditional Chinese medicine for treating chronic refractory wounds as claimed in claim 1, is characterized in that: the traditional Chinese medicine composition comprises, by weight, 50 parts of gypsum, 7 parts of borneol, 35 parts of calamine, 25 parts of angelica dahurica, 15 parts of talc, 15 parts of dandelion and 15 parts of herba scutellariae barbatae.
5. The externally applied traditional Chinese medicine for treating chronic refractory wounds and the preparation method thereof according to claim 1 are characterized in that: the preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight;
(2) calcining the traditional Chinese medicine gypsum and the calamine respectively, then crushing the gypsum and the calamine into 100-mesh 200-mesh fine powder for standby, crushing the borneol and the talcum into 100-mesh 200-mesh fine powder, extracting the angelica dahurica, the dandelion and the scutellaria barbata with water or 60-90% ethanol to obtain an extract, drying the extract to prepare 100-mesh 200-mesh fine powder, putting all the medicinal powder together, uniformly mixing, adding vaseline and preparing into ointment.
6. The external traditional Chinese medicine for treating chronic refractory wounds and the preparation method thereof according to claim 5 are characterized in that: and (3) crushing the traditional Chinese medicine in the step (2) into powder which is obtained by sieving the powder with a 100-200-mesh sieve.
CN202210029756.3A 2022-01-12 2022-01-12 External traditional Chinese medicine for treating chronic refractory wound and preparation method thereof Pending CN114159383A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641290A (en) * 2012-04-16 2012-08-22 陈维香 External medicinal powder for treating bedsore
CN108186840A (en) * 2018-03-22 2018-06-22 邓丽丽 A kind of wound for the treatment of accumulates Chinese medicine ointment of malicious rotten routed pain and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641290A (en) * 2012-04-16 2012-08-22 陈维香 External medicinal powder for treating bedsore
CN108186840A (en) * 2018-03-22 2018-06-22 邓丽丽 A kind of wound for the treatment of accumulates Chinese medicine ointment of malicious rotten routed pain and preparation method thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
姜张烨等: "王小平传承顾氏外科理论治疗下肢慢性溃疡经验总结", 《陕西中医》, vol. 42, no. 3, pages 366 - 368 *
江先胜: "中药洗剂对肛瘘术后创面恢复的影响Meta分析及用药规律总结", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》, no. 2, pages 056 - 850 *
王松等: "基于数据挖掘探讨中药外敷促进肛瘘术后创面愈合的用药规律", 《中医临床研究》, vol. 13, no. 29, pages 38 - 41 *
袁会娈等: "二黄三石散外用治疗Ⅲ期褥疮的疗效观察", 《中国中医药》, vol. 7, no. 6, pages 110 *
高翔等: "基于PI3K/Akt信号轴探究三石生新膏对大鼠压疮面愈合的影响", 《中国药理学通报》, vol. 37, no. 9, pages 1299 - 1304 *

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