CN114159365A - 一种抗菌牙膏 - Google Patents
一种抗菌牙膏 Download PDFInfo
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- CN114159365A CN114159365A CN202111604076.1A CN202111604076A CN114159365A CN 114159365 A CN114159365 A CN 114159365A CN 202111604076 A CN202111604076 A CN 202111604076A CN 114159365 A CN114159365 A CN 114159365A
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- extract
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- toothpaste
- liquorice
- honeysuckle stem
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Abstract
本发明公开了一种抗菌牙膏，属于日化领域。该牙膏中所含的功效成分由娑罗子提取物、忍冬藤提取物和甘草提取物组成，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为8‑20：2‑10：0.5‑5。本发明提供的抗菌牙膏以中草药为功效成份，对口腔常见的致病菌如大肠杆菌、金黄色葡萄球菌、牙龈卟啉单胞菌、幽门螺杆菌、变异链球菌有较好的抑制作用，具有较高的抑菌活力和抑菌谱,能应用于由这些致病菌所导致的口腔炎、牙周炎、龋齿、口臭等口腔护理。
Description
技术领域
本发明涉及一种以娑罗子提取物为主要成份的抗菌牙膏，属于日化领域。
背景技术
娑罗子为七叶树科植物七叶树AesculuschinesisBge.的干燥成熟种子，是我国一种常用中药材，其性甘，温，归肝、胃经。具有宽中理气，杀虫等功用，中医主要用于胃寒作痛，脘腹胀满，疳积虫痛，疟疾，痢疾等治疗。娑罗子的主要成分为七叶皂苷，具有抗炎作用、消肿胀、抗渗出、抗肿瘤等多种药理作用，是我国一种非常宝贵的天然药物原料。
目前，娑罗子在日化领域也有得到广泛应用，已有将其用于制备沐浴露、洗发露、霜膏、面膜等日化用品的报导，主要用于保湿、舒缓皮肤，而在牙膏方面的应用还很少。CN107753331A公开了一种含天师栗提取物的中药保健牙膏，主要发挥抗炎、抗渗出、抗过敏等作用。目前，将娑罗子用于抗菌牙膏的文献尚未见报导。
发明内容
本发明提供一种以娑罗子提取物为主要功效成份的抗菌牙膏，其目的之一是为了扩大娑罗子的应用范围尤其是在日化领域的应用范围，从而为更好利用我国这一特有天然药物资源奠定基础，其目的之二是为口腔健康的护理提供更好的产品。
上述目的是通过以下技术方案实现的：
一种抗菌牙膏，该牙膏中所含的功效成分由娑罗子提取物、忍冬藤提取物和甘草提取物组成，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为8-20：2-10：0.5-5。
优选地，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为10-15：3-8：1-3。
进一步优选地，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为12：5：2。经抑菌效果比较，该比例相比其它比例具有更好的抑菌活力，尤其是对变异链球菌的抑制活力更高。
优选地，该牙膏中所含的基质成分包括摩擦剂、保湿剂、增稠剂、发泡剂、防腐剂、芳香剂、甜味剂和溶剂，各基质成分占牙膏的重量比如下：
其中，所述摩擦剂为羟基磷灰石。
其中，所述保湿剂为木糖醇和/或聚乙二醇。
其中，所述增稠剂为卡波姆和/或阿拉伯胶。
其中，所述发泡剂为月桂酰肌氨酸钠。
所述防腐剂、芳香剂、甜味剂为本领域常规添加剂，可根据需要选择使用。
本发明以娑罗子提取物、忍冬藤提取物和甘草提取物作为抗菌牙膏的功效成分，其中，娑罗子提取物富含皂苷类成份，已有文献表明七叶皂苷具有较强的抑菌作用，而娑罗子提取物中所含有的多糖、油酸等成份也具有一定抑菌能力，因此本发明将其作为主要功效成份。忍冬藤为忍冬科植物忍冬(LonicerajaponicaThunb)干燥藤茎，研究表明其与金银花具有相近的化学成分和药理活性，是一种常用的清热解毒中药。甘草富含黄酮类物质，对金黄色葡萄球菌、芽孢杆菌、酵母菌、真菌、链球菌等具有抑制作用，也是一种常用的清热解毒中药。本发明以忍冬藤提取物和甘草提取物为辅助成份，主要是为了增加娑罗子提取物在口腔抑菌方面的活性和抑菌谱。
本发明的有益效果是：
(1)本发明提供的抗菌牙膏以中草药为功效成份，对口腔常见的致病菌如大肠杆菌、金黄色葡萄球菌、牙龈卟啉单胞菌、幽门螺杆菌、变异链球菌有较好的抑制作用，具有较高的抑菌活力和抑菌谱，能应用于由这些致病菌所导致的口腔炎、牙周炎、龋齿、口臭等口腔护理。
(2)本发明扩大了娑罗子在日化领域的应用范围，从而为更好利用我国这一特有的天然药物资源奠定了基础，同时也为企业发展提供了新动力和增长点。
(3)本发明所使用的牙膏基质配方是经过精心挑选和严密试验而得到，使用该基质制得的中草药牙膏不仅色泽均匀，而且具有较好的稳定性和货架期，储藏过程中不会发生气胀、分水等现象，使用过程中发泡力、颗粒感好，附着力、扩散性强，而且口齿清新，余味悠长，与市场同类产品相比具有很强的竞争力。
具体实施方式
下面结合具体实施例对本发明进行详细说明。
实施例1
一种中草药牙膏，配方表如下：
制备工艺：
1)将卡波姆、阿拉伯胶加入到混合罐中并用少量去离子水润湿；
2)将娑罗子提取物、忍冬藤提取物、甘草提取物、木糖醇、聚乙二醇400、尼泊金甲酯、糖精钠用剩余去离子水溶解后加入到上述混合罐中，搅拌1.5h，制成胶体；
3)将胶体转入到捏合机，加入羟基磷灰石、月桂酰肌氨酸钠、薄荷精油，捏合均匀，制成膏体；
4)将膏体转入到胶体磨研磨均质，真空脱气后陈化2h，进行灌装。
实施例2抑菌试验
参考QB/T 2738-2012评价方法对组合物的抗菌抑菌效果进行测试，测试细菌为大肠杆菌、金黄色葡萄球菌、牙龈卟啉单胞菌、幽门螺杆菌、变异链球菌。其中，幽门螺杆菌为口臭的可疑致病菌，大肠杆菌、金黄色葡萄球菌为口腔化脓性炎症相关致病菌，牙龈卟啉单胞菌为牙周炎症和口臭的可疑致病菌，变异链球菌是龋齿最主要的病原菌。
1)试验菌悬液的制备
①取冻干菌种，以毛细吸管加入适量营养肉汤，轻柔吹吸数次，使菌种融化分散。取含5.0mL营养肉汤培养基的试管，滴入少许菌种悬液，置37℃培养24h；用接种环取第1代培养的菌悬液，划线接种于营养琼脂培养基平板上，于37℃培养24h；挑取上述第2代培养物中典型菌落，接种于营养琼脂斜面，于37℃培养24h，即为第3代培养物；
②取第3代新鲜培养物，用吸管吸取3-5mL加入试管内，反复吹吸洗下菌苔，随后，用吸管将洗液移至另一无菌试管中，用电动混合器混合20s，或在手掌上震荡80次，以使细菌悬浮均匀；
③初步制成的菌悬液，粗测其含菌浓度，然后稀释至所需使用的浓度，保存在4℃冰箱内备用。
④用PBS液将试验菌悬液做适当稀释，回收菌数为1x104-9x104cfu/mL；
2)抑菌率测定
将试验样品用注射用水稀释至规定的浓度(0.01mg/ml)，然后吸取试验样品原液5.0mL放入灭菌试管中，30℃恒温5min。再吸取试验菌液0.1mL加入到含5.0mL样品原液的试管中，迅速混匀，并立即计时；作用3min后，取混合液0.5mL，加入到含4.5mL经灭菌的PBS试管中，充分混匀，放置10min后，吸取样液1mL，置于灭菌平皿内，用凉至40℃-45℃的营养琼脂培养基15mL作倾注，转动平皿，使其充分均匀，琼脂凝固后翻转平皿，37℃下培养48h后，进行活菌菌落计数并计算抑菌率。以PBS液代替试验样品，同时按以上步骤操作，作为对照。
实验重复3次，求其平均值。
表1抑菌性能测试结果
注：以上结果均为三个平行试验的平均值。样品1为娑罗子提取物、忍冬藤提取物、甘草提取物组成的组合物，重量比12：5：2；样品2为娑罗子提取物。
以上结果表明：娑罗子提取物对大肠杆菌的抑制作用最强，其次是金黄色葡萄球菌和幽门螺杆，对牙龈卟啉单胞菌也有一定抑制作用，但是对变异链球菌的抑制率很低，几乎不能抑制变异链球菌的生长。而组合物不仅对变异链球菌也具有较高的抑制率，而且还大幅提高了对金黄色葡萄球菌、牙龈卟啉单胞菌和幽门螺杆菌的抑制效果。结果表明：忍冬藤提取物和甘草提取物的添加，增加了娑罗子提取物的抑菌谱和抑菌力。
实施例3
一种中草药牙膏，配方表如下：
制备工艺：
1)将卡波姆、阿拉伯胶加入到混合罐中并用少量去离子水润湿；
2)将娑罗子提取物、忍冬藤提取物、甘草提取物、木糖醇、聚乙二醇400、尼泊金甲酯、糖精钠用剩余去离子水溶解后加入到上述混合罐中，搅拌1.5h，制成胶体；
3)将胶体转入到捏合机，加入羟基磷灰石、月桂酰肌氨酸钠、薄荷精油，捏合均匀，制成膏体；
4)将膏体转入到胶体磨研磨均质，真空脱气后陈化2h，进行灌装。
实施例4
一种中草药牙膏，配方表如下：
制备工艺：
1)将卡波姆、阿拉伯胶加入到混合罐中并用少量去离子水润湿；
2)将娑罗子提取物、忍冬藤提取物、甘草提取物、木糖醇、聚乙二醇400、尼泊金甲酯、糖精钠用剩余去离子水溶解后加入到上述混合罐中，搅拌1.5h，制成胶体；
3)将胶体转入到捏合机，加入羟基磷灰石、月桂酰肌氨酸钠、薄荷精油，捏合均匀，制成膏体；
4)将膏体转入到胶体磨研磨均质，真空脱气后陈化2h，进行灌装。
Claims (10)
1.一种抗菌牙膏，其特征在于：该牙膏中所含的功效成分由娑罗子提取物、忍冬藤提取物和甘草提取物组成，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为8-20：2-10：0.5-5。
2.如权利要求1所述的抗菌牙膏，其特征在于：所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为10-15：3-8：1-3。
3.如权利要求1所述的抗菌牙膏，其特征在于：所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为12：5：2。
4.如权利要求1-3任一项所述的抗菌牙膏，其特征在于，该牙膏中所含的基质成分包括摩擦剂、保湿剂、增稠剂、发泡剂、防腐剂、芳香剂、甜味剂和溶剂，各基质成分占牙膏的重量比如下：
5.如权利要求4所述的抗菌牙膏，其特征在于：所述摩擦剂为羟基磷灰石。
6.如权利要求4所述的抗菌牙膏，其特征在于：所述保湿剂为木糖醇和/或聚乙二醇。
7.如权利要求4所述的抗菌牙膏，其特征在于：所述增稠剂为卡波姆和/或阿拉伯胶。
8.如权利要求4所述的抗菌牙膏，其特征在于：所述发泡剂为月桂酰肌氨酸钠。
9.一种抗菌组合物，其特征在于：该抗菌组合物由娑罗子提取物、忍冬藤提取物和甘草提取物三种组成，所述娑罗子提取物、忍冬藤提取物和甘草提取物的重量比为8-20：2-10：0.5-5。
10.权利要求9所述的抗菌组合物在制备抗菌牙膏中的应用。
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