CN114129598A - 免疫病症的治疗 - Google Patents

免疫病症的治疗 Download PDF

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Publication number
CN114129598A
CN114129598A CN202111351585.8A CN202111351585A CN114129598A CN 114129598 A CN114129598 A CN 114129598A CN 202111351585 A CN202111351585 A CN 202111351585A CN 114129598 A CN114129598 A CN 114129598A
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cell
cells
stem cells
subject
ang1
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CN202111351585.8A
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Chinese (zh)
Inventor
S·伊茨库
P·西蒙斯
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Mesoblast International SARL
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Mesoblast International SARL
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Priority claimed from AU2014902194A external-priority patent/AU2014902194A0/en
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Publication of CN114129598A publication Critical patent/CN114129598A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
CN202111351585.8A 2014-06-10 2015-06-01 免疫病症的治疗 Pending CN114129598A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUAU2014902194 2014-06-10
AU2014902194A AU2014902194A0 (en) 2014-06-10 Treatment of immune disorders
AUAU2014902257 2014-06-13
AU2014902257A AU2014902257A0 (en) 2014-06-13 Treatment of immune disorders 2
CN201580030754.4A CN106659743B (zh) 2014-06-10 2015-06-01 免疫病症的治疗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580030754.4A Division CN106659743B (zh) 2014-06-10 2015-06-01 免疫病症的治疗

Publications (1)

Publication Number Publication Date
CN114129598A true CN114129598A (zh) 2022-03-04

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CN202111351585.8A Pending CN114129598A (zh) 2014-06-10 2015-06-01 免疫病症的治疗
CN201580030754.4A Active CN106659743B (zh) 2014-06-10 2015-06-01 免疫病症的治疗

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CN201580030754.4A Active CN106659743B (zh) 2014-06-10 2015-06-01 免疫病症的治疗

Country Status (9)

Country Link
US (4) US10624930B2 (cg-RX-API-DMAC7.html)
EP (2) EP3154565B1 (cg-RX-API-DMAC7.html)
JP (5) JP6800757B2 (cg-RX-API-DMAC7.html)
KR (4) KR20170007854A (cg-RX-API-DMAC7.html)
CN (2) CN114129598A (cg-RX-API-DMAC7.html)
AU (2) AU2015273799B2 (cg-RX-API-DMAC7.html)
CA (1) CA2950804C (cg-RX-API-DMAC7.html)
SG (1) SG11201609993YA (cg-RX-API-DMAC7.html)
WO (1) WO2015189063A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

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US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
CA2837895C (en) * 2011-06-03 2021-07-27 Mesoblast, Inc. Methods of treating or preventing neurological diseases
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
CN104136034B (zh) 2011-11-30 2018-04-24 安斯泰来再生医药协会 间充质基质细胞及其相关用途
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
SG11201609993YA (en) * 2014-06-10 2016-12-29 Mesoblast Internat Sàrl Treatment of immune disorders
JP7249951B2 (ja) * 2017-03-31 2023-03-31 ウィスコンシン アラムニ リサーチ ファンデーション 標的臓器の細胞外構成成分を使用する治療用細胞の作製
CN106929474B (zh) * 2017-03-31 2021-09-14 北京恒峰铭成生物科技有限公司 一种m2巨噬细胞诱导剂
WO2019108756A1 (en) 2017-11-29 2019-06-06 Figene, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
CN112007165B (zh) * 2020-08-27 2021-10-08 北京大学人民医院 巨噬细胞极化调节剂及其在促进血小板生成中的应用
JP2025540288A (ja) * 2022-12-09 2025-12-11 メゾブラスト・インターナショナル・エスアーエールエル 細胞組成物を用いた炎症治療方法

Citations (2)

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CN102899293A (zh) * 2012-11-01 2013-01-30 上海市肺科医院 促血管生成素1基因修饰的间充质干细胞、及其构建方法与应用
WO2013082543A1 (en) * 2011-11-30 2013-06-06 Advanced Cell Technology, Inc. Mesenchymal stromal cells and uses related thereto

Family Cites Families (11)

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US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US20050239897A1 (en) * 2004-03-22 2005-10-27 Pittenger Mark F Mesenchymal stem cells and uses therefor
AU2005287855B2 (en) * 2004-09-24 2011-06-16 Mesoblast, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)
WO2006108229A1 (en) 2005-04-12 2006-10-19 Angioblast Systems, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
CN102076844B (zh) * 2008-06-30 2013-08-07 成血管细胞系统公司 采用组合疗法的眼病和过度血管新生的治疗
NZ592726A (en) * 2008-11-19 2012-12-21 Anthrogenesis Corp Amnion derived adherent cells
JP5678360B2 (ja) * 2009-09-28 2015-03-04 株式会社ジーシー 間葉系幹細胞の培養方法
US20140017787A1 (en) * 2010-10-11 2014-01-16 Aline M. Betancourt Mesenchymal stem cells and related therapies
AU2015243575B2 (en) * 2014-04-07 2017-11-02 Mesoblast International Sarl Improved stem cell composition
SG11201609993YA (en) 2014-06-10 2016-12-29 Mesoblast Internat Sàrl Treatment of immune disorders

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2013082543A1 (en) * 2011-11-30 2013-06-06 Advanced Cell Technology, Inc. Mesenchymal stromal cells and uses related thereto
CN102899293A (zh) * 2012-11-01 2013-01-30 上海市肺科医院 促血管生成素1基因修饰的间充质干细胞、及其构建方法与应用

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
WO2015189063A1 (en) 2015-12-17
SG11201609993YA (en) 2016-12-29
US10624930B2 (en) 2020-04-21
CN106659743A (zh) 2017-05-10
KR20250143870A (ko) 2025-10-02
AU2020244403A1 (en) 2020-10-29
EP3154565B1 (en) 2023-05-03
EP4137146A1 (en) 2023-02-22
US20230141347A1 (en) 2023-05-11
JP2025109787A (ja) 2025-07-25
AU2020244403B2 (en) 2024-03-07
EP3154565A1 (en) 2017-04-19
JP2023090901A (ja) 2023-06-29
CA2950804C (en) 2023-08-22
KR20230038590A (ko) 2023-03-20
JP2017526619A (ja) 2017-09-14
US20200281984A1 (en) 2020-09-10
HK1231386A1 (en) 2017-12-22
CN106659743B (zh) 2022-03-01
KR20170007854A (ko) 2017-01-20
AU2015273799B2 (en) 2020-07-02
JP2021028337A (ja) 2021-02-25
JP7009594B2 (ja) 2022-02-10
US20250319134A1 (en) 2025-10-16
KR20240135079A (ko) 2024-09-10
CA2950804A1 (en) 2015-12-17
JP7680493B2 (ja) 2025-05-20
JP7279212B2 (ja) 2023-05-22
KR102865313B1 (ko) 2025-09-29
JP6800757B2 (ja) 2020-12-16
KR102704978B1 (ko) 2024-09-09
AU2015273799A1 (en) 2016-12-15
US11406669B2 (en) 2022-08-09
US12257270B2 (en) 2025-03-25
JP2022040254A (ja) 2022-03-10
US20170106023A1 (en) 2017-04-20

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