CN114127118A - 一种分离的抗原结合蛋白及其应用 - Google Patents
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract
一种分离的抗原结合蛋白，其具有下述性质中的一种或多种：1)能够以7x10‑12或更低的KD值结合源自人和猴的GITR蛋白，其中所述KD值通过BLI法测定；2)能够刺激免疫细胞增殖；3)能够刺激免疫细胞分泌IFN‑γ，所述分泌在T细胞活性测定中测得；4)能够抑制肿瘤生长和/或肿瘤细胞增殖；5)能够激活GITR信号通路；6)能够抑制GITR与GITRL结合。
Description
PCT国内申请，说明书已公开。
Claims (60)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019106460938 | 2019-07-17 | ||
| CN201910646093 | 2019-07-17 | ||
| PCT/CN2020/102472 WO2021008590A1 (zh) | 2019-07-17 | 2020-07-16 | 一种分离的抗原结合蛋白及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114127118A true CN114127118A (zh) | 2022-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080051564.1A Pending CN114127118A (zh) | 2019-07-17 | 2020-07-16 | 一种分离的抗原结合蛋白及其应用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20220356259A1 (zh) |
| CN (1) | CN114127118A (zh) |
| WO (1) | WO2021008590A1 (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133822A1 (en) * | 2006-01-19 | 2007-11-22 | Genzyme Corporation | Gitr antibodies for the treatment of cancer |
| WO2013039954A1 (en) * | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
| CN105829343A (zh) * | 2013-08-30 | 2016-08-03 | 美国安进公司 | Gitr抗原结合蛋白 |
| CN106459203A (zh) * | 2014-06-06 | 2017-02-22 | 百时美施贵宝公司 | 抗糖皮质激素诱导肿瘤坏死因子受体(gitr)的抗体及其用途 |
| US20170260282A1 (en) * | 2016-03-08 | 2017-09-14 | Janssen Biotech, Inc. | GITR Antibodies, Methods, and Uses |
-
2020
- 2020-07-16 CN CN202080051564.1A patent/CN114127118A/zh active Pending
- 2020-07-16 WO PCT/CN2020/102472 patent/WO2021008590A1/zh active Application Filing
- 2020-07-16 US US17/626,955 patent/US20220356259A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133822A1 (en) * | 2006-01-19 | 2007-11-22 | Genzyme Corporation | Gitr antibodies for the treatment of cancer |
| WO2013039954A1 (en) * | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
| CN105829343A (zh) * | 2013-08-30 | 2016-08-03 | 美国安进公司 | Gitr抗原结合蛋白 |
| CN106459203A (zh) * | 2014-06-06 | 2017-02-22 | 百时美施贵宝公司 | 抗糖皮质激素诱导肿瘤坏死因子受体(gitr)的抗体及其用途 |
| US20170260282A1 (en) * | 2016-03-08 | 2017-09-14 | Janssen Biotech, Inc. | GITR Antibodies, Methods, and Uses |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220356259A1 (en) | 2022-11-10 |
| WO2021008590A1 (zh) | 2021-01-21 |
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