CN114127098A - 嵌合的人乳头瘤病毒51型l1蛋白 - Google Patents
嵌合的人乳头瘤病毒51型l1蛋白 Download PDFInfo
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Abstract
一种嵌合的人乳头瘤病毒51型L1蛋白和编码其的多核苷酸，还涉及HPV 51型病毒样颗粒和其制备方法。所述嵌合的人乳头瘤病毒51型L1蛋白包含衍生于HPV 51型L1蛋白的N端片段，所述N端片段保持HPV 51型L1蛋白的免疫原性；和衍生于第二型别乳头瘤病毒L1蛋白的C端片段，所述第二型别乳头状瘤病毒L1蛋白具有相较于其他型别的L1蛋白表达量和可溶性较好的特性；其中所述嵌合的HPV 51型L1蛋白具有HPV 51型L1蛋白的免疫原性。所述嵌合的人乳头瘤病毒51型L1蛋白具有较高的表达量和可溶性，可用于疫苗的大规模生产。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
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| CN201910656042 | 2019-07-19 | ||
| CN2019106560423 | 2019-07-19 | ||
| PCT/CN2020/102555 WO2021013060A1 (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人乳头瘤病毒51型l1蛋白 |
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| BR112021005626A2 (pt) * | 2018-09-26 | 2021-06-29 | Xiamen University | mutante de proteína l1 de papilomavírus humano de tipo 51 |
| US20240075124A1 (en) * | 2021-01-14 | 2024-03-07 | Sinocelltech Ltd | Stable formulation of human papillomavirus virus-like particle vaccine |
| CN113201550B (zh) * | 2021-04-23 | 2023-12-26 | 上海博唯生物科技有限公司 | 一种表达hpv 51l1的多核苷酸及其表达载体、宿主细胞和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
| CN101481407A (zh) * | 2008-01-07 | 2009-07-15 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的修饰序列 |
| WO2017157173A1 (zh) * | 2016-03-15 | 2017-09-21 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
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| BR112021005626A2 (pt) * | 2018-09-26 | 2021-06-29 | Xiamen University | mutante de proteína l1 de papilomavírus humano de tipo 51 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
| CN101481407A (zh) * | 2008-01-07 | 2009-07-15 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的修饰序列 |
| WO2017157173A1 (zh) * | 2016-03-15 | 2017-09-21 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
| CN107188966A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
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| Title |
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| BEGUM AKUZUM. ET AL: "L1 recombinant proteins of HPV tested for antibody forming using sera of HPV quadrivalent vaccine", IMMUNE NETW, vol. 18, no. 3, pages 10 * |
| 郝亚茹,等: "HPV31 L1 C 端截短基因 可在昆虫细胞表达体系中高水平制备L1 VLP 疫苗", 基础医学与临床, vol. 39, no. 3, pages 343 - 347 * |
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| CN114127098B (zh) | 2024-04-02 |
| WO2021013060A1 (zh) | 2021-01-28 |
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