CN114126644A - 艰难梭菌的疫苗组合物 - Google Patents

艰难梭菌的疫苗组合物 Download PDF

Info

Publication number
CN114126644A
CN114126644A CN202080049940.3A CN202080049940A CN114126644A CN 114126644 A CN114126644 A CN 114126644A CN 202080049940 A CN202080049940 A CN 202080049940A CN 114126644 A CN114126644 A CN 114126644A
Authority
CN
China
Prior art keywords
ile
leu
glu
ser
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080049940.3A
Other languages
English (en)
Chinese (zh)
Inventor
金榕生
P·费尔格纳
陈朋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN114126644A publication Critical patent/CN114126644A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080049940.3A 2019-05-21 2020-05-21 艰难梭菌的疫苗组合物 Pending CN114126644A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962851040P 2019-05-21 2019-05-21
US62/851,040 2019-05-21
PCT/US2020/034070 WO2020237090A1 (en) 2019-05-21 2020-05-21 Vaccine compositions for clostridium difficile

Publications (1)

Publication Number Publication Date
CN114126644A true CN114126644A (zh) 2022-03-01

Family

ID=73458679

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080049940.3A Pending CN114126644A (zh) 2019-05-21 2020-05-21 艰难梭菌的疫苗组合物

Country Status (8)

Country Link
US (1) US20220062401A1 (https=)
EP (1) EP3972638A4 (https=)
JP (1) JP7637988B2 (https=)
CN (1) CN114126644A (https=)
BR (1) BR112021023119A2 (https=)
CA (1) CA3141165A1 (https=)
MX (3) MX2021014097A (https=)
WO (1) WO2020237090A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
EP4658302A1 (en) * 2023-02-02 2025-12-10 GlaxoSmithKline Biologicals S.A. Immunogenic composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
US20120282293A1 (en) * 2009-11-16 2012-11-08 University Of Maryland, Baltimore Multivalent Live Vector Vaccine against Clostridium difficile-Associated Disease
CN103974718A (zh) * 2011-12-08 2014-08-06 诺华股份有限公司 基于艰难梭菌毒素的疫苗
CN104755099A (zh) * 2012-04-04 2015-07-01 卫生署秘书局 艰难梭菌抗原
US20150291940A1 (en) * 2012-10-21 2015-10-15 Pfizer Inc. Compositions and methods relating to a mutant clostridium difficile toxin
US20180022784A1 (en) * 2015-02-19 2018-01-25 Immune Biosolutions Inc. Clostridium Difficile Toxins a and/or B Antigen and Epitope Antibody, and Pharmaceutical Uses Thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014086787A1 (en) * 2012-12-05 2014-06-12 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2015123767A1 (en) * 2014-02-18 2015-08-27 The Hospital For Sick Children Compositions and methods for treating or preventing clostridium infection
WO2019143552A1 (en) * 2018-01-16 2019-07-25 Children's Medical Center Corporation Compositions and methods for inhibiting wnt signaling

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
US20120282293A1 (en) * 2009-11-16 2012-11-08 University Of Maryland, Baltimore Multivalent Live Vector Vaccine against Clostridium difficile-Associated Disease
CN103974718A (zh) * 2011-12-08 2014-08-06 诺华股份有限公司 基于艰难梭菌毒素的疫苗
CN104755099A (zh) * 2012-04-04 2015-07-01 卫生署秘书局 艰难梭菌抗原
US20150291940A1 (en) * 2012-10-21 2015-10-15 Pfizer Inc. Compositions and methods relating to a mutant clostridium difficile toxin
US20180022784A1 (en) * 2015-02-19 2018-01-25 Immune Biosolutions Inc. Clostridium Difficile Toxins a and/or B Antigen and Epitope Antibody, and Pharmaceutical Uses Thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MICHAEL MAYNARD-SMITH ET AL.: "Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response", VACCINE, vol. 32, no. 6, 3 February 2014 (2014-02-03), pages 700 - 705, XP055101707, DOI: 10.1016/j.vaccine.2013.11.099 *
VIOLA FÜHNER ET AL.: "Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile", FRONT MICROBIOL, vol. 9, 6 December 2018 (2018-12-06), pages 1 - 16 *
王德慧: "艰难梭菌毒素受体结合区的免疫效应研究", 中国优秀硕士学位论文全文数据库 医药卫生科技辑, no. 10, 15 October 2014 (2014-10-15), pages 059 - 89 *

Also Published As

Publication number Publication date
MX2026001280A (es) 2026-03-02
JP2022532917A (ja) 2022-07-20
MX2026001281A (es) 2026-03-02
EP3972638A4 (en) 2023-09-13
US20220062401A1 (en) 2022-03-03
EP3972638A1 (en) 2022-03-30
BR112021023119A2 (pt) 2022-01-25
WO2020237090A1 (en) 2020-11-26
JP7637988B2 (ja) 2025-03-03
MX2021014097A (es) 2022-03-11
CA3141165A1 (en) 2020-11-26

Similar Documents

Publication Publication Date Title
Fagan et al. Structural insights into the molecular organization of the S‐layer from Clostridium difficile
US20230414748A1 (en) Scaffolded antigens and engineered sars-cov-2 receptor-binding domain (rbd) polypeptides
ES2615737T3 (es) Composición inmunogénica
Islam et al. Analysis of amino acid contributions to protein solubility using short peptide tags fused to a simplified BPTI variant
US20180371446A1 (en) Modified L-Asparaginase
RS55707B1 (sr) Izolovani polipeptid toksin a i toksin b proteina c. difficile i njihova upotreba
WO2013087857A2 (de) Antikörper gegen toxine von c. difficile
WO2013087874A1 (de) Antikörper gegen das cdt-toxin von c. difficile
EP3634981B1 (en) Lipidated streptococcus pneumoniae
CN114126644A (zh) 艰难梭菌的疫苗组合物
Pini et al. Characterization of the branched antimicrobial peptide M6 by analyzing its mechanism of action and in vivo toxicity
El Ghachi et al. Characterization of the elongasome core PBP2: MreC complex of Helicobacter pylori
Zhu et al. Expression and purification of the native C‐amidated antimicrobial peptide maculatin 1.1
Romano et al. Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes
Lee et al. DMTMM-Mediated Intramolecular Cyclization of Acidic Residues in Peptides/Proteins
KR20240085798A (ko) 항체 분자-약물 접합체 및 이의 용도
CN117586357A (zh) 一种具有免疫原性的呼吸道合胞病毒（rsv）多肽
Goodin et al. Yersinia pestis outer membrane type III secretion protein YscC: expression, purification, characterization, and induction of specific antiserum
TWI491731B (zh) 用以表現和／或製備細菌視紫紅質融合膜蛋白的載體、系統與方法
EP4090672A1 (en) Methods for identifying anti clostridial neurotoxin compounds
Wei Strategies to improve the immunogenicity of subunit vaccine candidates
WO2008020108A1 (es) Péptidos inmunogénicos frente a los géneros listeria y mycobacterium, anticuerpos y usos de los mismos
Monaci Optimizing vaccine design for prevention of neonatal sepsis
Goldsmith Structural basis for receptor binding and antibody-mediated neutralization by Bordetella adenylate cyclase toxin
US10188716B2 (en) Protective antigen complexes with increased stability and uses thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination