CN114073999A - Assembling device for micro-tube upper cover - Google Patents
Assembling device for micro-tube upper cover Download PDFInfo
- Publication number
- CN114073999A CN114073999A CN202110763267.6A CN202110763267A CN114073999A CN 114073999 A CN114073999 A CN 114073999A CN 202110763267 A CN202110763267 A CN 202110763267A CN 114073999 A CN114073999 A CN 114073999A
- Authority
- CN
- China
- Prior art keywords
- micro
- micro tube
- cover
- upper cover
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000007789 sealing Methods 0.000 claims abstract description 11
- 239000012472 biological sample Substances 0.000 abstract description 15
- 238000007689 inspection Methods 0.000 abstract description 8
- 238000012545 processing Methods 0.000 abstract description 7
- 238000004458 analytical method Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 238000002360 preparation method Methods 0.000 abstract description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 3
- 241000498849 Chlamydiales Species 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
Abstract
The invention provides an assembling device of an upper cover of a micro-tube, which is mainly used for sealing the upper cover of the micro-tube in a micro-tube container and moving the upper cover of the micro-tube to different micro-tube frames for automatic preparation, analysis and inspection of biological samples, so that the automatic processing process is more efficient. Wherein, the micro-tube upper cover is provided with a covering part for sealing the micro-tube container and an embedding groove which can be detachably connected with a driving device; the bottom edge of the driving device is provided with a positioning part and a rod body which can move up and down along the driving device and the positioning part and is embedded in the embedding groove of the upper cover of the micro tube, so that the upper cover of the micro tube forms detachable connection.
Description
Technical Field
The present invention relates to an assembling device for an upper cover of a micro tube, and more particularly, to an assembling device for sealing the upper cover of the micro tube in a micro tube container and moving the upper cover to different micro tube racks for automatic analysis and preparation of biological samples, so as to make the automatic processing process more efficient.
Background
At present; in recent years, in order to improve the consistency of the inspection quality and improve the limitation of the traditional manual inspection mode, in the field of molecular medicine inspection, automatic instruments and equipment are continuously and successfully developed and implemented. However, in the current common automated biological sample processing and testing apparatus on the market, especially in the system applied in the molecular detection field, the commonly used test consumables are micro multi-well plates (e.g., 24, 48, 96, 384 or 1536 well plates) or multi-row micro tubes, which have limitations in the application of automated testing. The existing sealed micro porous plate is coated by adopting a film hot pressing mode, but the mode is not easy to seal, each hole on the porous plate can be completely sealed, and the risk of misjudgment of experimental result reading data caused by short reaction sample volume due to heat steam dissipation after heating or the potential risk of cross contamination caused by liquid leakage among different holes exists. In addition, the process of detecting biological samples in the prior art is prone to cause unnecessary waste of resources, for example, when the number of samples to be detected is low, even if there are a plurality of unused holes, the used micro porous plate still needs to be discarded directly, which indirectly causes waste of resources.
In view of the above, through continuous research and experiments, the applicant has devised an assembling device for an upper cover of a micro-tube, which improves the defects of the prior art and the defects of an automatic detection instrument, thereby improving the detection efficiency.
Disclosure of Invention
The main objective of the present invention is to provide an assembly apparatus for an upper cover of a micro tube, which is used to seal the upper cover of the micro tube in a micro tube container and move the upper cover to different micro tube racks for automatic biological sample preparation, analysis and inspection, thereby avoiding the risk of leakage due to incomplete sealing and making the automatic processing process more efficient.
In the assembling apparatus for the micro tube upper cover, the micro tube upper cover has a covering portion for sealing the micro tube container and an embedding groove for detachably connecting with a driving device; the bottom edge of the driving device is provided with a positioning part and a rod body which can move up and down along the driving device and the positioning part and is embedded in the embedding groove of the upper cover of the micro tube, so that the upper cover of the micro tube forms detachable connection.
In the assembling device for the upper cover of the micro-tube, the driving device is provided with a slide rail, and a rod body is arranged on the slide rail, so that the rod body can move up and down along the slide rail.
In the assembling device for the upper cover of the micro tube, the slide rail of the driving device is provided with the limiting groove with a proper length, the rod body is horizontally extended at a proper position and is positioned on the wall part of the limiting groove, and when the rod body moves up and down along the slide rail, the wall part and the limiting groove form the limiting of the rod body.
In the assembling device for the upper cover of the micro tube, the positioning portion arranged on the driving device is in a sleeve shape, the upper edge of the positioning portion is provided with the locking portion, and the locking portion is locked into the sliding rail and fixed at the bottom end of the driving device.
The assembling device for the micro tube upper cover at least comprises a covering part and a wall part extending outwards from the top edge of the covering part, and the inner edge of the upper cover forms an embedding groove for the rod body of the driving device to extend into the embedding groove and be tightly combined with the micro tube upper cover.
In the assembling device for the micro tube upper cover, the inner edge of the wall portion of the micro tube upper cover horizontally and vertically extends to form a clamping groove, so that the opening of the micro tube container can be just embedded in the clamping groove to be tightly combined with the micro tube upper cover, thereby sealing the biological sample.
The covering part of the micro tube upper cover is transparent.
The invention has the beneficial effects that:
the assembling device of the micro-tube upper cover of the invention is detachably connected with the micro-tube upper cover through a driving device, then the micro-tube upper cover is covered on the micro-tube container, and the driving device is mechanically moved according to different requirements so as to extract and/or move the micro-tube container connected with the micro-tube upper cover for the automatic preparation, analysis and inspection of biological samples, thereby avoiding the leakage risk of incomplete sealing.
Drawings
FIG. 1 is an exploded perspective view of the present invention;
FIG. 2 is a cross-sectional view of the present invention;
FIG. 3 is a perspective view of the micro tube of the present invention with its upper cover placed on the micro multi-well plate;
FIG. 4 is a perspective view of the drive device of the present invention attached to the upper cover of a micro tube;
FIG. 5 is a cross-sectional view of the driving device of the present invention attached to the upper lid of a micro tube;
FIG. 6 is a perspective view of a micro tube container with a micro tube top cover according to the present invention attached thereto;
FIG. 7 is a cross-sectional view of a micro tube container with a micro tube top cap according to the present invention attached thereto;
FIG. 8 is a moving state diagram of the present invention;
FIG. 9 is a perspective view of the present invention with a microtube container positioned in a microtube rack;
FIG. 10 is a cross-sectional view of the present invention with a microtube container positioned in a microtube rack;
FIG. 11 is a diagram of the upper cover removal operation of the microtube of the present invention;
FIG. 12 is a perspective view of the present invention showing the removal of the upper cover of the micro tube;
FIG. 13 is a cross-sectional view of the upper cover of the disassembled micro tube of the present invention;
fig. 14 is a perspective view of another operational embodiment of the present invention.
Description of the reference numerals
1 drive device
11: sliding rail
111: spacing groove
12: rod body
121 the chlamydial part
13 positioning part
131 locking part
2: upper cover
21, a covering part
22 the chlamydial part
23, embedding groove
24: clamping groove
3: microtube container
4: micro porous plate
5: microtube rack
5a, a micro-tube frame.
Detailed Description
Please refer to fig. 1 and fig. 2, which are an exploded perspective view and a sectional view of the present invention. As shown in the figure, the present invention comprises a driving device 1, a micro tube upper cover 2 and a micro tube container 3. The driving device 1 is provided with a slide rail 11, and the slide rail 11 is provided with a rod body 12 which is driven by the driving device 1 and can move up and down along the slide rail 11. In this embodiment, the driving device may be a motor, the motor is connected to the rod 12 through a transmission mechanism, and the up-and-down movement of the rod 12 is controlled by the motor, which is easily implemented by those skilled in the art according to the prior art. In the present embodiment, the driving device 1 can be moved mechanically (the term "mechanical movement" in the present specification refers to a robotic arm module carried by an existing automated biological sample processing and detecting apparatus, and the robotic arm moves in a two-dimensional or three-dimensional direction in a generally linear manner); the slide rail 11 is provided with a limiting groove 111 with a proper length, the rod 12 is provided with a boss 121 horizontally protruding at a proper position and located in the limiting groove 111, and when the rod 12 moves up and down, the upper end and the lower end of the limiting groove 111 can limit the rod 12.
The driving device 1 is provided with a positioning portion 13 at the bottom edge of the slide rail 11. In this embodiment, the positioning portion 13 is in a sleeve shape, and the locking portion 131 is disposed on the upper edge thereof, and the locking portion 131 is locked into the slide rail 11 and fixed to the bottom end of the driving device 1, so that the bottom end of the rod 12 is inserted into the positioning portion 13.
The micro-tube upper cover 2 at least comprises a covering part 21 and a rampart 22 extending horizontally and vertically outwards from the top edge of the covering part 21, the inner edge of the upper cover 2 forms an embedding groove 23, and the diameter of the embedding groove 23 is equal to that of the positioning part 13; the inner edge of the wall part 22 forms a clamping groove 24, the diameter of the clamping groove 24 is equivalent to the diameter of the opening of the micro-tube container 3; the cover portion 21 is inserted into the hole of the micro tube container 3 or the micro multi-well plate to seal the biological sample to be tested in the hole of the micro tube container 3 or the micro multi-well plate. The lower end of the rod body 12 of the driving device 1 can be inserted into the embedding groove 23 and tightly combined with the micro-tube upper cover 2. In this embodiment, the covering portion 21 is transparent, and can be used to introduce various light sources with wavelength of 300-800nm, excite the fluorescent substance contained in the biological sample in the tube, and simultaneously, the emitted fluorescence can be guided out through the covering portion 21 for optical detection.
The opening of the micro tube container 3 has a diameter corresponding to the diameter of the clamping groove 24 of the micro tube upper cover 2, and is used for accommodating the following components: blood, body fluids, animal tissue, plant tissue, viruses, free nucleic acids, and biological samples of eukaryotic or prokaryotic cells awaiting detection.
Through the components, the drive device 1 is mechanically moved according to different requirements to extract and/or move the micro-tube container 3 connected with the micro-tube upper cover 2, so as to be used for automatic biological sample preparation, analysis and inspection, and avoid the leakage risk of incomplete sealing.
FIG. 3 is a perspective view of the micro tube of the present invention with the cover placed on the micro multi-well plate. As shown in the drawing, in the working example of the present invention, a plurality of micro-tube caps 2 are placed on micro-porous plates 4, respectively.
Please refer to fig. 4 and 5, which are a perspective view and a cross-sectional view of the driving device connecting to the upper cover of the micro tube according to the present invention. As shown in the figure, the rod body 12 of the driving device 1 of the present invention is inserted into the embedding groove 23 of the micro tube upper cover 2, so that the micro tube upper cover 2 is engaged with the lower end of the rod body 12, and the upper edge thereof is supported against the positioning portion 13 at the bottom end of the driving device 1, and then the micro tube upper cover 2 is extracted by mechanical movement and moved to the upper side of the target micro tube container.
Please refer to fig. 6 and 7, which are a perspective view and a cross-sectional view of the micro-tube top cap connecting to the micro-tube container according to the present invention. Referring to fig. 2, after the micro tube top cover 2 is engaged with the rod 12 of the driving device 1 and moved to the upper side of the micro tube container 3 on the target micro tube rack 5, the micro tube top cover 2 is engaged with the micro tube container 3 downward by the driving device 1. Wherein, the inner edge of the wall part 22 of the micro tube upper cover 2 is a clamping groove 24, so that the opening of the micro tube container 3 can be just embedded in the clamping groove 24 and tightly combined with the micro tube upper cover 2, thereby sealing the biological sample.
Fig. 8 and 9 are a perspective view and a cross-sectional view of a movement state of the present invention, and a microtube container placed on a microtube rack, in conjunction with fig. 10. As shown in the drawing, after the micro tube top cover 2 is covered, the mechanical movement of the present invention directly picks up the micro tube container 3 tightly combined with the micro tube top cover 2, and moves the micro tube container 3 from the micro tube rack 5 to another micro tube rack 5a by the mechanical movement. Therefore, the invention can simultaneously execute the steps of covering and moving in a single mechanical movement, simplifies the complicated steps and mechanical setting, ensures that the automatic processing process is more efficient, and can reduce the development cost of the automatic instrument.
Please refer to fig. 11 and 12 in combination with fig. 13, which are a drawing for disassembling the upper cover of the micro tube, a perspective view and a cross-sectional view for disassembling the upper cover of the micro tube according to the present invention. As shown in the figure, after the micro tube container 3 is transferred from the micro tube rack 4 to another micro tube rack 5a, the driving device 1 drives the rod 12 to move upward, because the upper edge of the micro tube upper cover 2 is supported against the positioning part 13 at the bottom end of the driving device 1, when the rod 12 moves upward, the lower end thereof will be separated from the micro tube upper cover 2, the micro tube upper cover 2 is removed, and finally the micro tube container 3 is left on the micro tube rack 5a for the subsequent detection step.
Please refer to fig. 14, which is a perspective view illustrating another exemplary embodiment of the present invention. As shown in the drawings, another operation embodiment of the present invention is described, in which the driving device 1 and the cover 2 of the micro tube are removed and covered in the same manner as described above, and will not be described herein, but the only difference in this embodiment is that the micro tube container 3 is changed to the micro multi-well plate 4. The micro-porous plate 4 has a plate-like structure and is provided with a plurality of micro-holes for loading the biological sample. The driving device 1 of the present invention can also cover the micro-tube top cover 2 directly on the micro-wells of the micro-multi-well plate and tightly combine with it. Thirdly, performing the operation; the micro multi-well plate 4 closely combined with the micro tube upper cap 2 can be directly extracted by the movement of the driving means 1, and the micro multi-well plate 4 can be moved to a specific position as necessary.
The foregoing embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various modifications and changes may be made without departing from the spirit and scope of the invention as defined in the appended claims.
In summary, the present invention uses the driving device with the positioning portion at the bottom edge, and the rod body capable of moving up and down on the driving device, and the micro-tube upper cover detachably connected to the rod body, to form the assembling device of the micro-tube upper cover. The micro tube upper cover is sealed in the micro tube container and moved to different micro tube racks for automatic biological sample preparation, analysis and inspection, thereby avoiding the leakage risk of incomplete sealing and enabling the automatic processing process to be more efficient.
Claims (6)
1. The assembling device for micro tube top cover includes at least one micro tube top cover and one driving device, and features that the micro tube top cover has one covering part for sealing the micro tube container and one embedding slot for detachable connection with one driving device; the driving device is provided with a positioning part and a rod body which can move upwards or downwards along the driving device and the positioning part and is embedded in the embedding groove of the upper cover of the micro tube, so that the upper cover of the micro tube forms detachable connection.
2. The apparatus for assembling the cover of a micro tube as set forth in claim 1, wherein the driving means is provided with a slide rail on which the rod is disposed, and the rod is moved up or down along the slide rail.
3. The assembly apparatus of claim 2, wherein the slide rail of the driving device has a limiting groove with a suitable length, the rod has a horizontally protruding wall at a suitable position, and the rod is limited by the wall and the limiting groove when moving up and down along the slide rail.
4. The assembly apparatus for the cover of the micro tube as set forth in claim 2, wherein the positioning portion provided to the driving means is formed in a sleeve shape, and a locking portion is provided at an upper edge thereof, and is fixed to the bottom end of the driving means by being locked into the slide rail by the locking portion.
5. The apparatus for assembling a cover for a microtube according to claim 1, wherein the top edge of the cover portion of the microtube cover extends horizontally and vertically outward to form a clamping groove, so that the opening of the microtube container can be inserted into the clamping groove and tightly combined with the microtube cover.
6. The apparatus for assembling a cover for a micro tube according to claim 1, wherein the cover portion of the cover for the micro tube is transparent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW109128466A TW202208062A (en) | 2020-08-20 | 2020-08-20 | Pipette cover and assembling device thereof that comprises a closure part for sealing a pipette container and a fitting notch for detachable connection with a drive device |
| TW109128466 | 2020-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114073999A true CN114073999A (en) | 2022-02-22 |
Family
ID=80283084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121529734.0U Active CN215996714U (en) | 2020-08-20 | 2021-07-06 | Assembling device for micro-tube upper cover |
| CN202110763267.6A Pending CN114073999A (en) | 2020-08-20 | 2021-07-06 | Assembling device for micro-tube upper cover |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121529734.0U Active CN215996714U (en) | 2020-08-20 | 2021-07-06 | Assembling device for micro-tube upper cover |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN215996714U (en) |
| TW (1) | TW202208062A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202208062A (en) * | 2020-08-20 | 2022-03-01 | 財桂生物股份有限公司 | Pipette cover and assembling device thereof that comprises a closure part for sealing a pipette container and a fitting notch for detachable connection with a drive device |
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|---|---|---|---|---|
| EP0454493A2 (en) * | 1990-04-26 | 1991-10-30 | Charles Terrence Macartney | Reinsertable closure for sample tubes |
| JP2001246267A (en) * | 2000-03-06 | 2001-09-11 | Nissei Sangyo Co Ltd | Microtube, microtube rack device, and information printer for printing information on the microtube |
| US20020064484A1 (en) * | 1999-12-03 | 2002-05-30 | Lin Fu-Chung | Device and method for separating components of a fluid sample |
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| TWI692377B (en) * | 2019-08-13 | 2020-05-01 | 創茂生技股份有限公司 | Cap for microtube, kits and methods comprising the same |
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| TWM606417U (en) * | 2020-08-20 | 2021-01-11 | 財桂生物股份有限公司 | Micro tube upper cover and assembling device thereof |
| CN215996714U (en) * | 2020-08-20 | 2022-03-11 | 财桂生物股份有限公司 | Assembling device for micro-tube upper cover |
-
2020
- 2020-08-20 TW TW109128466A patent/TW202208062A/en unknown
-
2021
- 2021-07-06 CN CN202121529734.0U patent/CN215996714U/en active Active
- 2021-07-06 CN CN202110763267.6A patent/CN114073999A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0454493A2 (en) * | 1990-04-26 | 1991-10-30 | Charles Terrence Macartney | Reinsertable closure for sample tubes |
| US6398281B1 (en) * | 1998-01-15 | 2002-06-04 | Mwg Biotech Ag | Lid gripping device |
| US20020064484A1 (en) * | 1999-12-03 | 2002-05-30 | Lin Fu-Chung | Device and method for separating components of a fluid sample |
| US20030003023A1 (en) * | 2000-02-16 | 2003-01-02 | Matti Korpela | Method for closing and opening of an opening |
| JP2001246267A (en) * | 2000-03-06 | 2001-09-11 | Nissei Sangyo Co Ltd | Microtube, microtube rack device, and information printer for printing information on the microtube |
| US20040164571A1 (en) * | 2003-02-06 | 2004-08-26 | Gianandrea Pedrazzini | Gripping device capable to grip a vial or other containers without using mechanical fingers or other mechanical gripping devices |
| CN101130173A (en) * | 2006-08-24 | 2008-02-27 | 广普生物科技股份有限公司 | Electric minim liquid shifter for real-time responding push action of hands |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN215996714U (en) | 2022-03-11 |
| TW202208062A (en) | 2022-03-01 |
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