CN1140600A - Preparation of medicament containing rare-earth for dermatomycosis - Google Patents
Preparation of medicament containing rare-earth for dermatomycosis Download PDFInfo
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- CN1140600A CN1140600A CN 95118811 CN95118811A CN1140600A CN 1140600 A CN1140600 A CN 1140600A CN 95118811 CN95118811 CN 95118811 CN 95118811 A CN95118811 A CN 95118811A CN 1140600 A CN1140600 A CN 1140600A
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Abstract
The medicament is compounded with Chinese medicinal material including Cortex pseudolaricis, Cortex erythrinae, dittany bark, pomegranate rind, etc. as well as rare earth nitrate, amino acids, salicylic acid and benzoic acid. It is used externally to treat dermatomycosis with obvious and fast effect.
Description
The present invention relates to a kind of compound method that contains rare earth treatment tinea topical agent, belong to field of medicaments.
At present, ringworm is a kind of common skin disease, generally adopts doctor trained in Western medicine, the traditional Chinese medical science or therapy of combining Chinese and Western medicine method, and oral medicine commonly used or medicine for external use are used in combination, but cure rate and effective percentage each is variant, effect is unsatisfactory.Untoward reaction is more after the medication, the relapse rate height.Though some medicine has inhibitory action to this disease, injured skin, pain is strong, is unfavorable for that the patient uses, and cure rate is not high yet.Though some medicine has no adverse reaction, therapeutic effect is not good.Though some medicine is effective in cure, contain antibiotics or hormone, life-time service can play side effect, and incompatible patient can not use to the skin hormonal medicaments.As Medicated Liquid for Fungal Infection of Hand and Foot, though certain curative effect is arranged, it is slow to take effect, and treatment effective percentage and cure rate are not high, and acid-base value is stronger, pain when putting on the skin, to affected part and around corrosion and zest big, cause easily and fester and concurrent infection.
The objective of the invention is to be to provide a kind of and treat tinea with the topical agent of preparations such as Chinese herbal medicine and pin acid rare earth.Damaging the skin of being put on the skin affected part to using other medicine for external use has the inhibition diffusion, and does not damage the epiderm skin of being put on the skin, a little less than the acid corrosion, to skin zero damage vestige on every side, the patient uses does not have pain, helps the patient and uses, instant effect, result of use is remarkable, the cure rate height, can effect a radical cure, be difficult for recurrence, no side effects, compound method is simple, easy to use, with low cost.
The objective of the invention is to realize by preparations such as following Chinese medicine and nitric acid rare earths:
With the Cortex Pseudolaricis after handling be 8～15%, Cortex erythrinae is 8～18%, Pericarpium Granati is 8～15%, the Fructus Kochiae is 8～13%, Cortex Dictamni is 8～13%, Cortex Meliae is 8～13%, Semen Arecae is 8～13%, Camphora is 5～14%, nitric acid rare earth is 5～15%, aminoacid is 4～10%, salicylic acid is 4～10%, benzoic acid is 4～10%.
The compound method technical process of treatment tinea medicament of the present invention:
(1) Cortex Pseudolaricis, Cortex erythrinae, Pericarpium Granati, the Fructus Kochiae, Cortex Dictamni, Cortex Meliae, the Semen Arecae that weigh up are pulverized the coarse powder after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol with 75% is made solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) Camphora that weighs up is dissolved with 95% ethanol after, add in the supernatant of (1), and salicylic acid, benzoic acid are added the back in the lump stir, make it to dissolve fully to get final product;
(3) nitric acid rare earth that weighs up being joined in the amino acid solution, is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pours in the supernatant in (2), puts to filter in 24 hours to get final product;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Treatment tinea topical agent compound method effect of the present invention is: through up to a hundred times compatibility test and formula adjustment, determined the kind of Chinese medicine, using dosage and allotment of labor's skill, it is the compound preparation of nitric acid rare earth and Chinese medicine, its therapeutical effect is the adduction of the two, nitric acid rare earth in this medicament coexists as in the individual system with other Chinese medicinal ingredients with the form of complex, played balance, potentiation, increase significantly than traditional oral medicine and external medication effect, rare earth element energy chafe cell in this medicine is to the Absorption of nutrient substance, strengthen the metabolism of skin, quicken the division and the hypertrophy of callus, strengthen the physiologically active of skin.Use the back good drug efficacy, drug effect is long, no pain, and instant effect, the mild or moderate patient only needs can cure for several times, and severe patient only needs can fully recover in 1～2 week, and safe and reliable, the illing skin of healing is bright and clean smooth, leaves no trace, and is bordering on healthy skin.Have removing dampness, parasite killing, antipruritic, sterilization, anticorrosion, suppress tinea bacterium survival ability, to treatment tinea corporis, tinea capitis, the tinea manuum, tinea pedis, flat tinea, feline tinea, scabies, skin itching disease, therapeutic effect is more obvious, and eczema, allergic dermatitis, psoriasis etc. are also had certain curative effect.This medicine has made full use of the mechanism of action of rare earth, has improved the treatment level of whole medicine, and is evident in efficacy, has been subjected to patient's welcome.
Since advanced development in 1989 the main curative effect of this tinea medicine for external use is carried out systematic research, obtained desirable therapeutic.Most light, moderate patient only need put on the skin to smear and can fully recover for several times.The end is healing person thoroughly, and test continues medication later and also all obtains curing.Begin we and related hospitals associating in 1993, carried out pilot experiment, cure all kinds of tinea 200 many cases altogether.
Fig. 1 is a process flow diagram of the present invention.
Table 1 is the curative effect comparisons of two kinds of medicines to the tinea capitis patient;
Table 2 is the curative effect comparisons to face tinea patient of two kinds of medicines;
Table 3 is the curative effect comparisons to tinea manuum patient of two kinds of medicines;
Table 4 is the curative effect comparisons to the tinea pedis patient of two kinds of medicines;
Table 5 is to human body skin toxicity and sensitization test (STT) result;
Table 6 is the toxicity test results to rabbit skin.
The model case write up of dermatophytosis medicine for external use treatment is as follows:
Case (1) patient is normal * * man, suffer from tinea corporis, spread all over back and trunk, performance annular and copper coin shape pathological changes, conscious odd itching, spring, summer are serious, once treat 1 year through hospital dermatology department in two families, and the oral administration and externally western medicines in treatment is all invalid.The back is followed up a case by regular visits to over 2 years and is not seen recurrence with three recoveries from illness course of treatment of this medicine treatment.Cure this type of patient 3 people.
Case (2) patient Wang * * man, suffer from tinea versicolor, suffer from cervical region shirtfront and back, show as the sepia of Semen Glycines size, itch, scratch desquamation.Ill 7 years, once how tame hospitalize is radical cure all, uses this medicine to cure after three months in 1991, after recur so far.Cure this type of patient 6 people.
Case (3) patient horse * * man, suffer from the tinea manuum, the middle finger skin of index finger is thick firmly very itches, and once two tame hospital dermatology departments treatments 1 year, the oral administration and externally Chinese medicine and western medicine was all invalid, and the back is followed up a case by regular visits to and was not seen recurrence in 2 years with recovery from illness course of treatment of this medicine treatment.
Case (4) patient Cai * * woman, suffer from the tinea manuum, right hand facies palmaris is firmly very itched immoderate, through certain Army Hospital's external antipsoric, treat 1 year invalid, she fully recovers with this medicine two courses of treatment in the back, follows up a case by regular visits to and do not see recurrence in 1 year.Cure this type of patient 30 people altogether.
Case (5) patient Lee * * man, suffer from tinea pedis, adularescent skin between toe, conscious Pruritus has ruddy behind the broken skin.Be coated with in 1989 and put this medicine treatment on the skin, not recurrence so far after the healing.Cure this type of patient 20 people.
Case (6) patient bag * * man, hands, vola or refer between located in groups intensive or dispersive vesicle, the bleb film is thicker, is difficult for breaking, conscious play is itched, and is coated with to put this medicine on the skin and cure, he this type of patient 6 people is cured in recurrence so far.
Case (7) patient's money * * woman, exsiccant fish scale bits skin is arranged on hands, the sole or between referring to, there is very thick hard and coarse skin at serious position, and chaps.Put two courses of treatment of this pharmaceutical treatment on the skin through being coated with, recurrence is not arranged so far, treat heavy person 8 people of such patient altogether, the lighter 6 people.The lighter is coated with and puts on the skin several times and can cure, and heavy person is coated with and puts 20～30 times on the skin and can cure.
Case (8) patient's height * * woman, belong to face's tinea, (hospital diagnosis is a feline tinea) uses this pharmaceutical treatment promptly to fully recover after a course of treatment, recurrence after this.
Case (9) patient discriminates * * woman, foot's right crus of diaphragm small thumb tinea unguium, soak six times with this medicament after symptom disappear gradually, recur so far.
Case (10) patient week * *, suffered from tinea capitis 3 years, once tens kinds of four tame hospitalize medications, all radical cures are used this medicament to be coated with and are put four recoveries from illness courses of treatment on the skin, follow up a case by regular visits to and do not see recurrence in 1 year.
Case (10 patient Peng * * man, eczema is suffered from the arm both sides, itches in the depths, outbreak repeatedly, touching difficulty was not more once effected a radical cure in three tame hospitalizes, and the back is used this medicament to be coated with and is put four recoveries from illness course of treatment on the skin, follow up a case by regular visits to and do not see recurrence in 1 year.Treat heavy person 4 people of such patient altogether, the lighter 6 people.
Case (12) patient Liu * * woman, suffered from scabies 23 days, the play of lower abdomen both sides is itched, especially night the most serious, be coated with and put six recoveries from illness of this medicament on the skin, up to not seeing recurrence.
Most preferred embodiment of the present invention:
Embodiment 1:
This medicine by the Cortex Pseudolaricis after handling be 9%, Cortex erythrinae is 12%; Pericarpium Granati is 9%, the Fructus Kochiae is 9%, Cortex Dictamni is 9%, bitter Pericarpium Citri Reticulatae is 9%, Semen Arecae is 9%, Camphora is 8%, nitric acid rare earth is 9%, aminoacid is 6%, salicylic acid is 6%, benzoic acid is 5% to form.
Its technical process is as follows:
(1) with component is 9% Cortex Pseudolaricis, 12% Cortex erythrinae, 9% Pericarpium Granati, 9% the Fructus Kochiae, 9% Cortex Dictamni, 9% Cortex Meliae, 9% the coarse powder of Semen Arecae pulverizing after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol 900ml with 75% makes solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) with component be 8% Camphora, dissolve in the supernatant that the back adds (1), and salicylic acid 6%, benzoic acid 5% are added the back stirring in the lump, get final product after making it to dissolve fully with 95% ethanol 24ml;
(3) with component be 9% nitric acid rare earth, joining in the amino acid solution of 90ml (aminoacid is 9% to calculate by component), is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pour in the supernatant in (2), put filtration in 24 hours;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Embodiment 2:
This medicine by the Cortex Pseudolaricis after handling be 9.8%, Cortex erythrinae is 10.2%; Pericarpium Granati is 9.8%, the Fructus Kochiae is 8%, Cortex Dictamni is 8%, Cortex Meliae is 8%, Semen Arecae is 8%, Camphora is 8.6%, nitric acid rare earth is 9.8%, aminoacid is 6.6%, salicylic acid is 6.6%, benzoic acid is 6.6% to form.
Its technical process is as follows:
(1) will weigh up component is 9.8% Cortex Pseudolaricis, 10.2% Cortex erythrinae, 9.8% Pericarpium Granati, 8% the Fructus Kochiae, 8% Cortex Dictamni, 8% Cortex Meliae, 8% the coarse powder of Semen Arecae pulverizing after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol 900ml with 75% makes solution, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) with component be 14% Camphora, the ethanol 24ml with 95% dissolves in the supernatant that the back adds (1), and salicylic acid 6.6%, benzoic acid 6.6% are added the back stirring in the lump, gets final product after making it to dissolve fully;
(3) with component be 9.8% nitric acid rare earth, joining in the amino acid solution of 98ml (aminoacid is 9.8% to calculate by component), is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pour in the supernatant in (2), put filtration in 24 hours and get final product;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Use compound method treatment tinea topical agent of the present invention,, directly use at affected part with clean brush pen or cotton excellent dip in liquid medicine, every day 1～3 time, per ten days is a course of treatment, and light, moderate patient only need smear and can cure for several times, can fully recover 2～3 courses of treatment to the severe patient treatment.Annotate: a kind of compounding method that contains rare earth treatment tinea medicament, at following each table
Middle be called for short " test medicine ".
Two kinds of medicines of table 1 compare tinea capitis patient's curative effect
Annotate: effective percentage is meant effectively and the total percentage rate of healing.
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ???I | ???II | ???I-II | ??+ | ??- | |||
| ????1 | Cure | Effectively | ???3 | ???2 | ????1 | ??2 | |
| ????2 | Effectively | Improve | ???2 | ???1 | ????1 | ??2 | |
| ????3 | Cure | Improve | ???3 | ???1 | ????2 | ??4 | |
| ????4 | Cure | Improve | ???3 | ???1 | ????2 | ??5 | |
| ????5 | Cure | Invalid | ???3 | ???0 | ????3 | ??7 | |
| ????6 | Cure | Invalid | ???3 | ???0 | ????3 | ??8 | |
| ????7 | Improve | Effectively | ???1 | ???2 | ????-1 | ???2 | |
| ????8 | Cure | Invalid | ???3 | ???1 | ????2 | ??6 | |
| Cure rate % | ?75％ | ?0 | ??34 | ???2 | |||
| Effective percentage % | ?87.5％ | ?25 | |||||
Rank test: n=8, t=2 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can find out clearly that from table 1 test medicine is 75% to the cure rate of tinea capitis, effective percentage is 87.5%, and contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is 25%, and cure rate is 0, through the two difference of rank test is significant, illustrates that the rare earth test medicine has higher curative effect.
Two kinds of medicines of table 2 compare face tinea patient's curative effect
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ????I | ????II | ????I-II | ??+ | ????- | |||
| ????1 | Cure | Effectively | ????3 | ????2 | ????1 | ??1 | |
| ????2 | Cure | Effectively | ????3 | ????3 | ????0 | ||
| ????3 | Cure | Effectively | ????3 | ????2 | ????1 | ??2 | |
| ????4 | Cure | Effectively | ????3 | ????2 | ????1 | ??3 | |
| ????5 | Effectively | Improve | ????2 | ????1 | ????1 | ??4 | |
| ????6× | |||||||
| ????7 | Effectively | Improve | ????2 | ????1 | ????1 | ??5 | |
| ????8 | Cure | Invalid | ????3 | ????0 | ????3 | ??6 | |
| ????9× | |||||||
| ????10 | Cure | Invalid | ????3 | ????0 | ????3 | ??7 | |
| Cure rate % | 75％ | 12.5％ | ?28 | ????0 | |||
| Effective percentage % | 100％ | 62.5％ | |||||
Illustrate: 6, No. 9 among the examination patient because of drug withdrawal midway, can't do observation of curative effect judgement.
Rank test: n=7, t=0 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can find out clearly that from table 2 test medicine is 75% to face tinea (feline tinea) cure rate, effective percentage is 100%, contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is 62.5%, cure rate is 12.5%, through the two difference of rank test is significantly, the rare earth test medicine be described and contrast the medicine therapeutic effect and have different significantly.
Two kinds of medicines of table 3 compare tinea manuum patient's curative effect
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ???I | ???II | ????I-II | ????+ | ??- | |||
| ????1 | Cure | Cure | ???3 | ????3 | ????0 | ||
| ????2 | Cure | Effectively | ???3 | ????2 | ????1 | ||
| ????3 | Improve | Improve | ???1 | ????1 | ????0 | ????3 | |
| ????4 | Cure | Effectively | ???3 | ????2 | ????1 | ????3 | |
| ????5 | Cure | Cure | ???3 | ????3 | ????0 | ||
| ????6 | Effectively | Effectively | ???2 | ????2 | ????0 | ||
| ????7 | Effectively | Cure | ???2 | ????2 | ????-1 | ??3 | |
| ????8 | Cure | Effectively | ???3 | ????2 | ????1 | ????3 | |
| ????9 | Cure | Improve | ???3 | ????1 | ????2 | ????6 | |
| ????10 | Effectively | Improve | ???2 | ????1 | ????1 | ????3 | |
| Cure rate % | 60％ | 30％ | ????21 | ??3 | |||
| Effective percentage % | 90％ | 70％ | |||||
Rank test: n=6, t=3 tables look-up and learns p＞a=0.05. so the curative effect difference of the two is not remarkable.
The rare earth test medicine checks the two not obvious with the effect of the contrast medicine fungal infection of hand and foot liquid medicine treatment tinea manuum by statistics as can be seen from Table 3, but rare earth test medicine comparison illustrate that according to all high many of medicine cure rate and effective percentage rare earth test medicine therapeutic effect is better than contrasting.
Two kinds of medicines of table 4 are to the comparison of tinea pedis curative effect
The continuous table of going up
The continuous table of going up
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ??I | ????II | ????I-II | ??+ | - | |||
| ????1 | Cure | Cure | ??3 | ????3 | ????0 | ||
| ????2 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | |
| ????3 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | |
| ????4 | Cure | Improve | ??3 | ????1 | ????2 | ?24.3 | |
| ????5 | Effectively | Cure | ??2 | ????3 | ????-1 | ||
| ????6 | Cure | Cure | ??3 | ????3 | ????0 | ||
| ????7 | Cure | Improve | ??3 | ????1 | ????2 | ?24.5 | |
| ????8 | Effectively | Cure | ??2 | ????3 | ????-1 | ||
| ????9 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | |
| ????10 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | - |
| ????11 | Cure | Effectively | ??3 | ????3 | ????1 | ?10.5 | |
| ????12 | Cure | Improve | ??3 | ????1 | ????2 | ?24.5 | |
| ????13 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | |
| ????14 | Cure | Effectively | ??3 | ????2 | ????1 | ?10.5 | |
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ????1 | ??II | ????I-II | ?+ | ?- | |||
| ????15 | Improve | Cure | ????1 | ???3 | ????-2 | ?24.5 | |
| ????16 | Cure | Cure | ????3 | ???3 | ????0 | ||
| ????17 | Effectively | Improve | ????2 | ???1 | ????1 | ?10.5 | |
| ????18 | Cure | Cure | ????3 | ???3 | ????0 | ?10.5 | |
| ????19 | Cure | Effectively | ????3 | ???2 | ????1 | ||
| ????20 | Improve | Effectively | ????1 | ???2 | ????-1 | ?10.5 | |
| ????21 | Cure | Effectively | ????3 | ???2 | ????1 | ?10.5 | |
| ????22 | Cure | Improve | ????3 | ???1 | ????2 | ?24.5 | |
| ????23 | Effectively | Effectively | ????2 | ???2 | ????0 | ||
| ????24 | Cure | Effectively | ????3 | ???2 | ????1 | ?10.5 | |
| ????25 | Cure | Improve | ????3 | ???1 | ????2 | ?24.5 | |
| ????26 | Effectively | Improve | ????2 | ???1 | ????1 | ?10.5 | |
| ????27 | Cure | Effectively | ????3 | ???2 | ????1 | ?10.5 | |
| ????28 | Cure | Cure | ????3 | ???3 | ????0 | ||
| The curative effect sequence number | Test medicine I | Fungal infection of hand and foot liquid medicine II | Score | Difference | Rank | ||
| ?????I | ??II | ????I-II | ??+ | - | |||
| ?????29 | Cure | Effectively | ???3 | ????2 | ????1 | ?10.5 | |
| ?????30 | Cure | Improve | ???3 | ????1 | ????2 | ?24.5 | |
| ?????31 | Cure | Improve | ???3 | ????1 | ????2 | ?24.5 | |
| ?????32 | Cure | Cure | ???3 | ????3 | ????0 | ||
| ?????33 | Cure | Effectively | ???3 | ????2 | ????1 | ?10.5 | |
| ?????34 | Cure | Cure | ???3 | ????3 | ????0 | ||
| ?????35 | Cure | Effectively | ???3 | ????2 | ????1 | ?10.5 | |
| ?????36 | Cure | Effectively | ???3 | ????2 | ????1 | ?10.5 | |
| Cure rate % | 80.6％ | 28％ | |||||
| Effective percentage % | 94.1％ | 75％ | |||||
Rank test: n=28, t=56 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can find out clearly that from table 2 test medicine is respectively 94.1% and 80.6% to the effective percentage and the cure rate of tinea pedis, contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is 80.6 and 75%, through the two difference of rank test is significantly, test medicine be described and contrast the different significantly of medicine therapeutic effect.
Table 5 human body skin toxicity and sensitization test (STT) result
10-15 year age group
Continuous table 30-35 year age group of going up
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| ????A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| ????B | The same | The same | The same | The same | The same |
| ????C | The same | The same | The same | The same | The same |
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| ????A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| ????B | The same | The same | The same | The same | The same |
| ????C | The same | The same | The same | The same | The same |
40-45 year age group
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| ????A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| ????B | The same | The same | The same | The same | The same |
| ????C | The same | The same | The same | The same | The same |
Result of the test from table 5 as can be seen, test medicine is to the skin zero damage effect.Complete human body skin is put on the skin behind this medicine without any abnormal response, does not also influence other physiological functions, is tried the position and surrounding skin is as good as.According to experimenter reflection, put this medicine on the skin after, being tried the position has slight refrigerant deep sense, with puckery itching, but this sensation disappearance in a few minutes is as good as afterwards and at ordinary times.This medicine only need be put on the skin 2-3 time general every day, at most 3-4 time (severe patient).As can be seen from the table, this medicine does not produce the effect of infringement skin along with the increase of access times and time.Therefore, using this medicine that skin is not produced tangible toxic reaction, is safe.
Table 6 pair family exempts from the toxicity test result of skin
| Processing mode | The skin lesion reaction | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| ????A | Skin is harmless | Skin is harmless | Skin is harmless | Skin is harmless | Do not see any abnormal conditions |
| ????B | The red cicatrix of fine rule is arranged | The incrustation of fine rule cicatrix is arranged | Not obvious cicatrix | Slightly see cut | Diet is movable normal, body weight, growth are normal |
| ????C | Skin is harmless | Skin is harmless | Skin is harmless | Skin is harmless | The same |
| ????D | The coking crust | Eschar is arranged | Residual eschar | Normally, slightly see the lightpink cut | The same |
Learn that from experimental observation the rare earth test medicine does not produce obvious toxic and side effects to skin, can not cause any damage normal skin.After the skin lesion position put on the skin this medicine, can play antiinflammatory, removing dampness, the effect of promotion wound healing.After can seeing that from result of the test the rabbit damaged skin is put this medicine on the skin, wound healing fast, and preventing from scar, this may be relevant with antiinflammatory, the bacteriostasis of this medicine.When this medicine is just put at rabbit cutaneous scarification position on the skin, show red thin-line-shaped, do not see obvious edema projection, and do not put the visible obviously edema of cut of this medicine on the skin, peripheral red projection, with comparing of applying ointment, the incrustation area is obviously bigger than normal.
Claims (2)
1. compounding method that contains rare earth treatment dermatophytosis medicament, it is characterized in that: it is the medicament with following weight percentages and method preparation: by the Cortex Pseudolaricis after handling be 8～15%, Cortex erythrinae is 8～18%, Pericarpium Granati is 8～15%, the Fructus Kochiae is 8～13%, Cortex Dictamni is 8～～15%, Cortex Meliae is 8～13%, Semen Arecae is 8～13%, Camphora is 5～14%, nitric acid rare earth is 5～15%, aminoacid is 4～10%, salicylic acid is 4～10%, benzoic acid is 4～10% to form.
2. a kind of compounding method that contains rare earth treatment tinea medicament according to claim 1 is characterized in that:
(1) Cortex Pseudolaricis, Cortex erythrinae, Pericarpium Granati, the Fructus Kochiae, Cortex Dictamni, Cortex Meliae, the Semen Arecae that weigh up are pulverized the coarse powder after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol with 75% is made solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) Camphora that weighs up is dissolved with 95% ethanol after, add in the supernatant of (1), and salicylic acid, benzoic acid are added the back in the lump stir, make it to dissolve fully to get final product;
(3) nitric acid rare earth that weighs up being joined in the amino acid solution, is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pours in the supernatant in (2), puts filtration in 24 hours;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118811A CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118811A CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1140600A true CN1140600A (en) | 1997-01-22 |
| CN1067879C CN1067879C (en) | 2001-07-04 |
Family
ID=5081789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95118811A Expired - Fee Related CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1067879C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086125C (en) * | 1999-08-02 | 2002-06-12 | 张延亭 | Externally used medicine for treating tinea |
| CN100374131C (en) * | 2000-09-22 | 2008-03-12 | 李溟 | Liniment for treating sweaty feet, odour feet and beriberi and preparation method thereof |
| CN102688429A (en) * | 2012-06-08 | 2012-09-26 | 王建国 | Medicinal tincture for treating fungal diseases |
| CN109464621A (en) * | 2018-11-23 | 2019-03-15 | 广西信业生物技术有限公司 | A kind of external preparation and preparation method thereof for treating eczema |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031799A (en) * | 1987-09-07 | 1989-03-22 | 张世麟 | The manufacture method of psoriasis cure |
| CN1045384C (en) * | 1989-05-05 | 1999-10-06 | 程立志 | Method for producing effective beriberi distillate "Once Effeclive" "Beriberi Annihilated" |
| CN1097138A (en) * | 1993-12-03 | 1995-01-11 | 陈保清 | Dermopathic Chinese medicine preparation of a kind of treatment and production method thereof |
-
1995
- 1995-12-27 CN CN95118811A patent/CN1067879C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086125C (en) * | 1999-08-02 | 2002-06-12 | 张延亭 | Externally used medicine for treating tinea |
| CN100374131C (en) * | 2000-09-22 | 2008-03-12 | 李溟 | Liniment for treating sweaty feet, odour feet and beriberi and preparation method thereof |
| CN102688429A (en) * | 2012-06-08 | 2012-09-26 | 王建国 | Medicinal tincture for treating fungal diseases |
| CN109464621A (en) * | 2018-11-23 | 2019-03-15 | 广西信业生物技术有限公司 | A kind of external preparation and preparation method thereof for treating eczema |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1067879C (en) | 2001-07-04 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangyin forest rare earth biochemical application Co., Ltd. Assignor: Zhang Hongjiang|Zhang Yusheng Contract fulfillment period: Contract performance period from May 19, 2001 to December 27, 2015, 14 years Contract record no.: Contract filing No. 033200010009 Denomination of invention: An agent for the treatment of skin diseases Granted publication date: 20010704 License type: Exclusive license Record date: 20030701 |
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Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2001.5.19 TO 2015.12.27, 14 YEARS Name of requester: JIANGYIN CITY LINSHENG RARE EARTH BIOCHEMICAL CO. Effective date: 20030701 |
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