CN1067879C - Preparation of medicament containing rare-earth for dermatomycosis - Google Patents
Preparation of medicament containing rare-earth for dermatomycosis Download PDFInfo
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- CN1067879C CN1067879C CN95118811A CN95118811A CN1067879C CN 1067879 C CN1067879 C CN 1067879C CN 95118811 A CN95118811 A CN 95118811A CN 95118811 A CN95118811 A CN 95118811A CN 1067879 C CN1067879 C CN 1067879C
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Abstract
The present invention relates to a preparation method of a medicament containing rare-earth for treating skin tinea diseases. The medicament containing rare-earth for treating skin tinea diseases is prepared from pseudolarix bark, erythrina bark, pomegranate rind, broom cypress fruit, dittany bark, chinaberry bark, betel nut, camphor, rare earth nitrate, amino acid, salicylic acid and benzoic acid. The medicament is prepared into an external medicament by Chinese herbal medicines, the rare earth nitrate, etc., and is used for treating skin tinea diseases. Besides, the medicament containing rare-earth for treating skin tinea diseases has diffusion inhibiting action on skin with injured affected parts which are smeared by other external medicaments, and has no injury to the epidermis of the smeared skin. The medicament has the advantages of weak acid corrosion, no injury trace for peripheral skin, no use pain sensation for patients, obvious use effect, quick effect, high cure rate, radical cure, difficult disease recurrence, no toxicity and no side effect.
Description
The present invention relates to a kind of medicament for the treatment of tinea, belong to field of medicaments.
At present, ringworm is a kind of common skin disease, accounts for more than 90% of dermatomycosis, generally adopts doctor trained in Western medicine, the traditional Chinese medical science or therapy of combining Chinese and Western medicine method, and oral medicine commonly used or medicine for external use are used in combination, but cure rate and effective percentage each is variant, effect is unsatisfactory.Untoward reaction is more after the medication, the relapse rate height.Though some medicine has inhibitory action to this disease, injured skin, pain is strong, is unfavorable for that the patient uses, and cure rate is not high yet.Though some medicine has no adverse reaction, therapeutic effect is not good, and treatment time is long.Though some medicine is effective in cure, closed antibiotics or hormone, life-time service can play side effect, and incompatible patient can not use to the skin hormonal medicaments.As Medicated Liquid for Fungal Infection of Hand and Foot, though certain curative effect is arranged, it is slow to take effect, and effective percentage and cure rate are not high.Some acidity is stronger, pain when putting on the skin, to favour portion and around to corrode zest big, cause easily and fester and concurrent infection, so such pharmacopoeia class is a lot of at present, but lack very good medicine.
The objective of the invention is to be to provide a kind of with preparations such as Chinese herbal medicine and nitric acid rare earths, topical agent treatment tinea.The skin that damages affected part to using other medicine for external use has the inhibition diffusion, and does not damage the epiderm skin of being put on the skin.A little less than the acid corrosion, to skin zero damage on every side, the patient uses does not have pain, and help the patient and use, instant effect, result of use is remarkable, and the cure rate height can effect a radical cure, is difficult for recurring, no side effects, preparation method is simple, and is easy to use, with low cost.
The objective of the invention is to realize by preparations such as following Chinese medicine and nitric acid rare earths:
Cortex Pseudolaricis is 8～15%, Cortex erythrinae is 8～18%, Pericarpium Granati is 8～15%, the Fructus Kochiae is 8～13%, Cortex Dictamni is 8～15%, Cortex Meliae is 8～13%, Semen Arecae is 8～13%, Camphora is 5～14%, nitric acid rare earth is 5～15%, aminoacid is 4～10%, salicylic acid is 4～10%, benzoic acid is 4～10%.
Preparation method of the present invention and technical process:
(1) will treat Cortex Pseudolaricis, Cortex erythrinae, Pericarpium Granati, the Fructus Kochiae, Cortex Dictamni, Cortex Meliae, the Semen Arecae that the medicament of tinea weighs up and pulverize the coarse powder after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol with 75% is made solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) Camphora that weighs up is dissolved with 95% ethanol after, add in the supernatant of (1), and salicylic acid, benzoic acid are added the back in the lump stir, make it to dissolve fully to get final product;
(3) nitric acid rare earth that weighs up being joined in the amino acid solution, is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pours in the supernatant in (2), puts filtration in 24 hours;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
The pharmacy effect that the present invention treats tinea is: through up to a hundred times compatibility test and formula adjustment, determined the kind of Chinese medicine, using dosage and preparation technology, this medicament is the compound preparation of nitric acid rare earth and Chinese medicine, its therapeutical effect is the adduction of the two, nitric acid rare earth in this medicament coexists as in the individual system with other Chinese medicinal ingredients with the form of complex, played balance, potentiation, increase significantly than traditional oral medicine and external medication effect, rare earth element energy chafe cell in this medicine is to the absorption of nutrient substance, strengthen the metabolism of skin, quicken the division and the hypertrophy of callus, strengthen the physiologically active of skin.Use the back good drug efficacy, drug effect is long, no pain, and instant effect, the mild or moderate patient only needs can cure for several times, and severe patient only needs can fully recover in 1～2 week, and safe and reliable, the skin lesion place skin of healing is bright and clean smooth, and preventing from scar is bordering on healthy skin.This medicament have removing dampness, parasite killing, antipruritic, sterilization, anticorrosion, suppress tinea bacterium survival function.To treatment tinea corporis, tinea capitis, the tinea manuum, tinea pedis, flat tinea, feline tinea, scabies, skin itching disease, effect is the most obvious, and eczema, allergic dermatitis, psoriasis etc. are also had certain curative effect.This medicament has made full use of the mechanism of action of rare earth, has improved the treatment level of whole medicine, and is evident in efficacy, has been subjected to patient's welcome.
Since advanced development in 1989 the main curative effect of this medicament is carried out systematic research, obtained desirable therapeutic.Great majority are light, moderate favour person only need put on the skin to smear and can fully recover for several times.Thorough healing person not, test continues medication later and also all obtains curing.Begin we and related hospitals associating in 1993, carried out pilot experiment, cure all kinds of tinea 200 many cases altogether.
Fig. 1 is a process flow diagram of the present invention;
Table 1 is the curative effect comparisons of two kinds of medicines to the tinea capitis patient;
Table 2 is the curative effect comparisons to face tinea patient of two kinds of medicines;
Table 3 is the curative effect comparisons to tinea manuum patient of two kinds of medicines;
Table 4 is the curative effect comparisons to the tinea pedis patient of two kinds of medicines;
Table 5 is to human body skin toxicity and sensitization test (STT) result;
Table 6 is the toxicity test results to rabbit skin.
Use the model case of this pharmaceutical treatment to be described below in detail:
Case (1) patient is normal * * man, suffer from ringworm of the body, spread all over back and trunk, performance annular and copper coin shape pathology, conscious odd itching, spring, summer are serious, once two hospital dermatology department treatments 1 year, the oral administration and externally western medicines in treatment was not all cured, three recoveries from illness course for the treatment of of this medicine treatment of rear usefulness, have no recurrence with note over 2 years, cure this type of patient 3 people.
Case (2) patient Wang * * man, the favour tinea versicolor, neck, shirtfront and back show as the sepia of soya bean size, itch, scratch furfur. Ill 7 years, once many hospitalizes are radical cure all, uses this medicine to cure after three months in 1991, after recur so far, cure this type of patient 6 people.
Case (3) patient horse * * man, suffer from the tinea manuum, the middle finger skin of index finger is firmly thick very itches, and once two hospital dermatology departments treatments 1 year, the oral administration and externally Chinese and Western medicine was all cured, and recovery from illness course for the treatment of of this medicine treatment of rear usefulness has no recurrence with remembering 2 years.
Case (4) patient Cai * * woman, suffer from the tinea manuum, right hand facies palmaris is firmly very itched immoderate, through certain Army Hospital's external application antipsoric, treats and does not heal in 1 year, and two recoveries from illness course for the treatment of of this medicine of rear usefulness are followed up a case by regular visits to and were had no recurrence in 1 year, cure altogether this type of patient 30 people.
Case (5) patient Lee * * man, suffer from the ringworm of the foot, adularescent skin between toe, conscious disturbing itched, and has ruddy after the broken skin. Be coated with in 1989 and put this medicine treatment on the skin, so far not recurrence after the healing. Cure this type of patient 20 people.
Case (6) patient bag * * man, hand, vola or refer between blister in groups intensive or that disperse is arranged, the blister film is thicker, is difficult for breaking, conscious play is itched, and is coated with to put this medicine on the skin and cure, he this patient 6 people is cured in recurrence so far.
Case (7) patient's money * * woman, dry fish scale bits skin is arranged on hand, the sole or between referring to, there is very thick hard and coarse skin at serious position, and chaps. Put the recovery from illness two courses for the treatment of of this pharmaceutical treatment on the skin through being coated with, such patient's severe one 8 people are treated in recurrence altogether so far, and the lighter 6 people, the lighter are coated with and put on the skin several times and can cure, and severe one is coated with puts 20～30 times on the skin and can cure.
Case (8) patient's height * * woman, belong to face's tinea disease (hospital diagnosis is the cat tinea) and use this pharmaceutical treatment namely to fully recover after a course for the treatment of, after this recurrence.
Case (9) patient discriminates * * woman, the ringworm of the foot is suffered from for many years by foot, right crus of diaphragm small thumb onychomycosis, soak six times with this medicament after symptom disappear gradually, recur so far.
Case (10) patient week * *, suffered from tinea capitis 3 years, once in four tame hospitalizes, tens kinds of medications, all radical cures are used this medicament to be coated with and are put four recoveries from illness courses of treatment on the skin, follow up a case by regular visits to and do not see recurrence in 1 year.
Case (11) patient Peng * * man, eczema is suffered from the arm both sides, the depths of itching, outbreak repeatedly, touching difficulty was not more once effected a radical cure in three tame hospitalizes, and the back is used this medicament to be coated with and is put four recoveries from illness course of treatment on the skin, follow up a case by regular visits to and do not see recurrence in 1 year.Treat heavy person 4 people of such patient altogether, the lighter 6 people.
Case (12) patient Liu * * woman, suffered from scabies 23 days, the play of lower abdomen both sides is itched, and dragon is the most serious its night, is coated with to put six recoveries from illness of this medicament on the skin, does not see recurrence so far.
Most preferred embodiment of the present invention:
Embodiment 1:
This medicament Cortex Pseudolaricis is 9%, Cortex erythrinae is 12%, Pericarpium Granati is 9%, the Fructus Kochiae is 9%, Cortex Dictamni is 9%, bitter Pericarpium Citri Reticulatae is 9%, Semen Arecae is 9%, Camphora is 9%, nitric acid rare earth is 9%, aminoacid is 6%, salicylic acid is 6%, benzoic acid is 5%.
Its technical process is as follows:
(1) with component is 9% Cortex Pseudolaricis, 12% Cortex erythrinae, 9% Pericarpium Granati, 9% the Fructus Kochiae, 9% Cortex Dictamni, 9% bitter Pericarpium Citri Reticulatae, 9% the coarse powder of Semen Arecae pulverizing after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol 900ml with 75% makes solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) with component be 8% Camphora, after the ethanol 24ml with 95% dissolves, add in the supernatant of (1), and salicylic acid 6%, benzoic acid 5% are added the back stirring in the lump, make it to dissolve fully to get final product;
(3) with component be 9% nitric acid rare earth, joining in the amino acid solution of 90ml (aminoacid is 9% to calculate by component), is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pour in the supernatant in (2), put filtration in 24 hours;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Embodiment 2:
This medicament Cortex Pseudolaricis is 9.8%, Cortex erythrinae is 10.2%, Pericarpium Granati is 9.8%, the Fructus Kochiae is 8%, Cortex Dictamni is 8%, bitter Pericarpium Citri Reticulatae is 8%, Semen Arecae is 8%, Camphora 6%, nitric acid rare earth are 9.8%, aminoacid is 6.6%, salicylic acid 6.6%, benzoic acid are 6.6%.
Its technical process is as follows:
(1) will weigh up component is 9.8% Cortex Pseudolaricis, 10.2% Cortex erythrinae, 9.8% Pericarpium Granati, 8% the Fructus Kochiae, 8% Cortex Dictamni, 8% bitter Pericarpium Citri Reticulatae, 8% the coarse powder of Semen Arecae pulverizing after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol 900ml with 75% makes solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) with component be 14% Camphora, after the ethanol 24ml with 95% dissolves, add in the supernatant of (1), and salicylic acid 6.6%, benzoic acid 6.6% are added the back stirring in the lump, make it to dissolve fully to get final product;
(3) with component be 9.8% nitric acid rare earth, joining in the amino acid solution of 90ml (aminoacid is 9.8% to calculate by component), is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pour in the supernatant in (2), filtered in 24 hours the lining;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Use the dermatophytosis topical agent of the present invention's preparation,, directly use at affected part with clean brush pen or cotton excellent dip in liquid medicine, every day 1～3 time, per ten days is a course of treatment, and light, moderate patient only need smear and can cure for several times, can fully recover 2～3 courses of treatment to the severe patient treatment.
Annotate: a kind of treatment tinea medicament of the present invention is called for short " test medicine " in following each table.
Two kinds of medicines of table 1 compare tinea capitis patient's curative effect
Annotate: effective percentage is meant effectively and the total percentage rate of healing.
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 1 | Cure | Effectively | 3 | 2 | 1 | 2 | |
| 2 | Effectively | Improve | 2 | 1 | 1 | 2 | |
| 3 | Cure | Improve | 3 | 1 | 2 | 4 | |
| 4 | Cure | Improve | 3 | 1 | 2 | 5 | |
| 5 | Cure | Invalid | 3 | 0 | 3 | 7 | |
| 6 | Cure | Invalid | 3 | 0 | 3 | 8 | |
| 7 | Improve | Effectively | 1 | 2 | -1 | 2 | |
| 8 | Cure | Invalid | 3 | 1 | 2 | 6 | |
| Cure rate % | 75％ | 0 | 34 | 2 | |||
| Effective percentage % | 87.5％ | 25 | |||||
Rank test: n=8, t=2 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can see clearly that from table 1 test medicine is 75% to the cure rate of tinea, effective percentage is 87.5%, and contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is 25%, and cure rate is 0, is significant through the two difference of rank test, illustrates that test medicine has higher curative effect.
Two kinds of medicine faces of table 2 tinea capitis patient's curative effect relatively
Illustrate: 6, No. 9 among the examination patient because of drug withdrawal midway, can't do observation of curative effect judgement.
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 1 | Cure | Effectively | 3 | 2 | 1 | 1 | |
| 2 | Cure | Effectively | 3 | 3 | 0 | ||
| 3 | Cure | Effectively | 3 | 2 | 1 | 2 | |
| 4 | Cure | Effectively | 3 | 2 | 1 | 3 | |
| 5 | Effectively | Improve | 2 | 1 | 1 | 4 | |
| 6X | |||||||
| 7 | Effectively | Improve | 2 | 1 | 1 | 5 | |
| 8 | Cure | Invalid | 3 | 0 | 3 | 6 | |
| 9X | |||||||
| 10 | Cure | Invalid | 3 | 0 | 3 | 7 | |
| Cure rate % | 75％ | 12.5％ | 28 | 0 | |||
| Effective percentage % | 100％ | 62.5％ | |||||
Rank test: n=7, t=0 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can find out clearly that from table 2 test medicine is 100% to face tinea (feline tinea) cure rate, contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is %62.5, cure rate is 12.5%, is significantly through the two difference of rank test, test medicine be described and contrast the medicine therapeutic effect and have different significantly.
Two kinds of medicines of table 3 compare tinea manuum patient's curative effect
Rank test: n=6, t=3 tables look-up and learns p＞a=0.05, so the curative effect difference of the two is not remarkable.
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 1 | Cure | Cure | 3 | 3 | 0 | ||
| 2 | Cure | Effectively | 3 | 2 | 1 | ||
| 3 | Improve | Improve | 1 | 1 | 0 | 3 | |
| 4 | Cure | Effectively | 3 | 2 | 1 | 3 | |
| 5 | Cure | Cure | 3 | 3 | 0 | ||
| 6 | Effectively | Effectively | 2 | 2 | 0 | ||
| 7 | Effectively | Cure | 2 | 2 | -1 | 3 | |
| 8 | Cure | Effectively | 3 | 2 | 1 | 3 | |
| 9 | Cure | Improve | 3 | 1 | 2 | 6 | |
| 10 | Effectively | Improve | 2 | 1 | 1 | 3 | |
| Cure rate % | 60％ | 30％ | 21 | 3 | |||
| Effective percentage % | 90％ | 70％ | |||||
Test medicine checks the two not obvious with the effect of the contrast medicine fungal infection of hand and foot liquid medicine treatment tinea manuum by statistics as can be seen from Table 3, but all high many of test medicine contrast medicine cure rate and effective percentage illustrates that the test medicine therapeutic effect is better than contrasting.
Two kinds of medicines of table 4 compare tinea pedis patient's curative effect
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 1 | Cure | Cure | 3 | 3 | 0 | ||
| 2 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 3 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 4 | Cure | Improve | 3 | 1 | 2 | 24.3 | |
| 5 | Effectively | Cure | 2 | 3 | -1 | ||
| 6 | Cure | Cure | 3 | 3 | 0 | ||
| 7 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 8 | Effectively | Cure | 2 | 3 | -1 | ||
| 9 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 10 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 11 | Cure | Effectively | 3 | 3 | 1 | 10.5 | |
| 12 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 13 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 14 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
The continuous table of going up
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 15 | Improve | Cure | 1 | 3 | -2 | 24.5 | |
| 16 | Cure | Cure | 3 | 3 | 0 | ||
| 17 | Effectively | Improve | 2 | 1 | 1 | 10.5 | |
| 18 | Cure | Cure | 3 | 3 | 0 | 10.5 | |
| 19 | Cure | Effectively | 3 | 2 | 1 | ||
| 20 | Improve | Effectively | 1 | 2 | -1 | 10.5 | |
| 21 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 22 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 23 | Effectively | Effectively | 2 | 2 | 0 | ||
| 24 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 25 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 26 | Effectively | Improve | 2 | 1 | 1 | 10.5 | |
| 27 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 28 | Cure | Cure | 3 | 3 | 0 | ||
Continuous table
| The curative effect sequence number | The test medicine I | Fungal infection of hand and foot liquid medicine II | {。##.##1}, | Divide | Difference | Rank | |
| Ⅰ | Ⅱ | Ⅰ-Ⅱ | + | - | |||
| 29 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 30 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 31 | Cure | Improve | 3 | 1 | 2 | 24.5 | |
| 32 | Cure | Cure | 3 | 3 | 0 | ||
| 33 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 34 | Cure | Cure | 3 | 3 | 0 | ||
| 35 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| 36 | Cure | Effectively | 3 | 2 | 1 | 10.5 | |
| Effective percentage % | 80.6％ | 28％ | |||||
| Effective percentage % | 94.1％ | 75％ | |||||
Rank test: n=28, t=56 tables look-up and learns p＜a=0.05, so there were significant differences for the curative effect of the two.
Can find out clearly that from table 2 test medicine is respectively 94.1% and 80.6% to the effective percentage and the cure rate of tinea pedis, contrast medicine fungal infection of hand and foot liquid medicine effective percentage only is 80.6 and 75%, through the two difference of rank test is significantly, illustrate that test medicine contrasts the medicine therapeutic effect significant difference is arranged.
Table 5 human body skin toxicity and sensitization test (STT) be 10-15 year age group as a result
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| B | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
| C | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
Continuous table 30-35 year age group of going up
40-45 year age group
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| B | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
| C | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| A | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any abnormal conditions |
| B | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
| C | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | Do not see any untoward reaction | The same |
Result of the test from table 5 as can be seen, test medicine is to the skin zero damage effect.Complete human body skin is put on the skin behind this medicine without any abnormal response, does not also influence other physiological functions, is tried the position and surrounding skin is as good as.According to experimenter reflection, put this medicine on the skin after, being tried the position has the deep sense of slight situation, with puckery itching, but this sensation disappearance in a few minutes is as good as afterwards and at ordinary times.This medicine only need be put on the skin 2-3 time general every day, at most 3-4 time (severe patient).As can be seen from the table, this medicine does not produce the effect of infringement skin along with the increase of access times and time.Therefore, using this medicine that skin is not produced tangible toxic reaction, is safe.
The toxicity test result of table 6 pair rabbit skin
| Processing mode | Skin injury and sensitivity response | Other symptoms | |||
| The same day | 48 hours | 5 days | 7 days | ||
| A | Skin is harmless | Skin is harmless | Skin is harmless | Skin is harmless | Do not see any abnormal conditions |
| B | The red cicatrix of fine rule is arranged | The incrustation of fine rule cicatrix is arranged | Not obvious cicatrix | Slightly see cut | Diet is movable normal, body weight, growth are normal |
| C | Skin is harmless | Skin is harmless | Skin is harmless | Skin is harmless | The same |
| D | The coking crust | Eschar is arranged | Residual eschar | The same | |
Learn that from experimental observation test medicine does not produce obvious toxic and side effects to skin, can not cause any damage normal skin.After the skin lesion position put on the skin this medicine, can play antiinflammatory, removing dampness, the effect of promotion wound healing.After can seeing that from result of the test the rabbit damaged skin is put this medicine on the skin, wound healing fast, and preventing from scar, this may be relevant with antiinflammatory, the bacteriostasis of this medicine.When this medicine is just put at rabbit cutaneous scarification position on the skin, show red thin-line-shaped, do not see obvious edema projection, and do not put the visible obviously edema of cut of this medicine on the skin, peripheral red projection, with comparing of applying ointment, the incrustation area is obviously bigger than normal.
Claims (2)
1, a kind of medicament for the treatment of tinea, it is characterized in that: it is to be prepared from following weight percentages: Cortex Pseudolaricis is that 8-15%, Cortex erythrinae are that 8-18%, Pericarpium Granati are 8～15%, the Fructus Kochiae is that 8-13%, Cortex Dictamni are that 8-15%, Cortex Meliae are that 8-13%, Semen Arecae are that 8-13%, Camphora are that 5-14%, nitric acid rare earth are that 5-15%, aminoacid are that 4-10%, salicylic acid are that 4-10%, benzoic acid are 4-10%.
2, the described a kind of medicament for the treatment of tinea of claim 1 is characterized in that:
(1) Cortex Pseudolaricis, Cortex erythrinae, Pericarpium Granati, the Fructus Kochiae, Cortex Dictamni, Cortex Meliae, the Semen Arecae that weigh up are pulverized the coarse powder after 40 orders sieve, put impregnating autoclave, press the tincture infusion process, ethanol with 75% is made solvent, seal cover flooded 5～7, stirred every day twice, filter, squeeze medicinal residues, collect the merging of press juice and filtrate;
(2) Camphora that weighs up is dissolved with 95% ethanol after, add in the supernatant of (1), and salicylic acid, benzoic acid are added the back in the lump stir, make it to dissolve fully to get final product;
(3) nitric acid rare earth that weighs up being joined in the amino acid solution, is that heating was stirred rearmounted 24 hours more than 10 hours in 80～100 ℃ of water-baths in temperature, pours in the supernatant in (2), puts filtration in 24 hours;
(4) fixed molten to 1000 milliliters with 75% ethanol, bottling gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118811A CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118811A CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1140600A CN1140600A (en) | 1997-01-22 |
| CN1067879C true CN1067879C (en) | 2001-07-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95118811A Expired - Fee Related CN1067879C (en) | 1995-12-27 | 1995-12-27 | Preparation of medicament containing rare-earth for dermatomycosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1067879C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086125C (en) * | 1999-08-02 | 2002-06-12 | 张延亭 | Externally used medicine for treating tinea |
| CN100374131C (en) * | 2000-09-22 | 2008-03-12 | 李溟 | Liniment for treating sweaty feet, odour feet and beriberi and preparation method thereof |
| CN102688429B (en) * | 2012-06-08 | 2013-11-27 | 王建国 | Medicinal tincture for treating fungal diseases |
| CN109464621A (en) * | 2018-11-23 | 2019-03-15 | 广西信业生物技术有限公司 | A kind of external preparation and preparation method thereof for treating eczema |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031799A (en) * | 1987-09-07 | 1989-03-22 | 张世麟 | The manufacture method of psoriasis cure |
| CN1047033A (en) * | 1989-05-05 | 1990-11-21 | 程立志 | " one-time efficacious " jiaoqijing (the fragrant manufacture method of revealing of " one-time efficacious " beriberi) |
| CN1097138A (en) * | 1993-12-03 | 1995-01-11 | 陈保清 | Dermopathic Chinese medicine preparation of a kind of treatment and production method thereof |
-
1995
- 1995-12-27 CN CN95118811A patent/CN1067879C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031799A (en) * | 1987-09-07 | 1989-03-22 | 张世麟 | The manufacture method of psoriasis cure |
| CN1047033A (en) * | 1989-05-05 | 1990-11-21 | 程立志 | " one-time efficacious " jiaoqijing (the fragrant manufacture method of revealing of " one-time efficacious " beriberi) |
| CN1097138A (en) * | 1993-12-03 | 1995-01-11 | 陈保清 | Dermopathic Chinese medicine preparation of a kind of treatment and production method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1140600A (en) | 1997-01-22 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangyin forest rare earth biochemical application Co., Ltd. Assignor: Zhang Hongjiang|Zhang Yusheng Contract fulfillment period: Contract performance period from May 19, 2001 to December 27, 2015, 14 years Contract record no.: Contract filing No. 033200010009 Denomination of invention: An agent for the treatment of skin diseases Granted publication date: 20010704 License type: Exclusive license Record date: 20030701 |
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Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2001.5.19 TO 2015.12.27, 14 YEARS Name of requester: JIANGYIN CITY LINSHENG RARE EARTH BIOCHEMICAL CO. Effective date: 20030701 |
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