CN114052247B - 一种含槲皮万寿菊素、6-羟基山奈酚和没食子酸的抗氧化组合物 - Google Patents
一种含槲皮万寿菊素、6-羟基山奈酚和没食子酸的抗氧化组合物 Download PDFInfo
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Abstract
一种抗氧化组合物，含有槲皮万寿菊素、6‑羟基山奈酚和没食子酸类成分。上述成分组合后有明显的协同增效作用，可显著提高组合物的抗氧化效果，可用于提高食品、饲料、药品等的产品的稳定性。
Description
技术领域
本发明属于添加剂领域，具体涉及一种含槲皮万寿菊素、6-羟基山奈酚和没食子酸类成分的抗氧化组合物及其用途。
背景技术
油脂、维生素、类胡萝卜素等作为有效成分，在食品、饲料、药品等中广泛使用。由于化学结构不稳定，在产品放置过程中，油脂、维生素、类胡萝卜素等有效成分会发生氧化反应，导致有效成分的含量降低，影响产品品质。其中油脂氧化后会分解为低分子的醛、酮、酸等有哈喇味的产物，不仅影响产品风味，对动物体的消化系统、肝脏等都会造成损伤。
为了减少有效成分的氧化损失，添加抗氧化剂是目前普遍采用的方法。市场上的抗氧化剂以化学合成的为主，如TBHQ(特丁基对苯二酚)、BHA(丁基羟基茴香醚)、BHT(二丁基羟基甲苯)、EQ(乙氧基喹啉)等。EQ，是性能优良的饲料抗氧化剂。TBHQ、BHA、BHT等除在饲料中应用外，还可应用与食品等领域。EQ、BHT等合成抗氧化剂成本低，但普遍存在不同程度的安全性问题，产品应用受到一定限制。
槲皮万寿菊素，化学名称为3,3,4,5,6,7-六羟基黄酮，具有抗氧化、抗炎、抗过敏、抗肿瘤等重要的药理作用，具有良好的抗氧化效果。
没食子酸是自然界存在的一种多酚类化合物，具有良好的抗氧化活性，在食品、生物、医药、化工等领域有广泛的应用。此外，没食子酸还常以其衍生物形式存在，其衍生物形式主要包括没食子酸盐类、没食子酸酯类、以及没食子酸糖苷类。
6-羟基山奈酚是一种天然的黄酮类成分，具有多种药理活性。
在使用时，不同抗氧化剂合理搭配使用，有时会起到协同增效作用。本申请即发现槲皮万寿菊素、6-羟基山奈酚与没食子酸类成分按一定比例复配使用，有明显的协同增效作用，能够有效延缓各类产品中有效成分的氧化过程，提高产品的稳定性。
发明内容
为了进一步提高抗氧化添加剂的抗氧化效果以及安全性，本发明提供了一种含槲皮万寿菊素、6-羟基山奈酚和没食子酸类成分的抗氧化组合物，通过将槲皮万寿菊素、6-羟基山奈酚与没食子酸类成分复配使用，产生明显的协同增效作用，提高组合物的抗氧化效果。
本发明的技术方案是：一种抗氧化组合物，其中含有槲皮万寿菊素，6-羟基山奈酚和没食子酸类成分。
本申请进一步提供了一种抗氧化组合物，组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为100:1至4:1，可优选80:1-10:1，可进一步优选60:1-20:1；槲皮万寿菊素和没食子酸类成分的重量比为200:1至1:1，可优选150:1-10:1，可进一步优选100:1-30:1。
更进一步，组合物中槲皮万寿菊素和6-羟基山奈酚的重量比可以是60:1、59:1、58:1、57:1、56:1、55:1、54:1、53：1、52:1、51:1、50:1、49:1、48:1、47:1、46:1、45:1、44:1、43:1、42:1、41:1、40:1、39:1、38：1、37:1、36:1、35:1、34:1、33:1、32:1、31:1、30:1、29:1、28:1、27:1、26:1、25:1、24:1、23:1、22:1、21:1、20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6:1、5:1或4:1。
更进一步，组合物中槲皮万寿菊素和没食子酸类成分的重量比可以是100:1、99:1、98:1、97:1、96:1、95:1、94:1、93:1、92:1、91:1、90:1、89:1、88:1、87:1、86:1、85:1、84:1、83:1、82:1、81:1、80:1、79:1、78:1、77:1、76:1、75:1、74:1、73:1、72:1、71:1、70:1、69:1、68:1、67:1、66:1、65:1、64:1、63:1、62:1、61:1、60:1、59:1、58:1、57:1、56:1、55:1、54:1、53：1、52:1、51:1、50:1、49:1、48:1、47:1、46:1、45:1、44:1、43:1、42:1、41:1、40:1、39:1、38：1、37:1、36:1、35:1、34:1、33:1、32:1、31:1、30:1、29:1、28:1、27：1、26：1、25:1、24:1、23:1、22:1、21:1、20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6：1、5:1、4:1、3:1、2:1或1:1。
更进一步，上述抗氧化组合中没食子酸类成分为没食子酸和/或其衍生物，优选地，没食子酸衍生物为没食子酸盐或酯或糖苷的形式。
更进一步，上述抗氧化组合物中还含有适应的载体、金属离子螯合剂、乳化剂等一种或多种成分。
上述抗氧化剂组合物可作为添加剂，加入食品、饲料、化妆品、营养保健品、药品中，保证产品品质的稳定性。
上述抗氧化组合物可作为添加剂，能够有效延缓食品、饲料、化妆品、营养保健品或药品中各成分的氧化过程，保证上述产品品质的稳定性。
上述抗氧化剂组合物能够有效延缓油脂、维生素、类胡萝卜素等成分的氧化过程，保证上述成分的稳定性。
本申请还提供一种添加剂制剂，即按照常规制备方法将上述组合物制备成任意一种可接受的适宜的饲料添加剂制剂，优选的，可加工成粉末、液体或微囊。
上述添加剂制剂能够有效延缓油脂、维生素、类胡萝卜素等成分的氧化过程，保证上述成分的稳定性。
上述添加剂制剂加入食品、饲料、化妆品、营养保健品、药品中，能够保证产品品质的稳定性。
本发明的有益效果是：
本申请发明人发现，槲皮万寿菊素、6-羟基山奈酚与没食子酸类成分按一定比例复配使用时，有明显的协同增效作用。同等添加量下，含槲皮万寿菊素、6-羟基山奈酚与没食子酸类成分按一定比例搭配的组合物对食品、饲料、化妆品、营养保健品、药品等中油脂、维生素、类胡萝卜素等的保护效果明显好于槲皮万寿菊素、6-羟基山奈酚或没食子酸类成分单独使用，可进一步减少产品有效成分氧化损失，保证产品在存放过程中品质稳定。
本申请的抗氧化组合物中各成分全部采用天然黄酮和多酚类化合物，产品安全性优于EQ等合成抗氧化剂。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明。
实施例1
将以下原料配比混合制备实施例1的抗氧化组合物：80％含量的槲皮万寿菊素40g，80％含量的6-羟基山奈酚1g，80％含量的没食子酸0.5g，载体淀粉50g，混合后得到组合物91.5g。组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为40:1，槲皮万寿菊素和没食子酸的重量比为80:1。
实施例2
将以下原料配比混合制备实施例2的抗氧化组合物：80％含量的槲皮万寿菊素100g，80％含量的6-羟基山奈酚1g，80％含量的没食子酸100g，载体淀粉100g混合后得到组合物301g。组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为100:1，槲皮万寿菊素和没食子酸的重量比为1:1。
实施例3
将以下原料配比混合制备实施例3的抗氧化组合物：80％含量的槲皮万寿菊素40g，80％含量的6-羟基山奈酚10g，80％含量的没食子酸0.2g，载体淀粉50g，混合后得到组合物100.2g。组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为4:1，槲皮万寿菊素和没食子酸的重量比为200:1。
对比例1
80％的槲皮万寿菊素。
对比例2
80％的6-羟基山奈酚。
对比例3
80％的没食子酸。
以食品为例，进行抗氧化效果评价：
(1)在煎炸用的棉籽油中分别添加实施例1-3和对比例1-3的产品，制备成6组含抗氧化成分300ppm的样品(以抗氧化活性成分的总含量计算)，另制备一组空白样品，即不添加抗氧化剂的棉籽油。
(2)将方便面饼分别使用上述7组样品进行油炸，每组三个平行，油炸后，在温度55℃、湿度60％条件下，放置5天，检测样品过氧化值。过氧化值按《GB5009.227-2016食品安全国家标准食品中过氧化值的测定》方法进行检测。
(3)检测结果如表1所示。
表1不同棉籽油样品油炸方便面饼的过氧化值测定结果
表1结果显示，相同用量条件下，按照本申请所述特定比例的槲皮万寿菊素、6-羟基山奈酚、没食子酸组合物的抗氧化效果，优于单独使用槲皮万寿菊素、6-羟基山奈酚、没食子酸的抗氧化效果，表明上述三种成分组合后具有协同增效的技术效果。
Claims (12)
1.一种抗氧化组合物，其特征在于，含有抗氧化成分，所述抗氧化成分为槲皮万寿菊素、6-羟基山奈酚和没食子酸类成分，其中，槲皮万寿菊素和6-羟基山奈酚的重量比为100:1至4:1，槲皮万寿菊素和没食子酸类成分的重量比为200:1至1:1。
2.根据权利要求1所述的一种抗氧化组合物，其特征在于，组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为80:1-10:1，槲皮万寿菊素和没食子酸类成分的重量比为150:1-10:1。
3.根据权利要求2所述的一种抗氧化组合物，其特征在于，组合物中槲皮万寿菊素和6-羟基山奈酚的重量比为60:1-20:1，槲皮万寿菊素和没食子酸类成分的重量比为100:1-30:1。
4.根据权利要求1-3任一项所述的抗氧化组合物，其特征在于，组合物中没食子酸类成分为没食子酸和/或其衍生物。
5.根据权利要求4所述的抗氧化组合物，所述没食子酸衍生物为没食子酸盐或没食子酸酯或没食子酸糖苷中的一种或多种。
6.根据权利要求1-3任一项所述组合物，其特征在于，其中还含有适应的载体、金属离子螯合剂、乳化剂中的一种或多种成分。
7.一种添加剂制剂，其特征在于，包含权利要求1-6任一项所述组合物，并按照任一种常规制剂方法制备得到。
8.根据权利要求7所述的添加剂制剂，其特征在于，所述制剂为粉末、液体或微囊。
9.根据权利要求1-6任一项抗氧化组合物的用途，其特征在于，所述抗氧化组合物作为添加剂，加入食品、饲料、化妆品、营养保健品或药品中，提高产品稳定性。
10.根据权利要求1-6任一项抗氧化组合物的用途，所述抗氧化组合物用于延缓油脂、维生素、类胡萝卜素的氧化过程。
11.根据权利要求7-8任一项添加剂制剂的用途，其特征在于所述制剂用于延缓食品、饲料、化妆品、营养保健品、药品中有效成分的氧化过程。
12.根据权利要求7-8任一项添加剂制剂的用途，其特征在于所述制剂用于延缓油脂、维生素、类胡萝卜素的氧化过程。
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