CN114042109A - Traditional Chinese medicine composition and patch for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution and preparation method - Google Patents
Traditional Chinese medicine composition and patch for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution and preparation method Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- Health & Medical Sciences (AREA)
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution, which comprises the following traditional Chinese medicines: flos Magnoliae, fructus Xanthii, radix Angelicae Dahuricae, and fructus evodiae. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is suitable for preventing and/or treating sneezing, watery nasal discharge, nasal obstruction and rhinocnesmus of children. The traditional Chinese medicine composition has the advantages of few traditional Chinese medicine varieties, few medicines, obvious curative effect and no side effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition, a patch and a preparation method thereof, wherein the traditional Chinese medicine composition is capable of inducing resuscitation and stopping nasal discharge, and warming yang and consolidating the constitution.
Background
The common symptoms of the infantile rhinopathy include sneezing, rhinorrhea, nasal obstruction and rhinocnesmus, and the traditional Chinese medicine has many reasons for the infantile rhinopathy, for example, in the "Liu He Ji medical six Books" of the golden era: for allergic rhinitis, clear nasal discharge is also seen. The invention relates to the etiology of allergic rhinitis, and the Ming Dynasty's essentials for syndrome treatment: the clear nasal discharge is caused by cold brain and cold lung. For allergic rhinitis: the nasal obstruction is characterized by sudden and repeated rhinocnesmus, sneezing, thin nasal discharge, nasal obstruction and the like, which are common and multiple rhinopathy and are equivalent to allergic rhinitis in western medicine. It is usually caused by lung qi deficiency, insecurity of defensive exterior, and invasion of wind-cold with deficiency.
The nasal disease of the children can be treated by western medicine or traditional Chinese medicine, and the western medicine treatment can adopt the following treatment schemes: 1. an antihistamine drug: the second generation or novel H1 antihistamine for oral or nasal administration is recommended to be effective in relieving symptoms such as nasal itching, sneezing and watery nasal discharge, and is the first therapeutic drug for mild intermittent and mild persistent allergic rhinitis. The treatment course is usually not less than 2 weeks. 2. Nasal glucocorticoids: is the first choice medicine for treating severe persistent allergic rhinitis, can also be applied to mild patients, and has the effect of improving symptoms such as nasal obstruction, watery nasal discharge, sneeze, rhinocnesmus and the like, and the treatment course is at least 4 weeks. 3. Anti-leukotriene drugs: is an important medicine for treating moderate and severe allergic rhinitis, is particularly suitable for children with lower respiratory tract symptoms (such as airway hyperresponsiveness, bronchial asthma and the like), and is often used together with nasal spray or inhaled glucocorticoid. 4. Chromone class of drugs: has certain effect on relieving nasal symptoms, but has slow effect. It can also be used for preventing pollen of pollen allergic people before spreading season. The eye drop is effective in relieving eye symptoms. 5. Decongestants: when the nasal obstruction is serious, the nasal decongestant with low concentration can be properly applied, and the continuous application is not more than 7 days. The use of oxymetazoline-based or xylometazoline-based children's preparations is recommended, and the use of naphazoline-containing preparations is prohibited. 6. Saline nasal irrigation: is an auxiliary treatment method for improving symptoms, cleaning nasal cavity and recovering nasal mucosa function, and the normal saline or 1-2% hypertonic saline is recommended. In the traditional Chinese medicine treatment scheme, cold pathogen is taken as the main component, and when the nasal discharge is marked by clear nasal discharge, pungent and warm exterior-releasing medicines can be adopted, such as: tongqiao Biyan Keli (rhinitis treating granule). When turbid nasal discharge is the main reason after the interior heat is removed, the combination of relieving stuffy nose and clearing away interior heat can be adopted as the following medicines: nasosinusitis oral liquid and nasosinusitis resuscitation inducing granule.
Patent document CN201710429496.8 discloses an ointment for treating sinusitis, which comprises the following components: flos Magnoliae, Bulbus Fritillariae Cirrhosae, herba Schizonepetae, semen Strychni, radix Angelicae Pubescentis, radix Scutellariae, rhizoma Ligustici, herba Menthae, medulla Tetrapanacis, furnace soil, radix Codonopsis, cortex Cinnamomi, radix Angelicae Dahuricae, herba Andrographitis, radix rehmanniae, rhizoma Chuanxiong, periostracum Cicadae, herba asari, rhizoma Zingiberis, radix Paeoniae alba, fructus evodiae, radix Glycyrrhizae, fructus forsythiae, fructus Xanthii, radix Paeoniae Rubra, herba Patriniae, ramulus Luffae, radix Angelicae sinensis, Bulbus Allii Fistulosi, rhizoma Zingiberis recens and yellow wine, and has good relieving and treating effects on chronic sinusitis.
Therefore, although the traditional Chinese medicine formula of the patent documents comprises flos magnoliae, fructus xanthil, radix angelicae dahuricae and fructus evodiae, the application of the medicine in relieving stuffiness and stopping nasal discharge, warming yang and consolidating the constitution is not involved, and the variety of the traditional Chinese medicines in the whole medicine formula is up to 30, so that the drug use risk of children is increased undoubtedly.
Therefore, there is a need to develop a traditional Chinese medicine composition for inducing resuscitation, stopping nasal discharge, warming yang and strengthening the body resistance, which has the advantages of less medicine consumption, obvious curative effect and no side effect.
The present invention has been made in view of the above circumstances.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for dredging orifices, stopping nasal discharge, warming yang and consolidating the constitution, which has the advantages of less medicine consumption, obvious curative effect and no side effect.
In order to realize the purpose of the invention, the invention provides a traditional Chinese medicine composition for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution, which comprises the following traditional Chinese medicinal materials: flos Magnoliae, fructus Xanthii, radix Angelicae Dahuricae, and fructus evodiae.
Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 1-10 parts of magnolia flower, 1-5 parts of cocklebur fruit, 1-10 parts of angelica dahurica and 1-5 parts of fructus evodiae.
Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 6 parts of magnolia flower, 3 parts of cocklebur fruit, 6 parts of angelica dahurica and 3 parts of fructus evodiae.
Further optionally, the Chinese medicinal composition is powder.
The invention also provides a preparation method of the traditional Chinese medicine composition for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution, which comprises the following steps:
weighing the medicinal materials according to the weight parts and mixing;
pulverizing the weighed Chinese medicinal materials to 50-100 meshes.
The invention also provides a patch which comprises a carrier and any one of the traditional Chinese medicine compositions.
Further optionally, the patch also comprises yellow wine, and the yellow wine and the Chinese medicinal composition are mixed to be prepared into paste and then are placed on the carrier to prepare the patch.
Further optionally, the ratio of the traditional Chinese medicine composition to the yellow wine is 1:1 to 2.
Further optionally, the carrier comprises at least one of a non-woven fabric, gauze, adhesive tape, plaster, or medical rubber.
The invention also provides application of the traditional Chinese medicine composition or the patch in preparation of a medicine, wherein the medicine is used for preventing and/or treating infantile diseases, and the diseases are selected from sneeze, watery nasal discharge, nasal obstruction and rhinocnesmus.
The medicinal materials used in the invention have the following effects:
flos Magnoliae: warm in nature and pungent in flavor, enter lung and stomach meridians. It is the essential herb for treating nasosinusitis headache because it is pungent and warm in nature, fragrant and flees, ascends the head and face, and is good at freeing nasal orifices;
fructus xanthil: pungent and bitter in flavor, warm in nature, and toxic. It enters lung meridian. Has effects in dispelling pathogenic wind and cold, relieving nasal obstruction, dispelling pathogenic wind and dampness, and relieving pain.
Radix angelicae: enter yangming, induce resuscitation with aromatics, dispel wind and alleviate pain. It is indicated for swelling and pain of gum, cheek and toothache.
Evodia fruit: pungent, bitter and hot in flavor. It is toxic and enters liver, spleen, stomach and kidney meridians. Has effects in dispelling cold, relieving pain, warming middle warmer, and tonifying yang.
The inventor of the invention carries out deep research on the infantile rhinopathy on the basis of years of traditional Chinese medicine clinical experience, and considers that the pathogenesis of the infantile rhinopathy is as follows: lung qi is weak, defensive exterior is not firm, wind-cold invades by deficiency, attacks nasal orifices, and acts positively, lung qi cannot be regulated, body fluid stops accumulating, nasal orifices are blocked, sneezing and thin nasal discharge are caused, spleen qi cannot be distributed to lung due to spleen deficiency, lung qi is also deficient, the root of lung qi is in kidney, kidney deficiency cannot take hold, qi cannot return to original qi, and wind pathogen invades the interior. Therefore, allergic rhinitis is diseased in the lung, but its pathological changes have a certain relationship with spleen and kidney. Aiming at the etiology and pathogenesis, the treatment principle is as follows: in the acute phase: mainly takes the treatment principle of expelling wind and clearing away cold, and tonifying qi and consolidating exterior; the treatment principle of tonifying spleen and kidney is the main principle in the remission stage. The invention combines the Chinese medicinal materials of magnolia flower, siberian cocklebur fruit, dahurian angelica root and evodia fruit to prepare powder or further prepares the powder into a patch for treating the infantile rhinopathy, and the formula thinking is as follows: flos Magnoliae is the monarch drug, and its pungent and warm property is selected to achieve the effect of relieving stuffy nose, and fructus Xanthii and radix Angelicae Dahuricae are ministerial drugs to enhance the effects of relieving stuffy nose and pain. The fructus evodiae is added to promote kidney yang circulation, expel wind and dispel cold, and fundamentally solve the symptoms of rhinitis induced by cold.
When the infantile rhinopathy is treated, the traditional Chinese medicine composition is generally prepared into a patch and then is externally applied, and the traditional Chinese medicine composition is specifically used for treating the infantile rhinopathy: the traditional Chinese medicine patch is respectively stuck to the Tiantu acupoint, the Shanzhong acupoint and the Dazhui acupoint, one plaster is applied every day for two hours every day, one treatment course is 7 days, the aim of solving symptoms is basically achieved, and the treatment course is solidified to basically achieve the standard of clinical cure
Compared with the prior art, the invention has the beneficial effects that:
(1) the traditional Chinese medicine composition and the patch have good curative effect on the infantile rhinopathy, and have the advantages of reasonable formula, no toxic or side effect, and safe and reliable curative effect;
(2) the traditional Chinese medicine composition and the patch have simple traditional Chinese medicine components, and reduce the adverse reaction of the medicine to children.
(3) The traditional Chinese medicine composition and the patch are suitable for infants and children to take, can enhance the immune function of the infants and children, and avoid the pain of injection and transfusion.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
Example 1
Taking 6g of flos magnoliae, 3g of fructus xanthil, 6g of radix angelicae and 3g of fructus evodiae; pulverizing the weighed Chinese medicinal materials, and sieving with a 80-mesh sieve to obtain the Chinese medicinal composition.
Examples 2 to 8
Examples 2-8 are the preparation of the composition of example 1, using the pharmaceutical ingredients and process conditions shown in table one.
Table one: the components of the Chinese herbs in examples 2-8 and the process conditions
Example 9
The present embodiment is a method for preparing the traditional Chinese medicine composition of embodiment 1 into a traditional Chinese medicine patch, and the method comprises the following steps:
the traditional Chinese medicine composition in the embodiment 1 is mixed with yellow wine according to the ratio of 1:1 to be prepared into paste, and then the paste is placed in the middle of medical gauze to obtain the traditional Chinese medicine composition.
Example 10
The traditional Chinese medicine composition in the embodiment 1 is mixed with yellow wine according to the ratio of 1:1.5 to be prepared into paste, and then the paste is placed in the middle of medical gauze to obtain the traditional Chinese medicine composition.
Example 11
The traditional Chinese medicine composition in the embodiment 1 is mixed with yellow wine according to the ratio of 1:2 to be prepared into paste, and then the paste is placed in the middle of medical gauze to obtain the traditional Chinese medicine composition.
Test examples
The experimental example is a clinical study on the treatment of infantile rhinopathy by using the traditional Chinese medicine patch. Case selection: randomly selecting 100 children with rhinopathy in Beijing Huimin Chinese medicinal hospital, wherein the average age of the children is 6 years old for 2 months, and the ratio of male to female is 1: 1;
the diagnosis basis is as follows: 1. sneezing, nasal discharge, nasal obstruction, nasal itching and other symptoms appear
2. Nasal mucosa is red and swollen or pale with red and swollen, and clear and turbid nasal discharge can be seen.
3. The symptoms are obviously aggravated when the patients meet the allergic substances
4. Blood routine examination increased total IGE or increased percentage of eosinophils.
According to the severity of symptoms of the children, the children are classified into four grades of mild, severe and severe, wherein the mild grade corresponds to the symptoms: sneezing occasionally in the morning without obvious discomfort. The lighter grades correspond to symptoms: sneezing is obvious in the morning, even nasal itching is caused, and aggravation is caused by wind cold, and no obvious discomfort exists. The heavier grade corresponds to symptoms: sneezing and clear nasal discharge are obvious in the morning, and clear nasal discharge is alternately accompanied by obvious nasal obstruction in the rest of the time. Severity levels correspond to symptoms: clear and turbid nasal discharge, severe nasal obstruction and even mouth opening and breathing with headache, which affect learning and life.
The treatment method comprises the following steps: the patch prepared in example 9 was applied to Tiantu acupoint, Tanzhong acupoint and Dazhui acupoint, one daily for two hours, and 7 days for one treatment period for two weeks.
Observation indexes are as follows: according to the cooperation and understanding degree of children, the visual simulation scale is adopted to respectively evaluate the clinical curative effect of the general symptoms and the nasal classification symptoms before and after treatment, and the evaluation criteria are as follows: the higher the score of each symptom from 0 to 10, the more obvious the improvement; the score assignment for each symptom is shown in table two.
Table two: symptom score assignment
The results of clinical experiments are as follows: the symptoms after diagnosis and treatment are divided into invalid, effective and recovery, wherein the total score is 0, 1-15, 16-18 and 19-30. The clinical test results after administration are shown in Table three.
Table three: clinical trial results after drug administration
| Number of cases before administration | Number of cure cases | Number of effective cases | Effective number of cases | Number of invalid cases | |
| Light and slight | 10 | 8 | 1 | 1 | 0 |
| Is lighter | 26 | 18 | 5 | 2 | 1 |
| Heavy weight | 42 | 12 | 19 | 8 | 3 |
| Severe severity of disease | 22 | 1 | 5 | 10 | 6 |
After two treatment courses, the symptoms of rhinocnesmus, sneeze, nasal obstruction and rhinorrhea of most of children patients are effectively improved to a certain extent, and no obvious adverse reaction is found in the treatment process.
The case analysis was as follows:
the patients male, 5 years old, appeared sneezing and nasal itching in the morning after the beginning of autumn, and the symptoms became worse when encountering cold air, and the body was examined to see that the nasal mucosa was pale and swollen with large amount of thin nasal discharge, the tongue was fat, large, light, white in fur and deep in pulse. Dialectical analysis: wind-cold attacking the exterior. The nasal paste is applied to Tiantu acupoint, Tanzhong acupoint and Dazhui acupoint one day, and sneezing is reduced obviously after 3 consecutive days, and nasal itching is stopped. The symptoms are healed after 1 week.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for dredging orifices, stopping nasal discharge, warming yang and consolidating constitution is characterized by comprising the following traditional Chinese medicinal materials: flos Magnoliae, fructus Xanthii, radix Angelicae Dahuricae, and fructus evodiae.
2. The traditional Chinese medicine composition for relieving stuffy nose and warming yang and consolidating constitution as claimed in claim 1, which is characterized by comprising the following traditional Chinese medicinal materials in parts by weight:
3. the traditional Chinese medicine composition for relieving stuffy nose and warming yang and consolidating constitution as claimed in claim 2, which is characterized by comprising the following traditional Chinese medicinal materials in parts by weight:
4. the Chinese medicinal composition for relieving stuffiness and nasal discharge and warming yang to consolidate constitution according to any one of claims 1 to 3, wherein the Chinese medicinal composition is powder.
5. A method for preparing the Chinese medicinal composition for relieving stuffiness and nasal discharge and warming yang to consolidate the constitution as claimed in any one of claims 1 to 4, which comprises the following steps:
weighing the medicinal materials according to the weight parts and mixing;
pulverizing the weighed Chinese medicinal materials to 50-100 meshes.
6. A patch characterized by comprising a carrier and the Chinese medicinal composition of any one of claims 1 to 4.
7. The patch according to claim 6, further comprising yellow wine, wherein the yellow wine is mixed with the Chinese medicinal composition to form a paste, and the paste is placed on the carrier to obtain the patch.
8. The patch according to claim 7, wherein the ratio of the traditional Chinese medicine composition to the yellow wine is 1:1 to 2.
9. The patch of any one of claims 6 to 8 wherein said carrier comprises at least one of a non-woven fabric, gauze, adhesive, plaster or medical rubber.
10. Use of a traditional Chinese medicine composition according to any one of claims 1 to 4 or a patch according to any one of claims 6 to 9 for the manufacture of a medicament for the prevention and/or treatment of a pediatric condition selected from the group consisting of sneezing, watery nasal discharge, nasal congestion and rhinocnesmus.
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Citations (3)
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|---|---|---|---|---|
| CN101152253A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating various rhinitis |
| CN107137688A (en) * | 2017-06-08 | 2017-09-08 | 王永月 | A kind of ointment for treating nasosinusitis |
| CN113521129A (en) * | 2021-08-25 | 2021-10-22 | 许红军 | Traditional Chinese medicine formula for treating rhinitis and preparation method thereof |
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|---|---|---|---|---|
| CN101152253A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating various rhinitis |
| CN107137688A (en) * | 2017-06-08 | 2017-09-08 | 王永月 | A kind of ointment for treating nasosinusitis |
| CN113521129A (en) * | 2021-08-25 | 2021-10-22 | 许红军 | Traditional Chinese medicine formula for treating rhinitis and preparation method thereof |
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| 丁冰等: "穴位贴敷治疗过敏性鼻炎选穴及用药规律", 《吉林中医药》 * |
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